Yu de wɔri bak bɔt di bɔku bɔku man ɔmon dɛn na yu bɔdi? Lɛ wi tɔk bɔt hyperandrogenism!

Yu de wɔri bɔt sɔm chenj dɛn we de apin na yu bɔdi? Sɔntɛm di rizin na we di androgen, we na wan kayn man ɔmon, de bɔku na di bɔdi. Dɛn kin kɔl dis sik we dɛn kɔl hyperandrogenism . Nɔ wɔri, wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wetin rili na hyperandrogenism?

Fɔ tɔk am simpul wan, hyperandrogenism min se yu bɔdi gɛt tumɔs androgens, we na wan kayn sɛks ɔmon. Andrכjen dεm implεnt fכ puberty, riprodaktiv hεlth, εn bכdi gro.

Naw luk, ɔmon na kemikal dɛn we de na wi bɔdi. Dɛn tan lɛk mɛsenja dɛn. Dɛn kin travul tru di blɔd ɛn tɛl wi ɔgan dɛn, mɔsul dɛn, ɛn ɔda tisu dɛn wetin fɔ du ɛn ustɛm fɔ du am.

Androgen dεm de kכmכt na כlman in bכdi. Bɔt na man dɛn de prodyuz mɔ. Uman dɛn kin mek lɛk wan pat pan twɛlv pan di tin dɛn we de na man in bɔdi. Tεstostεron na di men wan pan dεn andrכjen dεm ya.

di tεstikul dεm na di tεstikul dεm na di man dεm εn di ovary dεm na uman dεm de mek di andrכjen dεm. di adrenal gland dεm we de oba wi kidni dεm de mek dεn כmon dεm ya bak. dεn de εp bak fכ kכnvכlt wik andrכjen dεm to strכng wan dεm na ples dεm lεk fεt tisu εn skin.

De sayn dɛm fɔ dis sik, wae dɛn kɔl hyperandrogenism, kin difrɛn difrɛn wan wae yu ol ɛn yu man ɔ uman. Bɔku tin dɛn de we kin mek i apin, ɛn tritmɛnt dɛn de fɔ am.

Hyperandrogenism ɛn PCOS na di sem tin?

Bɔrku pipul dɛn kin tink se Hyperandrogenism ɛn Polycystic Ovary Syndrome (PCOS) na di sem sik. Pan ɔl we tayt padi biznɛs de bitwin dɛn tu, dɛn nɔto di sem.

Hyperandrogenism na wan impɔtant tin we de mek pɔsin gɛt PCOS. PCOS na di hכmon imbalans we di ovaria dεm de mek tu mכch man כmon dεm. I kin afɛkt uman dɛn.

So, pan ɔl we PCOS na kɔmɔn tin we kin mek pɔsin gɛt haypa androjen, ɔda tin dɛn kin de we kin mek pɔsin gɛt haypa ɛndrojen. Semweso, PCOS gɛt ɔda sayn dɛn lɛk ovarian sist, apat frɔm di sayn dɛn we de sho se pɔsin gɛt haypa ɛndrojenism.

Udat dɛn kin afɛkt mɔ pan dis sik? Aw i kɔmɔn?

Hyperandrogenism kin afɛkt ɛnibɔdi - yɔŋ pikin, big pipul, ɔlman. Bɔt i kin apin mɔ pan uman dɛn we dɔn rich di ej fɔ bɔn pikin .

bitwin 5% ɛn 10% pan di uman dɛn we dɔn rich di ej fɔ bɔn pikinDis tin we de apin de afɛkt pipul dɛn. Dat min se dis nɔ kin apin so ɔltɛm lɛk aw yu go tink.

Dis sik nɔ kin afɛkt bɔy pikin ɛn big man dɛn.

Wetin na di sayn dɛm fɔ dis?

Di sayn dɛm fɔ hyperandrogenism kin difrɛn difrɛn wan fɔ yu man ɔ uman ɛn if yu dɔn go tru puberty.

Bɔt na wan impɔtant tin we wi fɔ mɛmba. Ivin if yu gɛt dɛn sik ya, di androgen lɛvɛl na yu blɔd kin bi nɔmal. Dis na bikɔs ɛni wan pan dɛn sayn ya kin gɛt ɔda tin dɛn. Dɔn bak, ivin if blɔd tɛst sho se yu androgen lɛvɛl bɔku, yu nɔ go gɛt ɛni big sayn.

Di tin we impɔtant pas ɔl na dat if dɛn sik ya apin wantɛm wantɛm ɛn kwik kwik wan, yu fɔ rili go to dɔktɔ kwik kwik wan, bikɔs na dɛn kayn tin ya, di tin we kin mek yu gɛt di sik kin bi wan tumbu we de pul androgen.

