Yu gɛt wan sik we dɛn kɔl Myasthenia Gravis (gMG)? Yu kin si am se i nɔ izi fɔ du wok dɛn we yu de du ɛvride, yu kin fil lɛk se yu an ɛn fut dɛn de go swɛ, ɔ yu yay dɛn de ebi? A no se dis na ɛkspiriɛns we rili taya. Bɔt nɔr wɔri, nyu, advans tritmɛnt dɛn de fɔ ɛp fɔ mɛn dis sik. Tide, wi go tɔk bɔt tu pan dɛn nyu mɛrɛsin ya. Dɛn na Vyvgart ɛn Vyvgart Hytrulo. Lɛ wi tek tɛm luk wetin dɛn bi, aw dɛn de wok, ɛn if dɛn rayt fɔ yu.
Fɔ tɔk am simpul wan, wetin na Myasthenia Gravis?
Fɔ ɔndastand dis, lɛ wi luk wan smɔl stori bɔt wi bɔdi. Imajin se na yu bren na di ‘bɔs’. I de gi di kɔmand, "Rays yu an." Dis kɔmand de travul tru di nɛv dɛn lɛk ilɛktrik mɛsej along ‘waya.’ We dis mɛsej rich di mɔsul, di mɔsul de du in wok, we min se di an de es ɔp.
bכt fכ dis jכnkshכn bitwin di nεv εn di mכsul fכ kכrekt, wan spεshal protin we dεn kכ l asetilkolin rεsεpכta (AChR) nid fכ. Dis na lɛk plɔg.
Myasthenia Gravis (gMG) na wan sik we pɔsin kin gɛt we i de fɛt insɛf . Fɔ tɔk am simpul wan, wi bɔdi in ‘sɔlda dɛn’ ( di imyun sistɛm ) kin bigin fɔ atak di gud ‘plɔg dɛn’, di AChR dɛn we wi nɔ no. Dɛn kin yuz wɛpɔn dɛn we dɛn kɔl antibodies fɔ atak dɛn. dis kin mek di nεv mεsej dεm nכ de rich di mכsul dεm fayn fayn wan. Di rizɔlt? Di mɔsul dɛn kin wik ɛn dɛn kin taya izi wan. Dis kin mek yu gɛt sɔm sayn dɛm lɛk we yu aylid kin drɔp, i nɔ kin izi fɔ tɔk ɛn swɛla, ɛn yu an ɛn fut dɛn kin swɛla.
So aw dɛn Vyvgart ɛn Vyvgart Hytrulo mɛrɛsin ya kin ɛp?
Vyvgart (efgartigimod alfa-fcab) na wan protin we dεn mek spεshal wan na labכtכri. Dɛn kɔl dis wan monoklɔnal antibɔdi .
Dis drɔg de wok fayn fayn wan. Bad antibodi dεm de we de atak wi gud AChR dεm, εn dis dכg de go εn atak dεn antibodi dεm de. fכ bi prεsis, i de atak wan pat pan dεn antibodi dεm we dεn kכ l nyuonatal Fc rεsεpכta dεm (FcRn) . We dis apin, di bɔdi kin ebul fɔ pul dɛn bad bad antibodi dɛn de izi wan.
Dat min se di Vyvgart drɔg de pul dɛn ‘bad sojaman dɛn’ ( antibodies ) na di blɔd we de ambɔg wi nerve kɔnekshɔn. Dɔn di mɛsej dɛn we de na di nerv kin bigin fɔ go stret to di mɔsul dɛn bak, ɛn di wikɛd we yu kin wik kin go dɔŋ.
Vyvgart Hytrulo na di sem drɔg we Vyvgart, efgartigimod alfa. So i de wok di sem we. Bɔt apat frɔm dat, .I gɛt sɔntin bak we dɛn kɔl hyaluronidase. Dis kin ɛp di bɔdi fɔ tek di mɛrɛsin fayn fayn wan we dɛn injɛkt am ɔnda di skin.
Smɔl difrɛns de pan di we aw dɛn de gi di mɛrɛsin:
- Vyvgart: Dɛn kin gi am as intravenɔs salin sɔlvushɔn ( IV infusion ) fɔ lɛk 60 minit.
- Vyvgart Hytrulo: Dɛn kin gi am as smɔl injɛkshɔn ɔnda di skin (subcutaneous injection). Dis kin dɔn insay 20-90 sɛkɔn.
