Prɔblɛm de wit yu wayt blɔd sɛl dɛn? Lɛ wi lan bɔt Histiocytosis insay simpul wɔd dɛn!

Yu no se sɔntɛnde sɔm kayn sɛl dɛn na wi bɔdi kin bigin fɔ biev difrɛn we smɔl? Wan pan dɛn kayn tin ya we nɔ kin apin so ɔltɛm na in dɛn kɔl Histiocytosis. Dis kin tan lɛk se i de mek yu fred smɔl, bɔt nɔ wɔri. Lɛ wi tɔk bɔt am simpul wan ɛn di we we mek sɛns.

Wetin na Histiocytosis? In simpul wɔd dɛn...

Yu bɔdi gɛt wan kayn wayt blɔd sɛl we dɛn kɔl histiocytes. Pan dɛn wayt blɔd sɛl dɛn de, wan spɛshal kayn sɛl de we dɛn kɔl histiocytes . Dɛn pipul ya tan lɛk di wan dɛn we de gayd wi bɔdi. Na dɛn wan ya de fɛt di jem dɛm we de mek wi gɛt sik we dɛn kɔl patɔjɛns - vayrɔs , baktri dɛm , ɛn fɛns - ɛn ɛp fɔ mek wi imyun sistɛm gɛt wɛlbɔdi.

כltu, sכmtεm dεn histiocyte sεl dεm ya kin bigin fכ gro abnכmal, dat na, dεn kin bi `` mutant '' . afta dat, dεn abnכmal histiocyte sεl dεm ya de gro pasmak εn de kכmכt na difrεn pat dεm na wi bכdi. We dɛn gɛda pasmak, wi imyun sistɛm kin gɛt prɔblɛm. Di men tin na dat, inflamɛns , dat na, wan tin we tan lɛk swɛlin , kin apin na di bɔdi in tisu dɛn. Dis inflamɛns kin pwɛl wi ɔgan dɛn sɔntɛnde.

dis abnכmal histiocyte sεl dεm kin bכku na yu limf no dεm (dεn kin kכl dεm bak limf no dεm), skin, bon dεm, lכng dεm, liva, splin, כ εnisay na yu bכdi. Sɔntɛnde, i kin afɛkt jɔs wan pat na yu bɔdi. Wi kin kɔl dis ‘singl sistɛm’ kɔndishɔn. Ɔda tɛm dɛn i kin afɛkt bɔku pat dɛn na yu bɔdi. Wi kin kɔl dis ‘multisystem’ kɔndishɔn.

Di impɔtant tin na dat histiocytosis nɔto kansa . Bɔt sɔmtɛm, i kin biev lɛk kansa ɛn sho sɔm sayn dɛm we fiba kansa. Na dat mek na sik we pɔsin fɔ pe atɛnshɔn to smɔl. Bikɔs di sayn dɛm fɔ dis kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin ɛn aw di sik kin tranga kin difrɛn, sɔmtɛm i kin tranga fɔ no kwik kwik wan bɔt histiocytosis.

Wetin na di men kayn histiocytosis?

Naw yu go dɔn ɔndastand wetin na histiocytosis. Fɔ tru, i pas 100 kayn dɛn. Bɔt tri men kayn dɛn de we wi kin si ɛn tɔk bɔt bɔku tɛm. Mek wi tek wan luk pan dem.

1. Langerhans sel histiosaytosis (LCH): .

• dis na di kayn histiocytosis we kכmכn pas כl .
• Dis sik kin afɛkt yɔŋ pikin dɛn mɔ . I kin afɛkt bitwin 5 ɛn 9 pan ɛvri milyɔn pikin dɛn.
• Bɔrku tɛm, dis nɔr kin siriɔs, ɛn kin simpul lɛk ``asymptomatic'' . Bɔt i impɔtant fɔ mɛmba se sɔm tɛm dɛn de, dis kin rili bad ɛn ivin put in layf pan denja.

