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Aw di drɔg we dɛn kɔl Tarpeyo de wok?
Fɔ tɔk am simpul wan, IgA Nɛfropati kin bigin we wi bɔdi bigin fɔ mek abnɔmal IgA antibodi dɛn (IgA1). Nɔmal wan, di antibodi dɛn tan lɛk di sɛntinɛl dɛn na wi imyun sistɛm. Dɛn kin protɛkt wi frɔm tin dɛn lɛk baktri ɛn vayrɔs. bכt insay dis sik, sכm sכm difεkt de na di IgA antibodi dεm we dεn de prodyuz. Dɛn antibodi ya we nɔ fayn kin stik togɛda ɛn mek big big grup dɛn. Wi imyun sistɛm de luk dɛn grup ya lɛk se na ɛnimi. So, di imyun sistεm de stat fכ fכt dεn kכlכm dεm ya. Dis fɛt kin apin insay di kidni dɛn. dis kin mek di dilik filta yunit dεm we de insay di kidni dεm we dεn kכl glomeruli inflameshn . As tɛm de go, dis inflamɛns kin mek skata na dɛn say dɛn de ɛn i kin pwɛl di kidni dɛn.Dis damej kin mek di kidni dɛn nɔ ebul fɔ filta blɔd ɛn dɔti tin dɛn fayn fayn wan. Dis kin mek blɔd ɛn prɔtin pas tru di urine we nɔmal fɔ kɔmɔt na do. If dis damej kɔntinyu, di kidni dɛn kin fel ɛn dɛn kin nid fɔ dayalysis ɔ ivin transplant di kidni .Pɔsin wae gɛt dis sik nɔr kin gɛt bɔrku diskɔmfɔt fɔs. Bɔt as tɛm de go, dɛn sik ya kin apin bikɔs di kidni dɛn dɔn pwɛl.
| Di sayn we de sho se di sik de | Tɔk bɔt |
|---|---|
| Blɔd we de na di urine | Yurin kin tan lɛk pink ɔ rɛd. |
| Yurin we de fom | dis kin apin biכs εkstra protin de insay di urine. |
| Di bɔdi we de swel | An, fut, anklɛ, ɛn fes kin swel, mɔ na mɔnin. |
| Di ay blɔd prɛshɔn | Di ay blɔd prɛshɔn. |
| Taya ɛn taya | Fɔ fil taya ɔltɛm. |
| Di pen we de na di bɛlɛ we de dɔŋ | Pen na di ɔda pat na di bɔdi we de dɔŋ. |
Aw a fɔ yuz dis mɛrɛsin?
Tarpeyo na mɛrɛsin we kin kam insay kapsul fɔm. Yu fɔ tek am ɛvri mɔnin, at le wan awa bifo yu it .- Nɔ brok, chew, ɔ krɔs di mɛrɛsin. I fɔ swɛla ɔl.
- Nɔ it grep ɔ drink grep jus we yu de tek dis mɛrɛsin. Wi go tɔk bɔt wetin mek leta.
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Check Availability →Aw dɛn dɔn stɔdi bɔt di bɛnifit dɛn we dis mɛrɛsin de gi?
Insay wan big stɔdi fɔ si di sef ɛn ɛfɛktiv we Tarpeyo gɛt, dɛn kɔmpia am wit wan plesibo. Plɛsɛbo na dɔmi pil we nɔ gɛt ɛni mɛrɛsin. Dis na fɔ si wetin difrɛns de bitwin pipul dɛn we tek di rial mɛrɛsin ɛn di wan dɛn we tek di dɔmi pil. Ɔl di wan dɛn we tek pat pan di stɔdi bin gɛt IgA nɛfrɔpati ɛn dɛn bin gɛt ɛkstra prɔtin na dɛn urine. Dɛn ɔl bin de tek blɔd prɛshɔn mɛrɛsin dɛn bak, lɛk ACE inhibitor ɔ ARB, we de ridyus di prɛshɔn pan di kidni dɛn. Dɛn bin pik di wan dɛn we tek pat bay tu krayteria:- di urine protin-to-creatinine ratio (UPCR): dis de mכsu aw mכch protin de kכmכt na di urine insay 24 awa.
- εstimat glomerular filtration rate (eGFR): Dis de mכsu aw yu kidni dεm de wok fayn εn aw dεn de filta west. Di pipul dɛm we bin de pan di stɔdi bin gɛt smɔl to mɔdaret kidni funkshɔn dɛklin.
Us bɛnifit dɛn dɔn sho pan stɔdi dɛn?
