I thisenah hling ang maia red cell i nei em? (Acanthocytosis) chungchang hi i zir dawn teh ang!

I thisenah thisen sen (red blood cells) awm hi i hre ngai em? A tlangpuiin an zungbun a, ball flat te tak te ang mai an ni. Mahse, a châng chuan, heng thisen sen (red blood cells) te hian an pianzia an thlak danglam thei a, pianzia mak tak, hling nei, hling ang maia awm thei an ni. Chu chu he natna atana damdawi lam thumal `(Acanthocytosis)` an tih chu a ni. Ngaihtuah teh, Greek tawng "acan" tih awmzia chu hling, hling ang chi thil tihna a ni. "Cyte" tih hian cell tihna a ni. Chuvangin, "hling ang cells" tih hi a awmzia awlsam tak a ni.

Dik tak chuan kan thisenah hian heng hling cell (Acanthocytes) tlemte hi kan nei vek a. A tlangpuiin buaina lian tak a ni lo. Mahse, i thisenah heng hling cells hi i tam lutuk a nih chuan chutih lai chuan harsatna tenau thenkhat a lo chhuak tan thin. Eng thil nge thleng tih i hria em? Kan taksa peng pakhat kan nei a , chu chu spleen an ti a . Kan thisen tifaitu filter ang maiin hna a thawk a ni. Spleen hian a tih chu thisen chhunga cell hlui, chhe tawhte hriatchhuah a, tihchhiat hi a ni. Chuvangin, chu thisen sen hling tak takte chu spleen kal tlanga an kal chuan, spleen chuan, "Aw, hengte hi a buai deuhin a lang a, cell pangngai ang an ni lo," tiin a ngaihtuah thin. Tichuan, spleen chuan heng hling cells te hi rang takin a tichhia tan ta a ni. Chutiang a nih chuan i taksaa thisen zam hrisel tak tak awm zat chu a tlahniam thei a ni. Hei hi anemia emaw ``hemolytic anemia'' emaw an ti a. Chu chu thisen zam (red blood cells) a chhiat avanga thisen tlakchhamna a ni. Chu mai ni lovin, he ``Acanthocytosis'' an tih hi natna dang leh harsatna dang engemaw zat chhinchhiahna a ni thei bawk. Chuvangin, heng hling cells te hi thisenah a awm chuan doctor te tan natna hnuaia awm dangte pawh a hriat theih nan a pui thei bawk.

Chuti a nih chuan, he `(Acanthocytosis)` avang hian eng ang symptoms nge kan neih theih ang?

I spleen hian sickle cell natna avanga thisen sen (red blood cells) rang taka a tihchhiat chuan ``hemolytic anemia'' tih natna a lo awm thin. Symptoms i nei thei ang:

• Vun leh mit sen: Hei hi ``jaundice'' kan ti bawk a, mi thenkhatin yellow fever an neih huna thil thleng ang bawkin.
• Chau lutuk tih hriatna: Chau mai ni lovin, eng ang pawhin mut pawh ni ila, hah lutuk anga inhriatna.
• Thâwk harsa: Thawhrimna tlemte (dyspnea) pawha thawk harsa tihna.
• Rapid heartbeat: I ding reng lai pawhin i rilru a na lutuk tih hriatna (tachycardia).
• Zun chhunga thisen: A chang chuan zun hi a sen emaw, a dum emaw a lo awm thei (hematuria).
• Pum na: Hei hi ril a hring vang a ni fo.

Heng symptoms bakah hian symptom dang pawh a awm thei a, chu chu i taksaa heng scaly cells lo awm chhan natna hnuaia awm a zirin a ni. Mi ṭhenkhat tân chuan:

• I taksa rihna tihtlem: Nausen te tak te i nih chuan a thang chak lo thei.
• Muscle activity inrualremna lama harsatna: Balance hloh (ataxia) ang chi.
• Miin a thunun theih loh taksa peng hrang hrangte duh loh zawnga chetna: entirnan, mitmeng emaw, kawng hawi emaw (tics).
• Ngaihtuahna leh hriatreng harsa: I thluak a slow ang maia inhriatna (cognitive impairment).
• Chaw ei leh in lama harsatna a awm.
• Pale stools: Hei hi thau a hmin tha lo (steatorrhea) hian a awm thei.
• Zun rawng dum.

Heng symptoms pakhat emaw a aia tam emaw i neih chuan a rang thei ang bera doctor pan a tha ber.

Engvangin nge heng chi hrang hrang spiky cells hi kan thisenah hian a lo awm? A chhan engte nge ni?

