Wae yu ɔr pɔrsin wae yu sabi de trit fɔ sik lɛk lukimiya, yu kin gɛt sɔm kayn sayd ɛfɛkt wae yu nɔr bin de ɛkspɛkt. Tide, wi go tɔk bɔt wan kɔmbayn siriɔs riakshɔn we kin apin wit mɛrɛsin, mɔ di wan dɛn we dɛn kin gi fɔ tu kayn blɔd kansa. Dɔktɔ dɛn kɔl dis Difrɛns Sindrom . Bikɔs i kin rili siriɔs, bɔku tɛm dɔktɔ dɛn kin bigin fɔ trit di sik bifo dɛn kɔnfɔm fɔ tru, we kin mek i nɔ gɛt bɔku prɔblɛm dɛn we kin mek pɔsin in layf de pan denja.
Wetin na Difrɛns Sindrom?
Fɔ tɔk am simpul wan, Difrɛns Sindrom na wan grup we gɛt siriɔs riakshɔn we di bɔdi kin gɛt to sɔm mɛrɛsin dɛn we dɛn kin yuz fɔ trit tu kayn blɔd kansa, we na Acute Promyelocytic Leukemia (APL) ɛn Acute Myeloid Leukemia (AML) . I tan lɛk se sɔm pan di sɛl dɛn na wi bɔdi "go kray" wit dɛn mɛrɛsin ya ɛn bigin fɔ rilis bɔku tin wan tɛm. Dis na de tin wae kin mek yu gɛt ɛni wan pan de sik.
Imajin se dɛn no se yu padi gɛt APL ɛn bigin fɔ trit am. Insay sɔm dez, i kin jɔs gɛt fiva, i nɔ kin izi fɔ blo, ɛn i kin swel smɔl. Da tɛm de, dɔktɔ dɛn kin tink se dis na Difrɛns Sindrom.
Wetin na dɛn Difrɛns Ejen ya?
Difrɛns na wan kayn mɛrɛsin we dɔktɔ dɛn kin yuz fɔ trit APL. APL kin fil pas ɔda kayn AML to drɔgs we kin mek di sɛl dɛn machɔ, ɔ difrɛns . Dɛn drɔgs ya de ɛp di kansa sɛl dɛm (blast sɛl stej) fɔ divɛlɔp to nɔmal, wɛlbɔdi wayt blɔd sɛl dɛm. Na dat mek dɔktɔ dɛn kin yuz dɛn difrɛns drɔgs ya instead fɔ gi dɛn kemotɛrapi drɔgs dairekt wan.
Lɛk ɔda kansa mɛrɛsin dɛn, dɛn mɛrɛsin ya kin ɛp fɔ stɔp ɔ slo di kansa sɛl dɛn we de gro. Dɔktɔ dɛn kin yuz dɛn difrɛns ɛjɛn dɛn ya nɔmɔ, we dɛn jɔyn togɛda, ɔ we dɛn put dɛn togɛda wit kemotɛrapi. Dɛn kin ebul fɔ trit APL fayn fayn wan. Bɔt sɔm pipul dɛn we gɛt APL kin gɛt siriɔs sayd ɛfɛkt frɔm dɛn mɛrɛsin ya.
Us mɛrɛsin kin mek yu gɛt Difrɛns Sindrom?
dis kכndishכn kin kכz bay di difrεns ejen dεm we dεn gi APL. Sɔm ɛgzampul dɛn na:
- כl-trans-rεtinoik asid (ATRA) na wan fכm fכ vaytam in A.
- Arsenic Trioxide (ATO) na wan kayn asɛnik.
Dɔn bak, fɔ sɔm pipul dɛn we gɛt AML, dɔktɔ dɛnIsocitrate Dehydrogenase (IDH) inhibitors na wan klas ɔf kemotɛrapi drɔgs we dɛn kin yuz. dis IDH inhibito dεm (ivosidenib) εn (enasidenib) kin mek bak difrεns Sεndrכm. nכto dat nכmכ, bכt bak FLT3 inhibito dεm (e.g. (midostaurin) , (gilteritinib) ) kin mek dis kכndyushכn.
