Yu dɔn ɛva wɔnda aw dɛn fɛn di mɛrɛsin ɛn vaysin dɛn we wi de yuz tide? Ɔ aw fɔ mek di tritmɛnt fɔ sik dɛn lɛk ADHD, we kin apin to pikin dɛn, bɛtɛ mɔ? Di ansa na ‘klinik risach’. Na dat wi kin kɔl ``Klinik Trayal'' insay Inglish. We yu yɛri dis nem, i go tan lɛk se i siriɔs smɔl. Bɔt fɔ tru, dis na di bɛst ɛn sayɛns we fɔ gi pipul dɛn nyu tin dɛn we dɛn dɔn fɛn pan mɛrɛsin sayɛns. So lɛ wi tɔk bɔt dis jɔs tide.
Fɔ tɔk am simpul wan, wetin na klinik trial?
Klinik trial na sayɛns stɔdi we de tɛst if nyu tritmɛnt, drɔg, ɔ mɛrɛsin divays wok ɛn sef fɔ wan patikyula sik. I tan lɛk we wi mek nyu risɛp, wi kin gi wi famili fɔ test, fiks ɛni fɔlt, dɔn wi kin gi am to di gɔst dɛn afta wi dɔn kɔnfyus se i fayn.
Dis risach nɔto jɔs fɔ fɛn nyu tritmɛnt. I de tɔk bak bɔt aw fɔ mek di tritmɛnt dɛn we de naw bɛtɛ, nyu we fɔ no if pɔsin gɛt sik, ɛn aw fɔ avɔyd sik bifo i kam. Volontia dɛn de put an pan dis. Bɔt ɔl dis kin apin insay wan rili strikt sɛt ɔf lɔ ɛn ɛtikul fɔm.
Wetin na di pat dɛm fɔ dis risach?
Dɛn nɔ kin gi ɔlman nyu mɛrɛsin wan tɛm. I tan lɛk se yu de klaym stej, i de go bifo stɛp bay stɛp, stej bay stej. Dɛn kin du dis fɔ mek shɔ se di wan dɛn we de tek pat sef pasmak. Na 4 stej dɛn mɔ de.
| Tɛm | Men rizin ɛn ɛksplen |
|---|---|
| Faz I we yu de du | Dis na di fɔs tin we yu fɔ du. Na ya, dɛn kin gi wan rili smɔl grup fɔ pipul dɛn (sɔntɛm sɔm pipul dɛn we gɛt wɛlbɔdi) di nyu tritmɛnt. Di men gol na fɔ si if i sef . Dat min se, di men tin dɛm wae dɛn kin stɔdi ya na ɔmɔs pan di mɛrɛsin fɔ gi ɛn us sayd ɛfɛkt kin apin. |
| Faz II | If di fɔs pat dɔn wok fayn, di nɛks pat kin kam. Na ya, dɛn kin gi di tritmɛnt to big grup fɔ pipul dɛn we gɛt di sik we dɛn want fɔ gɛt. Na ya, wi de luk if dis tritmɛnt rili de wok (effective) . Dat min se, if di sik dɔn ridyus, if di sik dɔn wɛl, ɛn ɔda tin dɛn Wi kin gɛda mɔ infɔmeshɔn bak bɔt sef. |
| Faz III | Dis na di stej we big ɛn impɔtant pas ɔl. Wan big grup fɔ pasɛnt dɛn (sɔntɛnde, bɔku bɔku pipul dɛn) kin tek pat ya. Dɛn kin kɔmpia di nyu tritmɛnt wit di standad tritmɛnt we de naw ɔ sɔm tɛm dɛn kin kɔmpia am wit wan plesibo. Di aim na fɔ si if di nyu mɛrɛsin bɛtɛ pas di mɛrɛsin we de naw, i nɔ gɛt bɛtɛ sayd ɛfɛkt, ɛn udat de gɛt mɔ bɛnifit. If dɛn dɔn dis stej fayn fayn wan, dɛn kin gri fɔ mek dɛn pul di mɛrɛsin na di makit. |
| Faz IV | Dɛn kin kɔl dis bak ‘pɔst-makɛtin stɔdi’. Dat min se, wan stɔdi we dɛn du afta dɛn dɔn gri fɔ di mɛrɛsin ɛn ɔlman kin ebul fɔ gɛt am . Na ya, tawzin ɔ ivin ɔndrɛd tawzin pipul dɛn de yuz di mɛrɛsin, so i pɔsibul fɔ gɛda infɔmeshɔn bɔt di sayd ɛfɛkt dɛn we nɔ kin apin ɔltɛm ɔ di ifɛkt dɛn we kin de fɔ lɔng tɛm we dɛn nɔ bin dɔn no insay di fɔs stej dɛn. |
Aw yu kin pik pɔsin fɔ du risach?
Dis na tin bak we rili impɔtant. Bɔku tɛm, insay Faz III, dɛn kin sheb di wan dɛn we tek pat to tu ɔ mɔ grup dɛn. Wan grup kin gɛt di nyu tritmɛnt (Tritmɛnt Grup), ɛn di ɔda grup kin gɛt di standad tritmɛnt we de naw ɔ wan ``Placebo'' (Kɔntrol Grup).
