We yu luk na di miro ɛn si tu-tri grey ia wantɛm wantɛm, yu kin fred smɔl ɛn fil bad, nɔto so? I go mɔs bi se bɔku tɛm yu go tink se, "O, misɛf dɔn ol naw." Fɔ sɔm pipul dɛn, dɛn ia kin bigin fɔ grey we dɛn rili yɔŋ, sɔntɛnde we dɛn stil de na skul. Wetin mek dis kin rili apin? Na jɔs bikɔs wi de ol? Di las mɛdikal risach dɔn sho se dis kin bi bikɔs ɔf smɔl chenj na wi yon bɔdi we nɔbɔdi pan wi nɔ bin dɔn tink bɔt.
Wetin na dɛn fayn fayn sɛl dɛn ya we de gi ia in kɔlɔ?
Fɔ tɔk am simpul wan, yu ia kin gɛt in fayn fayn blak ɛn brawn kɔlɔ bikɔs ɔf wan spɛshal kayn sɛl we de na di say we yu ia shaft de. wi kכl dεn pigmεnt stεm sεl dεm , כ mכr prεsis ``Melanocyte Stem Sεl dεm - McSCs``. Dis na di men pat pan wi ia kɔlɔ faktri.
Bɔt dɛn stem sɛl dɛn ya nɔ kin ebul fɔ kɔla di ia dairekt wan. fכ du dat, dεn fכs fכ machכ εn bi "melanosayt dεm." dis melanosayt dεm na dεn wan dεm we de mek di pigmεnt we de gi di ia in kכla.
So di rizin we mek yu ia gɛt wɛlbɔdi ɛn blak na bikɔs dɛn stem sɛl dɛn ya dɔn machɔ as tɛm de go, dɛn dɔn bi pigmɛnt sɛl dɛn, ɛn dɛn de du dɛn wok fayn fayn wan. I sɔprayz fɔ no se dɛn pigmɛnt stem sɛl ya de liv fɔ lɔng lɔng tɛm, bɔt dɛn kin day bifo di ɔda sɛl dɛn we mek di ia shaft. Yu go dɔn notis se sɔm pipul dɛn nɔ kin lɔs dɛn ia as dɛn de ol, bɔt dɛn ia dɔn wayt ɔl. Na dis na di rizin. di sεl dεm na di ia shaft stil de wok, bכt di sεl dεm we mek di ia shaft dכn stכp fכ wok.
Wetin ‘stuck’ min? Di las tin we dɛn dɔn fɛn!
Fɔ lɔng tɛm, dɔktɔ ɛn sayɛnsman dɛn bin de tink se dɛn stem sɛl dɛn ya kin de na wan ples, dɛn kin machɔ we dɛn nid am, dɔn dɛn kin day we dɛn dɔn du dɛn wok. Bɔt di las risach we dɛn dɔn du dɔn chenj dis stori kpatakpata.
Wetin de rili apin na sɔntin we rili kɔmpleks ɛn we rili wɔndaful. Dɛn sɛl dɛn ya tan lɛk lizad we kin chenj in kɔlɔ. Dat min se dɛn kin muv bitwin difrɛn pat dɛn na di ia shaft ɛn chenj dɛn nature, pas fɔ de na wan ples.
Frɔm wetin dis nyu tin we dɛn dɔn fɛn, dɛn sɛl dɛn ya de wok insay saykl dɛn. Dat na:
1. di fכs stej: dεn de stat lεk stεm sεl dεm we nכ machכ.
2. Fɔnkshɔn: Dɔn i de travul go na ɔda pat na di ia shaft, machɔ, ɛn mek di pigmɛnt dɛn we de gi di ia in kɔlɔ.
3. Ritɔn joyn: We dɛn dɔn du di wok, dɛn sɛl dɛn de go bak to dɛn fɔs stet, dat na di stet we di stem sɛl dɛn de , ɛn go bak to dɛn fɔs ples.
As lɔng as dis saykl de kɔntinyu, wi ia go gɛt kɔlɔ.
So usay di prɔblɛm de?
Risach pipul dɛn dɔn kam fɔ no se as wi de ol, sɔntɛnde dɛn valyu stem sɛl dɛn ya kin stɔp na di rɔng ples na di ia shaft. Dɛn kin stɔp na wan pat pan di ia shaft we dɛn kɔl di fɔlikul bulj. we dεn stכk, dεn nכ kin kכmplit dεn saykl, we min se dεn nכ kin machכ εn go usay dεn nid fכ go fכ mek pigmεnt.
Di rizɔlt? Di nyu ia shaft nɔ de gɛt ɛni kɔlɔ. So i kin kɔmɔt wayt ɔ grey.
