Yu tink se di wan dɛn we gɛt kidni kin no bɔt dis we dɛn du MRI? Lɛ wi tɔk bɔt Nephrogenic Systemic Fibrosis (NSF)!

Yu gɛt ɛni prɔblɛm wit yu kidni? Ɔ dɔktɔ dɔn tɛl yu se yu kidni nɔ de wok fayn? Sɔntɛnde, we yu fɔ gɛt skan lɛk Magnɛtik Rizɔnans Imajin (MRI), yu nid fɔ tek tɛm smɔl bɔt di spɛshal day we dɛn yuz. Tide, wi go tɔk bɔt wan sik we kin apin pan dɛn kayn tɛm ya, bɔt i nɔ kin bɔku naw, bɔt i fayn fɔ no bɔt am. Dɛn kɔl dis Nɛfrɔjɛnik Sistɛm Faybrosis (NSF).

Wetin na dis NSF (Nɛfrɔjɛnik Sistɛm Faybrosis)? Fɔ tɔk am simpul wan...

Fɔ tɔk am simpul wan, Nephrogenic Systemic Fibrosis (NSF) na wan sik we nɔ kin apin so ɔltɛm. I kin apin mɔ pan pipul dɛn we gɛt sik na dɛn kidni, mɔ di wan dɛn we nɔ kin wok fayn na dɛn kidni. Dis kכndyushכn kin כnli afta dεn gi pכsin gadolinium-based contrast agents (GBCA) we dεn de skan, lεk MRI, fכ mek di imej dεm klia.

Tink bɔt am, na wi kidni dɛn de filta di tin dɛn we wi nɔ want na wi bɔdi ɛn pul dɛn kɔmɔt wit urine. So, we dεn tin ya we dεn kכl ``GBCA'' go insay di bכdi fכ pכsin we in kidni dεm nכ de wok fayn, dεn nכ de pul dεm fayn fayn wan na di bכdi. Na da tɛm de di risk fɔ NSF kin kam.

Yu no wetin de mek NSF? Yu skin kin tik, tayt, swel, ɛn it. Sɔntɛnde, ivin di jɔyn dɛn kin stif ɛn lɔk na wan pozishɔn. dis dεn kכl am ``jכyn kכntrakt''. Nɔto dat nɔmɔ, bɔt pan sɔm pipul dɛn, dis sik kin afɛkt di ɔgan dɛn we de insay di bɔdi, lɛk di chɛst mɔsul dɛn, di at, ɛn di lɔng dɛn. wetin kin apin na dat di tisu dεm we de rawnd dεn כgan dεm de tu tik εn tayt.

Di tin we impɔtant pas ɔl na dat, wans NSF dɔn apin, naw nɔ klia tritmɛnt de fɔ stɔp ɔ rivɛns am.

Bɔt, nɔ wɔri! Ivin di US Food & Drug Administration (FDA) dɔn advays tranga wan fɔ mek dɛn nɔ yuz sɔm ol GBCA dɛn pan pipul dɛn we gɛt kidni. Dɛn nɔ ripɔt se di nyu GBCA dɛn we de na di makit kin mek NSF pan di wan dɛn we gɛt kidni. Dat na big rilif.

Aw kɔmɔn tin NSF naw?

Infakt, i rili, rili rare naw. Infakt, dɛn nɔ dɔn ripɔt ɛni nyu kes fɔ NSF fɔ pas 10 ia. Afta 2006, we di mεdikal kɔmyuniti bin kam fɔ no di link bitwin dɛn ``(GBCA)`` ya ɛn kidni sik, di nɔmba fɔ ripɔt bɔt dis sik bin go dɔŋ bad bad wan.

Aw NSF de divɛlɔp? Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

di simptom dεm fכ NSF kin apin di sem de we dεn injεkt di gadolinium-containing contrast agents (GBCA) insay di bכdi. Ɔ, dɛn kin apia sɔm mɔnt afta dat. Insay wan stɔdi, lɛk 50% pan pipul dɛn kin gɛt dis sik insay 12 dez.

De men sayn wae yu kin si na:

• Di skin kin swel, tayt, ɛn tik: Dis kin afɛkt say dɛn lɛk di an, leg, ɛn chɛst ɛn bɛlɛ. Di fes nɔ kin afɛkt bɛtɛ.
• Dak spat ɔ bɔmp na di skin: Sɔntɛnde di skin kin rɔf, lɛk ɔrɛnj peel.
• Skin de fil it, inflam, ɔ pen.
• di inability fכ muv di limb dεm εn di joyn dεm nכmal wan biכs fכ tik εn swel na di skin.

Fɔ sɔm pipul dɛm, dɛn sayn ya kin afɛkt di bɔdi in insay ɔgan ɛn mɔsul dɛm bak. Na sɔm tin dɛn we yu go gɛt:

• Di mɔsul dɛn kin wik bad bad wan.
• biכs fכ di mכsul dεm tayt, di limb dεm nכ kin bεn כ εkstendi fayn fayn wan (i.e., di rεnj fכ muvmεnt de rεdכks).

