Yu dɔn ɛva yɛri bɔt pɔsin in leg we swel wantɛm wantɛm ɛn we de mek i fil pen ɛn dɔktɔ tɛl am se blɔd dɔn klɔt na in leg? Ɔ yɔŋ pɔsin we gɛt wɛlbɔdi, we i nɔ kin ebul fɔ blo wantɛm wantɛm ɛn i kin fil pen na in chɛst ɛn dɛn kin put am na ɔspitul? We wi yɛri tin dɛn lɛk dis, wi kin wɔnda wetin de apin. Bɔrku tɛm, wi kin si tin dɛm lɛk fɔ ol ɛn fɔ fat pasmak na in kin mek dis sik. Bɔt sɔntɛnde, di tin we kin mek wi gɛt dis sik kin bi sɔntin lɛk di kɔlɔ we wi yay gɛt, di we aw wi ia tan, ɔ wan jin we wi gɛt frɔm wi mama ɛn papa. Tide wi go tɔk bɔt dis kayn jenɛtik kɔndishɔn we de mek di blɔd klɔt mɔ ɛn mɔ. Dɛn kɔl dis
Prothrombin Gene Mutation .
Fɔ tɔk am simpul wan, wetin na dis Prothrombin Gene Mutation?
Dis kin tan lɛk sayɛns nem, bɔt di stori rili simpul. Lɛ wi luk fɔs aw blɔd kin klɔt nɔmal wan na wi bɔdi. We yu gɛt smɔl injuri, smɔl blɔd kin kɔmɔt ɛn afta sɔm tɛm i kin stɔp, nɔto so? Dat na bikɔs di blɔd we de klɔt na wi bɔdi de wok. Bɔku kayn prɔtin dɛn kin ɛp fɔ du dis. wi kכl dεn protin dεm ya Clotting Factors.
Prothrombin na wan pan dɛn kayn prɔtin dɛn de. Wan ɔda nem fɔ dis na
Factor II . nכmal wan, wi bכdi de כnli mek di כmכnt כf Prothrombin we i nid. Bɔt insay pɔsin in bɔdi we gɛt wan jɛnɛtik muteshɔn we dɛn kɔl Prothrombin Gene Mutation, dis prɔtin we dɛn kɔl Prothrombin de mek
bɔku bɔku wan pas aw dɛn nid am . Imajin, wetin go apin if pɔsin ad fayv ɔ siks spɔnj shuga to wan kɔp ti instead fɔ put tu spɔnj shuga? jכs lεk aw ti de te tu swit, we di prothrombin lεvεl dεm de inkrεs, wi bכdi de "stika" sכmtεm, כ
i kin kכlכt. Dis kin mek di blɔd klɔt na di vein dɛn, ivin if yu nɔ gɛt ɛni injuri. Dɛn blɔd klɔt ya kin mek na di dip vein dɛn na di leg dɛn. Wi kin kɔl dis kɔndishɔn
Dip Vein Thrombosis (DVT) . Sɔntɛnde, wan pat pan dis blɔd kin brok ɛn blok wan vein na di lɔng dɛn. Dis na wan sik we rili denja, we dɛn kɔl
Pulmonary Embolism (PE) .
Aw wi go gɛt dis jin? Wetin na homozygous ɛn heterozygous?
Dis rili izi fɔ ɔndastand. Wi kin gɛt ɛni jin as wan kɔpi frɔm wi mama ɛn wan kɔpi frɔm wi papa. Tink bɔt dis jin we de mek Prothrombin. 1.
Heterozygous: Yu kin gɛt dis jin we nɔ fayn frɔm yu mama
ɔ papa, dat na frɔm wan pan yu mama ɛn papa nɔmɔ. Di ɔda pɔsin kin gɛt di wɛlbɔdi, nɔmal jin. Bɔrku pipul na Sri Lanka ɛn ɔlsay na di wɔl gɛt dis sik. If na so i bi, di risk fɔ mek blɔd klɔt kin bɔku smɔl pas di avɛrej pɔsin. Fɔ tɔk smɔl, tu ɔ tri pan ɔl 1,000 pipul dɛm wae gɛt dis sik kin gɛt risk fɔ gɛt blɔd klɔt. 2. 2. .