Dɛn kin gi dɛn tu tritmɛnt ya wan tɛm insay di wik insay 4 wik saykl.
Aw yu go no if dis mɛrɛsin fayn fɔ yu?
Vyvgart ɔ Vyvgart Hytrulo kin fayn fɔ yu.
- If yu na big pɔsin wit gMG.
- If tɛst dɔn kɔnfyus se yu gɛt di AChR antibodi dɛm we wi bin tɔk bɔt na yu blɔd.
Yu dɔktɔ , mɔ wan dɔktɔ we de mɛn yu nyurolɔjis , go no if dis mɛrɛsin fayn fɔ yu bay di rizɔlt we yu gɛt fɔ du yu blɔd tɛst ɛn di mɛdikal istri.
Wetin di stɔdi dɛn we dɛn dɔn du bɔt dis mɛrɛsin se?
Dɛn bin du wan spɛshal klinik trayal we dɛn kɔl ADAPT trayal fɔ chɛk aw Vyvgart de wok fayn. Di men tin we dis trayal bin de pe atɛnshɔn pan na fɔ si aw di drɔg bin wok fɔ ridyus di simptom dɛn na gMG pasɛnt dɛn we gɛt AChR antibodies.
Fɔ no dis, di wan dɛn we du di risach bin yuz wan spɛshal tin we dɛn kɔl di Myasthenia Gravis-Specific Activities of Daily Living scale (MG-ADL) . Dis kin mɛzhɔ aw i nɔ kin izi fɔ di sik pipul dɛn fɔ du tin dɛn we dɛn kin du ɛvride (lɛk fɔ tɔk, fɔ swɛla, ɛn fɔ kɔmɔt na chia).
Insay di risach, dɛn bin sheb di sik pipul dɛn to tu grup.
1. Dɛn bin gi wan grup di drɔg we dɛn kɔl Vyvgart .
2. Dɛn bin gi di ɔda grup wan plesibo . Dat min se, sɔntin we tan lɛk di mɛrɛsin, bɔt nɔ gɛt ɛni aktif mɛrɛsin.
Di spɛshal tin bɔt dis na dat di sik pipul dɛn we tek di mɛrɛsin ɔ di dɔktɔ dɛn we gi di mɛrɛsin nɔ bin no udat gɛt di rial mɛrɛsin ɛn udat gɛt di plesibo.
| Infɔmeshɔn bɔt di wan dɛn we tek pat pan di risach | |
|---|---|
| Fɔ fit fɔ tek pat |
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| Diskwalifikeshɔn fɔ tek pat | |
Wetin na di tin dɛn we dɛn dɔn du we dɛn du di risach?
Di tin dɛn we kin apin kin rili ɛnkɔrej wi.
Klose to 68% pan di wan dɛm we tek Vyvgart bin impɔtant fɔ mek dɛn ebul fɔ du ɛvride aktiviti dɛm, we yu kɔmpia am wit 30% nɔmɔ pan di wan dɛm we tek di plasɛbo.
Dis sho klia wan aw Vyvgart de wok fayn fɔ pul di simptom dɛm fɔ gMG. Bikɔs Vyvgart Hytrulo gɛt di sem mɛrɛsin, di rizɔlt dɛn valid fɔ dat bak.
Yu tink se wi fɔ no bak bɔt di bad tin dɛn we kin apin to wi?
Lɛk ɛni mɛrɛsin, dɛn mɛrɛsin ya kin gɛt sɔm bad bad tin dɛn. I impɔtant fɔ no bɔt dɛn tin ya.
