We yu dɔktɔ tɛl yu ɔ pɔsin we yu sabi gɛt bɔdi kansa, dɛn kin dɔn tɔk bɔt ɔmon tɛrapi as tritmɛnt opshɔn. Yu kin wɔri smɔl we yu yɛri dis. Bɔt nɔ wɔri. Tide wi de tɔk bɔt wan kayn mɛrɛsin we rili wok we dɛn kin gi pipul dɛn we gɛt kansa sɛl dɛn we kin sɛnsitiv to di ɔmon we dɛn kɔl ɛstrojen (`Estrogen Receptor-Positive` ɔ `ER+`). Dɛn kɔl dɛn tin ya Aromatase Inhibitors.
Fɔ tɔk am simpul wan, wetin na dɛn Aromatase Inhibitors ya?
Okay, mek wi brok dis. Aromatase inhibitors, ɔ AIs fɔ shɔt, na wan klas ɔf drɔgs we dɛn kin yuz fɔ mɛn ɔmon. Dɛn kin yuz dɛn fɔ trit ER+ brɔst kansa, mɔ pan uman dɛn we dɔn pas 40 ia .
Naw, luk, ɛstrojen na ɔmon we impɔtant fɔ wi bɔdi, mɔ fɔ uman dɛn wɛlbɔdi we de bɔn pikin. Bɔt fɔ sɔm bɔdi kansa sɛl dɛn, dis ɛstrojen ɔmon tan lɛk it. Dat min se we ɛstrojen de, dɛn kansa sɛl dɛn de kin gro kwik kwik wan.
dis na di say we `AI` dכg dεm de kam in. wetin dεn dכg dεm ya de du na fכ blok wan εnzym we dεn kכl aromatase na wi bכdi. dis aromatase εnzym de kכnvכlt כda כmon dεm to εstrojen. so, we dis dכg de stכp di aromatase εnzym fכ wok, di εstrojen lεvεl dεm na di bכdi de dכn. Dɔn dɛn kansa sɛl dɛn de lɔs dɛn "fud", dɛn kin stɔp fɔ gro, ɛn dɛn kin kɔntrol di kansa. Yu ɔndastand?
Fɔ tɔk am simpul wan, wetin dis drɔg de du na fɔ stɔp di kansa sɛl dɛm fɔ gɛt di "fyuɛl" we dɛn nid.
Us sityueshɔn dɛn dɛn kin advays dis mɛrɛsin?
Bɔku tin dɛn de we yu dɔktɔ kin tɛl yu fɔ du dis ``AI`` tritmɛnt:
- If yu dɔn gɛt ɔpreshɔn fɔ ER+ brɔst kansa, dɛn kin gi yu dis mɛrɛsin fɔ ridyus di risk fɔ mek di kansa kam bak .
- If di kansa dɔn spre to di limf no dɛm we de nia de.
- if di kansa dכn spre to כda pat dεm na di bכdi (e.g. lכng, bon, bren, liva), wi kin kכl dis mεtastas kεnsar.
- If yu gɛt dis `ER+` kansa bifo yu menopause. dis tεm, yu ovaria dεm stil de prodyuz εstrojen, so dεn kin gi yu כda tritmεnt fכ kכntrכl da εstrojen כmon de wit `AI` mεdikeshכn.
- If man gɛt `ER+` brɔst kansa. (Yɛs, man dɛn kin gɛt bɔdi kansa bak, ɛn dɛn kin gɛt smɔl smɔl ɛstrojen bak na dɛn bɔdi).
- Sɔm stɔdi dɔn sho se pipul dɛn we gɛt mɔ risk fɔ gɛt bɔdi kansaDɛn se dis mɛrɛsin kin ɛp fɔ ridyus da prɔblɛm de, bɔt dɛn nɔ dɔn gɛt ɔfishal aprɔval yet.
di tכp dεm we dεn kin yus mכst fכ aromatase inhibito dεm
Bɔku kayn dɛn ``AI`` mɛrɛsin ya de na di makit. Yu dɔktɔ go pik di wan we go fayn fɔ yu sik.
| Di Nem fɔ Drug |
|---|
| Letrozole we dɛn kɔl |
| Anastrozol we dɛn kɔl |
| Exemestane we dɛn kɔl Exemestane |
Aw a kin gɛt dis tritmɛnt ɛn aw lɔng i kin tek?
Dis ``AI`` mɛrɛsin na pil we yu fɔ tek ɛvride . Sɔmtɛm, tritmɛnt kin bigin wit dis mɛrɛsin. Ɔda tɛm, yu dɔktɔ kin fɔs gi yu ɔda ɔmon mɛrɛsin we dɛn kɔl tamoxifen fɔ sɔm ia ɛn afta dat i kin chenj yu to di ``AI`` mɛrɛsin.
Bɔku tɛm, dɛn kin kɔntinyu fɔ du dis tritmɛnt fɔ lɛk fayv ia so . Afta fayv ia, if yu nɔ gɛt ɛni sayn fɔ gɛt kansa ɛn di tɛst dɛn nɔmal, yu kin stɔp di tritmɛnt.