Naw lɛ wi si aw dis kin afɛkt difrɛn pipul dɛn.

Fɔ gyal pikin dɛn (bifo dɛn bɔn pikin) .

• Di klitoris we dɔn big .
• Akni ɛn ɔyl skin.
• di ia we yu nɔ want fɔ gro na di bɔdi (hirsutism) . dis min se di "layt brawn ia" de tek di ples wit kכs, kכs kכs ia na say dεm lεk di כp lip, chin, chεst, bεlε, εn bak.

Fɔ man pikin dɛn (bifo dɛn bɔn pikin) .

• Penis we dɔn big .
• di ia we de gro kwik ɔ we pasmak na di prayvet eria ɛn di armpit.
• Dip we di vɔys de dip.

Fɔ uman dɛn we dɔn ol

• Akni ɛn ɔyl skin.
• di ia fכlikul dεm na di bכdi we yu nכ want ( hirsutism) .
• Menstrual saykl we nɔ kin apin ɔltɛm.
• I nɔ izi fɔ bɔn pikin (infertility) .
• Man patɛn ia we de lɔs ( androgenic alopecia) .

Fɔ big man dɛn

aw dis kin afekt big man dεm de dipכnt pan if di εkstra כmon dεm kכmכt frכm di adrenal gland dεm כ frכm sכmtin we dεn tek na do (lεk anabolic stεroyd injεkshכn). if di androgen dεm we de kכmכt na di adrenal gland dεm de inkrεs, di big man dεm nכ go notis εni big chenj dεm na di bכdi. Bɔt i kin mek di tɛstikul dɛn nɔ wok fayn ɛn i kin mek i nɔ izi fɔ bɔn pikin.

Wetin mek dis de apin? Wetin na di rizin dɛn?

di εndrכjen כmon dεm na di ovaria, di adrenal gland dεm, εn di fεt sεl dεm na uman dεm, εn di tεstikul dεm εn di adrenal gland dεm na man dεm de mek am.

כda כmon dεm de we de afekt di prodakshכn εn rilis fכ dεn andrכjen dεm ya. Fɔ ɛgzampul , di ɔmon we de mek pɔsin gɛt luteinizing (LH) ɛn di ɔmon we dɛn kɔl adrenocorticotrophic hormone (ACTH) . di tu כmon dεm na di pituitary gland de kכmכt.

if wan כ mכr pan dεn כgan dεm ya, כ wan pan dεn כmon dεm ya nכ de wok fayn, haypa androjenism kin apin.

Bɔku men rizin dɛn de fɔ dis:

• Polycystic ovary syndrome (PCOS) - dis na di kכmכn kכz.
• Adrenal Hyperplasia we dɛn kin bɔn wit (CAH) .
• Di sik we Cushing gɛt .
• Tכmכro dεm we de kכl andrכjen.
• Sɔm mɛrɛsin dɛn.

Naw lɛ wi luk ɛni wan pan dɛn rizin ya smɔl mɔ.

Polisistik ovari sindrom (PCOS) .

pan yכng εn ol uman dεm, PCOS na di mכst kכmכn kכz fכ pεrsistεnt haypa androjenism afta dεn dכn bכn. Bitwin 80% ɛn 90% pan di uman dɛn we gɛt haypa ɛndrojenism gɛt PCOS bak .

insay PCOS, di ovaria dεm de prodyuz mכr andrכjen dεm bikoz fכ di hכy lεvεl dεm we de kכntinyu fכ LH εn insulin (hyperinsulinemia). apat frכm dat, di insulin lεvεl we de inkrεs de mek di liva nכ de mek wan protin we dεn kכl Sex Hormone Binding Globulin (SHBG) . dis de mek di lεvεl fכ fri tεstostεron na di bכdi go כp.

Adrenal haypaplasia we dɛn bɔn wit `(CAH)`

di congenital adrenal hyperplasia (CAH) na wan grup fכ di jεnεtik kכndyushכn dεm we de afekt di adrenal gland dεm.

insay CAH, di jεnεtik mכtεshכn kin mek wan εnzym we dεn kכl 21-hydroxylase , we de εp di bכdi fכ mek כmon dεm. pan bכku pipul dεm we gεt CAH, dis εnzym we dεn nכ gεt de mek di adrenal gland dεm de mek mכr כda כmon dεm lεk tεstostεron.

di mכst kכmכn kכz fכ haypa androjenism pan uman dεm we gεt adrenal haypaplasia na nכn-klasik kכnεnital adrenal haypaplasia . dis na kכndishכn we di εnzym 21-haydroksylεz de pat pan di bכdi. dis kכndyushכn de afekt bכt 2% pan di uman dεm we gεt haypa androjenism.

