Lɛ wi lan bɔt di wɔndaful kɔmyunikeshɔn sistɛm na yu bɔdi: di Hypothalamic-Pituitary-Adrenal (HPA) Axis.

Yu dɔn ɛva tink se wi bɔdi gɛt wɔndaful kɔmyunikeshɔn sistɛm dɛn, dat na we dɛn fɔ kɔnɛkt wit wisɛf? I tan lɛk tɛlifon nɛtwɔk. Wan pan dɛn spɛshal sistɛm dɛn de na di HPA aks (Hypothalamic-Pituitary-Adrenal (HPA) Axis) . Dis na wan impɔtant pat na wi bɔdi we impɔtant fɔ kɔntrol strɛs . Wi go tɔk mɔ bɔt dis? Wetin na am, aw i de wok, ɛn wetin i de du to wi?

Wetin dis HPA aks de pan? Us kayn ɔgan sistɛm i de pan?

Di nem kin tan lɛk se i kɔmplikt smɔl, nɔto so? Bɔt fɔ tɔk am simpul wan, di HPA aks na wan kɔlekɛshɔn fɔ tri men ɔgan dɛn na wi bɔdi. Dɛn kin wok togɛda, lɛk wan tim. Dɛn ɔl na pat pan wi ɛndokrin sistɛm , we na di sistɛm we de mek ɔmon. Dɛn kin kɔl am bak di nyuro ɛndɔkrin sistɛm , bikɔs i de pul ɔmon dɛn na di blɔd fɔ ansa to tin dɛn we de kɔmɔt na di nervɔs sistɛm.

So, wetin na dɛn tri ɔgan ya?

• Hypothalamus: Dis tan lɛk smɔl kɔntrol sɛnta we de dip insay yu bren. Tink bɔt am lɛk di men switch bɔd na yu os. I kin mek tin dɛn lɛk yu bɔdi wam, angri, aw yu de fil, ɛn aw yu de slip balans. I de du dis bay we i de inflɔws yu ɔtonomik nɛvɔ sistɛm dairekt wan ɔ bay we i de manej ɔmon dɛn.

• Pituitary gland: Dis na gland bak we gɛt sayz lɛk pis we de ɔnda di bren, jɔs dɔŋ di haypothalamus we wi bin dɔn tɔk bɔt. Pan ɔl we i smɔl, di wok we i de du rili big. I de mek bɔku impɔtant ɔmon dɛn we wi bɔdi rili impɔtant. i de kכntro bak di wok we bכku כda εndokrin gland dεm de du. di antεriכr pat pan dis pituitary gland we dεn kכl di antεriכr pituitary de kכnekt to di HPA aks.

• Adrenal gland dɛm: Dɛn wan ya de ɔp yu kidni dɛm, lɛk smɔl hat dɛm. Dɛn na tu smɔl smɔl gland dɛn we tan lɛk tri an. Dɛn kin mek bak spɛshal ɔmon dɛn we kin ɛp fɔ kɔntrol bɔku impɔtant wok dɛn na wi bɔdi. di כta pat pan dεn adrenal gland dεm ya we dεn kכl di adrenal kכtεks de involv insay di HPA aks.

Dɔn gɛt am? Dis tri na di men pleya dem na di HPA aks.

So, wetin na di wok we dis HPA aks de du? Wetin mek i rili impɔtant to wi?

Fɔ tɔk am simpul wan, di men ɛn impɔtant wok we di HPA aks de du na fɔ mek ɛn pul wan ɔmon we dɛn kɔl kɔtisol insay di blɔd. Yu kin dɔn yɛri bɔt dis kɔtisol as di ‘strɛs ɔmon’. I de insay di klas ɔf stεrɔyd ɔmon dɛn we dɛn kɔl glukokɔtikoyd .

So, yu gɛt sɔm prɛshɔn, chalenj, fred, wɔri (wi kɔl disWe yu mit sɔntin we de mek yu strɛs, yu bɔdi kin rɛdi fɔ dil wit am wantɛm wantɛm bay we i de mek di HPA aks wok ɛn pul di kɔtisol. Dis na tin we rili ɔtomɛtik, we pɔsin kin du fɔ insɛf.