Homozygous: Dis kin apin smɔl. Wetin kin apin ya na dat yu kin gɛt di jin we nɔ fayn frɔm yu mama ɛn yu papa ɔl tu. Dis min se yu kin gɛt ɔl tu di kɔpi dɛn fɔ di jin we nɔ fayn
frɔm yu mama ɛn papa ɔl tu . insay dis kes, di risk fכ bכdi kכlכt de
bכku tεm pas di wan dεm we na `Hεterozygous`. Yu tink se mi pikin dɛn go gɛt dis frɔm mi?
Dis na prɔblɛm we bɔku mama ɛn papa dɛn gɛt.
- If yu gɛt di homozygous kɔndishɔn (we min se ɔl tu di kɔpi dɛn fɔ di jin nɔ fayn), yu go mɔs pas wan jin we nɔ fayn to ɛni wan pan yu pikin dɛn .
- if yu na hεterozaygכs (we min se yu nכ gεt wan jin we nכ de wok fayn), 50% chans de fכ wan pan yu pikin dεm go gεt da jin de. I tan lɛk se yu de flip kɔyn; yu kin gɛt am ɔ yu nɔ kin gɛt am.
Wetin na di sayn dɛm fɔ dis sik?
Na dis na di tin we impɔtant pas ɔl.
nכ simptom dεm nכ de we spεshal fכ di jεnεtik mכtεshכn we dεn kכl Prothrombin Gene Mutation. Dat min se, ivin if yu gɛt dis jin na yu bɔdi, yu nɔ go fil ɛni difrɛns ɔ prɔblɛm. Bɔku pipul dɛn nɔ kin ivin no se dɛn gɛt dis jin, ɛn dɛn kin liv dɛn wan ol layf ɛn nɔ kin mek ɛni blɔd klɔt. So usay di prɔblɛm de? Di prɔblɛm kin kam nɔmɔ if blɔd klɔt fɔm bikɔs ɔf dis jin. Dɔn wi kin si di sayn dɛn we gɛt fɔ du wit da blɔd de.
| Di say we di blɔd de klɔt | Simptom dɛm fɔ ɛkspɛkt |
|---|
| Dip vein trombosis (DVT) na di leg ɔ an | - Pen we yu kin fil wantɛm wantɛm, mɔ we yu tinap ɔ we yu de waka.
- Di leg ɔ an we de swel.
- Rɛd ɔ pepul skin.
- We yu tɔch am, da say de kin wam pas ɔda say dɛn.
|
| Na di lכng dεm (Pulmonary Embolism - PE) . | |
Impɔtant: Pulmonary embolism na wan mɛdikal imejensi . So, i rili impɔtant fɔ go na ɔspitul wantɛm wantɛm if di sayn dɛn we wi dɔn tɔk bɔt apin.
Ɔda tin dɛn de apat frɔm di jin dɛn we de mek di blɔd klɔt mɔ?
Yɛs, na fɔ tru. Wi bin se nɔto ɔlman we gɛt dis jin go gɛt blɔd klɔt. Bɔt we wan ɔ mɔ pan dɛn tin ya de, di prɔblɛm kin bɔku. I tan lɛk se yu de tɔn petrol pan faya.
- Smok: Smok kin pwɛl di blɔd vesel dɛn ɛn i kin mek di blɔd klɔt mɔ ɛn mɔ .
- We dɛn de du ɔpreshɔn pan yu: Afta dɛn dɔn du big ɔpreshɔn, yu kin de na bed fɔ sɔm dez, ɛn dis kin mek yu blɔd nɔ de rɔn bɛtɛ ɛn yu nɔ go gɛt bɛtɛ blɔd.
- Fat : As di bɔdi wet de go ɔp, dis risk de go ɔp as dɛn de put mɔ prɛshɔn pan di vein dɛn.
- bεlε: We uman bεlε, di risk fכ blכd kכlכt nכmal wan de inkrεs bikoz fכ di כmon chenj dεm na di bכdi εn di prεshכn pan di vein dεm we di pikin we de gro de mek.
