Wetin na dɛn lumps ya na di nɛk ɛn di armpit? Lɛ wi lan bɔt Rosai-Dorfman Disease!

Na nɔmal tin fɔ mek wi fred smɔl we wi si chenj dɛn na wi bɔdi, nɔto so? Ɛspɛshali if wi si smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Tide wi go tɔk bɔt wan rare kɔndishɔn we kin mek dɛn kayn lumps ya, bɔt nɔto bɔku pipul dɛn dɔn yɛri bɔt am. Dɛn kɔl dis sik we dɛn kɔl Rosai-Dorfman Disease.

Yu no wetin na Ross-Dorffman disease (RDD)?

Fɔ tɔk am simpul wan, wi bɔdi gɛt wan kayn wayt blɔd sɛl we dɛn kɔl histiocytes . Dɛn tin ya tan lɛk di polis ɔfisa dɛn na wi bɔdi, we de fɛt di jem dɛn we de mek wi gɛt sik, ɛn dɛn na impɔtant pat pan wi imyun sistɛm. כltu, we dεn histiosayt dεm ya de gro tu, dεn kכl am Rכs-Dכfman sik (RDD). Dis nɔto rili kansa (benign) , we min se nɔto denja sik we kin kɔmɔt na wan pat na di bɔdi to ɔda pat. Bɔt we dɛn sɛl ya gɛda pasmak, wi kin fil bad ɛn gɛt sɔm sayn dɛn.

כl di tεm dεm, dεn εksyכs histiosayt dεm ya kin kכmכt na di limf no dεm na wi nεk. Dɔn dɛn kin swel lɛk lumps na di nɛk. sכmtεm dכkta dεn kin kכl dis swel na di no dεm `(lymphadenopathy).` bכt i kin afekt nכto di nεk nכmכ, bכt i kin afekt di no dεm na כda pat dεm na di bכdi. sכmtεm, apat frכm di no dεm, dεn sεl dεm ya kin kכmכt bak na כda pat dεm na di bכdi (ekstranodal sayt dεm).

dis sik dεn kכl am bak `saynus histiocytosis wit masiv limfadenopathy`. dis na sik we nכ kin apin we de insay di grup we dεn kכl `nכn-Langerhans sεl histiocytosis`.

Wetin na di men kayn sik we dɛn kɔl Ross-Dorffmann disease (RDD)?

Dis sik nɔ de afɛkt ɔlman di sem we. Sɔm pipul dɛn kin gɛt swɛlin na wan ples, ɛn ɔda wan dɛn kin gɛt swel na bɔku say dɛn. כlso, dεn histiocytes ya kin kכmכt nכto כnli insay di lumps bכt bak na כda pat dεm na di bכdi. Dis na aw dɛn kin klas am.

• Klasik (Nodal) Ross-Dorffmann Disease (Klasik/Nodal RDD): Dis na di kayn we we dɛn kin gɛt mɔ. i kin min fכ swel di no dεm na di nεk. Bɔt di sayn dɛm kin difrɛn difrɛn wan dipen pan ɔmɔs no dɛm de afɛkt.
• εkstranodal RDD: insay dis tכp, dεn histiosayt dεm ya de kכmכt insay כda tisu dεm we nכto di limf no dεm. Na di skin kin afɛkt mɔ. Dɛn kɔl dis cutaneous RDD (CRDD) . pan tap dat, di kכndyushכn kin afekt wi sayn dεm, yay εn aylid, bon dεm, εn di sεntri nεv sεstem (CNS) – dat na di bren εn spεnal kכd. sכmtεm di rεspiretכri sistεm εn di gεstrointestinal sistεm kin afekt bak.

כlmost 40% pan di pipul dεm we gεt RDD kin gεt dεn histiocyte sεl dεm ya we dεn kכlekt na כda pat dεm na di bכdi, apat frכm di wכt dεm, lεk aw yu bin se.