Di sik we Cushing gɛt

Di sik we dɛn kɔl Cushing’s disease na wan kayn sik we dɛn kɔl Cushing syndrome . Cushing syndrome na wan sik we nɔ kin apin so ɔltɛm we di bɔdi gɛt tumɔs kɔtisol (we na ɔmon bak).

Di sik we dɛn kɔl Cushing kin kam bikɔs ɔf wan tɔŋ we nɔ gɛt kansa na di pituitary gland. dis tכmכro de kכl di εksyכs ACTH (adrenocorticotropic hormone), we de mek di kכtisol lεvεl go כp.

di ACTH we pasmak de mek di adrenal gland dεm de rilis di εksyכs andrכjen dεm, we na wetin de mek di haypa androjenism.

Cushing syndrome gɛt ɔda sayn dɛm:

• Pepul strɛch mak dɛn na di bɛlɛ.
• We yu de gɛt bɔku bɔku wet kwik kwik wan na yu fes, yu bɛlɛ, ɛn yu nɛk.
• Di ay blɔd prɛshɔn.

If yu gɛt sayn dɛn lɛk dis, i rili impɔtant fɔ go to dɔktɔ kwik kwik wan.

Tכmכro dεm we de kכl andrכjen

sכm adrenal gland tכmכro dεm, כ tכmכro dεm na di ovaria כ tεstikul dεm kin mek εn sekret andrכjen dεm. dis kin mek di androgen lεvεl na di bכdi hכy pas nכmal. di kכndyushכn fכ haypa androjenism we dεn tכmכro dεm ya kin kכz kin rili siriכs εn i kin kam wan wan .

Hyperandrogenism, we kin kam frɔm ovarian ɔ adrenal tumor, nɔ kin apin so ɔltɛm. Na lɛk 0.2% pan pipul dɛn nɔmɔ i kin afɛkt. Bɔt if yu gɛt sayn dɛn we de sho se yu gɛt di sik we dɛn kɔl hyperandrogenism wantɛm wantɛm, go to dɔktɔ wantɛm wantɛm.

Sɔm mɛrɛsin dɛn

Sɔm mɛrɛsin kin mek bak yu gɛt hyperandrogenism. Di men mɛrɛsin dɛm wae kin mek dis sik na:

• Anabolic-androgenic steroids (dεn na sεntetik fכm dεm fכ tεstostεron, we sכm atlet dεm de yuz mis fכ mek dεn wok fayn).
• sεntetik projεstin dεm (dεn na mεdikal dεm we de mek chenj dεm na di uterus εn dεn de yuz dεm fכ difrεn tin dεm).
• Antiepileptic drugs ( mɛrɛsin fɔ mek yu nɔ gɛt sik ).

Aw yu kin fɛn dis? (Diagnosis) .

If yu na uman ɛn yu sɔspɛkt se yu gɛt hyperandrogenism, yu dɔktɔ go du fyzikal ɛgzam ɛn luk fɔ sɔm sayn dɛm lɛk fɔ mek yu ia gro we yu nɔ want. Dɛn go aks yu sɔm kwɛstyɔn dɛn bak bɔt yu mɛdikal istri:

• di ej we di brεst dεn bigin fכ divεlכp.
• Di ej we di ia bigin fɔ apia na di prayvet eria.
• Ej we yu bigin fɔ gɛt mɔnt.
• yu kin pul yu ia (shave, yu don geht laser hair removal)?
• Yu dɔn ɛva yuz anabolic steroid ɔ testosterone we yu nɔ gɛt dɔktɔ in prɛskrishɔn?
• Tin dɛm lɛk aw yu prɛgnɛshɔn kin kam, ɔmɔs dez i kin te, ɛn ɔmɔs blɔd yu kin blɔd.

If yu dɔktɔ tink se yu gɛt haypa ɛndrojenism, dɛn go ɔda fɔ mek dɛn du blɔd tɛst fɔ chɛk sɔm ɔmon lɛvɛl. Dɛn tɛst ya kin ɛp fɔ no di sik.

Us kayn tɛst dɛn kin du?

