Bw’oba ggwe oba omuntu wo olina kookolo w’amabeere, osanga owulidde ekigambo ‘immunotherapy’ nga kisuulibwa bwe kituuka ku bujjanjabi. Omusawo wo ayinza n’okukyogerako. Kale, bujjanjabi buno obupya eri abantu bangi bwe buruwa? Ddala esobola okulwanyisa kookolo? Ka tukyogereko mu ngeri ennyangu gy’osobola okutegeera.
Kale, Immunotherapy kye ki?
Mu ngeri ennyangu, obujjanjabi bw’abaserikale b’omubiri bujjanjabi obukozesa enkola y’omubiri gwo ey’okulwanyisa endwadde (abaserikale b’omubiri) okuyamba okuzuula n’okusaanyaawo obutoffaali bwa kookolo. Kiba ng'okutendeka "eggye" ly'omubiri gwo lyenyini okutegeera n'okulumba "abalabe" abayitibwa obutoffaali bwa kookolo.
Mu kiseera kino, obujjanjabi buno businga kukozesebwa kujjanjaba kika kya kookolo w'amabeere ayitibwa ``Triple-negative breast cancer'', nga muzibu okujjanjaba, alina obulabe bwa maanyi okuddamu, era nga asaasaana mu bitundu by'omubiri ebirala (metastatic). Okunoonyereza era kugenda mu maaso okulaba engeri obujjanjabi buno gye bukola obulungi ku kookolo w'amabeere ``HER2-positive'' ne ``ER-positive''.
Obujjanjabi buno bukola butya?
Lowooza ku baserikale b’omubiri gwaffe ng’eggye erikuuma eggwanga. Eggye lino buli kiseera linoonya n’okusaanyaawo abalabe ng’obuwuka n’obuwuka obuyingira mu mubiri. Kyokka, obutoffaali bwa kookolo balabe ba makubo nnyo. Oluusi obutoffaali buno obwa kookolo bwekweka mu ngeri ez’enjawulo okwewala okukwatibwa amagye gaffe. Ng’omukessi w’omulabe.
Bino bye bikola obujjanjabi bw’abaserikale b’omubiri:
1. Okuyamba okutegeera omulabe: Eddagala erimu erijjanjaba obusimu obuziyiza endwadde lisumulula obutoffaali bwa kookolo, nga liraga bulungi abaserikale baffe abaziyiza endwadde nti "omulabe wuuno."
2. Okunyweza amagye: Ebika by’eddagala ebirala bikola nga binyweza obutoffaali (abaserikale) bw’abaserikale b’omubiri gwaffe, ne libawa amaanyi amangi okulwanyisa obutoffaali bwa kookolo.
Waliwo engeri bbiri enkulu ez’okukola kino:
- Active Immunotherapy: Kino kizingiramu okusoma obubonero obw’enjawulo (antigens) ku butoffaali bwo obwa kookolo w’amabeere n’okutendeka abaserikale b’omubiri gwo okulumba obubonero obwo bwokka.
- Passive Immunotherapy: Mu kino, eddagala ery’enjawulo erikolebwa mu laboratory liweebwa omubiri okutumbula obusobozi bw’omubiri obuliwo okulwanyisa kookolo.
Eddagala ki erijjanjaba abaserikale b’omubiri erikozesebwa ku kookolo w’amabeere?
Mu kiseera kino waliwo eddagala eriweweeza ku bulwadde bwa kookolo w’amabeere bibiri ebikulu.
1. Eddagala eriweweeza ku bulwadde bwa Pembrolizumab (Keytruda®):Eddagala lino likozesebwa ku `(Triple-negative breast cancer)`. Eddagala lino liziyiza puloteyina obutoffaali bwa kookolo bwe bukozesa okwekweka abaserikale b’omubiri. Kino kyanguyiza abaserikale b’omubiri okutegeera obutoffaali bwa kookolo. Oluusi eddagala lino liweebwa nga tannalongoosebwa n’oluvannyuma lw’okulongoosebwa okutangira kookolo okudda. Eddagala lino era likozesebwa ku kookolo asaasaanidde mu bitundu by’omubiri ebirala, singa wabaawo ``Biomarkers`` ezimu mu DNA y’ekizimba kya kookolo.