Di tin we impɔtant pas ɔl na dat dɛn kin yuz randomization fɔ disayd udat go go na us grup. I tan lɛk se yu de flip kɔyn. Dɛn kin du dis fɔ mek dɛn nɔ gɛt bias pan di rizɔlt frɔm di disizhɔn dɛn we dɛn kin disayd bay wetin di wan dɛn we de du di risach ɔ di sikman dɛn lɛk dɛnsɛf. Dis kin mek di tin dɛn we dɛn kin fɛn kin kɔrɛkt ɛn dɛn kin abop pan dɛn.
Wetin na `Placebo`?
` plesibo` Plɛsɛbo na pil, likwid, ɔ injɛkshɔn we tan lɛk rial drɔg bɔt nɔ gɛt ɛni aktif famasi ingridiɛnt. Dɛn kin yuz am fɔ no difrɛns pan di rial ifɛkt dɛm we nyu drɔg gɛt frɔm di saykilɔjik ifɛkt dɛm. Bifo pɔsin tek pat pan stɔdi, dɛn kin tɛl am klia wan se dɛn kin yuz ``plesbo''.
ADHD ɛn pikin dɛn klinik risach
ADHD (Attention-Deficit/Hyperactivity Disorder) na wan sik we kin apin to pikin dɛn. Dɛn dɔn du bɔku klinik trial dɛn ɔlsay na di wɔl fɔ fɛn di tritmɛnt dɛn we go wok ɛn we nɔ bad fɔ dis sik.
- Drug Tritment: Dɛn dɔn kɔnfyus di efficacy ɛn sef fɔ difrɛn mɛrɛsin dɛn we dɛn kin yuz fɔ ADHD tru risach lɛk dis.
- Bihayvya Tritmɛnt : Dɛn de du risach bak bɔt aw fɔ mɛn di sik bay we dɛn de chenj di pikin in bihayvya we dɛn nɔ tek mɛrɛsin.
- Kɔmbayn tritmɛnt dɛm: Sɔm risach de luk fɔ di rizɔlt dɛm wae yu de yuz ɔl tu di mɛrɛsin ɛn di tritmɛnt fɔ bihayvya togɛda.
Apat frɔm dat, dɛn de du risach bak bɔt di tin dɛn we de apin na di envayrɔmɛnt we kin mek pɔsin gɛt ADHD. fכ egzampl, dεn de invεstigat fכ εkspos to nyurotoksin lεk lid εn difrεn saykososial situeshכn dεm fכ no if dεn de kכntribyut to divεlכpmεnt fכ ADHD.
Impɔtant kwɛstyɔn dɛn fɔ aks yu dɔktɔ
If yu ɔ yu pikin de tink bɔt fɔ tek pat pan klinik trial, mek shɔ se yu tɔk to yu dɔktɔ ɛn aks dɛn kwɛstyɔn ya bifo yu disayd fɔ du sɔntin.
- Wetin na di men rizin fɔ dis stɔdi?
- Wetin dɛn dɔn si pan risach we dɛn dɔn du trade bɔt dis tritmɛnt?
- Wetin kin apin to mi sik ilɛksɛf a gɛt dis tritmɛnt ɔ a nɔ gɛt am?
- Wetin na di standad tritmɛnt dɛm wae de naw fɔ dis sik?
- Aw dis nyu risach kɔmpia to standad tritmɛnt dɛm?
- Wetin na di risk ɛn bɛnifit dɛn we a kin gɛt?
- Wetin a fɔ du if a nɔ fil fayn we a de du di risach?
- A kin pul in an pan di risach ɛnitɛm?
Bay di ansa to dɛn kwɛstyɔn ya, yu kin disayd fɔ du di rayt tin ɛn klia wan. Mɛmba se if yu fɔ tek pat ɔ nɔ fɔ tek pat, na yu disayd nɔmɔ.
Mɛsej we dɛn kin kɛr go na os
- Klinik trial na sayɛns stɔdi we dɛn dɔn plan fɔ du gud gud wan ɛn we de sho se nyu tritmɛnt dɛn sef ɛn i go wok fayn.
- Dɛn kin du dɛn tin ya insay difrɛn stej dɛn fɔ mek shɔ se di wan dɛn we tek pat kin sef.
- Dis risach impɔtant pasmak fɔ fɛn bɛtɛ tritmɛnt fɔ kɔndishɔn lɛk ADHD.
- Fɔ tek pat pan risach na sɔntin we pɔsin kin du fɔ insɛf. Yu gɛt rayt fɔ pul yu mɔni ɛnitɛm.
- Bifo yu tek pat pan ɛni risach, i impɔtant fɔ tɔk bɔt ɔl di ditil dɛm, di risk dɛm, ɛn bɛnifit dɛm wit yu dɔktɔ ɛn gɛt klia ɔndastandin.
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