Udat kin gɛt dis sik pas ɔlman?

Di sik we dɛn kɔl Ross-Dorffmann kin mɔna pikin dɛn, yɔŋ pipul dɛn, ɛn yɔŋ pipul dɛn . Dɛn kin no bɔt am pan pipul dɛm wae dɔn pas 20 ia. Bɔt dɛn dɔn ripɔt bak se pipul dɛn we dɔn pas 70 ia gɛt dis sik.

RDD, we kin afɛkt di tɛstikul, kin apin mɔ pan man dɛn we kɔmɔt na Afrika. Bɔt di skin kɔndishɔn we wi bin dɔn tɔk bɔt ``CRDD`` kin mɔs pan uman dɛn we kɔmɔt na Eshia. ``CRDD`` kin bכku pan pipul dεm wae de 20, 30, εn 40 ia.

Aw di sik we dɛn kɔl Ross-Dorfman nɔ kin bɔku?

Dis na sik we nɔ kin apin so ɔltɛm . I kin afɛkt lɛk wan pan ɛvri tu ɔndrɛd tawzin pipul dɛn. Fɔ ɛgzampul, na Amɛrika, dɛn kin ripɔt lɛk 100 nyu wan dɛn we gɛt di sik ɛvri ia. Dat min se na Sri Lanka, i ivin smɔl.

Wetin na di sayn dɛm wae de sho se yu gɛt Rose-Dorfman disease (RDD)?

di simptom dεm we yu go gεt go dipכnt pan usay na yu bכdi di εksyכs histiocytes dεm de kכmכt. If na di limf no dɛm nɔmɔ na yu nɛk de afɛkt, yu sayn dɛm kin smɔl ɔ ivin nɔr de. Bɔt if dɛn sɛl ya gɛda ɛn ambɔg di wok we wan ɔgan de du, yu sayn dɛn kin rili bad.

Klasik (nodal) simptom dɛm

כltεm di histiosayt dεm kin gɛda na di nεk tisu dεm. So, di tin we kin apin mɔ na we yu gɛt bɔku bɔku tin dɛn we nɔ de mek yu fil pen ɛn we dɔn swel na di tu say dɛn na di nɛk . Yu go mɛmba aw sɔntɛnde yu kin gɛt smɔl smɔl tin na yu nɛk we yu gɛt kol ɔ flu, nɔto so? Na so i bi, bɔt sɔntɛm i nɔ go mek pɔsin fil pen. Bɔt i dipen usay di tisu we afɛkt de, di swel kin de bak na ɔda say dɛn.

di men εria dεm fכ inflameshn we kin apin bikoz fכ inkrεs pan di histiocytes na:

• Yu nek
• Groin eria
• Di armpit dɛn
• Di midul pat pan di chɛst (mediastinum) .

Yu nɔr kin gɛt ɛni ɔda sayn pas fɔ swel, ɔr yu kin gɛt sɔm kayn sik lɛk:

• Fiva
• Pale skin
• Taya pasmak
• Nayt swet dɛn
• Nɔs we de rɔn
• We yu de lɔs yu wet we yu nɔ ɛksplen

Di simptom dɛm we de na di ɛkstranodal

Rose-Dorffmann disease (`CRDD`) kin afɛkt di skin ɛn i kin apia ɛnisay na di bɔdi. dis lכmp dεm we de fכm bay wan kכlekshכn fכ di histiocyte sεl dεm, kin gro sכmtεm. Di sayn dɛm wae yu kin si pan di skin na:

• Flat ɔ rayz bɔmp dɛn
• Lump dɛn we ful-ɔp wit pus ɔ we strɔng
• Yɔlɔ, pepul, rɛd, ɔ brawn bɔmp dɛn
• I kin skata ɔlsay na di skin ɔ na wan say nɔmɔ.

we dεn εksyכs histiosayt dεm ya afekt wan patikyula כgan כ bכdi sistεm, difrεn simptom dεm kin apin. Fɔ ɛgzampul, if RDD afɛkt di yay, i kin mek pɔsin si tu tɛm. If i afɛkt di sɛntral nervɔs sistɛm, i kin mek yu gɛt sik. If i afɛkt di lɔng dɛn, i kin mek pɔsin kɔf ɔltɛm. Semweso, di sayn dɛm kin difrɛn difrɛn wan fɔ di say we di sik afɛkt.