Imajin, if yu de waka na strit ɛn wantɛm wantɛm dɔg kam rɔn pan yu, yu at go rit kwik, yu bɔdi go swet, ɛn yu go blo kwik, nɔto so? Sɔmtɛm lɛk dat, dis HPA aks na in de pripia yu fɔ fes da imejensi de.

Dɔn bak, yu dɔn yɛri bɔt di ‘fayt-ɔ-flay rispɔns’ ? Na di we aw wi bɔdi kin rɛdi wantɛm wantɛm fɔ ɔl tu fɛt (fayt) ɔ rɔnawe (rɔn go) we wi si denja. dis kin kכl bak wit di HPA aks, εn di כmon adrenaline (epinephrine), we כda pat pan di adrenal gland dεm de mek.

Dɛn mek wi mɔtalman bɔdi fɔ gɛt strɛs ɛn fɔ du sɔntin. We wi gɛt prɔblɛm ɛn chenj, wi bɔdi kin ansa fɔ shɔt tɛm, pan bɔdi ɛn maynd, fɔ mek i ebul fɔ ajɔst. Dis strɛs rispɔns kin fayn sɔmtɛm. I de mek wi de wach, i de mek wi want fɔ du sɔntin, ɛn i de ɛp wi fɔ avɔyd denja. Bɔt, strɛs we nɔ de dɔn , ɔ we de te wi bɔdi kin ambɔg wi bɔdi.

Aw di HPA aks de wok? Aw dis chen ɔf ɔmon dɛn de wok?

Dis na sɔntin we kin apin lɛk chen riakshɔn. Imajin se yu gɛt prɔblɛm, fred, ɔ big prɔblɛm wantɛm wantɛm. Dɔn na dis kin apin:

1. fכs, yu כtonom nεv sεstem de dεtekt dis strεsful situeshכn εn i de sεnd signal to di haypothalamus na yu bren, we de se, "Imejensi! Akt naw!"

2. We di haypothalamus gɛt da signal de, i de pul wan ɔmon we dɛn kɔl kɔtikotropin-rilis ɔmon (CRH) insay di blɔd.

3. Dis CRH כmon de travul tru di bכdi εn de tεl di antεriכr pituitary gland , "Okay, naw na yu tכn!" Dɔn di pituitary gland de pul ɔda ɔmon we dɛn kɔl adrenocorticotropic hormone (ACTH) .

4. fכ finish, na dis ACTH כmon de travul tru di bכdi εn de akt pan di adrenal kכtεks , we de oba di kidni dεm, we de tεl am fכ "prodyuz kכtisol!"

Si? Na wan prɔses we de apin stɛp bay stɛp, we dɛn kɔnɛkt wan to di ɔda wan.

Bɔt, dis nɔ kin apin ɔltɛm. Bikɔs if i bin du dat, i nɔ bin fɔ fayn fɔ wi bɔdi. di HPA aks na wan vεri dilikεt nεgεtiv fכdbכk lכp.dat min se we di lεvεl fכ kכtisol na di bכdi inkrεs to di lεvεl we dεn nid, dat kכtisol we inkrεs de go bak εn i de gi signal di haypothalamus εn pituitary gland, "If, stכp fכ mek CRH εn ACTH." Dis na di rizin we mek wi kin kɔntrol wi strɛs rispɔns, dɛn kin aktiv am nɔmɔ we nid de, ɛn i kin kam bak to nɔmal.

Bɔt we wi strɛs ɔltɛm ɔ pasmak, ɔ fɔ sɔm ɔda rizin, sɔm tin dɛn we nɔ rayt kin apin na di we aw dis HPA aks de wok.

Us kɔndishɔn dɛn kin afɛkt di HPA aks? Prɔblɛm kin apin wit dis sistɛm?

Yes, di HPA aks kin ova aktif, bכt i kin bi כnda aktiv bak.

