Yu tink se di sem mɛrɛsin de wok fɔ ɔlman? Lɛ wi tɔk bɔt di fiuja fɔ mɛrɛsin: Prɛsishɔn Mɛdisin!

Yu dɔn ɛva wɔnda wetin mek di sem mɛrɛsin ɛn tritmɛnt nɔr de woke fɔ ɔl sik ɛn ɔl pɔrsin? Sɔmtɛm de mɛrɛsin wae yu kin gi yu padi fɔ di sem sik nɔr kin woke fɔ yu. Na dat mek di wɔl de tɔk bɔt dis nyu we fɔ mɛn pipul dɛn as sɔlv. Dɛn kɔl dis 'Prɛsishɔn Mɛdisin' ɔ ``(Prɛsishɔn Mɛdisin)''. Lɛ wi tɔk bɔt dis ditayli tide.

Wetin na Prɛsishɔn Mɛdisin?

Fɔ tɔk am simpul wan, dis na mɛrɛsin we rayt fɔ yu, we spɛshal fɔ yu. Imajin, yu jin, di envayrɔmɛnt we yu de liv, yu layf – dis na nyu we fɔ tek infɔmeshɔn bɔt ɔl dɛn tin ya ɛn yuz dɛn fɔ gi yu di bɛst wɛlbɔdi biznɛs. Dis we ya, sayɛnsman ɛn dɔktɔ dɛn kin tɔk bifo tɛm bɔt uskayn we fɔ mek dɛn nɔ gɛt sik, us kayn mɛrɛsin, ɛn us kayn grup go fayn. Dɛn kin kɔl dis bak ‘pɔsin in mɛrɛsin’.

Bɔku tɛm, wi kin si se bɔku tɛm dɔktɔ dɛn kin plan di tritmɛnt dɛn di we we go wok fɔ di ‘avɛrej pɔsin’. Dat min se, ‘wan-sayz-fit-ɔl’ we fɔ du tin. Insay dis, dɛn nɔ kin tink bɔku bɔt di smɔl smɔl difrɛns bitwin pipul dɛn. So, dis we fɔ du tin kin wok fayn fɔ sɔm pipul dɛn, fɔ sɔm sik dɛn. Bɔt, fɔ sɔm pipul dɛn, fɔ sɔm sik dɛn, i nɔ kin wok atɔl. Na dat na di sɔlv fɔ dis, we dɛn kɔl `(Precision Medicine)`. Dis min se yu fɔ pik di tritmɛnt we go fayn fɔ yu bɔdi, yu jin, ɛn yu layf.

Wetin na dis Prɛsishɔn Mɛdisin Initiativ?

Dis na wan rili impɔtant, spɛshal program we di Nashɔnal Instityut fɔ Wɛlbɔdi (NIH) na Amɛrika dɔn stat - dat na, di big institiushɔn de we de du risach bɔt sik ɛn wok fɔ mek wɛlbɔdi bɛtɛ - togɛda wit bɔku ɔda risach institiushɔn dɛn we gɛt nem na di wɔl. Di big tin we dɛn kin du na fɔ no wetin na di bɛst we fɔ yuz tin dɛn lɛk yu jin, di say we yu de, ɛn di we aw yu de liv yu layf fɔ trit ɛn avɔyd sik dɛn.

Dis ``Prɛsishɔn Mɛdisin Initiativ'' gɛt shɔt tɛm ɛn lɔng tɛm gol dɛm.

• " Di gol fɔ shɔt tɛm na fɔ briŋ dis kɔnsɛpt fɔ ``Precision Medicine'' to kansa risach. Sayɛnsman dɛm na di US Nashɔnal Kansa Instityut want fɔ ɔndastand di bayoloji ɛn jenɛtiks fɔ kansa dip wan ɛn divɛlɔp nyu, mɔ ifɛktiv tritmɛnt dɛm. Imajin, we kansa de divɛlɔp, if yu no gud gud wan us kayn kansa i bi ɛn us jenɛtik chenj dɛn mek i kam, yu kin gi am wan mɛrɛsin we de wok fɔ am, nɔto so?"
• " Gol fɔ lɔng tɛm"."Dis na fɔ ɛkstɛnd dis `(Precision Medicine)` to ɔl di aspek dɛm fɔ wɛlbɔdi biznɛs. Fɔ dis, di `(NIH)` dɔn stat wan spɛshal risach program we dɛn kɔl `(All of Us Research Program)`. Tru dis risach, dɛn de gɛda infɔmeshɔn frɔm wan big grup fɔ pipul dɛm we gɛt difrɛn jenɛtik bakgrɔn ɛn layf stayl, ɛn yuz da data de, dɛn de tray fɔ no aw fɔ mek wɛlbɔdi biznɛs bɛtɛ fɔ ɔlman."