Bɔt sɔm stɔdi dɛn dɔn sho se di kansa kin kam bak te to 20 ia afta dɛn dɔn trit am. dis dεn kכl am ‘let rεkכrεshכn’. So, e fayn fɔ tɔk to yu dɔktɔ opin wan bɔt di prɔblɛm dɛn we kin apin to yu.
Benefit dɛm fɔ tritmɛnt ɛn di sayd ɛfɛkt dɛm we pɔsin kin gɛt
di big advantej fכ dis tritmεnt na dat i kin kכlכsכl kכl ER+ brεst kεnsar. Stɔdi dɔn sho se 95% pan di pipul dɛm wae gɛt dis AI tritmɛnt afta dɛn du ɔpreshɔn nɔr go gɛt dɛn kansa bak insay 5 ia . Dat na big nyus, nɔto so?
Bɔt, lɛk ɔl di mɛrɛsin dɛn, dis wan kin gɛt sayd ɛfɛkt. Bikɔs, lɛk aw wi bin dɔn tɔk, ɛstrojen na ɔmon we de ɛp bak fɔ mek wi bon ɛn at gɛt wɛlbɔdi. So, we yu lכs di εstrojen lεvεl wit wan `AI`, sכm sayd ifekt dεm kin apin.
| Sayd Ifɛkt we i kin gɛt | Fɔ tɔk am simpul wan... |
|---|---|
| Ɔstioporosis ɛn bon dɛn we kin brok | Di bon dɛn kin wik ɛn di risk fɔ brok izi wan kin bɔku. |
| Mɔsul dɛn pen (Myalgia) . | Mɔsul dɛn kin at. |
| Pen na di jɔyn dɛn | Jɔyn pen, lɛk ni ɛn ɛlb. Dis na di sayd ɛfɛkt we dɛn kin gɛt mɔ. |
| Hot flash dɛn we de shayn | Wantɛm wantɛm, i kin fil lɛk se i wam pasmak ɛn i kin swet. |
| Di vagina dray we de dray | Pen kin apin we pɔsin de du mami ɛn dadi biznɛs. |
| Risk fɔ gɛt sik na di at ɛn di blɔd | Sɔm kayn we de mek di risk fɔ gɛt at sik bɔku. |
Aw fɔ bia wit di bad tin dɛn we kin apin to pɔsin?
Nɔ fred fɔ dɛn sayd ɛfɛkt ya. Di tin we impɔtant pas ɔl na fɔ tɔk to yu dɔktɔ bɔt dɛn. Ɛspɛshali if tin dɛn lɛk jɔyn pen na bad bad wan, yu nɔ nid fɔ bia wit am. Yu dɔktɔ kin gi yu sɔlv dɛn. Fɔ ɛgzampul:
- Dɛn kin gi yu mɛrɛsin fɔ mek yu fil pen, mɔ NSAID (e.g., ibuprofen).
- If yu si am se i nɔ izi fɔ tek am, yu kin chenj to difrɛn kayn AI instead ɔf di AI we yu de tek naw.
- Sɔntɛnde, dɛn kin tek tamoxifen in ples fɔ AI.
Di tin we impɔtant pas ɔl na fɔ tɛl yu dɔktɔ bɔt ɛnitin we nɔ fayn, pas fɔ disayd fɔ yu wan.
Ustɛm yu nid fɔ tɔk to di dɔktɔ?
Insay dɛn kayn tin ya, mek shɔ se yu tɔk to yu dɔktɔ.
- If di sayd ɛfɛkt dɛn wɔs pas aw yu bin de tink.
- If di mɛrɛsin we di dɔktɔ gi nɔ gi ɛni rilif frɔm di sayd ɛfɛkt dɛn.
- If yu notis sayn dɛm fɔ se kansa de kam bak (e.g., nyu lumps, pen we de kɔntinyu, i nɔ izi fɔ blo) , aks yu dɔktɔ us sayn dɛm fɔ luk fɔ.
Mɛsej we dɛn kin kɛr go na os
- di aromatase inhibito dεm na wan rili imכtant εn ifektiv כmon tritmεnt fכ εstrojen-sεnsitiv (ER+) brεst kεnsar.
- Dɛn mɛrɛsin ya de wok bay we dɛn de ridyus di ɛstrojen lɛvɛl na di bɔdi ɛn stɔp di kansa sɛl dɛn fɔ gro.
- Dis tritmɛnt de ridyus di risk fɔ gɛt kansa bak bad bad wan.
- Sayd ifekt dεm lεk di joyn dεm we de pen εn di bon dεm we de tכn kin apin, bכt dεn kin mεnεj bכku pan dεn tin ya.
- Di tin we impɔtant pas ɔl: Nɔ ɛva stɔp fɔ tek yu mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu. Tɔk wit am opin wan bɔt ɛni prɔblɛm we yu fil.
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