Yu kin tɔsti ɔltɛm ɛn yu kin pas bɔku urine? Lɛ wi tɔk bɔt Nephrogenic Diabetes Insipidus.

Yu kin fil tɔsti bak ɔl di de? I nɔ mata ɔmɔs wata yu drink, yu stil de fil lɛk se yu nɔ gɛt bɛtɛ wata? Yu nid bak fɔ pis bɔku tɛm ɛn bɔku bɔku wan? Yu kin tink se dis na nɔmal tin, ɔr yu kin ivin tink se na dayabitis. Bɔt dis kin bi bak wan sayn fɔ wan sik we nɔ kin apin so ɔltɛm we dɛn kɔl ‘Nephrogenic Diabetes Insipidus’. Lɛ wi tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wetin na Nɛfrɔjɛnik Dayabitis Insipidus?

Fɔ tɔk am simpul wan, nephrogenic diabetes insipidus na wan sik we yu kidni dɛn nɔ kin ebul fɔ rigul di wata we de na yu bɔdi fayn fayn wan. Wi bɔdi de mek wan ɔmon we dɛn kɔl Antidiuretic Hormone, ɔ ADH fɔ shɔt tɛm. Sɔm pipul dɛn kin kɔl am bak Vasopressin. dis כmon, ADH, de "tεl" wi kidni dεm aw bכku wata fכ kכmכt na di urine εn aw mכch fכ kip na di bכdi.

di kidni dεm fכ pכsin we gεt nεfrojεnik dayabεtis insipidus nכ de rεspכnd fayn to dis ADH כmon. dat min se pan כl we di ADH כmon de gi signal fכ "rεtεn wata εn rεdכks urine," di kidni dεm nכ de lisin to am. Wetin kin apin da tɛm de na dat di kidni dɛn kin mek mɔ urine pas aw i nid. Dis kin mek yu nɔ gɛt wata na yu bɔdi kwik kwik wan, sɔntɛnde i kin denja.

Aw dis sik kin kɔmɔn?

Sayɛnsman dɛn nɔ rili shɔ ɔmɔs pipul dɛn gɛt nephrogenic diabetes insipidus, bɔt dɛn biliv se na wan sik we nɔ kin apin so ɔltɛm . Dat min se nɔto sik we ɔlman kin gɛt.

Difrɛn kayn Dayabitis Insipidus de?

Yɛs, 4 kayn dayabitis insipidus de. Lɛ wi si wetin dɛn bi:

• Sɛntral Dayabitis Insipidus: Dis kin apin we di pituitary gland ɔ di haypothalamus we de na yu bren dɔn pwɛl. Dis na di pat dεm we de mek, stכr, εn rilis di ADH כmon. dis damej de mek di bכdi nכ de rεgεl ADH nכmal wan.
• Nephrogenic Diabetes Insipidus: Insay dis kayn dayabitis we wi de tɔk bɔt tide, di kidni dɛn nɔ kin ebul fɔ ansa di ADH ɔmon fayn fayn wan. Pan ɔl we di ADH ɔmon de de, i tan lɛk se di kidni dɛn nɔ de pe atɛnshɔn to am.
• Dipsogenic Diabetes Insipidus: Dɛn kin kɔl am bak ‘Primary Polydipsia’, dis kin apin bikɔs ɔf wan difrɛns na di tɔsti kɔntrol mɛkanism na yu haypothalamus. Dis kin mek yu tɔsti pasmak, yu kin fil se yu nid fɔ drink wata ɔltɛm , ɛn yu kin pis pasmak.
• Gestational Diabetes Insipidus: Dis kin apin nɔmɔ we uman gɛt bɛlɛ. sכmtεm wan εnzym we di plasεnta de mek de brok di ADH כmon. Dis kin go afta dɛn bɔn di pikin.

Wetin na di difrɛns bitwin Nɛfrojɛnik Dayabitis Insipidus ɛn Dayabitis Mɛlitus?

Dis na rili impɔtant tin we bɔku pipul dɛn kin kɔnfyus bɔt. We wi yɛri di wɔd "dayabitis," wi kin tink bɔt shuga, we min dayabitis. Bɔt pan ɔl we sɔm pan di sayn dɛn we de sho se pɔsin gɛt nɛfrojɛnik dayabitis insipidus ɛn dayabitis mɛlit (lɛk fɔ pis pasmak ɛn fɔ tɔsti pasmak) fiba, dɛn tu sik ya rili difrɛn.