If dis fibrosis, ɔ di tik we di tisu tik, go bifo, i kin mek di mɔsul dɛn, di lɔng dɛn, di εsophagus, di yay dɛn, ɛn ivin di at gɛt had tin dɛn. Dis kin mek dɛn ɔgan ya nɔ wok fayn. Dis kin mek i gɛt disabled fɔ lɔng tɛm, fɔ ɔltɛm ɛn sɔm tɛm dɛn kin ivin day.

Wetin na di men tin we de mek NSF de?

NSF kin kכz mכst bay we dεn de εkspכz di `(gadolinium-based contrast agents - GBCAs)` we wi bin dכn tכk bכt. dis kεmikכl we dεn kכl gadolinium dεn de yuz fכ klarify imej dεm na `(MRI)` skan. I stil nɔ klia bɛtɛ bɛtɛ wan aw gadolinium de mek NSF. כltu, i klia se link de bitwin kidni sik εn `(GBCAs)`. dεn sho bak se di risk de inkrεs if di כmכnt כf gadolinium we dεn gi di bכdi hכy, כ if dεn yuz sכm kayn `(GBCA)`.

NSF kin bɔku pan pipul dɛm wae gɛt krɛse sik (CKD) ɛn di wan dɛm wae de du dayalaysis bikɔs dɛn kidni nɔr de woke fayn.

Bɔt, mɛmba se, dɛn nɔ dɔn ripɔt ɛni nyu NSF kes fɔ lɛk 15 ia so!

Dis na bikɔs di GBCA dɛn we de naw stebul ɛn nɔ gɛt bɔku pɔyzin. Dɔn bak, dɛn dɔn jɔs yuz gadolinium fɔ pipul dɛn we gɛt sik na dɛn kidni. Ivin di FDA se pipul dɛm we gɛt kidni sik ɔ kidni prɔblɛm nɔ fɔ yuz di ol GBCA dɛm.

Udat go mɔs gɛt dis? (Di tin dɛn we kin mek pɔsin gɛt prɔblɛm)

Di men tin we kin mek pɔsin gɛt NSF na di kidni sik ɔ di kidni we nɔ de wok fayn. Dis kin min se dɛn dɔn du ɔpreshɔn pan in kidni bifo tɛm, we dɛn dɔn transplant in kidni, ɔ we dɛn gɛt wan kidni nɔmɔ. Dɔn bak, if pɔsin we gɛt sik na in kidni gɛt ɔda tin dɛn lɛk we i gɛt prɔblɛm wit di blɔd we de klɔt ɔ we i gɛt infɛkshɔn, di risk fɔ gɛt NSF kin bɔku smɔl.

Bɔt naw, dɔktɔ dɛn dɔn no mɔ bɔt di bad tin dɛn we ol GBCA dɛn kin du to pipul dɛn we nɔ gɛt bɛtɛ kidni wok. So, wit di saf we de tide, yu risk fɔ gɛt dis sik kin shɔt pasmak.

Wetin na di pɔsibul kɔmplikeshɔn dɛm we NSF kin gɛt?

Di kɔmplikɛshɔn dɛm we NSF kin gɛt kin rili siriɔs ɛn sɔm tɛm dɛn kin kil pɔsin. Di fɔs sayn na we di skin de tik ɔ tik. Bɔt as di sik de wɔs, dis stiffness kin afɛkt di ɔgan ɛn mɔsul dɛn we de insay di bɔdi bak. Fɔ ɛgzampul, yu mɔsul ɛn jɔyn dɛn kin so stif dat yu nɔ kin ebul fɔ muv dɛn, ɛn dis kin mek yu nɔ ebul fɔ waka. If NSF afɛkt di lɔng ɔr at, i kin mek i nɔ izi fɔ blo ɔ i kin mek di at nɔ ebul fɔ pɔmp blɔd.

Aw dɛn kin no dis sik kɔrɛkt wan? (Diagnosis) .

Di onli we fɔ no fɔ tru if yu gɛt NSF na fɔ gɛt skin bayɔpsi. Dis kin min se dɔktɔ tek smɔl sampul pan yu skin ɛn sɛn am na lɛb fɔ mek dɛn analays am. Bɔt, dɔktɔ go jɔs ɔda dis tɛst if, afta dɛn dɔn tek yu mɛdikal istri ɛn du fyzikal ɛgzam, dɛn gɛt rizin fɔ saspek se yu kin gɛt NSF.

Wetin na di tritmɛnt dɛm fɔ NSF?

Infakt, naw, no patikyula tritmɛnt nɔ de we dɛn dɔn gri fɔ fɔ NSF. Bikɔs dis sik nɔ kin bɔku, dɛn nɔ kin du bɔku risach bɔt aw fɔ mɛn am. Bɔt sɔm tritmɛnt dɛn de we dɛn dɔn ripɔt se kin gi sɔm rilif to sɔm NSF pasɛnt dɛn:

• Afta dɛn dɔn du MRI, dayalaysis kin pul di gadolinium na di bɔdi. Dis kin ɛp fɔ pipul dɛm wae gɛt krɛse sik. Bɔt no pruf nɔ de fɔ se dis go stɔp di divɛlɔpmɛnt fɔ NSF kpatakpata.
• Fyzikal tritmɛnt kin ɛp fɔ mek di jɔyn dɛn ebul fɔ chenj ɛn muv.
• Kidni transplant na opshɔn we sɔm NSF pasɛnt dɛn kin tink bɔt.