Wetin kin mek pɔsin gɛt di sik we dɛn kɔl Ross-Dorffman (RDD)?

Sayɛnsman dɛn stil nɔ no di rayt tin we kin mek pɔsin gɛt dis sik. Bikɔs RDD kin afɛkt ɛnibɔdi difrɛn we, sɔm tin dɛn kin de we kin mek i apin. fכ egzampl, risεch we dεn jכs du sho se di skin kכndyushכn ``CRDD`` de kכz fכ כda tin pas di sem tin dεm we de mek RDD rεgulεr.

rεsכch pipul dεn dכn fכnshכn i nכ tu te yet se sכm jin mכtεshכn dεm de fכn insay כda tכp dεm fכ RDD apat frכm CRDD. Dɛn chenj ya kin mek di sɛl dɛn gro we dɛn nɔ ebul fɔ kɔntrol.

Bɔrku pipul dɛm wae gɛt RDD gɛt dis sik wit ɔda mɛdikal kɔndishɔn dɛm. So, kin gɛt link bitwin dɛn kɔndishɔn dɛn de ɛn RDD. Dɛn nid fɔ du mɔ risach bɔt dis.

Dɛn dɔn si se RDD gɛt fɔ du wit dɛn kɔndishɔn ya:

• Vayral infεkshכn: εgzampl dεm na hεpi, Epstein-Barr vayrus, saytomegalovayrus, εn HIV infεkshכn.
• Kansa: Hodgkin lymphoma, non-Hodgkin lymphoma, ɛn kansa na di skin lɛk cutaneous clear-cell sarcoma. (Bɔt mɛmba se RDD nɔto kansa.)
• Ɔtoimyun kɔndishɔn dɛn: Lupus, Juvenile Idiopatik Atraytis, Ɔtoimyun Ɛmolaytik Anemia.

Aw dɛn kin no di sik we dɛn kɔl Ross-Dorffman disease (RDD)?

Yu dɔktɔ go fɔs du yu bɔdi ɛgzam ɛn aks bɔt yu sik dɛn. Dɛn go luk fɔ sayn dɛm fɔ RDD, lɛk di gland dɛm we swel ɛn di skin lumps. Dɛn go aks bak bɔt yu mɛdikal histri fɔ si if yu gɛt ɔ yu dɔn gɛt ɛni kɔndishɔn we gɛt fɔ du wit RDD.

Apat frɔm dat, di dɔktɔ kin du dɛn tɛst ya bak:

• Di we aw dɛn fɔ tek pikchɔ: Di dɔktɔ kin ɔda fɔ mek dɛn tek ɛkstrem rayt, ɔltra saund, MRI, CT, PET, PET/CT, ɔ bon skan, i kin dipen pan di kayn tisu we dɛn tink se gɛt histiocytes. Dɛn kin yuz dɛn tin ya fɔ si wetin de insay di bɔdi.
• Blɔd tɛst: Dɛn kin du bɔku blɔd tɛst, lɛk fɔ kɔnt ɔl di blɔd kɔunt (CBC) ɛn fɔ si di tin dɛn we de apin na di bɔdi.
• Bayopsi: Dis na tɛst we rili impɔtant.dis involv fכ tek sכm sכm sεmpl fכ di tisu we afekt (e.g., wan limf node we swel) εn egzamin di sεl dεm כnda maykroskכp fכ si if dεn gεt RDD kכntribyushכn. dis bayopsi kin no bak if כda sik de mek di sεl dεm de gro we nכ nכmal.

