Yu tink se wi fɔ no gud gud wan bɔt mɛrɛsin dɛn we de mek pɔsin nɔ gɛt bɛtɛ blɔd?

Sɔntɛm yu kin fil nɔs ɛn vɔmit sɔntɛnde, nɔto so? I rili nɔ kɔmfyut. So tide wi go tɔk bɔt wan kayn mɛrɛsin we kin ɛp fɔ kɔntrol ɛn stɔp dɛn tin ya lɛk nɔs ɛn vɔmit. Na dɛn tin ya wi kin kɔl antiemetic drugs . Lɛ wi si wetin na dɛn tin ya, aw dɛn de wok, ɛn ustɛm dɛn de yuz dɛn.

Wetin na dɛn mɛrɛsin ya we de mek pɔsin nɔ gɛt bɛlɛ?

Fɔ tɔk am simpul wan, ``Antimetic drugs`` na drɔgs we dɛn kin gi fɔ mek yu nɔ gɛt nɔs ɛn vɔmit, ɔ fɔ trit am if i apin. ``Anti-`` min ``against.'' Di wɔd ``-emetic`` kɔmɔt frɔm di wɔd ``emesis``. Insay mɛrɛsin, dɛn kin yuz di wɔd ``(emesis)`` bak fɔ vɔmit. So, dis na drɔgs we dɛn kin gi fɔ mek i nɔ vɔmit.

difrεn kayn ``Antimetic`` mεdikeshכn dεm de, we na difrεn ``drug klas``. Sɔm pan dɛm yu kin gɛt frɔm di famasi we yu nɔ gɛt prɛskrishɔn (dɛn kɔl dɛn ``Over-the-counter`` ɔ ``OTC`` mɛrɛsin dɛm). Bɔt sɔm pan dɛn kin jɔs tek wit prɛskrishɔn frɔm dɔktɔ (`` prɛskrishɔn`` mɛrɛsin). Bikɔs bɔku tin dɛn de we kin mek pɔsin nɔs ɛn vɔmit, sɔm patikyula ``Antimetic`` mɛrɛsin dɛn de we fayn fɔ ɛni wan pan di tin dɛn we kin mek pɔsin nɔ fil fayn.

Ustɛm a nid mɛrɛsin fɔ mek a nɔ vɔmit?

Naw yu go mɔs de tink se, ‘So ustɛm a go nid mɛrɛsin lɛk dis?’

Fɔ vɔmit na rili sɔmtɛm we wi bɔdi kin protɛkt wi bɔdi. Tink bɔt am, if yu it it we dɔn pwɛl, ɔ if yu bɛlɛ de at (bɛlɛ flu), i bɛtɛ fɔ vɔmit ɛn pul di pɔyzin kɔmɔt na yu bɔdi.

Bɔt if pɔsin de vɔmit bad bad wan ɔ i kin apin bɔku tɛm, i kin mek i gɛt siriɔs wɛlbɔdi prɔblɛm. Fɔ ɛgzampul:

• Bɔn kin ivin brok, mɔ pan di wan dɛn we dɔn ol.
• Di wata we nɔ de na di bɔdi na we di wata we de kɔmɔt na di bɔdi de lɔs.
• di εsophageal rupture, we dεn kכl bak Boerhaave’s syndrome.
• I nɔ kin want fɔ it igen .
• Nyutrishɔn dɛfisiɛns (`Malnutrition`).
• Di chenj dɛn we pɔsin kin gɛt na in maynd.
• Tut inɛmel kin west.
• di wund dεm we dεn sכj kin opin bak (`Riopening of surgical wounds`).

Bikɔs ɔf tin dɛm lɛk dis, sɔmtɛm dɔktɔ dɛn kin gi dis ``Antimetic`` mɛrɛsin fɔ mek yu nɔ vɔmit ɔ fɔ stɔp fɔ vɔmit we dɔn bigin.

Ɛp fɔ mek yu nɔs ɛn vɔmit ɔltɛm

If yu gɛt siriɔs ɔ lɔng tɛm nɔs ɛn vɔmit, yu dɔktɔ kin gi yu wan ``Antimetic'' mɛrɛsin. Lɛ wi luk sɔm ɛgzampul dɛn.