Udat dɛn kin nid IDH inhibito dɛn?
- Pipul dɛn we dɛn kansa dɔn kam bak.
- Pipul wae gɛt kansa wae nɔr kin izi fɔ trit.
- Pipul dεm we gεt spεsifi k jin mכtεshכn (IDH1 כ IDH2 mכtεshכn).
- Di wan dɛn we nɔ ebul fɔ bia wit standad kemotɛrapi tritmɛnt.
Udat kin gɛt Difrɛns Sindrom?
Bɔku pipul dɛn we gɛt APL nɔ kin gɛt bɛtɛ wayt blɔd sɛl (WBC) . Bɔt di wan dɛn we gɛt bɔku WBC kɔnt kin gɛt ay risk fɔ gɛt Difrɛns Sindrom. Insay dɛn kayn tin ya, bɔku tɛm dɔktɔ dɛn kin gi dɛn wan mɛrɛsin we dɛn kɔl Prednisone ɔ Dexamethasone fɔ ridyus di risk fɔ gɛt dis sik.
Aw kɔmɔn tin na Difrɛns Sindrom?
Dis na rili wan sik we nɔ kin apin so ɔltɛm . AML na di kayn lukimiya we kin bɔku pan big pipul dɛn, pan ɔl we i kin mek lɛk 1% pan ɔl di kansa dɛn. Insay Amɛrika, APL kin apin to lɛk wan pan ɛvri 250,000 pipul dɛm.
Frɔm di wan dɛn we gɛt AML ɛn APL:
- Na lɛk 25% pan di APL pasɛnt dɛn we dɔn gɛt ATRA ɛn ATO drɔgs dɔn gɛt Difrɛns Sindrom.
- Dɛn dɔn ripɔt dis kɔndishɔn bitwin 14% ɛn 19% pan di AML pasɛnt dɛn we de tek IDH inhibito.
Wetin kin mek dis Difrɛns Sindrom?
Risach pipul dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin mek sɔm pipul dɛn kin ansa APL tritmɛnt dis we. Fɔs stɔdi dɔn sho se di kansa mɛrɛsin dɛn kin mek di lukimiya sɛl dɛn pul bɔku bɔku kemikal dɛn we de na di imyun sistɛm wantɛm wantɛm. Dɛn kɔl dis saytokin rilis sindrom . Dis inflamɛns we dɛn nɔ kin kɔntrol kin mek yu gɛt difrɛn sayn dɛn, frɔm we nɔ kin at to we i kin rili bad.
Wetin na di sayn dɛm wae de sho se yu gɛt Difrɛns Sindrom?
Pɔsin we gɛt APL kin bigin fɔ gɛt di sayn dɛm fɔ Difrɛns Sindrom insay wan ɔ tu wik afta i bigin fɔ gɛt ATRA ɛn/ɔ Arsenic Trioxide. Bɔt if yu de tek IDH inhibitor tritmɛnt fɔ AML, i kin tek smɔl tɛm fɔ mek di sayn dɛn sho.I kin go (dεn sik ya kin apun εnisay frכm wan de to fayv to siks mכnt afta yu bigin yus di mεdikeshכn).
Dis na de sayn dɛm wae dɛn kin si mɔr:
- Kɔf .
- εkstra wata we de bכku rawnd yu at εn yu lכng (Pleural Effusion) .
- Renal Failure we nɔ de wok fayn .
- Lɔw blɔd prɛshɔn (Hypotension) .
- Di ɔksijɛn we nɔ de bɔku na di blɔd (Hypoxemia) .
- I nɔ izi fɔ blo (Dyspnea) .
- Swel (inflammation) na di an, fut, ɛn nɛk.
