Di wɔd "kansa" de mek wi ɔl fred smɔl, nɔto so? Bɔt we di sayɛns bɔt mɛrɛsin dɔn go bifo, bɔku nyu ɛn fayn we dɛn dɔn kam fɔ fɛt kansa. Tide, wi go tɔk bɔt wan saksesful tritmɛnt we dɛn de tɔk bɔt bɔku, mɔ fɔ brɔst kansa. Dɛn kɔl dis Targeted Therapy . Lɛ wi tek tɛm luk wetin i bi, aw i de wok, ɛn wetin yu nid fɔ no bɔt am.
Fɔ tɔk am simpul wan, wetin na Targeted Therapy?
Tink bɔt dis, kemotɛrapi, as wi kin no, kin pwɛl di sɛl dɛn we kin sheb kwik kwik wan. Dis nɔ kin jɔs pwɛl di kansa sɛl dɛn bɔt i kin pwɛl di sɛl dɛn we gɛt wɛlbɔdi na wi bɔdi. Na dat mek bɔku tɛm, kemotɛrapi kin mek yu gɛt sayd ɛfɛkt lɛk we yu ia de lɔs ɛn yu nɔs.
Bɔt dis tritmɛnt we dɛn kɔl Targeted Therapy rili difrɛn frɔm dat. Fɔ bi prɛsis, dis na rili ‘smat’ tritmɛnt. I de tɔch ɛn atak di kansa sɛl dɛn nɔmɔ . Dis we fɔ trit de yuz wi bɔdi in yon imyun sistɛm fɔ pwɛl di kansa sɛl dɛm, ɔr de blok di signal dɛm we di kansa sɛl dɛm nid fɔ gro. Dis kin mek di sɛl dɛn we gɛt wɛlbɔdi nɔ pwɛl bɛtɛ. Di bɛnifit fɔ dis na dat di sayd ɛfɛkt dɛn kin smɔl pas di wan dɛn we kin gɛt kemotɛrapi.
Dis tritmɛnt kin woke pan tu men we dɛn:
1. Yuz Antibodi dεm: Na spεshal sεl dεm na wi bכdi in imyun sistεm de mek dεn antibodi dεm ya. Dɛn kin mek dɛn antibodi ya artificially na di lab ɛn gi dɛn to di bɔdi as drɔg. Dɛn tin ya kin atak di kansa sɛl dɛn ɛn stɔp dɛn fɔ gro ɔ pwɛl dɛn.
2. Smɔl mɔlyul drɔgs: Dis na drɔgs we pɔsin kin tek as pils. Dɛn de wok bay we dɛn de blok di sayn dɛn we de insay di kansa sɛl dɛn we de ɛp dɛn fɔ sheb ɛn gro.
Yu dɔktɔ go no us kayn tritmɛnt we yu want fɔ tek go fayn fɔ yu bay di rayt kayn bɔdi kansa we yu gɛt.
HER2-Positiv Breast Kansa ɛn In Tritmɛnt
כlmost 20% pan di pipul dεm we gεt brεst kεnsar, כ lεk wan pan fayv pipul dεm, gεt difεkt na wan jin we dεn kכl `HER2`. Dis difrɛns kin mek di jin mek bɔku kɔpi dɛn. if tu mכch pan di `HER2` protin de pan di kεnsar sεl dεm, wi kin kכl da kεnsar de "HER2-positiv brεst kεnsar."
If yu kansa na `HER2-positiv`, spεshal, hεli ifektiv tεrapi tritmεnt dεm de fכ am.
- Trastuzumab we dɛn kɔl : .Dis na di men tεrapi we dεn tכk bכt fכ `HER2-positiv` kεnsar. Dis drɔg de ɔnda difrɛn brand nem dɛm lɛk `Herceptin`, `Kanjinti`, `Ogivri`. Na injɛkshɔn we dɛn kin gi insay wan vein. Dɛn biliv se i kin kɔntrol di kansa pan tri men we dɛn:
- Di kansa sɛl dɛn kin stik na di say we dɛn de ɛn stɔp dɛn fɔ gro.
- I de ɛp fɔ pwɛl di kansa sɛl dɛn bay we i de gi sayn to wi yon imyun sistɛm.
- We dɛn gi am wit kemotɛrapi, i kin mek dɛn tritmɛnt dɛn de wok fayn mɔ ɛn mɔ.
- Pertuzumab: Dis drɔg, we de ɔnda di brand nem `Perjeta`, na ɔda antibodi we dɛn gi `HER2-positiv` kansa. Bɔku tɛm dɛn kin gi am togɛda wit `Trastuzumab` ɛn di kemotɛrapi drɔg `docetaxel`. Bɔt i nɔ fayn fɔ uman dɛn we gɛt bɛlɛ, bikɔs i kin ambɔg di pikin we nɔ gɛt bɛlɛ.
- Ɔda mɛrɛsin dɛn: `Ado-trastuzumab emtansine (Kadcyla), `Margetuximab (Margenza), ɛn `Fam-trastuzumab deruxtecan-nxki (Enhertu)` na dɛn bak na mɔdan drɔgs dɛn we dɛn kin gi fɔ dis kayn kansa, mɔ we di kansa dɔn skata (advans) ɔ we ɔda tritmɛnt dɛn nɔ wok.
- Pil dɛm: Lapatinib (Tykerb) ɛn Neratinib (Nerlynx) na drɔgs dɛm we dɛn kin tɔch fɔ HER2-positiv kansa we dɛn kin tek as pils. Bɔku tɛm dɛn kin gi dɛn tin ya bak afta ɔda tritmɛnt dɛn.