Di stɔdi sho se pipul dɛn we tek Tarpeyo nɔ bin gɛt bɛtɛ kidni damej pas di wan dɛn we tek plasɛbo. Dis bɛnifit bin kɔntinyu afta 9 mɔnt we dɛn tek di mɛrɛsin.di protin lεvεl dεm we de dכn na di urine
we 9 mכnt dכn, di protin lεvεl dεm na di urine fכ di wan dεm we de tek Tarpeyo dכn dכn bay 35%, we yu kכmpεr to 5% nכmכ pan di wan dεm we tek di plasεbo. Dis ridyushɔn bin de fɔ 24 mɔnt.| Tɛm | Tarpeyo (% dεkrεshכn na UPCR) . | Plɛsibo (% dikrishɔn na UPCR) . |
|---|---|---|
| 3 mɔnt | 5% . | 4% . |
| 6 mɔnt | 24% . | 8% . |
| 9 mɔnt | 35% . | 5% . |
| 24 mɔnt | 34% . | 4% . |
Di wok we di kidni de du (eGFR) .
We 24 mɔnt dɔn, di wan dɛn we tek Tarpeyo bin gɛt smɔl smɔl we aw dɛn kidni bin de wok pas di wan dɛn we bin tek plasɛbo. Pɔzitiv (+) valyu min se di kidni wok dɔn bɛtɛ, ɛn negatif (-) valyu min se i dɔn wɔs.| Tɛm | Tarpeyo (eGFR difrɛns) . | Plɛsibo (eGFR difrɛns) . |
|---|---|---|
| 9 mɔnt | + 1,5 mL/min/1,73 m2 | - 4,0 mL/min/1,73 m2 |
| 24 mɔnt | - 5,3 mL/min/1,73 m2 | - 11,2 mL/min/1,73 m2 |
Aw fɔ avɔyd ɛn kɔntrol di bad bad tin dɛn we kin apin to pɔsin?
Tarpeyo na mɛrɛsin we de stɔp di imyun sistɛm, so yu kin gɛt infɛkshɔn mɔ. Yu kin gɛt kol, flu, ɛn urinary tract infection bɔku tɛm. Stay away frɔm pipul dɛm wae gɛt sik dɛm wae kin pas lɛk chikinpoks ɛn mizɛl. Di bɛst we fɔ mek yu nɔ gɛt di sik na fɔ was yu an ɔltɛm ɛn nɔ de nia pipul dɛn we sik. Tɔk to yu dɔktɔ bɔt aw fɔ gɛt vaysin. Kɔl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni wan pan dɛn sayn ya fɔ sho se yu gɛt di sik:- Fiva ɔ kol kol
- Bɔdi pen
- Kɔf
- Taya pasmak
- Ed we de at we nɔ de chenj
- Vishɔn chenj ɔ mɛmori lɔs
- Wan blo we de mek pɔsin fil pen
Us tɛst dɛn fɔ du we dɛn de tek di mɛrɛsin?
Yu dɔktɔ go ɔda fɔ du difrɛn tɛst fɔ si aw yu bɔdi de du di mɛrɛsin. Dis na di men wan dɛn:- We dɛn de mɛzhɔ di blɔd prɛshɔn
- Urinalysis fכ chεk di amount of protin we de insay di urine
- Blɔd tɛst fɔ chɛk aw di kidni de wok
- Blɔd tɛst fɔ di epataytis B vayrɔs
Us ɔda tin dɛn kin miks wit dis mɛrɛsin?
Sɔm mɛrɛsin ɛn it kin afɛkt di we aw Tarpeyo de wok. So, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn ɛn ɛbul prɔdak dɛm) . Tek tɛm mɔ bɔt dɛn tin ya:- Sɔm antifungal ɛn antibayɔtik mɛrɛsin dɛn (e.g., klarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral)
- Sɔm mɛrɛsin dɛn we dɛn kin yuz fɔ HIV
- Grepfruit ɔ grepfruit jus
Fɛn ɔut aw yu kin gɛt dis mɛrɛsin.
Tarpeyo na wan spɛshal drɔg. Dis min se i dia ɛn dɛn kin yuz am fɔ sɔm patikyula mɛrɛsin dɛn. So, i kin bi se i nɔ de na ɔl di famasi dɛn. Bɔku tɛm, dɛn kin gɛt dis kayn mɛrɛsin na ɔspitul famasi ɔ spɛshal famasi. Yu dɔktɔ go gayd yu fɔ no aw fɔ gɛt dis mɛrɛsin ɛn usay fɔ gɛt am.Mɛsej we dɛn kin kɛr go na os
- IgA Nεfropati na sik wae yu yone imyun sistεm de pwεl yu kidni dεm.
- Tarpeyo na wan tεrapi we dεn de tכk bכt we de ridyus di prodakshכn fכ di rכng IgA antibodi dεm we de mek dis sik.
- Tek dis mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek am. Nɔ ɛva stɔp fɔ tek di mɛrɛsin ɔ chenj di doz we yu nɔ go to yu dɔktɔ.
- Yu fɔ no di prɔblɛm we kin apin we pɔsin gɛt di sik. If yu gɛt sɔm sayn dɛn lɛk fiva ɛn kɔf, go to dɔktɔ wantɛm wantɛm.
- Kɔntakt yu dɔktɔ ɔltɛm ɛn mek dɛn du di tɛst dɛn we yu nid di rayt tɛm.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin, vaytamɛn, ɔ Ayurveda/ɛbul prɔdak we yu de tek.
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