- Fɔ tek bɔn kɔntrol pils ɔ ɔmon tɛrapi: Di risk kin bɔku bikɔs ɔf di ɛstrojen ɔmon we de insay sɔm bɔn kɔntrol pils ɛn ɔmon tɛrapi.
- We pɔsin de ol: Di risk fɔ mek blɔd klɔt kin bɔku we pɔsin de ol.
- Fɔ de na di sem pozishɔn fɔ tu lɔng:
- Fɔ de na bed na ɔspitul fɔ bɔku dez.
- We yu wɛr kas we yu brok yu leg.
- Fɔ travul wit plen, bɔs, ɔ motoka fɔ bɔku awa wan tɛm.
Aw a go no if a gɛt dis sik?
Dɛn nɔ go ebul fɔ no dis wit blɔd tɛst ɔltɛm (lɛk we dɛn de kɔnt ful blɔd). Dɛn nid fɔ du wan patikyula
jenɛtik tɛst fɔ dis. Dɛn kin du dis bay we dɛn tek blɔd sɛmpul. Bɔt, dɔktɔ nɔ kin tɛl ɔlman fɔ du dis tɛst. Bɔku tɛm, dɔktɔ kin sɔprayz dis ɛn i kin tɛl dɛn fɔ du tɛst pan dɛn kayn tin ya:
- If yu dɔn gɛt pas wan blɔd we dɔn klɔt bifo.
- If yu gɛt blɔd we yu yɔŋ, yu gɛt wɛlbɔdi, ɛn yu nɔ gɛt ɛni ɔda sik.
- If yu fambul we de nia yu na yu famili (mama, papa, brɔda ɛn sista) gɛt dis kayn prɔblɛm we de mek yu blɔd klɔt.
Aw dɛn kin trit am?
Na ya wi nid fɔ mek tu klia pɔynt dɛn. 1.
Tritmɛnt fɔ di jenɛtik muteshɔn: Frɔm di mɛdikal sayɛns we de naw,
no we nɔ de fɔ trit ɔ chenj wi jin. Dis min se di Prothrombin Gene Mutation go de wit yu fɔ di res ɔf yu layf. 2.
Tritmɛnt fɔ blɔd we dɔn rɔtin: Bɔt wi kin
kɔntrol di risk fɔ mek blɔd klɔt we dis jin de mek ɛn trit wan blɔd we dɔn fɔm . If yu gɛt DVT ɔ PE, bɔku tɛm yu dɔktɔ go bigin fɔ trit yu bay we i go gi yu wan kayn mɛrɛsin we de mek blɔd nɔ klɔt (we wi kin kɔl blɔd tina). We wi de tɔk bɔt mɛrɛsin, dɛn kin kɔl dɛn tin ya
antikɔagulɛnt . Insay sɔm imejensi, dɛn kin gi dɛn drɔgs we dɛn kɔl
trombolytics bay injɛkshɔn fɔ sɔlv ɛn pul di blɔd we dɔn klɔt. Na smɔl tɛm nɔmɔ dɛn kin yuz kateshɔn ɔ ɔpreshɔn fɔ pul di blɔd we dɔn klɔt. Di tɛm we dɛn kin tek di tritmɛnt kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Fɔ sɔm pipul dɛn, if dɛn tek di mɛrɛsin fɔ lɛk tri mɔnt so, i go du fɔ dɛn. Ɔda pipul dɛn kin nid fɔ tek mɛrɛsin we de mek dɛn blɔd tan lɛk dɛn layf ɔl. Yu dɔktɔ go disayd fɔ du dat bay aw yu sik ɛn di tin dɛn we go mek yu gɛt prɔblɛm.
Aw dis sik kin afɛkt di bɛlɛ?
Dis na impɔtant tin fɔ bɔku uman dɛn.
- If yu gɛt dis Prothrombin Gene Mutation ɛn yu dɔn gɛt blɔd klot trade , yu dɔktɔ kin se yu fɔ tek wan smɔl doz (prɛventiv) ɛvride blɔd tina (lɛk heparin) ɔl di tɛm we yu gɛt bɛlɛ ɛn fɔ sɔm wiks afta dɛn bɔn yu pikin. Dɛn kayn injɛkshɔn ya nɔ de ambɔg yu pikin.