Us bɛnifit wi kin gɛt frɔm Prɛsishɔn Mɛdisin?

Dis ``Precision Medicine'' we fɔ du kin mek yu wɛl bɔdi ɛn di mɛrɛsin we yu de gɛt pan bɔku we dɛn. Luk dɛn bɛnifit dɛn ya:

• Yu dɔktɔ kin yuz yu jenɛtik infɔmeshɔn fɔ ɛp fɔ kia fɔ yu ɛvride. Imajin aw dat go valyu! Fɔ ɛgzampul, sɔm mɛrɛsin dɛn kin mek pipul dɛn we gɛt sɔm jin dɛn gɛt mɔ sayd ɛfɛkt. If yu no yu jenɛtik infɔmeshɔn, dat go ɛp yu fɔ avɔyd fɔ tek dɛn mɛrɛsin dɛn de.
• Wi kin ɔndastand mɔ bɔt wetin mek sik kin apin. Dis min se insted fɔ jɔs trit di sayn dɛm, wi kin trit di rut kɔz fɔ di sik.
• Yu kin no bifo tɛm us tritmɛnt dɛn we go fayn fɔ yu . Dɔn yu kin ridyus di yus fɔ mɛrɛsin dɛn we nɔ nid ɛn di sayd ɛfɛkt dɛn. Yu de sev tɛm ɛn mɔni.
• Mɔ advans we dɛn de fɔ mek dɛn nɔ gɛt sik, fɔ no if dɛn gɛt sik, ɛn fɔ mɛn dɛn. I ivin pɔsibul fɔ no if sɔm sik dɛn de we kin mek pɔsin gɛt sɔm sik dɛn bifo dɛn bigin.
• Yu ilɛktronik wɛlbɔdi rɛkɛd (EHR) – di rɛkɛd fɔ yu sik, mɛrɛsin, ɛn tɛst we dɛn kin kip na kɔmpyuta sistɛm – go izi fɔ gɛt. Dis go mek am izi fɔ dɔktɔ dɛn fɔ gɛt yu mɛdikal infɔmeshɔn ɛn plan tritmɛnt.

Usay dɛn de yuz Prɛsishɔn Mɛdisin naw?

Dɔktɔ dɛn dɔn ɔlrɛdi de yuz dis ``Prɛsishɔn Mɛdisin'' we fɔ du bɔku tin dɛn pan mɛrɛsin. Pan ɔl we i stil de bigin, di tin dɛn we dɔn apin kin rili ɛnkɔrej wi. Na sɔm ɛgzampul dɛn ya:

• Prɛsishɔn ɔnkɔlɔji
• Kansa imyunotɛrapi
• Famakojinɔmiks
• Sik dɛn we nɔ kin bɔku

Wi go tɔk mɔ bɔt ɛni wan pan dɛn tin ya? Dɔn yu go ɔndastand mɔ bɔt aw dis impɔtant.

Wetin na prɛsishɔn ɔnkɔlɔji?

di dכkta dεm kin kכl kεnsar bay di pat pan di bכdi we i de insay (e.g. lכng kεnsar, brεst kεnsar) כ di kayn tisu (e.g. limfoma). bכt wit dis ``Precision Medicine'', dεn de fכn di mכlikul finga prεnt dεm naw fכ difrεn kεnsar dεm.Dat min se, jɔs lɛk wi finga prɛnt, wi kin no di smɔl smɔl kemikal dɛn ɛn di chenj dɛn we de apin na di jɛnɛtiks we difrɛn fɔ ɛni kansa. we dεn yuz dεn mak dεm ya, dεn kin kכl kεnsar dεm mכr insay di tכp dεm εn sכbtayp dεm.