If yu gɛt sik na yu kidni, i go fayn fɔ mek yu nɔ gɛt gadolinium. Bɔt sɔntɛnde, i kin nid fɔ tek gadolinium fɔ gɛt di bɛst pikchɔ dɛn frɔm MRI. If dɛn kayn tin ya apin, dɔktɔ dɛn fɔ wej di bɛnifit dɛn we di MRI gɛt wit di prɔblɛm dɛn we kin apin we pɔsin gɛt gadolinium. If yu gɛt prɔblɛm wit yu kidni ɛn yu dɔktɔ ɔda fɔ mek dɛn du MRI wit day, mek shɔ se yu aks yu dɔktɔ if yu de pan denja fɔ gɛt NSF.

We dɛn de fɔ avɔyd NSF? (Prɛvenshɔn) .

Di bɛst we fɔ mek dɛn nɔ gɛt NSF na fɔ avɔyd fɔ yuz ol GBCA pan pipul dɛn we gɛt kidni sik. Nyu GBCA dɛn sef ɛn nɔ gɛt bɔku pɔyzin to di wan dɛn we gɛt kidni.

Di FDA se pipul dɛn we gɛt sɔm kayn kidni kɔndishɔn nɔ fɔ yuz day we gɛt gadolinium pas nɔmɔ ɔda tin nɔ de fɔ du.

Fɔ pipul dɛm we gɛt nɔmal kidni wok, i nɔ tan lɛk se ɛni risk de fɔ yuz GBCA.

Wetin na di mɔtaliti rit bikɔs ɔf NSF?

Bifo 2019, di FDA bin dɔn ripɔt 3,094 kes dɛm fɔ NSF ɛn 742 pipul dɛm we gɛt fɔ du wit dis. Bɔt lɛk aw wi bin dɔn tɔk, dɛn nɔ dɔn ripɔt ɛni nyu kes insay pas 10 ia. Di men rizin fɔ dis na bikɔs di FDA ɛn di mɛdikal kɔmyuniti no bɔt di ifɛkt we GBCA gɛt pan di wan dɛn we gɛt kidni.

Ustɛm wi fɔ go to dɔktɔ?

If yu gɛt kidni sik ɛn yu gɛt ɛni wan pan dɛn tin ya, go to dɔktɔ wantɛm wantɛm bikɔs dɛn kin bi sayn fɔ NSF:

• Skin de tayt ɔ tik.
• Skin we de it ɔ we de inflam.
• Rɛd ɔ dak spat dɛn na di skin.

Wit di sefty protɔkɔl dɛm we de naw, di chans fɔ mek dɛn no se yu gɛt NSF rili smɔl. Bɔt if yu gɛt sik na yu kidni ɛn yu nid fɔ du MRI, tɔk to yu dɔktɔ bɔt NSF ɛn di prɔblɛm dɛn we kin apin to yu. Pan ɔl we di nyu GBCA dɛn nɔ gɛt pɔyzin ɛn i tan lɛk se dɛn sef, i fayn ɔltɛm fɔ sheb yu wɛlbɔdi istri wit yu dɔktɔ ɛn tɔk bɔt di prɔblɛm dɛn we kin apin.

Mɛsej we dɛn kin kɛr go na os

Okay, so naw yu get beta andastan fo wetin wi don de tok abaut, NSF. Lɛ wi tɔk bak bɔt di tin dɛn we impɔtant pas ɔl:

• NSF na sik we nɔ kin bɔku, mɔ pan pipul dɛn we gɛt kidni sik, ɛn i kin kam wit sɔm ol MRI kɔntrast ɛjɛn dɛn.
• I nɔ izi fɔ mek dɛn ripɔt ɛni nyu kes fɔ NSF naw. Dis na bikɔs dɛn de yuz nyu kɔntrast ɛjɛn dɛn we sef ɛn di dɔktɔ dɛn no.
• Di men sayn dɛm na di skin we de tik, tayt, it, ɛn prɔblɛm wit di jɔyn dɛn.
• If yu gɛt sik na yu kidni, mek shɔ se yu tɔk to yu dɔktɔ bɔt di day dɛn we yu yuz ɛn di risk fɔ gɛt NSF bifo yu du MRI.
• Natin nɔr de fɔ frayd, bikɔs wit di we aw dɛn de du tin naw, dis risk kin rili smɔl. Bɔt, i fayn fɔ mek wi no ɔltɛm.

Fɔ kia fɔ yu wɛlbɔdi na di tin we impɔtant pas ɔl. If yu gɛt ɛni kwɛstyɔn ɔ tin we de mɔna yu, nɔ ɛva delay fɔ go to dɔktɔ.

` Nefrogenic systemic fibrosis, kidni sik, MRI skan, gadolinium, skin sik, GBCA, sik dɛm we nɔ kin bɔku