If yu gɛt sayn dɛm fɔ hyperandrogenism, yu dɔktɔ kin ɔda fɔ du blɔd tɛst lɛk dɛn wan ya:

• Tɔtɔl tɛstostɛron: Dis de mכsu di tכtal כmכnt כf tεstostεron na yu bכdi. Dis lεvεl kin hכy sכmtεm pan uman dεm we gεt PCOS. If i rili ay, i kin bi tumbu na di ovaria ɔ di tɛstikul.
• Fri tεstostεron : Dis tεstostεron nכ de tay pan εni protin. dis na sכm sכm tכtal tεstostεron. Dis lεvεl kin inkrεs bak pan uman dεm we gεt PCOS.
• Androstenedione : Dis na stεroyd כmon we nכ gεt bכku androjenik ifekt pan di bכdi. כltu, i de mεntal wok lεk intamεdiεt stεp fכ prodyuz tεstostεron εn εstrojen na di bכdi. If in lɛvɛl dɛn ay, PCOS kin de.
• Dehydroepiandrosterone sulfate (DHEAS) : DHEAS na wan sεks כmon we di adrenal gland dεm de mek. fכ dat, na gud indikεtכ fכ adrenal androgen prodakshכn. I nɔmal fɔ mek uman dɛn we gɛt PCOS gɛt di DHEAS lɛvɛl we go ɔp smɔl. If i rili ay, i kin bi sayn fɔ se i gɛt adrenal tumor.
• 17-hydroxyprogesterone : fכ mכsu di lεvεl fכ 17-hydroxyprogesterone na di bכdi na bεsik tεst fכ chεk fכ prεsεns fכ nכn-klasik kכnεjital adrenal haypaplasia, wan kכndyushכn we na wan kכz fכ haypa androjenism.

Bikɔs ɔda tin dɛn kin de we kin mek yu gɛt di sayn dɛn we de sho se yu gɛt di sik we dɛn kɔl hyperandrogenism, yu dɔktɔ go tɛl yu fɔ du ɔda blɔd tɛst fɔ mek dɛn nɔ no bɔt dɛn tin dɛn de bak.

apat frכm dat, dεn kin du imej tεst dεm lεk dεn wan ya fכ no di kכz fכ haypa androjenism:

• wan pelvik ɔltra saund fɔ chɛk fɔ ovarian sist (ɔda sayn fɔ PCOS) ɔ ɔda lumps.
• fכ chεk fכ adrenal gland tכmכro , dεn kin du CT skan (Computed tomography - CT) כ MRI skan (Magnetic resonance imaging - MRI) tεst.

di dכkta dεm de aim fכ ridyus di androgen prodakshכn frכm di ovaria כ adrenal gland dεm, ridyus di fri androgen lεvεl dεm, εn blכk di androgen akshכn.

Bɔt pipul dɛm wae gɛt hyperandrogenism kin go to dɔktɔ fɔ trit di men sayn dɛm lɛk di ia wae dɛn nɔr want fɔ gro, akni, ɛn wae dɛn nɔr kin gɛt mɔnt ɔltɛm.

Wetin na di tritmɛnt dɛm fɔ dis?

Tritmɛnt fɔ haypa ɛndrojenism de dipen pan di kɔz. Fɔ ɛgzampul:

• dεn kin kכntro di adrenal haypa androjenism wit lכw dכz k כtikostεroyd .
• If tumbu dɛn de na di ovaria, di tɛstikul, ɔ di adrenal gland dɛn, dɛn kin nid fɔ du ɔpreshɔn fɔ pul dɛn. pan uman dεm we de pεrimenopausal כ mεnoposal we gεt siriכs haypa androjenism, i kin nid fכ du oophorectomy (sכjεkshכn fכ pul wan כ di tu ovaria dεm) bak.
• If na wan mɛrɛsin we yu de tek, yu dɔktɔ go tɛl yu fɔ stɔp di mɛrɛsin ɔ fɔ chenj to ɔda mɛrɛsin.

Antiandrogen mεdikeshכn dεm na kכmכn tritmεnt bak fכ hyperandrogenism. Dɛn kin blok di tin dɛn we di androgen dɛn lɛk tɛstostɛron kin du.

Bɔku kayn mɛrɛsin dɛn de we de mek pɔsin nɔ gɛt di sik we dɛn kɔl antiandrogen:

• כral kכntraseptiv/bכt kכntrכl pil dεm we gεt εtinyl εstradiol (εstrojen) εn antiandrojεnik prכjεstεron: εgzampl dεm na pil dεm we gεt sayproterכn asetεt (e.g. Diane®-35), drospirenכn (e.g. Yasmin®, Yaz®) כ diεnogεst (e.g. Valette®). Dɛn tin ya kin trit akni, di ia we yu nɔ want fɔ gro ɛn we yu nɔ kin gɛt yu ia ɔltɛm.
• Spironolactone (Spironolactone - Aldactone®) : Dis antiandrogen de trit akni ɛn di ia we yu nɔ want we di ɔmon de mek.
• Sayprotɛron : Dis mɛrɛsin de ɛp fɔ trit PCOS, fɔ mek di tɛstostɛron lɛvɛl smɔl, ɛn fɔ ridyus di ɔyl we de mek pɔsin gɛt akni.