HPA aks disfכnkshכn

We wi de strɛs ɔltɛm, di wok we dis HPA aks de du kin ambɔg, ɛn di kɔtisol lɛvɛl na di bɔdi kin kɔntinyu fɔ ay ɔltɛm . dis kכndyushכn dεn kin kכmכn fכ kכl am HPA aks disfכnkshכn . dis pεrsisεnt hεy kכtisol lεvεl de inkrεs di risk fכ difrεn hεlth prכblεm dεm. Fɔ ɛgzampul:

• di imyun sistεm dεn nכ de wok fayn: i de inkrεs fכ sik, i de inkrεs inflameshn ɔlsay na di bכdi, εn di risk fכ divεlכ p sכm כtoimyun kכndishכn dεm (i.e., sik dεm we di bכdi in imyun sistεm de atak in yon sεl dεm).
• Mental hεlth prכblεm: Dεn kin apun wit yu mכd dizayd (e.g., pwεl hat), wae yu de wɔri , εn post-traumatic stress disorder (PTSD) kin apun.
• Sik dɛm wae de mɛk pɔrsin fil fayn: Dayabitis , fɔ fat pasmak , ɛn sɔm kayn kansa kin mek pɔrsin gɛt mɔr sik.
• Di sik dɛm we de kam pan di at ɛn di blɔd: Tin dɛm lɛk ay blɔd prɛshɔn ɛn fɔ pwɛl di blɔd vesel dɛm.

Apat frɔm dat, sɔm pipul dɛn we de stɔdi bɔt dis de kam fɔ no se di we aw di HPA aks nɔ de wok fayn kin gɛt fɔ du wit di we aw pɔsin kin mɛmba tin ɛn di tin dɛn we kin mek pɔsin nɔ ebul fɔ mɛmba tin dɛn lɛk Alzaima . HPA aks disfכnkshכn na kכmpleks fysiolojikal kכnsεpt. Dɛn stil de du risach bɔt wetin kin mek i apin ɛn aw i kin afɛkt pɔsin in wɛlbɔdi.

Yu tink se tritmɛnt de fɔ dis?

Te naw, no dairekt tritmɛnt nɔ de we de tɔch di HPA aks disfɔkshɔn. Bɔt di wan dɛn we de stɔdi bɔt dis de wok tranga wan fɔ mek i gɛt sɔntin fɔ du wit difrɛn sik dɛn we pɔsin kin gɛt ɛn fɔ mek tritmɛnt dɛn.

HPA aks suprεshכn

na di כda say, sכmtεm di HPA aks kin bi dysfunctional. Dɛn kɔl disHPA aks sɔpreshɔn . Dis kכndyushכn kin apin spεshal wan we wi de yuz εksojen prodyuz glukokortikoyd , כ k כtikostεroyd (lεk prεdnisolone), fכ sכm mεdikal kכndyushכn dεm fכ lכng tεm.

Wetin na sɔm pan di kɔndishɔn dɛn we dɛn kin yuz kɔtikosterɔyd fɔ?

• Asma we gɛt asma
• COPD (Chronic Obstructive Pulmonary Disease) - dat na, na wan sik we nɔ de mɛn na di lɔng.
• Afta dɛn dɔn transplant ɔgan dɛn
• Fɔ sɔm kayn kansa
• Rimatɔlɔjik kɔndishɔn (e.g. at at) .
• Sɔm prɔblɛm dɛn we kin mek pɔsin fil pen

we dεn sכpres di HPA aks dis we, di bכdi in prodakshכn fכ kכtisol de dכn. Dis kin mek di bɔdi nɔ ebul fɔ ansa strɛs ɛn i kin mek di bɔdi nɔ ebul fɔ fɛt infɛkshɔn bak. di lכw kכtisol lεvεl de inkrεs di risk fכ infεkshכn plεnti tεm, sכmtεm i kin rili bad. If i rili bad, we dɛn stɔp di HPA aks kin mek i gɛt wan imejensi we kin mek pɔsin in layf de pan denja we dɛn kɔl adrenal kraysis .

Bɔt nɔto ɔlman go gɛt HPA aks sɔpreshɔn frɔm we dɛn tek kɔtikosterɔyd. Bɔt if yu de tek dɛn mɛrɛsin ya, i impɔtant fɔ tɔk to yu dɔktɔ bɔt di bad tin dɛn we kin apin to yu ɛn di bad tin dɛn we kin apin to yu ɛn mek yu no gud gud wan.

Aw wi kin kip wi HPA aks hεlty?