2. Di sik we dɛn kɔl Ɛrdheim-Chester (ECD): .

• Dis kayn kin afɛkt big pipul dɛn mɔ .
• Dis na tin bak we nɔ kin apin so ɔltɛm .
• Lɛk LCH, ECD kin kɔmɔt frɔm smɔl to siriɔs ɛn i kin mek pɔsin in layf de pan denja.

3. Di sik we dɛn kɔl Rosai-Dorfman (RDD): .

• Lɛk LCH, RDD kin apin mɔ pan pikin dɛn , bɔt i kin apin bak pan big pipul dɛn.
• Dis na tin bak we nɔ kin apin so ɔltɛm. Na lɛk wan pan ɛvri tu ɔndrɛd tawzin pipul dɛn kin gɛt dis sik.
• Di men kayn dis na ‘klasik RDD’ . dis na we yu limf no dεm (gland dεm) kin swεla.
• Di ɔda kayn na ‘ɛkstranodal RDD’ . insay dis, כda כgan dεm we nכ de na di limf no dεm de afekt. dis min se di histiocyte sεl dεm we pasmak kin kכmכt na di skin, di bon dεm, כ כda ples dεm.

Aw dis sik nɔ kin bɔku we dɛn kɔl Histiocytosis?

Yɛs, lɛk aw a bin dɔn tɔk bifo tɛm, histiocytosis na sik we nɔ kin apin so ɔltɛm . infakt, di mכr agresiv, kεnsar fכm dεm fכ am de mek lεs dan 1% pan כl di kεnsar dεm we dεn no na di sכft tisu εn limf no dεm. So yu kin imajin aw dis nɔ kin apin so ɔltɛm.

Wetin na di sayn dɛm fɔ Histiocytosis?

naw lε wi si us simptom dεm dεn sho na dis histiocytosis kכndishכn. Dɛn sayn ya kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin . di rizin fכ dis na biכs di כgan dεm εn tisu dεm we di εksyכs histiocyte sεl dεm de kכmכt, lεk aw a bin mεnshכn, εn di mak we dεn tisu dεm de damej, de afekt dis.

Na sɔm pan de sayn dɛm wae yu kin si (ɛn mɔr kin de):

• Skin rash : yu kin si dis speshali na di εria dεm we gεt hεri na di ed fכ yכŋ pikin dεm (wi kכl dεm ‘cradle cap’ ) כ na di nεpi εria.
• Fiva .
• Taya, taya .
• Ed de at.
• Kɔf ɔ shɔt briz .
• We yu de lɔs yu wet we yu nɔ ɛksplen .
• Bɔn pen .
• di limf no dεm we swεla (dis na wetin swel min).
• Di we aw pɔsin de si kin chenj ɔ di yay we de bɔl .
• Fɔ pis bɔku tɛm ɛn fɔ tɔsti pasmak .
• Skin bump (i kin ivin apia na di aylid).
• I nɔ kin izi fɔ pe atɛnshɔn ɔ fɔ mɛmba tin dɛn .
• Prɔblɛm dɛn we de wit balans ɛn kɔdineshɔn .

Aw di sayn dɛm kin apin? dipכnt pan usay di histiosayt dεm de kכmכt!

dis simptom dεm de dipכnt pan usay insay di bכdi di histiocyte sεl dεm de kכmכt. di men sayt dεm we di akyumyuleshכn de difrεn dipכnt pan di kayn histiocytosis.

sayt dεm we kin afekt insay Langerhans sεl histiocytosis (LCH):

• Bon
• Kanda
• Limf no dɛm (we de swel) .
• Liva
• Spleen we de na di bɔdi
• Mɔt
• Lɔng
• Sεntri nεv sεstem (dat na di bren εn di spεnal kכd) .

Di say dɛm wae kin afɛkt pan Erdheim-Chester disease (ECD):

• Lɔng bon dɛn (espɛshali na di leg dɛn) .
• Yay
• Sɛntral nervɔs sistɛm
• Lɔng
• At
• Blɔd vesel dɛn
• Kidni dɛn
• di כgan dεm we de na di bak pat pan di bכdi (wi kכl dεm di 'retroperitoneum' ) .

