Yu no bɔt di sik we dɛn kɔl Whipple’s Disease? Lɛ wi tɔk bɔt dis rare infection in simpul wɔd!

Sɔntɛnde yu kin fil lɛk se yu bɔdi wik bad bad wan, yu gɛt bɛlɛ prɔblɛm, yu gɛt jɔyn pen, bɔt yu nɔ ebul fɔ fɛn rizin fɔ dat? Sɔntɛm dis na sik we bɔku pipul dɛn nɔ yɛri bɔt, bɔt i impɔtant fɔ no. Tide wi go tɔk bɔt wan pan dɛn kayn sik ya we nɔ kin bɔku, bɔt if dɛn trit am fayn, i kin mɛn. Dat na di sik we dɛn kɔl Whipple’s Disease.

Wetin na di sik we dɛn kɔl Whipple’s Disease?

Fɔ tɔk am simpul wan, di sik we dɛn kɔl Whipple na wan sik we nɔ kin apin so ɔltɛm we kin kam na yu smɔl intestinal . dis kin kכz fכ di it we yu de it nכ de digεst fayn εn di nyutriεnt dεm we i nid nכ de abzכp insay yu bכdi (dεn kכl dis ``malabsorption''). Tink bɔt am, wi kin it it fɔ gɛt ɛnaji ɛn it fɔ wi bɔdi. So if i nɔ absɔb am fayn, bɔku prɔblɛm dɛn kin apin. dis sik kin apin we wan baktri we dεn kכl ``Tropheryma whipplei'' kam insay di bכdi. Dis baktri kin de na di grɔn, dat na, na grɔn. Bɔt di gud nyus na dat wit di rayt ``antibiotics'', dis baktri kin kɔmɔt na di bɔdi, ridyus di simptom dɛm, ɛn wɛl kpatakpata .

Aw kɔmɔn sik na Whipple in sik?

Na dis na di impɔtant tin. Pan ɔl we di baktri dɛm we de mek dis sik ((Tropheryma whipplei)) bɔku na di envayrɔmɛnt, mɔ na di grɔn, di sik we dɛn kɔl Whipple na wan sik we nɔ kin apin so ɔltɛm . Di wan dɛn we de stɔdi bɔt mɛrɛsin bin tɔk se ivin na kɔntri lɛk Amɛrika, dɛn se na lɛk nayn pipul dɛn pan wan milyɔn pipul dɛn kin gɛt dis sik. Dis min se nɔto ɔlman we gɛt dis bɔdi kin gɛt dis sik. Wi nɔ stil no di rayt tin we mek i apin.

Wetin na di sayn dɛm fɔ Whipple in sik?

Di sayn dɛm fɔ Whipple in sik nɔ kin apin wantɛm wantɛm. Dɛn kin divɛlɔp smɔl smɔl fɔ sɔm stej dɛn .

Di simptom dɛm fɔ di fɔs pat (Prodromal Phase) .

I kin bigin wit bad bad pen na di jɔyn dɛn . Dis pen kin kam ɛn go. I kin afɛkt yu big jɔyn dɛn mɔ – yu anklɛ, ɛlb, hip, ni, ɛn sholda . sכmtεm dכkta dεn kin kכl dis εli stej di ``prodromal phase.'' Dis kin las fכ sεvin כ et ia , εn afta dat כda simptom dεm kin bigin fכ sho. Imajin aw i nɔ kin izi fɔ mek yu gɛt pen na yu jɔyn fɔ lɔng lɔng tɛm ɛn yu nɔ fɛn ɛni rizin.

Di sayn dɛn we kin kam leta

Afta sɔm tɛm, dɛn sayn ya kin apin bak:

• Bɛlɛ we de at: Nɔto jɔs we yu bɛlɛ de at ɔltɛm, i kin bi pen we kin wɔs afta yu dɔn it ɔ i kin kɔntinyu fɔ de.
• Daya (wata stɔl): Wata stɔl we kin apin bɔku tɛm insay di de. Dis kin mek di wata we de na di bɔdi nɔ gɛt bɛtɛ wata ɛn i kin lɔs di tin dɛn we de insay di bɔdi.
• Swel (Edima): Yu kin notis se yu de swel, mɔ na di leg ɛn anklɛ. If i fil lɛk dimple we yu prɛs am wit yu finga, i kin bi ɛdima.
• We pɔsin kin taya bɔku tɛm:I nɔ mata aw yu slip, yu bɔdi kin fil lɛk se yu nɔ gɛt layf ɛn yu nɔ kin fil fɔ du ɛnitin.
• Fiva: Fɔ fil wam fɔ natin.
• Di kɔlɔ we di skin kin chenj: Sɔm say dɛn, mɔ di wan dɛn we de na di san, kin dak pas aw i kin dak.
• di limf no dεm we swεla: Sכm sכm sכm sכm sכm sכm dεm na ples dεm lεk di nεk, di armpit dεm, εn di groin.
• We yu nɔ ebul fɔ ɛksplen: We yu nɔ de it bɔku bɔku it ɔ yu nɔ de du ɛksɛsayz.