- Bɔt ivin if yu gɛt dis jin, if yu nɔ ɛva gɛt blɔd na yu layf , bɔku tɛm yu nɔ nid ɛni tritmɛnt we yu gɛt bɛlɛ.
Bɔt dis na sɔntin we dɔktɔ fɔ disayd bay yu wan wan sityueshɔn. If yu de plan fɔ gɛt bɛlɛ ɔ yu kam fɔ no se yu gɛt bɛlɛ, i impɔtant fɔ tɛl yu dɔktɔ we de mɛn uman dɛn ɛn ɔda dɔktɔ dɛn se yu gɛt dis jenɛtik kɔndishɔn.
Ustɛm yu fɔ go to dɔktɔ?
Dis rili impɔtant. If yu no di sayn dɛm ɛn tek akshɔn kwik, dat kin mek yu nɔr gɛt siriɔs sik.
| Di sayn dɛm wae yu de gɛt | Akshɔn we dɛn fɔ tek |
|---|
| Di sayn dɛm fɔ DVT na pen, swel, rɛd, ɛn wam wam na yu leg ɔ an. | Kɔl yu famili dɔktɔ wantɛm wantɛm, ɔ go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu . |
| Di sayn dɛm fɔ PE na di chɛst pen, i nɔ kin izi fɔ blo, ɛn di at kin bit kwik kwik wan. | Go na di Imejɛnsi Dipatmɛnt (ETU) we de nia yu wantɛm wantɛm ɛn nɔ de te. Dis na imejensi we kin mek pɔsin in layf de pan denja. |
| If yu dɔn ɔlrɛdi de yuz blɔd tin dɛn (anticoagulants). | Mek shɔ se yu go na blɔd tɛst ɛn klinik dɛn lɛk aw yu dɔktɔ dɔn disayd. |
Fɔ dɔn, nɔ panik if yu kam fɔ no se yu gɛt di Prothrombin Gene Mutation. Mɛmba se bɔku pan di pipul dɛn we gɛt dis jin kin liv fayn layf ɛn nɔ gɛt ɛni prɔblɛm. Di tin we impɔtant pas ɔl na fɔ no bɔt dis, nɔ de nia di tin dɛn we kin mek yu gɛt prɔblɛm (lɛk fɔ smok, fɔ fat pasmak), fɔ liv fayn layf, ɛn go to dɔktɔ wantɛm wantɛm if yu gɛt ɛni sayn fɔ se yu blɔd dɔn rɔtin.
Mɛsej we dɛn kin kɛr go na os
- Prothrombin Gene Mutation na jεnεtik kכndyushכn we de pas dכn tru jεnereshכn. Nɔto yu fɔlt.
- We pɔsin gɛt dis jin, i nɔ de mek blɔd nɔ klin. Bɔku pipul dɛn nɔ kin gɛt ɛni prɔblɛm.
- Nɔr sayn nɔr de we gɛt fɔ du wit dis jin. Di sayn dɛm kin apin nɔmɔ if blɔd klɔt, lɛk DVT ɔ PE, kam.
- Ɔltɛm, de wach fɔ si di sayn dɛm we de sho se yu leg de swel, yu de fil pen (DVT), ɛn yu de fil pen wantɛm wantɛm na yu chɛst ɛn yu nɔ de blo shɔt (PE).
- Pulmonary Embolism (PE) na wan mɛdikal imejensi we nid fɔ gɛt tritmɛnt kwik kwik wan.
- If yu nɔ smok, kɔntrol yu bɔdi wet, ɛn liv yu layf tranga wan, dat kin mek yu nɔ gɛt bɔku blɔd.
- If yu no se yu gɛt dis sik, i rili impɔtant fɔ tɛl ɛni dɔktɔ we yu si dɛn, bifo dɛn du yu ɔpreshɔn, ɔ we yu gɛt bɛlɛ.
- If yu de tɔk to yu dɔktɔ ɔltɛm ɛn fala in advays, dat go rili bɛnifit yu wɛlbɔdi.
Prothrombin Gene Mutation, Factor II mutation, Blɔd klot, Dip Vein Thrombosis, Pulmonary Embolism, DVT, PE, Jɛnɛtik sik dɛn, Blɔd tinna, Antikoagulant
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