Tritmɛnt fɔ di sayn dɛm

Pipul wae gɛt hyperandrogenism kin go fɔ tritmɛnt spɛshal fɔ dɛn simptom dɛm:

• Akni : Di tritmɛnt fɔ akni na mɛrɛsin dɛn we dɛn kin put pan pɔsin, antibayɔtik we dɛn kin tek lɛk tetracycline , antiandrogens (inklud ɔmon tɛrapi, bɔn kɔntrol pil), ɛn isotretinoin pils.
• Hirsutism (unwanted hair growth) : Bɔku uman dɛn we gɛt hirsutism kin yuz we dɛn lɛk fɔ waks, sheb, ɛn fɔ pul dɛn ia wit lɛsa. Dɛn kin tek bɔn kɔntrol pils bak.
• Pεriכd we nכ de rεgulεr : Uman dεm kin yuz כmon bכt kכntrכl mεtכd fכ rεgεl dεn mεnstral saykl.

We dɛn simptom ya nɔ de ansa to standad tritmɛnt bikɔs ɔf di ɔmon imbalans, yu dɔktɔ kin tink bɔt mɔ pawaful antiandrogen mɛrɛsin.

Yu nɔ tink se dɛn go ebul fɔ stɔp dis?

כnכfכs, no klia we de fכ mek yu nכ gεt haypa androjenism.

Nɔ we nɔ de we dɛn dɔn pruv fɔ mek dɛn nɔ gɛt PCOS, we na di kɔmɔn tin we kin mek pɔsin gɛt hyperandrogenism. Bɔt yu kin du smɔl smɔl tin dɛn fɔ mek yu nɔ gɛt di sik. Fɔ ɛgzampul, we wi de it tin dɛn we gɛt fayn fayn tin dɛn fɔ it, .Fɔ du ɛksɛsayz ɔltɛm ɛn fɔ kɔntrol yu wet kin ɛp fɔ ridyus di ifɛkt dɛm we PCOS ɛn hyperandrogenism kin gɛt.

Wetin go apin tumara bambay? (Prɔgnosis) .

Bɔrku tin wae kin mek pɔrsin gɛt hyperandrogenism kin nid tritmɛnt fɔ ɔl yu layf. Sɔntɛnde, uman dɛn we gɛt hyperandrogenism bikɔs ɔf PCOS go lɔs bɔku bɔku wet ɛn dɛn PCOS go go. Bɔt bɔrku pipul dɛn go nid tritmɛnt fɔ ɔl dɛn layf fɔ ridyus di sayn dɛm wae de sho se dɛn gɛt hyperandrogenism.

Di sayn dɛm wae de sho se yu gɛt haypa ɛndrɔjen kin afɛkt yu sɛlf-ɛstimɛnt ɛn yu maynd wɛl bɔdi. If dɛn sayn ya de mek yu fil strɛs, wɔri, ɛn/ɔr pwɛl hat, i impɔtant fɔ go to ɛp frɔm saykayatrist ɔr advaysa.

Ustɛm a fɔ go to dɔktɔ?

If dɛn no se yu gɛt hyperandrogenism ɛn yu de tek mɛrɛsin fɔ am, yu go nid fɔ go to dɔktɔ ɔltɛm fɔ mek shɔ se yu tritmɛnt de wok fayn fayn wan.

If hyperandrogenism de afɛkt yu maynd wɛl bɔdi, i impɔtant fɔ go to saykayatrist ɔ advaysa fɔ ɛp yu.

Fɔ dɔn, mɛsej we yu kin kɛr go na os:

Hyperandrogenism na wan tin we kin apin to uman dɛn. De sayn dɛm wae de kam kin mek yu shem ɛn nɔr kin fil fayn. Bɔt mɛmba se nɔto yu wan de, ɛn dɛn kin trit dis sik. Tɔk to yu dɔktɔ bɔt aw fɔ trit yu. Dɔn bak, if i de afɛkt yu maynd wɛlbɔdi, mek shɔ se yu go to dɔktɔ we de mɛn yu maynd ɔ pɔsin we de gi yu advays. Fɔ kia fɔ yu wɛlbɔdi na di tin we impɔtant pas ɔl.

` Hyperandrogenism, Androgen, Testosterone, PCOS, Hirsutism, Akni, Ɔmon Imbalans, Uman dɛn Wɛlbɔdi, Ɔmon Imbalans