Sɛntral Nɛvɔs Sistɛm Isyu dɛn

Bitwin 20% ɛn 40% pan di pipul dɛm wae gɛt dis sik kin gɛt prɔblɛm wit dɛn sɛntral nɛvɔ sistɛm . Dis na sik we rili siriɔs. Di sayn dɛm kin bi:

• Prɔblɛm fɔ balans: Yu kin fil se yu nɔ de tinap tranga wan we yu de waka ɛn yu nɔ kin ebul fɔ tinap stret.
• Kɔnfyushɔn: Nɔ no usay yu de, di tɛm, ɛn ivin pipul dɛn we yu sabi.
• I nɔ izi fɔ swɛla: Fɔ fil lɛk se yu de chok we yu de swɛla it ɔ drink.
• Memori lɔs: Fɔgɛt ivin tin dɛn we dɔn apin i nɔ tu te yet.
• Pɔsin kin chenj: Fɔ fil lɛk se yu nɔto di sem pɔsin we yu bin de, yu kin vɛks izi wan, ɛn yu kin vɛks kwik kwik wan.
• Seizure: Yu nɔ kin no natin wantɛm wantɛm ɛn yu kin gɛt kɔnvulshɔn.
• Di tin dɛn we kin mek pɔsin nɔ ebul fɔ tɔk: I nɔ kin tɔk fayn, i nɔ kin ebul fɔ tɔk klia wan.

Wetin kin mek pɔsin gɛt di sik we dɛn kɔl Whipple?

As dɔktɔ dɛn no, wan patikyula kayn bɔdi (Tropheryma whipplei) we kin bɔku na grɔn kin mek di sik . Ɛnibɔdi we gɛt dis bɔdi kin gɛt di sik. Bɔt, lɛk aw wi bin dɔn tɔk, di sik we dɛn kɔl Whipple’s disease nɔ kin bɔku. So, i stil nɔ klia wetin mek na sɔm pipul dɛn nɔmɔ kin gɛt am .

Bɔt, risach dɔn sho se dɛn tin ya kin mek pɔsin gɛt dis sik mɔ ɛn mɔ :

• Ej: Dɛn dɔn sho se di sik we dɛn kɔl Whipple kin afɛkt pipul dɛn we ol bitwin 65-84 ia , bɔt i kin apin bak pan pipul dɛn we yɔŋ pas dat.
• We pɔsin de na grɔn ɔ animal we dɛn de mɛn: Risach dɔn sho se pipul dɛn we de wok wit grɔn ɔ animal mɛn kin gɛt dis sik. Speshali, pipul dɛm wae de du fam, gadin, ɔr wok wit animal kin gɛt bɔrku risk. Yu kin ivin gɛt dis bɔdi we yu plant smɔl tin na yu os gadin.
• Di chenj dɛn we de apin na di jɛnɛtiks:wan link de bitwin di sik we Whipple de gi εn di jin we de mek di protin `(IFR4)`. dis protin de εp di imyun sεl dεm na wi bכdi lεk `(B sεl dεm)` εn `(T sεl dεm)` fכ divεlכp. dεn fכnshכn bak se i lεnk to wan mכtεshכn na di jin `(HLA-B27)`. Dɛn tin ya kin dip smɔl, bɔt fɔ tɔk am simpul wan, sɔm chenj dɛn we kin apin na wi jin dɛn kin mek wi gɛt dis.
• Wik imyun sistɛm: If yu gɛt sik we de afɛkt yu imyun sistɛm (lɛk HIV), ɔ if yu tek imyun suprɛsant (dɛn kin gi dɛn tin ya fɔ sɔm sik dɛn, sɔntɛnde fɔ tin dɛn lɛk at at sik, ɔ afta dɛn dɔn transplant yu ɔgan), yu kin gɛt dis sik bak.

Wetin na di prɔblɛm dɛn we kin kam wit di sik we dɛn kɔl Whipple?