• Nausea ɛn vɔmit we kin mek pɔsin gɛt raytin ɛn kemotɛrapi (CINV): Nɔs ɛn/ɔ vɔmit na kɔmɔn sayd ɛfɛkt dɛn we kemotɛrapi kin gɛt. Rɛdyeshɔn tɛrapi to di bren, di gastrointestinal trakt, ɔ di liva kin mek dɛn sayd ɛfɛkt ya bak. Fɔ dis rizin, dɔktɔ dɛn kin se yu fɔ tek wan mɛrɛsin we de mek yu nɔ gɛt bɛlɛ we yu de tek kemotɛrapi ɔ redyushɔn tɛrapi. Dis na bikɔs if yu nɔs ɛn vɔmit pasmak, dat kin rili denja fɔ pɔsin we gɛt kansa.
• Nɔs ɛn vɔmit we yu gɛt bɛlɛ (dɛn kin kɔl am bak `mɔnin sik`): Sɔm dɔktɔ dɛn kin se yu fɔ bay `antiemetics` fɔ dis. semweso, fכ `hyperemesis gravidarum`, dכkta dεm kin rεkכmand fכ it ova di kכnta כ prεskrishכn `antiemetics`.

Di tin we impɔtant pas ɔl na fɔ tɔk to yu dɔktɔ bɔt ustɛm ɛn aw fɔ yuz dɛn `(Antimetic)` mɛrɛsin ya. Sɔntɛnde, mɔ na situeshɔn lɛk `(CINV)`, yu kin nid fɔ yuz mɔ pas wan `(Antimetic)`. If yu gɛt nɔs ɛn vɔmit we yu gɛt bɛlɛ , yu fɔ rili tɔk to dɔktɔ bifo yu tek ɛni mɛrɛsin na di famasi.

Wan mɛrɛsin fɔ mek yu nɔs ɛn vɔmit wantɛm wantɛm

Sɔntɛnde, we nɔs ɛn vɔmit kin apin, dɔktɔ dɛn kin gi dis ``Antimetic`` mɛrɛsin fɔ mek i nɔ apin. Tink bɔt am dis we.

Bɔrku mɛrɛsin, lɛk anestetik (we dɛn kin yuse fɔ anestezi) ɛn opioid , kin mek yu nɔs ɛn vɔmit as sayd ɛfɛkt. Dɔktɔ dɛn kin yuz dɛn mɛrɛsin ya fɔ tin dɛn lɛk ɔpreshɔn. So, fɔ mek yu nɔ gɛt nauses ɛn vɔmit afta yu du ɔpreshɔn (postoperative nausea and vomiting - PONV), dɛn go gi yu wan antiemetic.

Vertigo ɛn muvmɛnt sik kin mek bak yu nɔs ɛn vɔmit. If yu go de na say we yu go gɛt dɛn kayn sik ya (fɔ ɛgzampul, we yu de travul fɔ lɔng tɛm, lɛk na bɔs ɔ ship), yu dɔktɔ go tɛl yu fɔ tek wan mɛrɛsin we de mek yu nɔ gɛt bɛlɛ.

Apat frɔm dis, ɔda tin dɛn kin de we dɔktɔ kin gi yu ``Antimetic''.

Us mɛrɛsin dɛn de fɔ stɔp fɔ vɔmit?

Naw lɛ wi si us kayn mɛrɛsin dɛn de we de mek pɔsin nɔ gɛt bɛlɛ. Na sɛvin kategori dɛn de fɔ ``Antimetic'' drɔgs. Bɔku kayn drɔgs de na ɛni wan pan dɛn.

1. Sεrotonin antagonist dεm

dis na wan kayn ``Antimetic`` we dεn kin gi spεshal fכ trit nכs εn vכmit. Sɔm ɛgzampul dɛn bɔt dɛn tin ya na:

• `Granisetron (Kytril®)`
• `Ondansetron (Zofran®)`
• `Palonosetron (Aloxi®)`

Dis mɛrɛsin na di US Food and Drug Administration ( FDA ) dɔn gri fɔ mek dɛn nɔ gɛt dɛn tin ya:

• `CINV` (kansa tritmɛnt-indyuz nɔs ɛn vɔmit) ɛn nɔs ɛn vɔmit we kin kam bikɔs ɔf redyushɔn tɛrapi.
• `PONV` (dat min se yu go gɛt nɔs ɛn vɔmit afta yu dɔn ɔpreshɔn).