Aw dɛn kin trit di sik we dɛn kɔl Ross-Dorffmann (RDD)?

Sɔntɛnde, RDD kin go insay spontan rɛmishɔn we nɔ gɛt ɛni tritmɛnt. Dis min se di sik go bɛtɛ fɔ insɛf. Bɔt, i nɔ kin izi fɔ tɔk bɔt di tɛm we i go tek. I kin tek sɔm mɔnt ɔ ivin ia fɔ mek i wɛl. Bɔt sɔntɛnde, i nɔ kin go fɔ insɛf, ɔ i kin kam bak. If dɛn nɔ trit di sik, i kin wɔs.

Di tritmɛnt we yu go gɛt go dipen pan aw RDD dɔn afɛkt yu.

• Wae yu wach: If yu nɔr gɛt sɔm kayn sik wae de ambɔg yu layf, yu dɔktɔ kin disayd fɔ wach yu sik. Dis na di sem tin lɛk "watchful waiting" we fɔ du tin.
• Ɔpreshɔn: Dɛn kin pul di lumps bay ɔpreshɔn. If yu gɛt `CRDD` (cutaneous RDD), ɔ if di lumps de blok yu aywe ɔ afɛkt yu spɛshal kɔd, dɛn kin du ɔpreshɔn.
• Redyushɔn tɛrapi: If ɔpreshɔn nɔ ebul fɔ pul di histiocytes, dɛn kin gi redyushɔn tɛrapi. Dis min se dɛn fɔ yuz mashin fɔ dayrɛkt di raytin bim dɛn we dɛn want fɔ go na di sɛl dɛn, ɛn pwɛl dɛn.
• Kimotɛrapi: If di sik rili bad, ɔ if ɔda tritmɛnt dɛn lɛk ɔpreshɔn nɔ dɔn ridyus di sayn dɛn, dɛn kin tink bɔt kemotɛrapi. Dis min se dɛn fɔ yuz mɛrɛsin dɛn we de kil di sɛl dɛn we de gro fast fast, lɛk di kansa sɛl dɛn.
• Kɔtikosterɔyd: Kɔtikosterɔyd, lɛk prɛdnison, kin mek di jɔyn dɛn nɔ swel ɛn i kin mek di sik nɔ kam. Dis na wan kayn mɛrɛsin we de ridyus di inflamɛns.
• Immunotherapy: Dɛn tritmɛnt ya de ɛp yu yone imyun sistɛm fɔ fɛn ɛn pwɛl di histiocyte sɛl dɛn we pasmak.

Wetin na di fiuja fɔ pɔrsin wae gɛt Ross-Dorffman disease (RDD)?

Yu prɔgnosis de dipen pan sɔm tin dɛm. di nכmba fכ di sεl dεm we dεn afekt, usay na yu bכdi di εksyכs histiocytes de, εn aw yu de rεspכnd fayn to tritmεnt. Bɔku tɛm, RDD kin sɔlv fɔ insɛf. Bɔt sɔm tɛm dɛn de, dɛn kin nid fɔ gɛt tritmɛnt, ɔ siriɔs prɔblɛm dɛn kin apin.

Jɛnɛral wan, di mɔ di nɔmba fɔ di sɛl dɛn we dɛn afɛkt nɔ bɔku, na di mɔ i go fayn.. If ekstranodal RDD de, we de afɛkt di skin, chɛst, ɔ di ɔpa respiratory trakt, di autkam go mɔs bi gud. כltu, if di histiocytes de na di lכw rεspiretכri trakt, kidni, כ liva, di tin kin bכku sכmtεm.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Nɔ fɔgɛt fɔ tɔk to yu dɔktɔ bɔt dɛn tin ya, bikɔs i rili impɔtant fɔ mek yu ɔndastand yu sik gud gud wan:

