Sɔm sik dɛn de we kin kɔmɔt frɔm yu mama ɛn papa, nɔto so? Ɔ sɔm sik dɛn de we rili at fɔ mɛn ɔltogɛda ivin if dɛn tek mɛrɛsin ɔ ɔpreshɔn. Imajin, wetin go apin if we bin de fɔ chenj di jin dɛn na wi yon bɔdi ɛn mɛn wan sik we de na in rut? Jin tɛrapi na wan pan di big op fɔ tumara bambay. Pan ɔl we dis stil rili nyu, dɛn kin tek am se na sɔntin we go mek big difrɛns pan mɛrɛsin sayɛns.
Wetin na jin tɛrapi simpul wan?
Fɔ tɔk am simpul wan, jin tɛrapi na mɛrɛsin we wi kin yuz wi yon jɛnɛtik matirial fɔ mek wi nɔ gɛt sik dɛn ɛn fɔ mɛn dɛn. Frɔm trade trade, wi bin de yuz tin dɛn lɛk drɔgs, pils, srɔp , injɛkshɔn, ɔ ɔpreshɔn. Bɔt wit dis we fɔ du tin, dɔktɔ dɛn kin afɛkt di we aw yu de mek yu yon jɛnɛtiks ɛn kɔrɛkt di tin we de mek yu gɛt sik.
Tink bɔt wi bɔdi lɛk big bildin. Di blueprint we dɛn yuz fɔ bil da bildin de na wi jin dɛn . Sɔntɛnde, smɔl mistek ɔ fɔlt kin de na dis blueprint. Na da mistek de kin mek sɔm sik dɛn. So jin tɛrapi na fɔ kɔrɛkt da rɔng blueprint de. Dat min se:
- Fɔ ridyus di prɔtin dɛn we kin mek pɔsin sik: We sɔm jin dɛn nɔ de wok fayn, dɛn kin mek prɔtin dɛn we kin ambɔg di bɔdi. Dis we ya kin mek dɛn nɔ bɔku.
- fכ mek gud protin dεm go bכku: sכmtεm di bכdi nכ de prodyuz inof protin dεm we i nid. If na so i bi, dis we ya kin tɛl di jin dɛn fɔ mek dɛn prɔtin dɛn de fayn fayn wan.
- fכ mek nyu כ modifyed protin dεm: Dis we ya kin mek nyu kayn protin insay di bכdi we kin fכt wan sik.
Aw dis kin wok na wi bɔdi?
Fɔ ɔndastand dis, lɛ wi lan smɔl fɔs bɔt jin. Ɛni sɛl na wi bɔdi gɛt nyukliɔs. Insay da nyukliɔs de, tin dɛn de we dɛn kɔl kromozom . Dɛn kromozom ya na DNA . Dis DNA gɛt di infɔmeshɔn we de sho ɔltin frɔm yu ia kɔlɔ, yu yay kɔlɔ, ɛn ayt.
Dɛn patikyula pat dɛn ya na di DNA na di tin dɛn we wi kɔl jin . I tan lɛk wan risɛp we de na big buk fɔ kuk (DNA). Dɛn jin ya de gi instrɔkshɔn bɔt aw fɔ mek di prɔtin dɛn we impɔtant fɔ mek wi bɔdi wok. Dat risɛp de tɛl wi aw fɔ mek di kek.
Sɔntɛnde as wi de ol, pɔyzin de na di envayrɔmɛntwe dεn de εkspos to kεmikכl dεm, כ we dεn gεt frכm in mama εn papa, sכm sכm chenj dεm (jin vεryכnt/mכtεshכn) de apin insay dεn jin dεm ya. I tan lɛk se lɛta ɔ wɔd we de insay da risɛp de nɔ rayt. Dɔn di prɔtin (kek) we dɛn mek bak nɔ rayt. Na dat na di rut fɔ bɔku sik dɛn.
Jinɛt tɛrapi nɔ jɔs de tray fɔ trit di sayn dɛn we de sho se pɔsin gɛt wan sik. I de tray fɔ kɔrɛkt di jenɛtik mistek we mek di sik bigin.