Dayabitis na sik we bɔku pipul dɛn kin gɛt. I kin kam bikɔs di ɔmon we dɛn kɔl insulin nɔ de ɔ di bɔdi nɔ de yuz insulin fayn fayn wan, we kin mek di shuga na di blɔd bɔku. Bɔt nefrojɛnik dayabitis insipidus na prɔblɛm we kin apin we di kidni dɛn nɔ de ansa di ADH ɔmon ɛn i nɔ gɛt natin fɔ du wit di blɔd shuga lɛvɛl . So, i bɛtɛ lɛ yu nɔ kɔnfyus di tu, nɔto so?

Wetin na di tin dɛm wae kin mek pɔrsin gɛt Nephrogenic Diabetes Insipidus?

Wi kidni dɛn de wok fɔ filta blɔd ɛn pul dɔti ɛn ɛkstra wata na di bɔdi as urine. di כmon we dεn kכl ADH (vasopressin) de εp fכ bεlε bitwin di wata we wi de drink εn di urine we wi de pul.

Imajin, we pɔsin we gɛt wɛlbɔdi swet bɔku ɔ drink smɔl wata, di ADH lɛvɛl kin go ɔp, ɛn dis kin tɛl di kidni dɛn fɔ ‘mek smɔl urine, kip wata na di bɔdi.’ Semweso, we inof wata de na di bɔdi, di ADH lɛvɛl kin go dɔŋ, ɛn dis kin tɛl di kidni dɛn fɔ ‘i nɔ bad, jɔs mek urine naw.’

Bɔt if yu bɔdi nɔ de ansa ADH fayn, yu kidni dɛn kin mek tumɔs urine. Dis na wetin kin apin pan nefrojɛnik dayabitis insipidus. Dis kכndyushכn kin kכmכt frכm yu (hereditary) כ i kin divεlכp εni tεm na yu layf (acquired) .

Akwyayz nɛfrɔjɛnik dayabitis insipidus

Dis na di kayn we we pipul dɛn kin gɛt mɔ. I kin apin we sɔntin de ambɔg di bɔdi in ebul fɔ ansa to ADH. Fɔ ɛgzampul, i kin kam bikɔs ɔf sɔm tin dɛn we kin afɛkt yu kidni. Dɛn kayn kɔndishɔn dɛn ya na:

• amyloidosis – Dis na we wan abnכmal protin de dכn insay כgan dεm inklud di kidni dεm.
• Sɔm kayn kansa dɛn
• Kidni sik we nɔ de mɛn
• Kidni infεkshכn, fכ egzampl, payelonephritis
• Polisistik kidni sik – Dis na we di sist dεm we fulכp wit wata de fכm na di kidni dεm.
• Mɛdula spɔnj kidni

Ɔda rizin dɛn de we kin afɛkt dis:

• Sɔm mɛrɛsin dɛn: Ɛspɛshali litiɔm (we dɛn kin yuz fɔ sɔm mental sik dɛn) we dɛn yuz am fɔ lɔng tɛm.
• di potashכm lεvεl dεm we de na di bכdi (hypokalemia) .
• di kalsiכm lεvεl we de go כp na di bכdi (hypercalcemia) .
• Siklɔs sɛl anemia
• Sjögren’s syndrome – Dis na sik wae de kam pan di imyun sistεm.
• di urinary tract obstruction – fכ egzampl, sכmtin lεk urinary ston.

Hɛridit nɛfrɔjɛnik dayabitis insipidus

dis de kכz fכ mכtεshכn dεm na di jin dεm AVPR2 כ AQP2. Dɛn jin ya de tɛl di bɔdi ɔmɔs wata fɔ ad to di urine. we dεn jin dεm ya nכ de wok fayn, di kidni dεm nכ kin ebul fכ ansa ADH. Di sayn dɛm fɔ nephrogenic diabetes insipidus, we dɛn bɔn wit, kin apin insay di fɔs mɔnt dɛm we pɔsin de liv .

Wetin na di sayn dɛm wae de sho se yu gɛt Nephrogenic Diabetes Insipidus?

Imajin, yu sabi pɔsin, lɛ wi se Sumana. Sumana de tɔsti ɔl di de we nɔbɔdi nɔ go biliv. I de wok wit wan big bɔtul wata we de nia de. Bɔt insay wan awa we i dɔn drink, i kin tɔsti bak, ɛn i kin gɛt fɔ go tɔylɛt bak bɔku tɛm, ɛn i kin pis bɔku tɛm. Sɔntɛnde, i kin grap tu ɔ tri tɛm insay nɛt fɔ pis. I bin tink se, ‘Sɔntɛm na bikɔs a de drink bɔku wata.’ Bɔt dɛn tin ya na di men sayn dɛm fɔ nefrojɛnik dayabitis insipidus.