Lɛ wi ɛksplen dis prɔses smɔl mɔ.
| We | Wetin ɔda (simply) . |
|---|---|
| Yɔŋ ia we gɛt wɛlbɔdi | di stεm sεl dεm (McSC dεm) de muv kכrekt, machכ (dεn de bi melanosayt), εn de gi pigmεnt to di ia. Dɔn dɛn kin go bak to di fɔs we aw dɛn bin de. Dis saykl de kɔntinyu. |
| We yu ol/we yu ia tɔn wayt | sכm stεm sεl dεm kin stכk na wan pat pan di ia shaft we dεn kכl ‘bulge’. Dɛn nɔ kin ebul fɔ muf go bifo ɔ machɔ. |
| Faynal rizulyt | Bikɔs no sɛl nɔ de fɔ mek di ia we dɛn jɔs de gro kin wayt ɔ grey. |
Dis kin gi yu bak wan clue bɔt kansa?
Yɛs. Dis tin we dɛn dɔn fɛn kin impɔtant nɔto jɔs fɔ mek di ia grey, bɔt i kin impɔtant bak fɔ ɔndastand di kansa na di skin . na di mכst siriכs kayn kεnsar na di skin , mεlanoma , de divεlכp frכm dεn pigmεnt sεl dεm (melanosayt dεm).
Wan pan di tin dɛn we kin mek di mɛlanoma kansa sɛl dɛn kin denja pas ɔl na we dɛn kin ebul fɔ chenj di we aw dɛn tan izi wan. Insay mɛrɛsin, dɛn kin kɔl dis ‘plasticity’ . Dis abiliti na di rizin we mek i nɔ izi fɔ kɔntrol ɛn mɛn di mɛlanoma kansa ɔltogɛda.
dis nyu risach sho se wi nכmal, hεlty pigmεnt sεl dεm dεn tu gεt hכy digri fכ ‘plasticity’. So, sayɛnsman dɛn naw de sɔspɛkt se dis denja bihayvya we di mɛlanoma kansa sɛl dɛn gɛt kin bi bikɔs ɔf dis ‘abiliti fɔ chenj’ na di nɔmal pigmɛnt sɛl dɛnsɛf, usay dɛn kɔmɔt.
So yu tink se i go pɔsibul fɔ fɛn mɛrɛsin fɔ dis?
Dis na di kwɛstyɔn we de na ɔlman in maynd. naw we dεn dכn fכnshכn di ‘stכk’ prכsεs, di nεks gol fכ risechכr dεm na fכ fכn we f כ rilis dεn stכk sεl dεm ya εn sεnd dεm bak na dεn rayt ples . If dɛn ebul fɔ du dat, i kin mek di ia nɔ tɔn grey, ɛn sɔntɛm i kin ivin mek i nɔ pɔsibul fɔ mek di ia blak bak.
Bɔt dis stil de na di risach stej. No mɛrɛsin nɔ de fɔ dis yet. Bɔt ripɔt dɔn de bɔt sɔm pipul dɛn we dɛn grey ia dɔn tɔn grey bak bikɔs ɔf di mɛrɛsin dɛn we dɛn kin gi fɔ ɔda sik dɛn. Sɔntɛm dɛn mɛrɛsin dɛn de de ‘fri’ dɛn sɛl dɛn ya we dɔn trɔp we dɛn nɔ no.
wi nid fכ invεstigat mכr bak if tin dεm lεk strεs εn smok de afekt di blכk we dεn sεl dεm ya de blok, biכs wi no se dεn tin ya de afekt bכku prכsεs dεm na di bכdi bad bad wan.
Mɛsej we dɛn kin kɛr go na os
- di men rizin we mek yu ia de tכn wayt na biכs di spεshal stεm sεl dεm we de gi yu ia kכla, we dεn kכl Melanocyte Stem Cells, dεn ‘stכk’ na di rכng ples na di ia shaft.
- Dis na nyu tin we sayɛnsman dɛn dɔn fɛn. Risach pipul dɛn de tray fɔ fɛn tritmɛnt we go fri dɛn sɛl dɛn ya we dɔn trɔp ɛn stɔp di ia fɔ tɔn grey.
- Dis tɛm, no patikyula mɛrɛsin nɔ de we go mek di ia nɔ tɔn grey. Tek tɛm wit wetin de na di makit.
- Te dɛn gɛt difinitiv tritmɛnt, fɔ adopt wɛlbɔdi abit dɛn lɛk fɔ it balans it, fɔ avɔyd fɔ smok, ɛn fɔ kɔntrol strɛs go ɛp yu ɔl wɛlbɔdi ɛn yu ia wɛlbɔdi.
- If yu notis wan chenj we nɔ kɔmɔn na yu skin ɔ yu ia (e.g., nyu spat, we de grey kwik kwik wan), nɔ panik, bɔt fɔ tru, go to yu dɔktɔ fɔ advays.
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