Bɔt sɔntɛnde, dɔktɔ dɛn kin gi dɛn mɛrɛsin ya fɔ ɔda sik dɛn. Dɛn kɔl dis `ɔf-lɛbul` yus, we min se dɛn de yuz dɛn fɔ ɔda tin dɛn pas di wan dɛn we di FDA dɔn gri fɔ.

2. Di tin dɛn we dɛn kin yuz fɔ fɛt di sik we dɛn kɔl antihistamin

Antihistamin, mɔ di wan dɛn we de blok di histamine 1 (H1) riseptɔ, na dɛn dɔktɔ dɛn kin yuz mɔ fɔ kɔntrol di sayn dɛn we gɛt fɔ du wit alɛji. Bɔt sɔm pan dɛn tin ya na FDA-apruv fɔ mek dɛn nɔ gɛt ɛn trit nɔs ɛn vɔmit we kin kam bikɔs ɔf muvmɛnt sik ɛn vertigo. Sɔntɛnde, dɔktɔ dɛn kin gi dɛn ɔf-lɛbul if ɔda antiɛmɛtik fɔ nɔs ɛn vɔmit we uman gɛt bɛlɛ nɔ wok. Na sɔm kayn antihistamin fɔ vɔmit:

• `Dimenhydrinate` tablɛt dɛn we pɔsin kin it (`Dramamine®`)
• Difenhaydramin kapsul ɔ tablɛt (Benadryl®) .
• Vitamin B6 wit `Doxylamine succinate` – Dis na di fכs layn tritmεnt fכ nכs εn vכmit we uman bεlε.
• `Mɛklizin (Antivɛt®, Bɔnin®, Dramamin-N®)`
• `Promɛtazin (Phenergan®)`

Mεdikeshכn dεm lεk diphenhydramine εn dimenhydrinate kin εp bak fכ mek PONV (post-operative nausea εn vכmit), bכt dεn nכ kin bi di fכs layn mεdikeshכn fכ am.

3. Glukokɔtikoyd dɛn

Glucocorticoids (ɔ corticosteroids) na wan klas ɔf drɔgs we dɔktɔ dɛn kin yuz mɔ fɔ dɛn anti-allergic ɛn anti-inflammatory prɔpati. Bɔt sɔm glukɔkɔtikoyd dɛn kin wok bak lɛk antiɛmɛtik.

Dexamethasone (Baycadron Elixer®, Decadron®, Zema-Pak®, ɛn ɔda brand dɛm) na di men glucocorticoid we dɔktɔ dɛn kin yuz fɔ mek dɛn nɔ gɛt CINV (kansa tritmɛnt-induced nausea) ɛn PONV (post-operative nausea).

Sɔntɛnde dɔktɔ dɛn kin gi wan `(Glucocorticoid)` wit ɔda kayn `(Antimetic)` fɔ mek yu nɔ gɛt nɔs ɛn vɔmit. Bɔt nɔ lɛk sɔm ɔda `(Antimetic)`, `(Glucocorticoids)` nɔ kin ebul fɔ mɛn nɔs ɛn vɔmit wans i dɔn bigin. Dat min se, dɛn jɔs gi dɛn fɔ mek i nɔ apin.

4. Antikolinɛrijik dɛn

Anticholinergics (we dɛn kin kɔl bak antimuscarinics) na wan kayn mɛrɛsin we de blok di akshɔn fɔ wan kemikal we dɛn kɔl acetylcholine (wan nyurotransmitta). Dɛn kin ɛp fɔ trit difrɛn kayn tin dɛn (lɛk we pɔsin nɔ kin ebul fɔ urinary ɛn COPD), ɛn dɛn kin ɛp bak fɔ mek pɔsin nɔ fil fayn ɛn fɔ vɔmit.

Scopolamine (Maldemar, Scopace, Transderm Scop®) na di men antikolinerjik drɔg we dɛn kin yuz fɔ vɔmit. Dɔktɔ dɛn kin yuz am fɔ:

• Prɛvent `PONV` (pɔst-ɔpareshɔn vɔmit).
• Fɔ mek yu nɔ gɛt ɔ trit nɔys we kin kam wit ``moshɔn sik`` (vomit we yu de travul).