Pɔrsin wae gɛt nephrogenic diabetes insipidus kin gɛt sɔm kayn sik lɛk:

• Sayn dɛm fɔ se yu nɔ gɛt wata na yu bɔdi: yu mɔt kin dray, yu lip kin brok, yu kin taya pasmak, yu kin fil lɛk yu ed de tɔn, ɛn sɔntɛnde yu kin gɛt blu yay we yu tinap. Tink bɔt am lɛk se yu de na di san fɔ lɔng tɛm we yu nɔ gɛt wata.
• Polidipsia: Fɔ fil lɛk se yu nɔ de gɛt inof wata ilɛksɛf yu drink bɔku.
• Fɔ pis pasmak (Polyuria): If big pɔsin pis pas 3 lita fɔ wan de (nɔmal wan i kin pis bitwin 5-20 lita!), ɛn if pikin pis pas 2 lita fɔ wan de, i kin sɔprayz. Di urine bak gɛt bɔku layt kɔlɔ, lɛk wata.

If yכŋ pikin gεt dis kכndyushכn, dεn kin sho sayn dεm lεk dis biכs dεn nכ כndastand aw fכ tכk:

• Rɔnbɛlɛ
• fεil fכ tכn εn gεt wet – I nכ de gεt wet כ gro tכng pas כda pikin dεm.
• Fiva we kin kam ɔltɛm
• Kכnstant rεstεs εn kray (Irritability) – i lεk se di pikin de pan distres.
• I nɔ kin want fɔ it, i nɔ kin it milk igen
• Seizures – Dis na sayn we denja.
• Fɔ vɔmit
• Fɔ gɛt fɔ chenj wet dayapɛt ɔltɛm.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl Nephrogenic Diabetes Insipidus?

If yu gɛt dɛn sik ya, di fɔs tin we yu fɔ du na fɔ go to dɔktɔ. I go aks yu kwɛstyɔn dɛn, chɛk yu, ɛn if nid de, ɔda tɛst dɛn lɛk:

• Blɔd tɛst: Chɛk di lɛvɛl we di ilɛktrɔlayt dɛn lɛk sɔdiɔm de na di bɔdi, ɛn di kidni dɛn we de wok.
• Test fɔ yu urine:Luk di kɔnsɛntreshɔn na di urine (aw i dil), ɛn wetin de insay di urine.
• Tɛst fɔ mek yu nɔ gɛt wata: Dis kin min se yu nɔ fɔ drink ɛni wata fɔ sɔm awa, dɔn yu fɔ wach yu wet, aw yu de urine, ɛn aw yu de blɔd ɛn yu urine ɛvri awa. Dis na tɛst we at fɔ du, bɔt i rili impɔtant fɔ no if pɔsin gɛt di sik. dis na di onli we fכ no kכrekt wan if di kidni dεm de rεspכnd to ADH. Dɛn kin du dis tɛst ɔnda dɔktɔ in sɔpɔtishɔn na ɔspitul.
• Test wit ADH ɔmon: Sɔntɛnde, dɛn kin gi ADH ɔmon as injɛkshɔn wit di tɛst we dɛn kin du fɔ mek dɛn nɔ gɛt wata, dɔn dɛn kin chɛk if di urine kɔnsɛntreshɔn chenj. Insay nεfrojenik dayabεtis insipidus, ivin if dεn gi ADH, di urine kכnsantreshכn nכ de chenj bכku.
• MRI skan fɔ yu pituitary gland (Magnetic resonance imaging): If yu sɔspɛkt se yu gɛt wan sik lɛk sɛntral dayabitis insipidus, luk fɔ ɛnitin we nɔ fayn na yu bren.
• Jɛnɛtik tɛst: If sɔmbɔdi na yu famili gɛt dayabitis insipidus, ɔ if yu sɔspɛkt se na wan we dɛn kin gɛt frɔm dɛn mama ɛn papa.

Yu tink se kɔmplit mɛrɛsin de fɔ Nephrogenic Diabetes Insipidus?

Fɔ tɔk tru, naw, no kɔmplit mɛrɛsin nɔ de fɔ di nephrogenic diabetes insipidus.