Di eria dɛm wae kin afɛkt pan Rosai-Dorfman sik (RDD):

• di limf no dεm (sεf na di nεk, bכt i kin apin כdasay bak) .
• Kanda
• Sɔft tisu
• Di ɔpa respiratɔri trakt
• Bon
• Retroperitoneum (ɔgan dɛn we de biɛn di bɛlɛ) .
• Yay

Wetin kin mek pɔsin gɛt Histiocytosis?

Sayɛnsman dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek pɔsin gɛt histiocytosis, bɔt dɛn dɔn kam fɔ no se i kin gɛt sɔntin fɔ du wit di chenj dɛn we de apin na di jɛnɛtiks .

Fɔ tɔk am simpul wan, ɔl di sɛl dɛn na wi bɔdi gɛt tin dɛn we dɛn mek wit jɛnɛtiks, ɔ sɔm tin dɛn we dɛn kin tɛl am fɔ du. Dɛn instrɔkshɔn ya de sho aw dɛn sɛl dɛn de fɔ biev. So, we chenj dεm na dεn instrכkshכn dεm ya, we dεn kכl mכtεshכn, apin, di sεl dεm kin bigin fכ biev bכku. fכ egzampl, we di jεnεtik mכtεshכn kin mek wan sεl lεk histiocyte kכpi insεf εn bigin fכ spre we i nכ ebul fכ kכntrol.

we dεn no dεn jεnεtik mכtεshכn ya dεn dכn alaw risecharch dεm fכ divεl כp nyu tritmεnt fכ histiocytosis. dis tritmεnt dεm de wok bay we dεn de mek di bad bad sεl chenj dεm we de alaw di histiocyte sεl dεm fכ gro we dεn nכ de kכntrכl.

Aw yu kin no di histiocytosis?

If yu sɔspɛkt se yu gɛt histiocytosis, yu dɔktɔ go fɔs du yu bɔdi ɛgzam ɛn aks bɔt yu mɛdikal histri. Dɔn, dɛn go disayd us tɛst fɔ du bay di sayn dɛm we yu gɛt ɛn di ɔgan dɛm we dɛn tink se di histiocytes we pasmak de afɛkt.

Na sɔm tɛst dɛn we yu kin du:

• Di we aw fɔ tek imej : .
• Yu dɔktɔ kin ɔda wan spɛshal skan we dɛn kɔl FDG PET/CT skan . Dis kin no tin dɛm lɛk tumbu ɔlsay na di bɔdi.
• Apat frɔm dat , dɛn kin nid fɔ du tɛst dɛn lɛk CT skan, MRI skan, bon skan, ɔltra saund skan, ɛkstrem rayt, ɔ ɛkokadiogram (we dɛn kin skan di at).

• Labɔrɔtɔri tɛst dɛn : .
• Yu dɔktɔ go tɛst wata sɛmpul dɛn lɛk yu blɔd ɔ yu urine fɔ si if sayn dɛn de fɔ histiocytosis.
• Dɛn kin chɛk yu blɔd sɛl kɔnt. Dɛn kin luk bak fɔ sɔm patikyula ɔmon ɔ prɔtin dɛn we de sho aw yu ɔgan dɛn de wok. If wan ɔgan nɔ de wok fayn, i kin sho se tumɔs histiocytes de na da ɔgan de.

• Bayopsi tɛst `(Bayopsi)` : .
• Wetin dis de du na we di dɔktɔ tek wan tisu sɛmpul ɛn chɛk am ɔnda maykroskɔp fɔ si if yu gɛt histiocytosis.
• i de luk bak fכ spεsifi k jεnεtik mכtεshכn dεm we de asai wit histiocytosis.
• Sɔntɛnde, if i nɔ pɔsibul fɔ tek bayɔpsi, dɛn kin tɛst di jɛnɛtik matirial we de na yu blɔd. Dɛn kɔl dis ‘likwid bayɔpsi’ .