2. Dostarlimab (Jemperli®): Eddagala lino likozesebwa ku kookolo w’amabeere akomyewo oluvannyuma lw’obujjanjabi obulala era ng’alina akabonero akalaga ekizimba.
Ekikulu nti eddagala lino lyonna si nti lisaanira buli mulwadde. Omusawo wo yekka y’asobola okuzuula oba obujjanjabi buno bukusaanira, okusinziira ku kika, omutendera, n’okubeerawo kw’ebiraga obulamu ebitongole mu kookolo wo.
Obujjanjabi bw’abaserikale b’omubiri buweebwa butya?
Obujjanjabi buno butera okuweebwa nga saline solution okuyita mu musuwa (intravenous - IV). Enteekateeka y’obujjanjabi eyinza okwawukana okusinziira ku mbeera gy’olimu. Naye abantu abasinga bafuna obujjanjabi buno buli luvannyuma lwa wiiki 3 ku 6 . Oluusi obujjanjabi buno buyinza okwetaaga okugenda mu maaso okumala emyezi egiwerako okutuuka ku myaka ebiri.
Ka tuyige n’ebizibu ebivaamu.
Okufaananako n’obujjanjabi bwonna obwa kookolo, obujjanjabi bw’abaserikale b’omubiri busobola okuleeta ebizibu. Naye tezikosa buli muntu mu ngeri y’emu. Abantu abamu bayinza okufuna obuzibu obutonotono, ate abalala bayinza obutawulira kintu kyonna. Ekisinga obukulu kwe kubuulira omusawo wo ku buzibu bwonna amangu ddala nga bwe kisoboka.
Ka tulabe ebizibu ebitera okuvaamu n’eby’amaanyi.
| Ekika ky’ebizibu ebivaako | Ebintu by’olina okusuubira |
|---|---|
| Ebizibu ebitera okuvaamu |
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| Tekitera kubaawo bizibu bya maanyi |
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Totya olw’ebizibu bino. Omusawo wo ne ttiimu y’abasawo bulijjo babatunuulidde. Bajja kukuwa eddagala eryetaagisa n’okukuwa amagezi okuliddukanya.
Obujjanjabi buno buba buwanguzi butya?
Obujjanjabi bw’abaserikale b’omubiri (immunotherapy) bwe bumu ku bujjanjabi obupya era obusuubiza mu by’obujjanjabi bwa kookolo. Okusingira ddala, kiyambye okwongera ku muwendo gw’okuwona n’okwongera ku bulamu bw’abalwadde abalina kookolo eyali azibu okujjanjaba, gamba nga kookolo w’amabeere ow’emirundi esatu.
Okunoonyereza okumu okunene kwalaga nti abalwadde abaafuna eddagala eriweweeza ku busimu obuziyiza endwadde erya Pembrolizumab awamu n’eddagala eriweweeza ku bulwadde bwa ddagala lyawangaala okusinga abo abaafuna eddagala lyokka.
Ebikumi n’ebikumi by’okunoonyereza kwatandika dda okwetoloola ensi yonna okunoonyereza ku bulungibwansi bw’obujjanjabi obuziyiza endwadde ku bika bya kookolo w’amabeere eby’enjawulo. N’ekyavaamu, omulimu guno gugenda mu maaso buli lunaku.
Obubaka Obutwala Awaka
- Immunotherapy si ddagala eritta obutoffaali bwa kookolo nga chemotherapy. Kisitula abaserikale b’omubiri gwo gwennyini okuyamba okulwanyisa kookolo.
- Buno bujjanjabi bukulu nnyo naddala eri `(Triple-negative breast cancer)`.
- Nga obujjanjabi bwonna, waliwo ebizibu ebivaamu, naye bisobola okuddukanyizibwa , kale totya kwogera na musawo wo ku buzibu bwonna.
- Obujjanjabi bw’abaserikale b’omubiri essuubi ddene mu kujjanjaba kookolo.Okunoonyereza kukyagenda mu maaso ku nsonga eno, era kisoboka okuba nti abantu abalala bangi bajja kuganyulwa mu kino mu biseera eby’omu maaso.
- Engeri esinga okumanya oba obujjanjabi buno bukusaanira kwe kwogera n’omusawo wo ow’obulwadde bwa kkansa. Bajja kusobola okuddamu ebibuuzo byo byonna.
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