Tritmɛnt fɔ HER2-Negativ Brest Kansa
if yu kansa sεl dεm nכ gεt di `HER2` jin dεfekt we wi bin dכn tכk bכt, we min se nכ tu mכch `HER2` protin de, den dεn kכl da kεnsar de "HER2-negative brεst kεnsar." Dɔn dɛn go gi yu difrɛn kayn tritmɛnt.
Spɛshal targeted therapy drugs de fɔ dis kayn kansa bak.
- Drug dεm lεk `Everolimus (Afinitor), `Palbociclib (Ibrance),` εn `Ribociclib (Kisqali)` dεn kin gi dεm wit כmon tεrapi. Dis na tritmɛnt dɛn we dɛn kin gi uman dɛn, mɔ afta dɛn dɔn menɔpauz, we dɛn kansa dɔn skata.
- PARP Inhibitors: If yu kansa na HER2-negative ɛn yu gɛt BRCA jin muteshon, dɛn kin gi yu spɛshal klas ɔf drɔgs we dɛn kɔl PARP inhibitors, lɛk Olaparib (Lynparza) ɛn Talazoparib (Talzenna). Dis na di tεrapi dεm bak we dεn de tכk bכt we spεshal tכk to di kεnsar sεl dεm.
Di impɔtant tin na dat ɔl dɛn tritmɛnt ya de bay di jɛnɛtik ɛn sɛl lɛvɛl we yu kansa gɛt. So i impɔtant fɔ tek tɛm tɔk bɔt dis wit yu dɔktɔ ɛn pik di tritmɛnt we go fayn fɔ yu.
Wetin na di kɔmɔn sayd ɛfɛkt dɛm?
As wi bin dɔn tɔk, pan ɔl we di sayd ɛfɛkt dɛn nɔ bɔku pas di kemotɛrapi, di tritmɛnt we dɛn de gi pɔsin we dɛn want fɔ mɛn kin stil mek sɔm sayd ɛfɛkt dɛn. Dɛn tin ya kin difrɛn frɔm wan drɔg to ɔda drɔg. If yu gɛt ɛni bad bad tin we apin to yu , tɛl yu dɔktɔ wantɛm wantɛm . Bɔku tɛm, dɛn kin ebul fɔ kɔntrol dɛn.
| Di Kɔmɔn Sayd Ɛfɛkt dɛn |
|---|
| Alɛji riakshɔn - skin rash, it. |
| Nɔs ɛn dayarɛa. |
| Fiva ɛn kol kol. |
| Bɔdi de pen, taya, ɛn wik. |
| Trɔbul fɔ blo ɛn swel. |
| Diziz we pɔsin kin gɛt . |
Aw fɔ no if ɛnitin apin we nɔ izi fɔ yu?
If yu gɛt wan ɔr mɔr pan dɛn sik ya, i kin bi imejensi. Nɔ ɛva ignore dɛn. Kɔl yu dɔktɔ wantɛm wantɛm. If yu nɔ ebul fɔ rich to am, go na di Imejɛnsi Dipatmɛnt (ETU) na di ɔspitul we de nia yu.
| Pe atɛnshɔn gud wan to dɛn sayn dɛn ya! | |
|---|---|
| Fiva: Fiva we pas 100.4 Fɛnayt (38 Sɛlshiɔs). If yu gɛt fiva afta yu dɔn kol, tɛl yu dɔktɔ wantɛm wantɛm. | Prɔblɛm na yu mɔt: Nyu sos na yu mɔt, wayt spat, tɔng we swel, ɔ di gam we de blɔd. |
| Trot we de at: Dray, so, skrach, ɔ "swɛl" filin na di trot. | Kɔf: Nyu kɔf ɔ we de kɔntinyu fɔ kɔf. |
| Prɔblɛm dɛn we yu kin gɛt we yu de pis: Yu kin pis bɔku tɛm, yu kin gɛt infekshɔn na yu urinary tract, ɔ yu kin gɛt blɔd na yu urine. | Bɛlɛ prɔblɛm: Bɔrku at, nɔs, vɔmit, kɔnstipɛshɔn, ɔ dayarɛa we kin te pas 2-3 dez. |
| I nɔ kin izi fɔ blo: I kin shɔt fɔ blo ivin if yu tray smɔl. | Blɔd we nɔ de kɔmɔt: Blɔd de na di stɔl. |
| Swɛlin: Swɛl na di leg ɔ anklɛ eria. | Taya bad bad wan: Fɔ fil se yu taya sote yu nɔ ebul fɔ du natin. |
Mɛsej we dɛn kin kɛr go na os
- Targeted Therapy na wan mכdan tritmεnt we de spεshal tכk εn atak brεst kansa sεl dεm, we difrεn frכm rεgulεr kεmothεrapi.
- Di kayn tritmɛnt we yu go gɛt go dipen pan di kayn kansa we yu gɛt (e.g., if na `HER2-positiv` ɔ `HER2-negative`). Dɛn kin du spɛshal tɛst dɛn fɔ no dis.
- Dɛn tritmɛnt ya kin gɛt sayd ɛfɛkt bak, so tɔk to yu dɔktɔ bɔt ɛni chenj ɔr pwɛl hat we yu fil.
- Ɔltɛm, de wach fɔ di imejensi simptom dɛm lɛk ay fiva, i nɔ izi fɔ blo, ɛn swel we nɔ kɔmɔn. If yu notis ɛni wan pan dɛn tin ya, go to dɔktɔ wantɛm wantɛm.
- Kansa tritmɛnt na wan joyn. Yu dɔktɔ ɛn wɛlbɔdi tim na yu bɛst padi dɛn pan dis joyn. So abop pan dɛn ɛn wok wit dɛn.
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