Mu butuufu eddagala eriweweeza ku kweraliikirira likola litya? Ka twogere ku nsonga eno mu ngeri ennyangu!

Omusawo akuwadde eddagala eriwonya ekiwuubaalo? Oba waliwo gw’omanyi akozesa eddagala lino? Wadde nga waliwo emboozi nnyingi mu bantu ezikwata ku ddagala lino, abantu bameka ddala abamanyi engeri gye likwata ku bwongo ne kiki ekivaamu? Abantu bangi batya eddagala lino, naye ekivaako okutya okwo kwe butamanya. Kale, kino ka tukitegeere mu ngeri ennyangu era mu ngeri entegeerekeka leero, nga tulinga ayogera ne mukwano gwaffe.

Eddagala lino eriweweeza ku kweraliikirira lye liruwa?

Wadde eddagala lino liyitibwa ‘antidepressants’, terikozesebwa kujjanjaba kwennyamira kwokka, embeera y’obwongo ereetera omuntu okuwulira okweraliikirira okw’amaanyi n’okubulwa essuubi. Eddagala lino lyasooka kuleetebwa mu myaka gya 1950. Leero, ng’oggyeeko okwennyamira, eddagala lino era likkirizibwa ku mbeera nga OCD (Obsessive-Compulsive Disorder), Social Phobia, Panic Disorder, GAD (Generalized Anxiety Disorder), ne PTSD (Posttraumatic Stress Disorder).

Okugatta ku ekyo, abasawo oluusi bayinza okumuwa eddagala lino ku mbeera ng’obulumi obutawona, obuteebaka, n’omutwe omuzito. Kino kiyitibwa okukozesa ‘off-label’. Kino kitegeeza nti eddagala lino terinnakkirizibwa mu butongole ku mbeera eyo, naye omusawo alowooza nti omulwadde ajja kuliganyulwamu.

Eddagala lino likwata litya ku bwongo bwaffe?

Mu ngeri ennyangu, eddagala lino likola nga likyusa emiwendo gy’eddagala erimu mu bwongo bwaffe. Eddagala lino tugiyita neurotransmitters . Zino ze zifuga ebintu bingi, gamba ng’embeera yaffe, enneewulira zaffe, otulo, n’okwagala okulya.

Kilowoozeeko bw’otyo. Obutoffaali bw’obusimu mu bwongo bwaffe bukozesa ‘ababaka’ bano abayitibwa neurotransmitters okuwuliziganya ne bannaabwe. Akatoffaali k’obusimu akamu kasumulula omubaka ono, ne kayisa obubaka mu katoffaali akaddako. Obubaka bwe bumala okutuusibwa, omubaka addizibwa mangu mu kasenge akaasooka (kino kiyitibwa reuptake ).

Eddagala eriweweeza ku kweraliikirira kye lisinga okukola kwe kulwawo enkola eyo ey’okuddamu okugikwata katono. Olwo omubaka oyo (okugeza, serotonin) asigala mu bbanga wakati w’obutoffaali bw’obusimu obubiri (the synapse) okumala ebbanga. Olwo kisobola okukola okumala ebbanga eddene ne kitereeza embeera yaffe.

Ebika by’ebiziyiza okuddamu okuyingira mu mubiri ebitera okukozesebwa

Eddagala eriweweeza ku kweraliikirira erisinga okuwandiikibwa mu kiseera kino liri mu kibinja kino. Bino byawuddwamu ebika ebikulu ebiwerako.

1. SSRIs (Ebiziyiza okuddamu okukwata Serotonin ebisunsuddwa) .

Lino lye ddagala erisooka abasawo lye batera okuwandiika. Nga erinnya bwe liraga, bino bigenderera nnyo ekirungo ekitambuza obusimu ekiyitibwa serotonin . Serotonin kikulu eri ebintu nga embeera yaffe, enneeyisa yaffe, n’okujjukira.

Bw’omala okutandika okumira eddagala lino, kiyinza okutwala wiiki eziwera, oluusi okutuuka ku myezi 2-3, okulaba ebivaamu mu bujjuvu. Kale kikulu okubeera omugumiikiriza. Ekirala, tolekera awo kumira ddagala lino mu bwangu nga tolina magezi ga musawo. Okukola ekyo kiyinza okuleeta obubonero obutasanyusa (antidepressant discontinuation syndrome).

Serotonin Syndrome - Ekintu eky'okweraliikirira!