As wi bin dɔn tɔk, di sik we dɛn kɔl Whipple kin kam bikɔs di bɔdi nɔ kin ebul fɔ tek di fat, kabɔhaydrɛt, vaytamɛn, ɛn ɔda tin dɛn we de insay di it we de pas na yu smɔl intestin fayn fayn wan . Na sik we de go bifo ɛn i kin wɔs as tɛm de go . Dis min se if dɛn nɔ trit am, nyu, siriɔs wɛlbɔdi prɔblɛm kin kam.

Kɔmplikɛshɔn dɛn lɛk dis kin apin:

• Anemia (low red blood cell count): Dis kin mek yu taya ɔltɛm, wikɛd, ɛn yu kin gɛt blɛsin.
• Dimɛnshɔn (we yu nɔ de mɛmba ɛn yu maynd nɔ de wok fayn): Dis kin apin if di nervɔs sistɛm dɔn afɛkt.
• At grɔmbul: Yu kin yɛri dis we dɔktɔ de chɛk yu wit stetɔskɔp.
• Oculomasticatory myorhythmia: Dis na wan patikyula sayn, usay i tan lɛk se di yay ɛn di jaw de muv togɛda .
• Pleural effusion: Dis kin mek i nɔ izi fɔ blo.
• Yuveitis: Di sayn dɛm kin bi fɔ rɛd, pen, ɛn fɔ si fayn fayn wan.

Di tin we impɔtant pas ɔl na dat, if di sik we Whipple gɛt afɛkt yu sɛntral nervous system, i kin kil yu. So e fayn fɔ go to dɔktɔ wantɛm wantɛm if yu gɛt sɔm sayn dɛn.

Aw dɔktɔ dɛn kin no se pɔsin gɛt Whipple in sik?

We yu go to dɔktɔ, i go fɔs chɛk yu bɔdi . Dɔn, dɛn go aks bɔt yu mɛdikal histri , inklud ɛni wɛlbɔdi prɔblɛm we yu gɛt naw ɔ we yu bin dɔn gɛt trade. Dɛn kin aks bak bɔt ɛni mɛrɛsin we yu de tek ɛn if ɛnibɔdi na yu famili dɔn gɛt ɛni wan pan dɛn sik ya. Apat frɔm dat, dɛn kin du dɛn tɛst ya:

• Complete Blood Count (CBC) : Dis de chɛk aw di bɔdi in blɔd sɛl dɛn de, if anemia de, ɛn if sayn dɛn de fɔ se i gɛt di sik.
• כp εndoskopi fכ di sכmכl intestin: insay dis, dεn de put wan tכb wit sכmכl kεmεra tru di mכt εn luk insay di sכmכl intestin. Dis we ya, dɛn kin chɛk ɛni chenj we de de, sayn dɛm fɔ infɛkshɔn. Dɛn go put yu na slip bifo dɛn du dis, so yu nɔ go fil ɛni pen.
• Polymerase Chain Reaction (PCR) test : Dis na spεshal tεst we kin εp fכ no if di baktri (T. whipplei) de. Dɛn kin du am pan wan pat pan di tisu we dɛn tek frɔm bayɔpsi ɔ sɔntɛm pan ɔda bɔdi wata.
• Smɔl intestin bayɔpsi : We dɛn de du ɛndoskopi, dɛn kin tek wan smɔl pat pan di tisu frɔm di smɔl intestin ɛn chɛk am ɔnda maykroskɔp. Bɔrku tɛm dɛn kin yuse dis fɔ kɔnfirm di sik we Whipple gɛt. i kin luk fכ spεshal chenj dεm na di intestinal tisu we di baktri dεm de mek.

Aw dɛn kin trit di sik we dɛn kɔl Whipple?

I kin tek sɔm tɛm fɔ pul di bɔdi we de mek pɔsin gɛt di sik we dɛn kɔl Whipple’s kpatakpata kɔmɔt na di bɔdi. So, di tritmɛnt kin tek lɔng tɛm smɔl. Bɔt if yu peshɛnt, yu kin gɛt gud rizulyt.