• "Dɔkta, us pat na mi bɔdi ɛksaktɔli afɛkt mi RDD kɔndishɔn?"
• "A go nid fɔ gɛt ɛni ɔda imej tɛst (lɛk skan) ɔ blɔd tɛst?"
• "A nid tritmɛnt, ɔ i pɔsibul se mi RDD kɔndishɔn go sɔlv fɔ insɛf?"
• "Aw a fɔ wɔri bɔt dis RDD sityueshɔn?"
• "Wetin na di bɛst tritmɛnt we di dɔktɔ rikɔmɛnd fɔ mi?"
• "Us sayd ɛfɛkt a kin ɛkspɛkt afta tritmɛnt?"
• "Wetin na di chans fɔ mek mi RDD kɔndishɔn kam bak afta tritmɛnt?"
• "Aw often a nid fɔ kam fɔ chɛk-ap fɔ monitar mi kɔndishɔn?"

Yu tink se Ross-Dorffman disease (RDD) na kansa?

Nɔ, dis na kwɛstyɔn we bɔku pipul dɛn kin aks. Rose-Dorffman sik nɔto kansa (benign) . Dat min se i nɔ de skata frɔm wan pat na di bɔdi to ɔda pat lɛk kansa (malignancy). כltu, di lumps we de fכm bikoz fכ RDD kin afekt di כgan dεm, intafεr dεn fכnshכn, εn mek kכmplikεshכn. Yu dɔktɔ na di bɛst pɔsin fɔ no aw yu RDD kɔndishɔn de afɛkt yu bɔdi ɛn if yu fɔ wɔri bɔt am.

Udat bin fɛn di sik we dɛn kɔl Ross-Dorffman (RDD)?

I fayn fɔ no dis bak. Insay 1965, wan sayɛnsman we nem Pierre Paul Louis Lucien Destombes bin kam fɔ no se 4 pipul dɛn we sik gɛt RDD. Dɔn insay 1969, tu sayɛnsman dɛn we nem Juan Rosai ɛn Rɔnald Dɔfman bin stɔdi wan ɔda grup we gɛt di sem kayn sik. Naw pipul dɛn kin kɔl dis sik Rosai-Dorfman sik, we dɛn jɔyn dɛn nem togɛda. Na smɔl tɛm nɔmɔ dɛn kin kɔl am bak Rosai-Dorfman-Destombes sik, fɔ ɔnɔ ɔl di tri sayɛnsman dɛn.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Ross-Dorffmann disease (RDD) kin bi wan chalenj fɔ no bɔt am bikɔs i nɔ kin bɔku ɛn i kin afɛkt ɛnibɔdi difrɛn we . No wan tritmɛnt gaydlain nɔ de fɔ RDD. Na dat mek i impɔtant fɔ tɔk to yu dɔktɔ opin wan, ɔndastand aw yu gɛt di sik, ɛn no bɔt di tritmɛnt dɛn we yu go gɛt.

Yu kin gɛt mild RDD we go sɔlv fɔ insɛf. Ɔ, yu kin nid fɔ gɛt kɔmbayn tritmɛnt dɛn. Aks yu dɔktɔ aw yu tritmɛnt plan ɛn di tin dɛn we yu de op fɔ gɛt go fit yu sik.

Mɛmba se nɔto yu wangren de . We yu de dil wit dis kayn sik we nɔ kin apin so ɔltɛm, i rili impɔtant fɔ fala di advays we dɔktɔ gi yu ɛn fɔ kɔntinyu fɔ gɛt trɛnk na yu maynd. If yu gɛt ɛni kwɛstyɔn ɔ dawt, tɔk bɔt am wit yu dɔktɔ. Nɔ fred, bikɔs awareness na di bɛst wɛpɔn fɔ fɛt dɛn kayn tin ya.

` Rosai-Dorfman Disease, RDD, histiocytes, lymphadenopathy, nek lumps, skin sik, CRDD, sik dɛm we nɔ kin bɔku, imyun sistɛm