Us sik dɛn dɛn de yuz jin tɛrapi fɔ naw?
Infakt, bɔku tritmɛnt dɛn we dɛn kin gi jin tɛrapi stil de na di klinik trial stej. Dis min se dɛn de tɛst dɛn fɔ si if dɛn sef ɛn if dɛn wok bifo dɛn gi dɛn to pipul dɛn. Di men eria dɛm we dɛn de du risach naw fɔ dis we na:
- Kansa
- Makula dijenereshɔn ɛn ɔda sik dɛn we kin apin na di yay
- Sɔm tin dɛn we kin apin we pɔsin gɛt frɔm in mama ɛn papa
- HIV /AIDS
Bɔt naw, sɔm we dɛn de fɔ mɛn di jin dɛn we di US Food and Drug Administration (FDA) dɔn gri fɔ, we min se dis nɔto jɔs drim igen. Fɔ ɛgzampul:
- Luxturna®: Dis na wan tɛm tritmɛnt fɔ pipul dɛm wae nɔr de si fayn bikɔs ɔf sɔm kayn sik dɛm wae dɛn kin gɛt frɔm dɛn yay .
- Zolgensma®: Dɛn dɔn gri fɔ dis fɔ trit Spinal Muscular Atrophy, we na wan bad bad sik we kin afɛkt pikin dɛn we nɔ rich 2 ia yet.
Difrɛn kayn tritmɛnt de fɔ dis tritmɛnt?
Yɛs, tri men we dɛn de we dɛn kin du jin tɛrapi. Lɛ wi si wetin dɛn bi.
| Di we aw dɛn kin trit am | Wetin yu jɔs de du? |
|---|---|
| Jin Adishɔn | Dɛn kin put wan wɛlbɔdi kɔpi fɔ di sem jin insay wan sɛl we gɛt wan jin we nɔ de wok fayn ɔ we dɔn pwɛl. I tan lɛk se yu kam wit nyu mashin we bɛtɛ pas am fɔ tek ples fɔ wan we dɔn brok. |
| Jin Saylɛns | Wetin dis de du na fɔ stɔp di wok we wan jin we nɔ fayn we de mek pɔsin gɛt sik. I tan lɛk fɔ mek pɔsin we de gi bad advays nɔ tɔk natin bay we yu de sɛt mɔt. |
| Jin Ɛditin | Dis na di we we dɔn go bifo pas ɔl. wetin dεn de du ya na fכ ‘kכt aut' כ ‘kכrekt’ di kכrekt pat pan di DNA εn arenj am bak. I tan lɛk se yu dɔn ɛras wan rɔng wɔd na buk ɛn rayt di kɔrɛkt wɔd na in ples. Dɛn kin yuz tɛknɔlɔji dɛn lɛk CRISPR/cas9 fɔ dis. |
Aw dɛn kin put jin dɛn insay di bɔdi?
dis hεlty jin dεm nכ de go dairekt insay wi sεl dεm. Dɛn nid motoka. Dɛn kɔl da motoka de ‘vɛktɔ’ . Imajin se yu de sɛn wan pak. wan kɔriɔ (di vektɔ) de tek da pasɛl de (di jin) jɔs usay i nid fɔ go (di sɛl).
Bɔku tɛm, dɛn kin yuz vayrɔs dɛn as dɛn ‘vɛktɔ’ ya. Naw yu kin de tink se, "I nɔ go mek yu sik if yu put vayrɔs na yu bɔdi?" Wetin sayɛnsman dɛn kin du ya na fɔ pul ɔl di pat dɛn na wan vayrɔs we kin mek pɔsin sik, ɛn lɛf di pat dɛn nɔmɔ we kin go insay di sɛl dɛn. Dɔn, dɛn kin put di wɛlbɔdi jin insay di vayrɔs ɛn put am insay di bɔdi.