A awlsam zawngin sawi ila, `(Acanthocytosis)` awm chhan ber chu thisen sen cell membrane pawn lam, chu chu `(cell membrane) a nghawng vang a ni.` He cell membrane hi thau `(lipids)` leh proteins atanga siam a ni. Chuvangin, heng thil pawimawh tak takte tichhe thei natna emaw, dinhmun emaw a awm chuan thisen sen (red blood cells) te chu a zungbun pangngai chu a inthlak a, chu hling ang mai chu an nei tan ta a ni.

Heng modified stem cells te hi a hmaa kan sawi tawh ang khan spleen an paltlang hian awlsam takin an filter thei lo. Chuvangin, spleen hian a tichhe vek a ni. A châng chuan heng cell te hi tihchhiat ai chuan spleen hian an ruh thenkhat chu a ti hrual a, thisenah a thawn kir leh thin. Heng modified stem cells te hi `(spur cells)` an ti \hin.

Acanthocytosis thlentu ber thenkhat chu hetiang hi a ni:

• Liver natna khirh tak: Spur cells hi thin natna khirh tak, a chang chuan nunna atana hlauhawm, thin natna chhinchhiahna a ni fo thin. Liver natna vei thenkhat chuan spur cell anemia (SPA) an tih natna an nei thin. Chumi awmzia chu an thisenah spur cells an nei tihna a ni a, chubakah red blood cells an nei tlem hle bawk.
• Abetalipoproteinemia: Hei hi a tlem hle a, genetic natna a ni. Chu chu nu leh pa atanga fate rochun a ni tihna a ni. He natna hian taksain thau leh thau-a inthiar theih vitamin (vitamins A, D, E, K) te chu a hip tha thei lo a ni.
• Neuroacanthocytosis: Hei hi genetic disorder hmuh tur awm lo tak a ni bawk. Hei hian taksa chetna thunun theih lohna a thlen thin. Entirnan, chorea-acanthocytosis, McLeod syndrome, pantothenate-kinase associated neurodegeneration (PKAN), leh Huntington natna ang chi 2 te hi a ni.

Heng chhan lian ber berte bakah hian dinhmun dang thenkhat chuan ``Acanthocytosis`` a thlen thei bawk:

• Anorexia nervosa hi ei duh lohna avanga lo awm a ni.
• Thyroid gland hnathawh a tlahniam (Hypothyroidism).
• Myelodysplastic syndrome hi ruhro natna a ni.
• Kal natna.
• Surgery hmanga riltam (spleen) lakchhuah (spleenctomy).
• Damdawi thenkhat (entir nan, cholesterol tihhniamna damdawi ``statins'' ang chi).

Doctor-te hian engtin nge acanthocytosis hi an hriat theih?

I doctor chuan acanthocytosis hi peripheral blood smear (PBS) hmangin a hre thei ang. Hei hian i thisen sample tlemte lak a, microscope hmanga en a huam a ni. Hei hian heng cell pangngai lo, spiky cells te hi a awm tih chiang takin a tarlang ang.

Tichuan, heng sebaceous cysts awm chhan dik tak hriat nan thisen test engemaw zat i neih belh a ngai dawn a ni. Chungte chu:

• Thisen chhiar kim (CBC) 1.1.
• Liver hnathawh dan test a ni
• Kidney function test a ni
• Thyroid hormone test a ni
• Thisen thau level test `(Lipid panel)` tih a ni
• Genetic tests: Hriselna lama natna thenkhat nena inzawm genetic mutations awm leh awm loh enfiah thin.

Chu bakah, i doctor chuan i taksa chhunga tissue emaw, taksa peng emaw a chhiatna a awm leh awm loh enfiah nan imaging scan ang chi test pawh a rawt thei bawk.

Hei hi eng enkawlna nge ni?

Acanthocytosis enkawl dan hi a chhan a innghat a ni. A tam zawkah chuan a hnuaia natna awm chu uluk taka enkawl a nih chuan thisen sen (red blood cells) chu a pangngaiin a awm leh thin.

Ngaihtuah teh, liver natna leh ``Neuroacanthocytosis`` ang chi natna enkawlna te hi a natna lan chhuah dan control nan a ni ber. Heng natnate hi tihdam kim a harsa tlangpui. Hun kal zelah an na zual deuh deuh thin. Amaherawhchu, thin natna khirh takah chuan thin thlak (liver transplant) chauh a tihdamna a awm fo thin.

Abetalipoproteinemia tih hming pu genetic condition i neih chuan thau hrisel lo i ei tlem a ngai mai thei a, calorie i neih tlem a ngai mai thei. Thisen sen hrisel tak siam turin vitamin (A, D, E, K) i hmuh theih nan vitamin supplement i ei a ngai mai thei bawk.