- Fiva we nɔ gɛt rizin.
- We yu de gɛt mɔ wet fɔ natin.
Impɔtant: If yu gɛt wan ɔr mɔr pan dɛn sik ya, i nɔr min se yu rili gɛt Difrɛns Sindrom. Bɔt i impɔtant fɔ tɛl yu dɔktɔ wantɛm wantɛm if yu notis ɛni wan pan dɛn sayn ya.
Wetin na di prɔblɛm dɛn we kin kam wit Difrɛns Sindrom?
Sɔntɛnde, dis sik kin mek yu gɛt siriɔs prɔblɛm. Fɔ ɛgzampul:
- At we nɔ de wok fayn .
- Renal Failure we nɔ de wok fayn .
- Lɔng we nɔ de wok fayn .
- Blɔd we de kɔmɔt na di lɔng dɛn (Pulmonary Hemorrhage) .
- Nyumonia .
- Sepsis ( na wan bad bad infεkshכn we de spre כlsay na di bכdi).
If yu gɛt ɛni wan pan dɛn sik ya, kɔl yu dɔktɔ wantɛm wantɛm . If i nɔ izi fɔ yu fɔ blo ɔ yu de fil pen na yu chɛst, kɔl 911 (ɔ yu lokal imejensi nɔmba) wantɛm wantɛm . Dɛn kin trit pipul dɛm wae gɛt APL na ɔspitul te di risk fɔ difrɛns sik pas.
Aw dɛn kin no bɔt Difrɛns Sindrom?
E kin tranga fɔ no dis sik pan pɔrsin wae gɛt APL, bikɔs bɔrku ɔda kayn sik de wae kin mek pɔrsin gɛt dis kayn sik. If i siriɔs, dɔktɔ dɛn kin bigin fɔ trit di sik dɛn jɔs lɛk aw dɛn tink se dɛn gɛt Difrɛns Sindrom, ivin bifo dɛn ebul fɔ kɔnfɔm se na di rayt wan.
Yu dɔktɔ go tɛl yu fɔ du sɔm tɛst fɔ no if yu gɛt di sik ɛn fɔ mek yu nɔ no ɔda sik dɛn. Dɛn tin ya kin bi:
- Kɔmplit Blɔd Kɔnt (CBC) .
- Chɛst X-ray .
- Echocardiogram (na tɛst we de chɛk aw di at de wok).
- CT skan na di chɛst .
- Bronchoscopy (na tɛst we dɛn kin yuz kamɛra fɔ luk insay di lɔng dɛn).
- Ɔda blɔd tɛst dɛn (Bloodwork).
Yu tink se mɛrɛsin de fɔ Difrɛns Sindrom?
Bɔrku tɛm, pipul dɛm wae gɛt akyu promyelocytic leukemia (APL) kin mek dɛn wɛl frɔm difrɛns sik if dɛn gɛt tritmɛnt kwik ɛn fayn . Naw, APL na sik we bɔku pipul dɛn kin mɛn. So natin nɔ de fɔ fred.
Aw dɛn kin trit Difrɛns Sindrom?
Dɔktɔ dɛn kin trit di sayn dɛm fɔ difrɛns sindrom wit kɔtikosterɔyd ɔ glukokɔtikoyd mɛrɛsin, lɛk dɛksametazɔn . If tin tranga, yu dɔktɔ kin tɛl yu bak se yu fɔ stɔp fɔ tek yu kansa tritmɛnt fɔ sɔm tɛm te yu sik nɔ de igen.
Bɔrku pipul dɛm wae gɛt APL kin trit na ɔspitul te di risk fɔ difrɛns sindrom dɔn pas. If yu na ɔtpeshɛnt ɛn dɛn tink se difrɛns de, yu dɔktɔ dɛn kin disayd fɔ kip yu na ɔspitul fɔ wan nɛt fɔ mek dɛn ebul fɔ mɛn yu ɔ fɔ mek dɛn wach yu. Yu mɛdikal tim go ɛp fɔ kɔnfɔm yu diagnosis ɛn trit ɛni kɔndishɔn wae de kɔz yu sik fayn fayn wan.