Dis na di men tin wae dɛn kin du as tritmɛnt:

• Antibayɔtik : Dɛn kin bigin di tritmɛnt wit antibayɔtik we dɛn kin put insay di bɛlɛ (IV) fɔ tu to 4 wik . Bɔku tɛm, dɛn kin du dis na ɔspitul. Afta dat, yu go nid fɔ tek antibayɔtik we yu kin it fɔ at le di nɛks 12 mɔnt . Sɔntɛnde, yu kin nid fɔ tek dɛn fɔ lɔng tɛm, te to tu ia. I rili impɔtant fɔ tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu.
• Fluid replacement : If yu nɔ gɛt wata bikɔs ɔf dayarɛa, dɛn kin gi yu IV fluid fɔ ɛp fɔ stɔp am. Ɔ, dɛn kin tɛl yu fɔ drink ilɛktrɔlayt drink (lɛk Jeevani) fɔ tek ples fɔ di wata ɛn sɔl we dɔn lɔs.
• Vitamin ɛn nyutriɛnt supamakit : Yu dɔktɔ kin tɛl yu fɔ tek supamakit fɔ mek yu gɛt bɔku vaytamɛn (lɛk vaytamɛn D, B12, ɛn ayɔn) ɛn tin dɛn we yu intestin nɔ ebul fɔ tek fayn fayn wan. I kɔmɔn fɔ mek pipul dɛn nɔ gɛt bɛtɛ tin fɔ it na dis sik.

Ɛni bad tin de we di tritmɛnt kin du?

Yɛs, sɔm sayd ɛfɛkt dɛn kin apin, mɔ wit antibayɔtiks. Bɔt dɛn tin ya nɔ kin apin to ɔlman, ɛn ivin if dɛn kin apin, bɔku tɛm dɛn nɔ kin siriɔs.

• Dayarɛa (bɛlɛ de at) .
• Diziz we pɔsin kin gɛt
• Nɔs ɛn vɔmit
• Rash na di skin
• Yist infεkshכn (especially in di vagina in uman) .

If sɔntin lɛk dis apin, i impɔtant fɔ tɛl yu dɔktɔ . Dɛn kin ebul fɔ chenj di mɛrɛsin ɔr gi yu ɔda tin fɔ ridyus di sayd ɛfɛkt dɛm.

Wetin pɔsin we gɛt di sik we dɛn kɔl Whipple kin gɛt?

Lɛk bɔku pipul dɛn, yusɛfWae yu bigin fɔ trit yu, yu go bigin fɔ fil fri kwik kwik wan. Bɛlɛ pen ɛn jɔyn pen go stɔp smɔl smɔl. Bɔt i kin tek tu ia fɔ mek yu smɔl intestinal wɛl fayn fayn wan. So, i impɔtant fɔ peshɛnt wit tritmɛnt.

Bɔrku tɛm , di sik we Whipple gɛt kin wɛl ɔltogɛda wit tritmɛnt . Bɔt sɔntɛnde, di sik kin kam bak afta dɛn dɔn dɔn di tritmɛnt. Na dat mek dɔktɔ dɛn go kɔntinyu fɔ chɛk yu.

Yu dɔktɔ go aks yu fɔ kam insay fɔ mek dɛn du tɛst fɔ fala yu ɔltɛm fɔ lɔng tɛm. Fɔ ɛgzampul, dɛn kin aks yu fɔ mek dɛn du ɔpa ɛndoskopi:

• Ɛvri siks mɔnt fɔ di fɔs ia fɔ di tritmɛnt.
• Wan tɛm insay di ia fɔ di nɛks tri ia .
• Dɔn wan tɛm ɛvri tri ia fɔ di res ɔf yu layf .

Dɛn kin du dis fɔ chɛk if di sik dɔn kam bak. So, nɔ mis di fɔlɔp visit dɛn lɛk aw di dɔktɔ tɛl yu fɔ du.

Yu tink se dɛn kin ebul fɔ avɔyd di sik we Whipple gɛt?

Dat na tin we at fɔ tɔk smɔl. Bikɔs di baktri dɛm we de mek wi gɛt Whipple in sik de ɔlsay na wi envayrɔmɛnt, mɔ na di grɔn . Bɔt nɔto ɔlman we gɛt am kin gɛt dis sik we dɛn kɔl Whipple.

Bɔt pipul dɛm wae gɛt wik imyun sistɛm ɔr wae de tek imyun suprɛsant kin gɛt bɔrku risk fɔ gɛt dis sik. If yu na wan pan dɛn pipul ya, i go fayn fɔ wɛr glɔv ɛnitɛm we yu de wok wit dɔti ɔ dɔti, ɛn was yu an fayn fayn wan afta yu dɔn wok . Tek tɛm mɔ if yu de mek gadin ɔ yu de wok wit animal dɛn.

Aw a kin kia fɔ misɛf?