Tu men we dɛn de fɔ du dis:
1. In vivo (insay di bכdi): na ya, dεn de injεkt di ‘vεktכr’ we gεt di jin dεm dεn de injεkt dεn wan dεm dεn wan insay di bכdi lεk vaksin.
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Wetin na di bɛnifit ɛn bad tin dɛn we pɔsin kin gɛt we i de mɛn pipul dɛn we gɛt jin?
Lɛk ɔltin, dis we fɔ du tin gɛt in gud ɛn bad tin dɛn.
| Bɛnifit dɛn | Di bad tin dɛn we kin apin ɛn di prɔblɛm dɛn we kin apin |
|---|---|
| Wan nyu op:Sik dɛn we dɛn bin de tink se nɔ go ebul fɔ mɛn, naw dɛn de gɛt nyu tritmɛnt. | Nɔr kɔmplit garanti: Dis stil na nyu tin, so i nɔr pɔsibul fɔ se di tritmɛnt go bi 100% saksesful. Sɔntɛm, sɔm bad tin dɛn kin apin we yu nɔ bin de ɛkspɛkt. |
| Fɔ trit di rut fɔ di sik: Bifo yu stɔp di sayn dɛm, yu kin kɔrɛkt di tin we de mek yu gɛt di sik. | Wan kɔmpleks prɔses: We dɛn kam wit jɛnɛtik matirial frɔm ɔdasay, di bɔdi in imyun sistɛm kin riak agens am. |
| Tritmɛnt kwik: If dɛn gi tritmɛnt bifo di sik pwɛl di bɔdi, dɛn kin avɔyd da damej de. | Nɔ no bɔt di tin dɛn we kin apin to pɔsin fɔ lɔng tɛm: Bikɔs dis na nyu tin, dɛn nɔ no yet ustɛm di tin dɛn we kin apin to pɔsin go apin afta bɔku ia. |
A fɔ tɔk to mi dɔktɔ bɔt dis?
If yu ɔ sɔmbɔdi na yu famili gɛt wan sik we pɔsin kin gɛt frɔm in mama ɛn papa, kansa, ɔ wan sik we at fɔ trit, lɛk di wan dɛn we wi dɔn tɔk bɔt na ya, i rili impɔtant fɔ tɔk to yu dɔktɔ bɔt am.
Jin tɛrapi stil nɔto kɔmɔn tritmɛnt na Sri Lanka. Bɔt i impɔtant fɔ no bɔt dɛn tin ya we de apin ɔlsay na di wɔl. Sɔntɛm tumara bambay, dɛn tritmɛnt ya kin bi kɔmɔn tritmɛnt.
De tin wae impɔtant pas ɔl na, nɔr mek yu yone trit disizhɔn bay wetin yu rid ɔr yɛri na intanɛt. Ɔltɛm, aks yu dɔktɔ in advays. I kin ɛksplen to yu us tritmɛnt dɛn we bɛtɛ fɔ yu sik, di wan dɛn we sef, ɛn di bɛst we de.
Dis teknɔlɔji go tek sɔm tɛm fɔ divɛlɔp, bɔt i de sho se mɛdikal sayɛns de tray ɔltɛm fɔ fɛn sɔlv fɔ wan sik, ilɛksɛf i siriɔs. Dat na big op fɔ wi ɔl.
Mɛsej we dɛn kin kɛr go na os
- Jin tɛrapi na nyu mɛrɛsin we de mɛn sik dɛn bay we wi de chenj wi yon jin.
- Dis na fɔ trit di rut kɔz fɔ di sik pas di sayn dɛm.
- Dis we fɔ du tin gɛt big prɔmis fɔ trit siriɔs tin dɛn lɛk kansa ɛn sik dɛn we pɔsin kin gɛt frɔm in mama ɛn papa.
- Dis stil de bɔku pan di risach stej, ɛn i gɛt bɛnifit ɛn risk.
- If yu intres pan dɛn kayn tritmɛnt ya tide, i rili impɔtant fɔ tɔk bɔt dɛn wit yu dɔktɔ.
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