Wetin a kin du fɔ ridyus di risk fɔ gɛt Difrɛns Sindrom?
Natin nɔr de fɔ rili du fɔ ridyus yu risk fɔ gɛt dis sik. If yu de tek kemotɛrapi ɔ ɔda kayn kansa mɛrɛsin, tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛni sayn we yu gɛt . Dɔn bak, no us sayn dɛm fɔ luk fɔ (as wi bin dɔn tɔk bɔt ɔp) ɛn tɔk to yu dɔktɔ if yu gɛt ɛnitin fɔ wɔri bɔt. Dis na di tin we impɔtant pas ɔl.
Wetin na de lukin-grɔn fɔ Difrɛns Sindrom?
De luk fɔ difrɛns sεndrכ m kin jεnarali gud fɔ bɔrku pipul dεm. Bɔrku tɛm, yu kin kɔntinyu fɔ trit yu antikansa, ilɛksɛf yu de trit yu wit stɛroyd ɔ afta yu dɔn trit yu. Yu mɛdikal tim go tɔk to yu bɔt yu tritmɛnt opshɔn dɛm.
Ustɛm yu fɔ go to dɔktɔ fɔ advays bɔt Difrɛns Sindrom?
If yu gɛt ɛni sayn fɔ difrɛns sik we yu de du tritmɛnt fɔ kansa, kɔl yu dɔktɔ wantɛm wantɛm . I kin tranga fɔ yu ɔ yu dɔktɔ fɔ no if na di tritmɛnt fɔ kansa ɔ na ɔda sik de mek yu gɛt di sik. If yu trit yu kwik kwik wan, dat kin ɛp fɔ mek yu nɔ gɛt di sik ɛn fɔ mek yu nɔ gɛt bɔku prɔblɛm dɛn.
Di tritmɛnt fɔ kansa kin tranga. Bɔt i kin mek wi at pwɛl fɔ no se di tritmɛnt insɛf gɛt bad bad tin dɛn. Difrɛns Sindrɔm na wan grup wae kin mek pɔrsin in layf pan denja wae dɛn de trit yu blɔd kansa. Bɔt dɛn kin trit am if dɛn no am ɛn trit am kwik . Bikɔs di sik kin wɔs kwik kwik wan, dɔktɔ dɛn kin bigin fɔ trit yu bifo yu tɛst rizɔlt kɔnfirm se yu gɛt Difrɛns Sindrom. If yu trit yu kwik kwik wan, dat kin ɛp fɔ mek yu nɔr gɛt di sik ɛn mek yu go bak na di rod fɔ wɛl.
Mɛsej we dɛn kin kɛr go na os
- Difrɛns Sindrom na siriɔs riakshɔn we kin apin bikɔs ɔf sɔm mɛrɛsin dɛn we dɛn kin gi fɔ di kayn lukimiya we dɛn kɔl APL ɛn AML.
- Sɔm kayn sik lɛk fiva, i nɔ kin izi fɔ blo, ɛn di bɔdi kin swel.
- If yu notis dɛn sayn ya, i impɔtant fɔ tɛl yu dɔktɔ wantɛm wantɛm .
- If dɛn no am kwik ɛn trit am wit mɛrɛsin lɛk Dexamethasone, bɔku tɛm i kin mɛn.
- Nɔ fred we yu yɛri dis. Yu mɛdikal tim go ɛp yu. De tin wae impɔtant pas ɔl na fɔ mek dɛn no bɔt ɛni chenj, ɛni sayn.
` Difrεns sεndrכm, lukimiya, kεnsar tritmεnt, sayd ifekt, APL, AML, ATRA, simptom dεm
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