Acanthocytosis hi anorexia emaw hypothyroidism emaw avanga lo awm a nih chuan a hnuaia natna awm chu enkawl a nih chuan a tha zawk tlangpui. Tin, damdawi pakhatin acanthocytosis a thlen tih hriat a nih chuan damdawi chu tihtawp a nih veleh a reh tlangpui bawk.

Hetiang dinhmun hi ka neih chuan eng nge ka beisei ang?

A then phei chuan acanthocytosis an tih hi enkawlna hmangin a dam kim thei a ni. Chumi awmzia chu thisen sen (red blood cells) te chu a pangngaiah an kir leh tihna a ni.

Mahse, a tam zawkah chuan i hriselna result chu heng sebaceous glands te lo thanglian chhan leh a enkawlna i tan thuai danah a innghat a ni.

Entirnan, natna `(Neuroacanthocytosis)` leh `(Abetalipoproteinemia)` te hian taksa peng hrang hrangah hun rei tak chhung a tichhe thei a ni. Amaherawhchu, natna hi a hmaa hriatchhuah a, enkawl a nih chuan, ., hian natna lan chhuah dan a tikhawtlai thei.

A tlangpuiin liver natna nei `(Acanthocytosis)` i neih chuan a na deuh thei. A chunga kan sawi tak `(spur cell anemia)` vei tam tak chu thla engemaw zat chhungin an thi. Chuvangin i dinhmun hriat dan tha ber chu i enkawltu doctor hnen atangin a ni. I hriselna zawng zawng leh heng spur cells lo awm chhan hi a en ang a, i chunga thil thleng chu a sawifiah ang.

He `(Acanthocytosis)` hi a lo awm loh nan kawng a awm em?

Dik tak chuan acanthocytosis hi genetic disease avanga lo awm a nih chuan ven dan tur a awm lo. A chhan chu kan rochun thil a nih vang a ni. Mahse, thil dang engemaw avanga he natna vei theihna tur tihziaawmna tur thil kan tih theih a awm.

• Zu in loh emaw tihtlem emaw: Hei hian zu in kaihhnawih thin natna a veng thei a ni.
• Chaw tha ei: I taksa hian thisen zam (red blood cells) siam turin nutrient dik tak a neih a ngai a ni. I tana ei tur dik thlang tura tanpuina i mamawh chuan dietitian rawn rawh.
• Enkawlna dawng hmasa rawh: Sebaceous cyst thlentu natna thenkhat chu enkawl loh chuan a na nghal thei. Chuvangin, natna lan chhuah veleh doctor pan a, a natna hriatchhuah a, enkawl tan a pawimawh hle.

Engtin nge ka hriselna ka enkawl ang?

A pawimawh ber chu i acanthocytosis thlentu underlying condition atana i doctor-in a pek dan zawm hi a ni.

Acanthocytosis tih hming pu genetic condition i neih chuan genetic counseling lak hi ngaihtuah rawh . Genetic counselor chuan he natna hian nang leh i chhungte a nghawng theih dan tur leh, a thlentu genetic mutation chu i fate hnena i thlen theih dan tur te a hrilh thei che a ni.

Doctor hnenah eng zawhna nge ka zawh ang?

Doctor hmu tura i kal dawnin hetiang zawhna hi zawt hreh suh:

• Ka thisenah heng hling cell (Acanthocytes) te hi ka awm hi ka ngaihtuah tur em ni?
• Hei hi a chhan hriat tumin eng test dang nge ka tih a ngai ang?
• Eng ang enkawlna nge min rawt?
• Heng enkawlna atang hian eng ang result nge ka beisei theih ang?
• Genetic counselor ka hmu tur em ni?

A tawp berah chuan ka sawi tur chu... (Take-Home Message)

Doctor-te’n an hmuhchhuah che hian i thisen sen (red blood cells) awm dan pawh an en bawk. `(Acanthocytosis),` i vei tih hmuhchhuah a nih chuan i thisenah thisen sen (red blood cells) pangngai lo engemaw zat i nei tihna a ni. Lungngai suh. A châng chuan, enkawlna hian i thisen zam (red blood cells) chu a normal-ah a hruai kir leh thei a ni. A nih loh leh, a hnuaia natna awm chu control turin a pui thei bawk. Mahse, a chang chuan i thisena acanthocytes awm hi natna khirh tak, thin natna nasa tak ang chi chhinchhiahna a ni thei. Chuvangin, `(Acanthocytosis)` neih hian i hriselna a nghawng dan chiang taka sawifiah turin i doctor tha ber a ni. A thusawi i ngaithla a, a enkawlna dik tak i zawm chuan, chu natna chu thunun theih a ni fo.

` Acanthocytosis, Thisen sen, Scutellaria, Spleen, Thisen tlakchhamna, Thin natna