Bɔt nɔ wɔri. Dɛn kin ebul fɔ manej am. Yu dɔktɔ kin ebul fɔ chenj di mɛrɛsin dɛn we yu de tek we de mek yu gɛt di prɔblɛm (lɛk lithium). Dɔn bak, if ɔda ɔndalayn kɔndishɔn de (lɛk kidni sik ɔ kalsiɔm/potashɔm imbalans), if yu trit am fayn , sɔntɛnde i kin rivɛns ɔ kɔntrol nɛfrojɛnik dayabitis insipidus.

So aw yu de trit dis?

Insay kes dɛm we i nɔ go ebul fɔ chenj (fɔ ɛgzampul, we dɛn bɔn am), di tritmɛnt kin mɔ fɔ mek pɔsin nɔ gɛt wata na in bɔdi ɛn fɔ mek i gɛt gud kwaliti layf. Dis kin inklud:

• Drink wata ɔltɛm: Dis na di tin we impɔtant pas ɔl. Yu fɔ drink wata ɔl di de, ɛnitɛm we yu fil tɔsti. Mek shɔ se yu drink mɔ wata, mɔ di de dɛn we di ples wam, we yu de du ɛksɛsayz, ɔ we yu de swet. Kip wan bɔtul wata nia yu na nɛt, bak.
• Di chenj dɛn we dɛn kin mek na di it we dɛn de it:
• Di it we nɔ gɛt bɔku sɔl: If yu it bɔku sɔl, dat kin mek yu tɔsti mɔ ɛn mɔ ɛn yu kin pis.
• Di it we nɔ gɛt bɔku prɔtin: Sɔntɛnde dɛn kin tɛl yu fɔ stɔp di prɔtin, bikɔs dɛn nid wata bak fɔ pul di dɔti tin dɛn we dɛn kin mek we dɛn de digest di prɔtin.
• Mɛrɛsin dɛn we de ridyus di urine we de kɔmɔt:
• Thiazide diuretiks:I sɔprayz fɔ no se dɛn diuretics ya, we dɛn gi dɛn to pipul dɛn we gɛt nephrogenic diabetes insipidus, kin rili ridyus di urine we dɛn kin mek. I kɔmplikt smɔl, bɔt dɛn yusful.
• Amiloride: Dɛn kin gi am togɛda wit thiazides, mɔ fɔ NDI we lithium kin mek.
• Prɛskrishɔn Nɔn-stɛroyd Anti-Inflammatory Drugs (NSAID): Fɔ ɛgzampul, indometasin. dis dεm de εp fכ mek di kidni dεm sכmtεm sεnsitiv to ADH.

Us it ɛn drink dɛn pɔsin we gɛt dis sik fɔ avɔyd?

Yu dɔktɔ kin tɛl yu fɔ lɛ yu nɔ drink bɔku rɔm, drink dɛn we gɛt kafinɛ (lɛk kɔfi, ti, ɛn sɔm sɔft drink dɛn), it dɛn we gɛt sɔl (lɛk pikɛl, dray mit, sosish, ɛn chips), ɛn sɔntɛm it dɛn we gɛt bɔku prɔtin, bikɔs dɛn tin ya kin mek yu bɔdi nɔ gɛt mɔ wata ɛn yu kin it mɔ wata.

Yu tink se we dɛn de fɔ mek yu nɔ gɛt Nephrogenic Diabetes Insipidus?

No pruf nɔ de fɔ mek dis nɔ apin. Ɛspɛshali di kayn we aw dɛn bɔn am nɔ kin ebul fɔ stɔp. Bɔt fɔ di kayn we we dɛn dɔn gɛt:

• If yu de tek mɛrɛsin wae kin mek yu gɛt NDI, lɛk lithium, i impɔtant fɔ tɔk to yu dɔktɔ bɔt am ɛn mek dɛn chɛk yu kidni fɔ wok ɔltɛm.
• Di risk kin ridyus bay we dɛn trit di ɔndalayn wɛlbɔdi prɔblɛm dɛn kwik ɛn fayn fayn wan (kidni sik, ilɛktrɔlayt imbalans).

If a gɛt dis sik, wetin a fɔ ɛkspɛkt?

Dis na di bɛst nyus. If dɛn trit dɛn fayn ɛn gɛt wɛlbɔdi layf , pipul dɛn we gɛt nephrogenic diabetes insipidus nɔ kin gɛt bɔku big big prɔblɛm dɛn ɛn dɛn kin liv nɔmal layf. Yu kin wok ɛn ɛnjɔy layf lɛk aw i nɔmal.