Risach pipul dεm dכn si se kansa dεm we de divεlכp na difrεn pat dεm na di bכdi kin gεt bכku tin dεm we fiba pan di mכlikul lεvεl. So, dis ``Precision oncology`` de alaw dכkta dεm fכ pik tritmεnt bays pan di ``DNA signature`` fכ pכsin in kεnsar. Dis min se insted fɔ gi ɔlman di sem mɛrɛsin, dɛn kin gi tritmɛnt we spɛshal fɔ da kansa de, fɔ da chenj we de na di jɛnɛtiks. Dis kin mek di tritmɛnt go fayn pasmak.

Wetin na kansa imyunotɛrapi?

Yu no se di imyun sistɛm na yu bɔdi kin mek sɔm kansa nɔ kam? dis na biכs i gεt di innate abiliti fכ no εn pwεl di sεl dεm we nכ nכmal. Bɔt sɔntɛnde, kansa sɛl dɛn kin so kɔni dat dɛn kin avɔyd dis imyun sistɛm, ayd, ɛn gro.

Bɔt, tru dis we we dɛn kɔl ``Kansa imyunotɛrapi'', sayɛnsman dɛn de trik kansa sɛl dɛn naw! Yu no aw fɔ du am? Yu kin yuz yu yon imyun sistɛm fɔ kɔntrol kansa, ɛn sɔntɛnde yu kin ivin mɛn am kpatakpata. Dis rili wɔndaful, nɔto so?

Dɛn kayn ``Kansa imyunotɛrapi'' drɔgs kin falamakata di akshɔn we yu bɔdi in natura imyun sistɛm mɔlyul dɛn de du, ɔ ivin mek dɛn strɔng. Dɛn kayn drɔgs ya na:

• Antikansa antibodi dεm kin tay pan kansa sεl dεm εn pwεl dεm.
• di mεtכd dεm we de tek yu כwn imyun sεl dεm, "supercharge" dεm na di lab, εn riintrodכks dεm insay yu bכdi.
• Tritmɛnt vaysin na spɛshal vaysin dɛm wae de tich yu imyun sistɛm fɔ atak kansa sɛl dɛm.

Wetin na Famakojinɔmiks?

Dis na dip tɔpik smɔl, bɔt i rili impɔtant. Famakojinɔmiks na di stɔdi bɔt aw yu DNA de ansa di mɛrɛsin dɛn we yu de tek. dis fil de kam togεda fכmכkכlכji – di stכdi fכ dכg dεm – εn jεnomiks – di stכdi fכ jin dεm – fכ mek sef, ifektiv drog dεm εn dכz dεm we tayl to di spεsifi k chenj dεm na yu jin dεm.

Fɔ tɔk am simpul wan, di gol fɔ ``Famakojinɔmiks'' na fɔ muf kɔmɔt nia di ‘wan saiz fit ɔlman'' we. Naw, pipul dɛn we de stɔdi bɔt dis dɔn no se bɔku tin dɛn de we kin afɛkt aw yu bɔdi de du difrɛn mɛrɛsin dɛn. Nɔto jɔs yu ej, yu man ɔ uman, ɔ yu bɔdi saiz. Yu jin dɛnsɛf de ple big pat pan dis. ``Precision Medicine'' de tray fɔ gi yu di rayt mɛrɛsin, pan di rayt doz, fɔ yu bɔdi. Dɔn di mɛrɛsin go wok fayn ɛn i nɔ go gɛt bɛtɛ sayd ɛfɛkt.

Sik dɛn we nɔ kin bɔku ɛn prɛsishɔn mɛrɛsin

Di wan dɛn we de stɔdi bɔt dis bin tɔk se na lɛk 25-30 milyɔn pipul dɛn na Amɛrika nɔmɔ de sɔfa wit tin dɛn we nɔ kin apin so ɔltɛm. Dɛn kayn sik pipul ya de na Sri Lanka bak. Fɔ no ɛn trit dɛn sik ya rili at. Dɛn dɔn stɔdi ɔndrɛd pan dɛn kayn rili kɔmpleks mɛdikal prɔblɛm ya tru di ‘Undiagnosed Disease Program’ na di (NIH). Tru da risach de, dɛn dɔn ebul fɔ no bɔku pan dɛn kayn sik dɛn de. Wit di divεlכpmεnt כf jεnεtik tεknכlכji, i dכn pכsibul fכ no di εksakεt jεnεtik dεfεkt dεm we de mek dεn sik dεm ya we nכ kin apin.