5. Nyurokinin-1 rεsεptכr antagonist dεm

di nyurokinin-1 (NK-1) risεptor antagonist dεm de wok bay we dεn de blכk wan nεchכral sכbstans na yu bren we dεn kכl nyurokinin we de mek yu nכs εn vכmit. Dɛn mɛrɛsin ya kin rili wok fɔ trit CINV (kansa-induced nausea) ɛn PONV (post-operative nausea). Dɛn gɛt bak tin dɛm wae de mek pɔrsin nɔr de wɔri (anxiolytic) ɛn wae de mek pɔrsin fil bad.

Di mɛrɛsin dɛn we de insay dis kategori na:

• `Aprepitant (Aponvie®, Ɛmɛnd®` ɛn `Sinvanti®)`
• `Fosaprepitant (Emend®` ɛn `Focinvez®)`
• `Netupitant` ɛn `palonosetron` kɔmbaynshɔn (`Akynzeo®)`
• `Rolapitant (Varubi®)`

6. Di wan dɛn we de agens di dopamin

Dopamine antagonist na wan kayn mɛrɛsin we de stɔp sɔm kayn sɛl dɛn na yu bren fɔ faya. Dɛn na men tritmɛnt fɔ sɔm kayn mɛntɛl hεlth kכndyushכn εn sεmtin dεm, mɔr di saykosis εn schizophrenia . Bɔt sɔm pan dɛn kayn tin ya kin ɛp bak fɔ mek pɔsin nɔ fil fayn ɛn fɔ vɔmit.

difrεn kayn dopamin antagonist dεm de we dεn kin yus fכ vכmit:

• `Amisulprayd (Barhemsys®)`
• ``Klɔrpromazin (Tɔrazin®)''.
• `Dropɛridɔl (Inapsin®)`
• `Halopɛridɔl (Haldol®)`
• `Mεtoklopramid (Reglan®, Gimoti®)`
• ``Olanzapin (Zyprexa®, Libalvi®, Simbyax®)`
• `Proklɔrpɛrazin (Kɔmpro®)`

Dopamin antagonist dεm na כda we fכ `CINV` (kansa-induced vomiting) we כda `(Antimetic)` mεdikeshכn dεm nכ de wok. Dɛn kin ɛp bak fɔ mek dɛn nɔ gɛt `PONV` (pɔst-ɔpareshɔn vɔmit).

7. Kanabanoyd dɛn

Kanabinoyd na wan klas ɔf kɔmpawnd dɛn we de insay di kanaba plant (marijuana). Dɛn kin tay pan di kanaba rεsεpכta dεm na yu bren, di gεstrointestinal sistεm, εn di imyun sεl dεm.

di kanabanoyd dεm we dεn mek na mכlikul dεm we dεn mek fכ miks di ifekt dεm we tεtrahaydrokanabinol (THC) de gi. Naw, tu kayn sintetik kanaba de na di makit fɔ yuz as antiemetics:

• `Dronabinol (Marinol®)`
• `Nabilɔn (Sɛsamɛt®)`

Dɛn tin ya na FDA-apruv fɔ CINV (kansa tritmɛnt-indyuz vɔmit), ɛn dɛn fɔ yuz dɛn nɔmɔ if fɔs layn antiɛmɛtik dɔn fel.

Cannabinoids na di nyu kayn antiemetic. Risach pipul dɛn stil de lan ɛn du risach bɔt aw dɛn de wok.

Aw wi kin gɛt dis mɛrɛsin? (Di we aw dɛn kin gi di mɛrɛsin)

Bɔku ``Antimetic`` mεdikeshכn dεm de insay mכr dan wan ``fכm``. Dɛn kin tan lɛk dis:

• Pils we dɛn kin tek bay mɔt, we min pils we dɛn kin swɛla ɔ we dɛn kin it.
• IV (intravenous) sכlushכn, we na likwid mεdikeshכn dεm we dεn gi insay wan vein.
• Injεkshכn insay yu mכsul (intramuscular).
• di pat dεm na di skin (transdεmal) – Dis na mεnli fכ Skopolamin (wan anticholinergic).
• Pil dɛn we de na di rɛktal (suppositories).

Dɛn mɛrɛsin ya kin mek pɔsin gɛt sayd ɛfɛkt?

di sayd ifekt dεm we kin apin wit εvri kayn `(Antimetic)` kin difrεn. Yu dɔktɔ go tɛl yu bɔt dɛn sayd ɛfɛkt ya bifo yu bigin fɔ tek di mɛrɛsin. Nɔ fred fɔ aks kwɛstyɔn ɛn sheb wetin yu de tink. If yu gɛt ɛni sayd ɛfɛkt we de mɔna yu afta yu dɔn bigin fɔ tek wan `(Antimetic)`, tɔk to yu dɔktɔ.