So, aw wi go tek kia ɔf dis prɛshɔ HPA aks ɛn kip am fɔ wok fayn fayn wan? Infakt, di wan dɛn we de du risach stil de lan bɔku tin bɔt dis HPA aks ɛn wetin wi kin du fɔ protɛkt am. Bɔt, di bɛst ɛn impɔtant tin rayt naw na fɔ kɔntrol strɛs ɛn manej am fayn fayn wan.

Na tru se wi nɔ go ebul fɔ pul ɔl di strɛs we wi gɛt na wi layf kpatakpata. Dat nɔto tin we pɔsin kin du. Bɔt wi kin tray fɔ mek di bad tin we i de du to wi bɔdi nɔ bɔku bay we wi nɔ go mek i nɔ ebul fɔ bia.

Na sɔm simpul tin dɛn we yu kin ad pan yu layf ɛvride we go ɛp yu:

• Tray fɔ du tin dɛn we go mek yu rilaks: Tray fɔ du tin dɛn lɛk fɔ tink gud wan , yoga , ɛksesaiz fɔ blo dip dip wan, ɛn fɔ rilaks yu mɔsul dɛn fɔ sɔm minit dɛn insay di de. Dɛn tin ya go ɛp fɔ mek yu maynd kol.
• Tek kia ɔf yu bɔdi gud gud wan: It tin dɛn we gɛt fayn fayn tin dɛn fɔ it ɛn we gɛt balans. Ɛksesaiz ɔltɛm. Gɛt inof slip (bɔku tɛm fɔ 7-8 awa) ɛvride.
• Kɔntinyu fɔ tink gud wan: Luk ɔltin fayn fayn wan. Tɛl tɛnki ɛn gladi fɔ wetin yu gɛt.
• Lɛf tin dɛn we yu nɔ ebul fɔ kɔntrol:Ɔndastand se wi nɔ go ebul fɔ kɔntrol ɔltin na dis wɔl. Natin nɔ de fɔ mek yu wɔri ɛn wɔri ɔltɛm bɔt tin dɛn we yu nɔ go ebul fɔ chenj.
• Yuz fɔ se ‘nɔ’: If yu rili bizi, if yu dɔn ɔlrɛdi fil strɛs, nɔ tek ɔda rispɔnsibiliti ɛn wok dɛn ɛn mek yu strɛs mɔ.
• Spend tɛm wit pipul dɛn we de sɔpɔt yu ɛn mek yu gladi: Spend mɔ tɛm wit gud padi ɛn fambul dɛn we de mek yu kol, mek yu laf, gi yu maynd trɛnk, ɛn ivin gi yu prɛktikal ɛp we nid de.

If yu de wɔri bɔt yu strɛs ɛn yu fil se i de kam tranga fɔ bia wit am, nɔ shem fɔ aks yu dɔktɔ ɔ pɔsin we yu kin abop pan fɔ ɛp yu ɛn gayd yu.

Fɔ dɔn, di tin we impɔtant pas ɔl we wi fɔ mɛmba

Stress na sɔmtin wae wi ɔl kin ɛkspiriɛns to sɔm digri na wi layf, na pat pan de mɔtalman ɛkspiriɛns. Laki, wi bɔdi gɛt wan rili kleva ɛn spɛshal we we dɛn kɔl di HPA aks fɔ dil wit dɛn kayn trɛtin ɛn chalenj ya ɛn protɛkt wi frɔm denja.

Bɔt wi fɔ mɛmba bak se we wi de strɛs pasmak ɔ we wi de strɛs fɔ lɔng tɛm, di dilik balans we dis HPA aks gɛt kin lɔs, i nɔ kin wok fayn, ɛn difrɛn wɛlbɔdi prɔblɛm dɛn kin apin. Risach pipul dεm stil de stכdi di insay εn ausayd dis HPA aks, dat na, כl di wok dεm we i de du dip wan.

Insay da tɛm de, di bɛst tin we wi kin du na fɔ tray fɔ de fa frɔm tin dɛn we kin mek wi strɛs as wi ebul ɛn kɔntrol di strɛs we kin apin. If yu fil se yu layf tu strɛs ɛn yu de si am se i nɔ izi fɔ bia, tɔk to dɔktɔ bɔt dat. Dɛn rɛdi fɔ ɛp ɛn gayd yu.

` HPA aks, strεs, kכtisol, haypothalamus, pituitary gland, adrenal gland dεm, כmon dεm