| Tayp fɔ di sayd ɛfɛkt | Diskripshɔn ɛn wetin fɔ du |
|---|---|
| Siriɔs kɔndishɔn dɛn we nid fɔ go to dɔktɔ wantɛm wantɛm | |
| Alɛji we pɔsin kin gɛt | Di sayn dɛm lɛk di skin we de rɔsh, we de swel ɔnda di skin, ɛn we i nɔ izi fɔ blo. Dɛn tin ya kin apin insay wan awa ɔ te to tri wik afta yu dɔn tek di mɛrɛsin. If yu gɛt prɔblɛm fɔ blo ɔ yu fil se yu nɔ ebul fɔ blo, tɛl yu dɔktɔ wantɛm wantɛm ɔ go na di ɔspitul imejensi dipatmɛnt (ETU) we de nia yu. |
| Infushɔn/Injɛkshɔn Riakshɔn dɛn | Ay blɔd prɛshɔn, kol, shek shek, chɛst, bɛlɛ, ɔ bak pen we yu de tek di mɛrɛsin ɔ afta di mɛrɛsin. Tɛl yu dɔktɔ bak bɔt dɛn tin ya. |
| Kɔmɔn sayd ɛfɛkt dɛn | |
| Infεkshכn dεm na di rεspiretכri sistεm | Fiva, kol, kɔf, nɔs we de rɔn , ɛn ɔda tin dɛn Drink bɔku wata, rɛst, ɛn avɔyd ples dɛn we pipul dɛn kin bɔku. |
| Ed de at | Yu kin gɛt kɔmɔn ed pen ɔ maygren. Tɔk to yu dɔktɔ bɔt dis. |
| Infεkshכn na di urinary tract (UTI) . | Yu kin avɔyd di sayn dɛm lɛk fɔ pis ɔltɛm, fɔ bɔn na yu blad, ɛn blɔd na yu urine if yu drink bɔku wata. If yu gɛt dɛn sik ya, tɛl yu dɔktɔ. |
| Ɔda | Mɔsul dɛn kin pen ɛn nɔ kin fil fayn. Bɔku tɛm, dɛn tin ya kin stɔp insay sɔm dez. If dɛn kɔntinyu fɔ du dat, tɛl yu dɔktɔ. |
Di tin we impɔtant pas ɔl: If yu gɛt ɛni ɔda kayn sik lɛk dis, nɔ ignore am, tink se na smɔl tin, ɛn fɔ tru, tɔk to yu dɔktɔ.
A nid fɔ wɔri bɔt ɔda mɛrɛsin ɛn vaysin dɛn?
Yɛs, na fɔ tru. Vyvgart ɛn Vyvgart Hytrulo na mɛrɛsin dɛn we de afɛkt yu imyun sistɛm. So,
- Bifo yu bigin dis tritmɛnt, tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek (inklud vaytamɛn ɛn tradishɔnal mɛrɛsin dɛn) .
- Vaysin: If yu nid fɔ gɛt ɛni vaysin insay dis tritmɛnt saykl, tɛl yu dɔktɔ bifo tɛm.
- Vaysin dɛn we nɔ gɛt layf: Fɔ ɛgzampul, vaysin dɛn we de agens mɔmp, nyumonia, ɛn influenza. Wi nɔ no fɔ tru if dɛn tin ya nɔ kin wok fayn.
- Layf vaysin dɛn:I nɔ fayn fɔ gɛt vaysin lɛk mizɛl, mɔmp, ɛn rubɛla insay dis tritmɛnt tɛm.
Nɔ chenj yu tritmɛnt plan, stɔp fɔ tek di mɛrɛsin, ɔ chenj di doz te yu dɔktɔ tɛl yu fɔ du am.
Dɔn, fɔ liv wit Myasthenia Gravis kin tranga. Bɔt wit di mɔdan tritmɛnt dɛm lɛk Vyvgart, chans de fɔ mek yu kwaliti fɔ liv bɛtɛ pasmak. Di tin we impɔtant pas ɔl na fɔ de tɔk to yu dɔktɔ ɔltɛm ɛn fala wetin i tɛl yu fɔ du.
Mɛsej we dɛn kin kɛr go na os
- Vyvgart ɛn Vyvgart Hytrulo na tu nyu drɔgs fɔ trit Myasthenia Gravis (gMG) pan pasɛnt dɛn we gɛt AChR antibodies.
- Dɛn tin ya de wok bay we dɛn de pul di bad bad antibodi dɛm we de mek di sik kɔmɔt na di bɔdi ɛn mek di mɔsul dɛn wik.
- Wan dɔktɔ we de mɛn yu nyuro go no if dis mɛrɛsin fayn fɔ yu.
- Kɔmɔn sayd ɛfɛkt lɛk infɛkshɔn na di say we yu de blo ɛn ed we de at kin apin, ɛn yu fɔ no bak bɔt siriɔs tin dɛn lɛk alɛji. Tɛl yu dɔktɔ if yu gɛt ɛni ɔda sayn we nɔ kɔmɔn.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔda mɛrɛsin ɛn vaysin dɛn we yu de tek.
- Dɛn nɔ fɔ ɛva stɔp ɔ chenj di tritmɛnt if dɛn nɔ gɛt dɔktɔ advays.
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