Naw di NIH dɔn mek dis program go na sɔm ɔda sɛnta dɛn ɔlsay na di kɔntri fɔ stɔdi mɔ sik dɛn. Dɛn de wok wit sɔm ɔda patna dɛn fɔ mek dɛn ebul fɔ mek fayn tritmɛnt kwik kwik wan fɔ dɛn sik ya we nɔ kin bɔku. Precision Medicine na big op fɔ pipul dɛm lɛk dis.

Wetin na di difrɛns bitwin ‘Prɛsishɔn Mɛdisin’ ɛn ‘Pɔshɔnal Mɛdisin’?

Akɔdin to di US Nashɔnal Risach Kɔnsil, ‘Personalized Medicine’ na wan ol wɔd we dɛn kin yuz fɔ tɔk bɔt ‘Precision Medicine’. Dat min se di tu wɔd dɛn min di sem tin.

Bɔt di kansul dɔn de wɔri smɔl se we pipul dɛn se ‘personalized’, dɛn kin tink se ɛnibɔdi go gɛt difrɛn, tayla-mɛd tritmɛnt. Bɔt, di tin we ``Prɛsishɔn Mɛdisin'' de pe atɛnshɔn pan nɔto jɔs pan yu. Bifo dat, na fɔ no us tritmɛnt dɛn de wok fayn fɔ us grup fɔ pipul dɛn – dat na, ɔda pipul dɛn we gɛt di sem jenɛtik kwaliti ɛn layf we yu gɛt. Naw, ``Prɛsishɔn Mɛdisin'' na di wɔd we dɛn kin yuz pas ɔl ɛn dɛn kin tek am se na di wɔd we fit pas ɔl. Bɔt pipul dɛn stil de yuz di tu wɔd dɛn fɔ chenj. Di impɔtant tin na dat dis we fɔ du tin de tray fɔ gi tritmɛnt we kɔrɛkt, we go wok fayn, pas fɔ trit ɔlman di sem we.

Wetin na di impɔtant tin we wi want fɔ kɛr go na os frɔm dis stori?

Yu jin, di envayrɔmɛnt we yu de liv, yu layf – ɔl dɛn tin ya kin afɛkt yu wɛlbɔdi. Di ɔltimat gol fɔ ``Precision Medicine`` na fɔ stɔdi ɔl dɛn tin ya ɛn tek akshɔn fɔ protɛkt ɛn ɛp yu. Dɔn, instead fɔ gi ɔlman di sem tritmɛnt, yu dɔktɔ dɛn kin mek wan plan fɔ avɔyd ɛn trit sik dɛn we go fayn fɔ yu. Dɔktɔ dɛn dɔn ɔlrɛdi de yuz ``Precision Medicine`` pan bɔku eria dɛn na mɛrɛsin. Bɔt, bɔku tin dɛn de we kin apin we i go chenj di wɛlbɔdi biznɛs tumara bambay we i at fɔ imajin. So, dis na rili big op fɔ wi wɛlbɔdi biznɛs tumara bambay!

"Mɛmba se, ``Prɛsishɔn Mɛdisin'' nɔto fɔ mek wan spɛshal mɛrɛsin fɔ ɔlman, bɔt fɔ pik di tritmɛnt we fit ɛn we go wok fɔ wan grup we gɛt di sem kayn kwaliti dɛn we yu gɛt."

As dis teknɔlɔji de go bifo, wi go ebul fɔ fɛt bɔku ɔda sik dɛn fayn fayn wan. So, i rili impɔtant fɔ mek wi no bɔt nyu tin dɛn lɛk dis.

` Prɛsishɔn Mɛdisin, Jɛnɛtiks, Kansa Tritmɛnt, Pɔshɔnal Mɛdisin, Fiuja Mɛdisin, Ɛlth Tɛknɔlɔji