Oluusi, bw’omira eddagala eddala eryongeza ku muwendo gwa serotonin, gamba nga SSRI, obungi bwa serotonin mu bwongo busobola okweyongera mu ngeri eteetaagisa. Kino kiyinza okuba eky’akabi.

2. SNRIs (Ebiziyiza okuddamu okukwata Serotonin-Norepinephrine) .

Zino ddagala lya mutindo gwa mulembe katono eryajja oluvannyuma lw’eddagala lya SSRI. Zikwata ku busimu bwombi obutambuza obusimu obuyitibwa serotonin ne norepinephrine . Norepinephrine kikulu nnyo mu kufaayo kwaffe n’okubeera obulindaala. Eno y’ensonga lwaki eddagala lino oluusi likozesebwa okujjanjaba obulumi obutawona (e.g., diabetic neuropathy, fibromyalgia).

• Ebyokulabirako ebitera okukozesebwa: Eddagala lya Duloxetine (Cymbalta), Venlafaxine (Effexor) .
• Ebizibu ebitera okuvaamu: okuziyira, akamwa okukala, obukoowu, otulo, okuziyira, okutuuyana.

3. NDRIs (Ebiziyiza okuddamu okukwata eddagala lya Norepinephrine ne Dopamine) .

Eddagala lino lyongera ku miwendo gy'obusimu obutambuza obusimu obuyitibwa norepinephrine ne dopamine . Dopamine kikulu nnyo eri essanyu lyaffe, okukubiriza n’okufaayo kwaffe.

• Ekyokulabirako ekikulu: Bupropion (Wellbutrin). Lino ddagala eriyinza n’okukuyamba okulekera awo okunywa sigala.
• Special note: Alina ebizibu ebitono mu kwegatta okusinga eddagala eddala eriweweeza ku kweraliikirira. Wabula tekisaanira bantu abali mu bulabe bw’okukonziba.

Ebika ebirala, ebikadde naye nga bikyali bikulu

Wadde eddagala lino terikozesebwa nnyo kati, liyinza okuba ery’omugaso ennyo eri abantu abamu abataddamu ku ddagala mpya. Kyokka zirina ebizibu bingi.

Eddagala eriweweeza ku kweraliikirira erya tricyclic ne tetracyclic (TCAs) .

Lino ddagala nkadde eribadde likozesebwa okuva mu myaka gya 1950. Wadde nga zikola bulungi ng’eddagala eppya, zirina ebizibu bingi. Ng’ekyokulabirako, ziyinza okuleeta otulo, okukala akamwa, okugejja, n’enkyukakyuka mu kukuba kw’omutima.

• Ebyokulabirako ebitera okukozesebwa: Amitriptyline, Nortriptyline, Clomipramine.

Ebiziyiza monoamine oxidase (MAOIs) .

Zino nazo ddagala nkadde nnyo era nga tezitera kukozesebwa. Bw’oba ​​okozesa bino , olina okwegendereza ennyo ku by’olya. Kubanga singa olya emmere erimu amino acid ‘Tyramine’ (e.g., cheese ekaddiye, soya sauce, ennyama ezimu, ebibala ebimu), puleesa yo eyinza okulinnya mu ngeri ey’akabi. Ekirala, bino okumira n’eddagala eddala eriweweeza ku kweraliikirira kya bulabe nnyo.

Ebirungo ebizimba omubiri ebiyinza okumira okuyamba ku ddagala

Zino si ddagala, wabula ddagala eriyamba mu mmere oba emmere erimu ebiriisa ebiyinza okuyamba ku mbeera z’obujjanjabi ezimu. Tezikirungi kukozesebwa zokka ku kiwuubaalo. Wabula osobola okuzikozesa wamu n’obujjanjabi obwa bulijjo, ng’omusawo bw’akuwa amagezi.

• SAMe (S-adenosyl-methionine): Eddagala erikolebwa omubiri eriyamba okukola obusimu obutambuza obusimu.
• Omega-3 Fatty Acids: Zino naddala ezisangibwa mu mafuta g’ebyennyanja ziyinza okuyamba okukendeeza ku buzimba obumu mu bwongo.
• Vitamiini D: Okunoonyereza kulaga nti waliwo akakwate wakati w’obutaba na vitamiini eno efunibwa okuva mu musana n’okwennyamira.

Naye jjukira nti si kirungi bino okubitwala nga bw’oyagala. Yogerako n’omusawo wo era ozikozese ng’akkirizza. Kubanga oluusi bino bisobola okukwatagana n’eddagala eddala ly’omira.