Wetin na di tritmɛnt dɛm fɔ Histiocytosis?

di tritmεnt fכ histiocytosis dipכnt pan plεnti tin dεm . Speshal wan:

• Aw yu sik dɛn kin rili bad .
• If yu gɛt wan lɛsin ɔ bɔku (dɛn na eria dɛn we nɔmal tisu).
• Usay na di bɔdi dɛn `lɛsin` ya de ?
• Ilɛksɛf dɛn lumps ya gɛt kansa ɔ nɔto kansa .

Dɔktɔ dɛn kin disayd fɔ tritmɛnt bay dɛn tin ya. Na sɔm tritmɛnt dɛn ya:

• Wach ɛn wet : If yu histiocytosis nɔr siriɔs ɛn yu nɔr gɛt ɛni big sayn, yu dɔktɔ kin jɔs tɛl yu fɔ wach yu kɔndishɔn.
• Ɔpreshɔn: If di histiocyte sel dεm dכn kכlekt na wan pat nכmכ na di bכdi, dεn kin du כpεrayshכn fכ pul da pat de.
• Radiation therapy : Dis involv fɔ yuz mashin fɔ dayrɛkt ay-ɛnaji bim dɛm fɔ redyushɔn to di lɛsin dɛm. dis rayt dεm de kil di sεl dεm we nכ nכmal εn slo di tכmכro dεm we de gro. Sɔntɛnde, redyushɔn tɛrapi kin ɛp bak fɔ ridyus di sayn dɛm.
• Kεmothεrapi (dεn kin kכl am bak ‘chemo’) : Dis involv fכ sεnd kεmikכl dεm na yu bכdi fכ pwεl di εksyכs histiocyte sεl dεm we dεn spre כlsay na yu bכdi. di dכkta dεm nכmכ de rεkomεnd ‘chemo’ if di histiocyte sεl dεm dכn spre כlsay na yu bכdi.
• Kɔtikosterɔyd : Mɛrɛsin dɛn lɛk prɛdnison de insay dis kategori. dis kin ridyus di inflameshn (swεlin) we de kכmכt wit di histiocytosis. Dɛn kin gi dɛn mɛrɛsin ya dɛn wan ɔ dɛn kin gi am wit ɔda tritmɛnt dɛn lɛk kemotɛrapi.
• Immunotherapy : Dis de wok bay we i de mek yu yon imyun sistεm strכng, i de εp am fכ no εn pwεl di sεl dεm we de du bad, lεk di histiocytes we nכ de nכmal.
• Targeted therapy : Dis na spɛshal tritmɛnt. dis tritmεnt dεn de yuz fכ histiocytosis kכndishכn dεm we de asai wit sכm jεnεtik mכtεshכn dεm.

Yu tink se Histiocytosis kin wɛl ɔltogɛda?

I at fɔ se ‘yes’ ɔ ‘nɔ’ to dis, bikɔs i dipen pan di tin we de apin. Bɔrku pipul dɛm wae gɛt histiocytosis kin go insay wetin dɛn kɔl ‘durable remission.’ Dat min se, dɛn kin go we dɛn nɔ gɛt ɛni sayn ɔ sayn fɔ di sik.

sכm kayn histiocytosis, spεshal wan we di histiocytosis de כnli na wan ples na di bכdi, kin kכmplit kכl wit כpεrayshכn . Yu dɔktɔ go gi yu fɔlɔp visit fɔ chɛk fɔ si if i gɛt di sik bak.

Bɔt if di kayn histiocytosis we yu gɛt nɔr kin wɛl ɔl, yu dɔktɔ go tɛl yu fɔ gɛt tritmɛnt plan wae go ɛp yu fɔ kɔntrol di sik.

Wetin na di prɔgnosis fɔ dis kɔndishɔn?