Na sɔm pan di kɔmɔn (bɔt nɔto ɔl) sayd ɛfɛkt dɛm we kin apin wit ɛni kayn ``Antimetic'':

• Serotonin antagonists: Ɛd we de at, diziz, ɛn kɔnstipɛshɔn.
• Antihistamines: Fɔ mek pɔsin slip.
• Glucocorticoids: I nɔ kin slip, i kin gladi, ɛn i kin chenj di we aw i de fil.
• Anticholinergics: Mɔt kin dray, yu kin si chenj, ɛn yu kin slip.
• NK-1 rεsεpכta antagonist dεm: I kin mek yu ed at, diziz, εn pan sכm pipul dεm, i kin mek yu gεt bad bad alerjik (anaphylaxis).
• Dopamin antagonist dεm: diziz, ed pen, εn muvmεnt prכblεm, lεk dystonia (involuntary muscle contractions) εn tardive dyskinesia (invכlכntri bכdi muvmεnt, spεshal fכ di fes εn mכt).
• Kanabinoyd dɛn: .Vertigo, low blood pressure, ɛn dysphoria (dɛn kin fil bad bad wan ɔr nɔr kin satisfay).

I fayn fɔ tek dis mɛrɛsin if a gɛt bɛlɛ?

If yu de sɔfa wit nɔs ɛn vɔmit we yu gɛt bɛlɛ, yu fɔ tɔk to yu ɔbstetrician-gynecologist (Ob/Gyn) ɔ ɔda dɔktɔ. Bɔku tɛm dɛn go se yu fɔ chenj di it dɛn we yu de it ɔ di tɛm dɛn we yu de it dɛn. If dat nɔ ɛp, dɛn kin gi yu mɛrɛsin.

Bɔku stɔdi dɛn dɔn sho se sɔm mɛrɛsin dɛn we de mek pɔsin nɔ gɛt bɛlɛ kin sef fɔ yuz we uman gɛt bɛlɛ. Bɔt di sefty infɔmeshɔn fɔ ɔda pipul dɛn de agens dɛnsɛf ɔ dɛn nɔ bɔku. Yu ɛn yu dɔktɔ go disayd togɛda wetin bɛtɛ fɔ yu.

As yu kam fɔ no se yu gɛt bɛlɛ so, go to dɔktɔ fɔ tɔk bɔt di mɛrɛsin dɛn we yu de tek. Dɔn bak, yu fɔ rili tɔk to dɔktɔ bifo yu bigin fɔ tek ɛni nyu mɛrɛsin we yu gɛt bɛlɛ.

Wetin yu kin du if yu mis wan doz fɔ mɛrɛsin?

If yu mis wan doz fɔ wan ``Antimetic'' mɛrɛsin, mɔ if na mɛrɛsin we de mek yu nɔ gɛt nɔs ɛn vɔmit we kin kɔntinyu, lɛk ``CINV,'' tɔk to yu dɔktɔ. I go advays yu bɔt wetin fɔ du.

Wetin na di mɛsej we wi want fɔ kɛr go na os frɔm dis atikul?

Nɔbɔdi nɔ lɛk fɔ gɛt nɔys ɛn vɔmit. Sɔntɛnde, dɛn tin ya we nɔ kin fayn fɔ wi bɔdi kin nid fɔ bi. Bɔt ɔda tɛm dɛn, dɛn kin rili bad. Laki, di mɛrɛsin dɛn we de mek yu nɔ gɛt bɛlɛ kin ɛp fɔ mek yu nɔ gɛt ɛn/ɔ trit yu nɔs ɛn vɔmit, ilɛksɛf na kwik ɔ i de go bifo. Bɔku tin dɛn de we yu kin pik frɔm. Yu ɛn yu dɔktɔ go disayd wetin bɛtɛ fɔ yu. So, if yu de gɛt dis prɔblɛm, nɔ fred fɔ tɔk to dɔktɔ, okay?

`Antiemetics, nɔs, vɔmit, antiemetics, sayd ɛfɛkt, bɛlɛ, kansa tritmɛnt