Di tin we impɔtant pas ɔl na fɔ tek di antibayɔtik jɔs lɛk aw di dɔktɔ tɛl yu, fɔ di ful tɛm . Nɔ mis wan de, ɛn tek di mɛrɛsin fɔ di ful tɛm we di dɔktɔ tɛl yu. Bɔrku pipul dɛn go nid fɔ tek antibayɔtik fɔ at le wan ia afta dɛn dɔn no se dɛn gɛt dis sik. Sɔm pipul dɛn kin nid fɔ tek antibayɔtik fɔ di res ɔf dɛn layf. Dat na di dɔktɔ fɔ disayd.

We yu gɛt Whipple’s disease, yu bɔdi kin mis bɔku impɔtant tin dɛn fɔ it . Ivin if yu gɛt fridɔm frɔm tritmɛnt, i stil fayn fɔ go to dɔktɔ we de mɛn di it dɛn bɔt wetin yu fɔ it ɛn drink . Dis go ɛp yu fɔ gɛt di rayt it ɛn fɔ gɛt wɛlbɔdi wet.

Ustɛm a fɔ go to di dɔktɔ bak?

If yu kɔntinyu fɔ gɛt di sayn dɛm fɔ Whipple in sik afta yu dɔn bigin fɔ trit yu, ɔ if di sik kam bak jɔs afta di tritmɛnt dɔn (fɔ ɛgzampul, if yu gɛt bɛlɛ pen ɔ yu jɔyn pen), mek shɔ se yu go to yu dɔktɔ. Nɔ delay. Dis kin min se di sik dɔn kam bak, ɔr ɔda prɔblɛm kin de.

Wetin mek dɛn kɔl dis sik "Whipples disease"?

Dis na gud tin fɔ no. Dɛn gi di sik ɛn di baktri dɛm we de mek i kam wit am in nem to wan man we nem Jɔj H. Whipple, we na wan man we de stɔdi bɔt di sik ɛn we bin tɔk bɔt di sik fɔs insay 1907. Na afta 80 ia, di wan dɛn we de stɔdi bɔt dis bin kam fɔ no di bɔdi we de mek i gɛt dis sik. Dɛn gi di baktri in nem Tropheryma whipplei. Di nem na tu Grik wɔd dɛn we dɛn jɔyn, "trophe" we min it ɛn "eryma" we min ɔbstrɔkshɔn . I min se i de mek i nɔ de tek di bɔdi fayn . Yu nɔ tink se na nem we fit am?

Baktri de ɔlsay rawnd wi (ɛn insay wi bɔdi). Nɔmal wan, di baktri dɛm we wi kin mit ɛvride nɔ kin mɔna wi. Bɔt dis baktriyal infɛkshɔn we nɔ kin bɔku, we na di sik we dɛn kɔl Whipple, difrɛn smɔl. Na wan kɔmɔn baktri we de na grɔn we dɛn kɔl Tropheryma whipplei kin mek am.

Yu kin gɛt dis baktri (T. whipplei) we yu de wok ɔ we yu de mek gadin. Bɔt nɔto ɔlman we gɛt am go gɛt dis sik we dɛn kɔl Whipple. Bɔt gud tin na dat, bɔku tɛm dɛn kin mɛn di sik if dɛn no am kwik ɛn trit am fayn.

Di tin dɛn we impɔtant pas ɔl we yu nid fɔ mɛmba

Whipple’s Disease na wan sik we nɔ kin bɔku frɔm baktri , bɔt dɛn kin mɛn am if dɛn trit am fayn .

• If yu gɛt sayn dɛn lɛk pen na yu jɔyn dɛn, yu bɛlɛ de at, yu de gɛt dayarɛa, ɛn yu de lɔs yu wet , mek shɔ se yu go to dɔktɔ. Nɔ ignore dɛn tin ya.
• Di tritmɛnt na fɔ tek antibayɔtik fɔ lɔng tɛm . I rili impɔtant fɔ fala dɛn di rayt we.
• If yu de wok wit dɔti, mɔ if yu nɔ gɛt bɛtɛ wɛlbɔdi, was yu an fayn fayn wan ɛn yuz glɔv .
• Ivin afta di sik dɔn wɛl, i impɔtant fɔ go fɔ chɛk-ap ɔltɛm (`fɔl-ɔp`) lɛk aw di dɔktɔ tɛl yu.

Nɔr frayd dis sik. I impɔtant fɔ mek dɛn no bɔt yu ɛn aks fɔ dɔktɔ advays. Nɔto yu wan de, ɛn dɔktɔ dɛn de we go ɛp yu wit ɛni prɔblɛm. If yu gɛt ɛni dawt, nɔ shek fɔ tɔk to dɔktɔ.

` Whipple in Sik, Bakterial Infεkshכn, Sכm Intestinal, Malabsכpshכn, Tropheryma whipplei, Jכint Pen