Di prɔgnosis fɔ yu kɔndishɔn de dipen pan bɔku tin dɛm. Fɔ sɔm pipul dɛm, histiocytosis kin bɛtɛ fɔ insɛf if dɛn nɔ gɛt ɛni tritmɛnt . Fɔ ɛgzampul, lɛk 40% pan di pipul dɛm wae gɛt RDD kin wɛl if dɛn nɔr gɛt tritmɛnt. כlso, we LCH de afekt כnli wan pat pan di bכdi (wi kכl am ‘localized LCH’) , bכku tεm i kin bεtε fכ insεf.

Bɔt, insay ɔda kes dɛm, histiocytosis nid fɔ gɛt bɔku tritmɛnt ɛn tek tɛm wach, pan pikin ɛn big pipul dɛm.If i rili bad, histiocytosis kin mek di ɔgan dɛn pwɛl ɛn ivin i kin mek pɔsin in layf de pan denja .

So, i bɛtɛ fɔ aks yu dɔktɔ bɔt di prɔgnosis we spɛshal fɔ yu diagnosis.

Yu tink se dɛn kin mek dɛn nɔ gɛt Histiocytosis? Aw dɛn go ebul fɔ ridyus di prɔblɛm?

Fɔ tɔk tru, no we nɔ de fɔ mek yu nɔ gɛt histiocytosis, bɔt tritmɛnt kin ɛp yu fɔ kɔntrol yu sik dɛn.

Bɔt wan tin de. If yu lɛf fɔ smok, dat kin mek yu nɔ gɛt LCH (Langerhans cell histiocytosis), we na wan kansa na yu lɔng. If yu lɛf fɔ smok ɔ yu nɔ de smok, dat kin mek yu fil fayn bak we yu gɛt tritmɛnt. If yu nid ɛp fɔ lɛf fɔ smok, aks yu dɔktɔ bɔt di program dɛn fɔ rifer pɔsin fɔ lɛf fɔ smok.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

If dɛn dɔn no se yu gɛt histiocytosis, na nɔmal tin fɔ gɛt bɔku kwɛstyɔn na yu maynd. E fayn fɔ tɔk to yu dɔktɔ bɔt ɔl dis ɛn ɔndastand yu sik gud gud wan. Na sɔm kwɛstyɔn dɛn we yu kin aks:

• Us kayn histiocytosis a gɛt?
• A go nid tritmɛnt?
• Us tritmɛnt dɛn yu kin advays?
• Us sayd ɛfɛkt dɛn kin ɛkspɛkt we dɛn de trit am?
• Wetin na di tin dɛn we kin apin we pɔsin gɛt tritmɛnt?
• Yu tink se mi sik kin wɛl ɔltogɛda?

Faynal Mɛsej fɔ Tek-Hom

Fɔ tɔk am simpul wan, histiocytosis na di nem we dɛn kin gi wan grup we nɔ kin apin so ɔltɛm na di blɔd we kin kam bikɔs di histiocytes, we na wan kayn wayt blɔd sɛl, kin bɔku pasmak na di tisu dɛn. Sɔm pan dɛn tin ya kin rili simpul, ɛn nɔ kin mek pɔsin gɛt ɛni sayn, ɛn ɔda wan dɛn kin rili bad ɛn dat kin mek pɔsin in layf de pan denja .

כlman we gεt histiocytosis gεt εksyכs histiocytosis na in tisu dεm, we de mek inflameshn (swεla). Bɔt di sayn dɛm, di tritmɛnt dɛm, ɛn aw di sik kin kɔmɔt kin difrɛn bad bad wan, ivin pan pipul dɛm wae gɛt di sem kayn histiocytosis .

Yu dɔktɔ na di bɛst pɔsin fɔ ɔndastand di sik we yu gɛt ɛn di spɛshal tin dɛn we de apin to am. So, fɔ ɔndastand yu diagnosis ɛn tritmɛnt plan gud gud wan, nɔ ɛva fred fɔ aks kwɛstyɔn. Tɔk to yu dɔktɔ bɔt ɔltin we de na yu maynd.

` Histiocytosis, Wait bכdi sεl dεm, Histiocytes, Imyun sistεm, LCH, ECD, RDD, Simptom dεm, Tritmεnt