Bɔt if dɛn nɔ de manej am fayn, dis kin mek i gɛt siriɔs prɔblɛm dɛn. Lɛ wi tek wan luk pan wetin dɛn bi:

• Wae yu nɔr gɛt wata na yu bɔdi: Dis na di prɔblɛm we kin apin pas ɔl ɛn we kin rili siriɔs. If yu nɔ gɛt wata na yu bɔdi bad bad wan, dat kin mek yu nɔ no natin, yu kin gɛt sik, ɛn yu kidni nɔ kin wok fayn.
• Ilektrolayt disturbans: Dis na chenj we di ilektrolayt dεm (lεk sכdiכm εn potashכm) de chenj na di bכdi. Dis kin afɛkt di at rit ɛn di nerv fɔ wok.
• Infεkshכn: Tin dεm lεk Urinary Tract Infεkshכn (UTI) εn kidni infεkshכn.
• divεlכpmεnt dilay, di bren dεm we de pwεl εn di intelektual disabiliti na bεlε pikin dεm. Dis kin rili denja fɔ yɔŋ pikin dɛn. So, if pikin gɛt dɛn sik ya, dɛn fɔ bigin fɔ trit am wantɛm wantɛm.
• Kidni we nɔ de wok fayn: I kin apin fɔ lɔng tɛm if dɛn nɔ kɔntrol am fayn.
• Hydronephrosis: Bikɔs di blad kin ful-ɔp ɔltɛm, di urine kin bak ɛn di kidni dɛn kin swel.

Ustɛm yu fɔ go to dɔktɔ?

If yu gɛt ɛni dawt ɔ wɔri bɔt di kayn urine we yu de pas, mɔ if yu de pas bɔku urine wit urinate pasmak, yu fɔ go to dɔktɔ.

Di urine we big pɔsin de pas fɔ wan de kin difrɛn frɔm wan pɔsin to ɔda pɔsin, mɔ dipen pan ɔmɔs wata i de drink. Bɔt if yu de pis pas 2-3 lita pan de (sɔm difinishɔn dɛn se pas 3 lita), ɔ if yu de pis bɔku bɔku wan (mɔ pas sɛvin ɔ et tɛm insay di de) , i kin bi sayn fɔ prɔblɛm.

Bifo yu go to dɔktɔ, i kin rili ɛp fɔ mek yu rayt ɔmɔs wata yu de drink ɛn ɔmɔs urine yu de mek (dɛn kin mɛzhɔ am if i pɔsibul). Dis go mek am izi fɔ di dɔktɔ fɔ ɔndastand yu sik.

So, wetin na di tin dɛn we wi fɔ mɛmba frɔm dis stori? (Mɛsej we dɛn kin tek go na os)

Nephrogenic Diabetes Insipidus na wan sik we nɔ kin apin so ɔltɛm we yu kidni dɛn nɔ kin ansa di ɔmon ADH we de na yu bɔdi fayn fayn wan, we kin mek yu prodyuz tumɔs urine. Dis kin mek yu nɔ gɛt wata kwik kwik wan.

• Di men sayn dɛm na we yu tɔsti pasmak ɛn we yu de pis pasmak ɛn wata .
• Dis nɔ fɔ kɔnfyus wit dayabitis; insay dis kes, di blɔd shuga lɛvɛl nɔmal.
• Dis kכndyushכn kin de we dεn bכn am כ divεlכp leta na layf.
• Pan ɔl we no kɔmplit mɛrɛsin nɔ de, if yu gɛt di rayt mɛrɛsin ɛn chenj di we aw yu de liv yu layf (espɛshali if yu drink bɔku wata ɛn kɔntrol di tin dɛn we yu de it), yu kin liv nɔmal, wɛlbɔdi layf.
• If yu tink se yu ɔ yu pikin gɛt ɛni wan pan dɛn sik ya, go to dɔktɔ wantɛm wantɛm. Nɔ panik, bɔt di tin we impɔtant pas ɔl na fɔ tɛl yu ɛn tek di step dɛn we yu nid. Nɔto yu wan de, ɛn dɔktɔ dɛn kin ɛp yu.

` Nephrogenic diabetes insipidus, kidni sik, we yu de pis pasmak, we yu tɔsti pasmak, ADH, vasopressin, we yu nɔ gɛt wata