He thisen cancer chungchang hi i hriat duh bawk em? Acute Monocytic Leukemia (AMoL) chungchang hi han sawi ila!

Acute Monocytic Leukemia, emaw AMoL tih hi i hre tawh em? A hming hi a mak deuhin a lang thei a, mahse thisen tichhe thei cancer chi khat a ni. Kan taksa thisen siamna kawngah thil engemaw a kal sual a, thisen cell hrisel ai chuan cancer cell a lo awm tan ta se han ngaihtuah teh? Chutiang chiah chu a ni. Hei hi thawnthu pawi tak ni mahse, a awlsam zawngin, i hriatthiam theih dan tur angin sawi ila.

He Acute Monocytic Leukemia an tih hi eng nge ni?

A awlsam zawngin Acute Monocytic Leukemia (AMoL) hi cancer chi khat a ni a, leukemia group Acute Myeloid Leukemia (AML) an tih zingah a tel a ni. Leukemia hi thisen cancer a ni tih i hria a. Chuvangin he AMoL hi thisen cancer a ni bawk . Kan taksa chhunga thisen cell siamna kawngah chhiatna a awm chuan a thleng thin. A dik tak chuan thisen cell hrisel lo ni tur cell puitling lo, chu chu blast , an tih cell te chu an inthlak danglam a, cancer cell an lo ni ta a ni.

AMoL-ah chuan heng cell puitling lo, a nih loh leh blast te hi thisen var chi khat , monocytes tia koh an lo nih chuan an track-ah an ding reng a ni. Mahse, monocyte hrisel tak ni lovin, a puitling lo, a nih loh leh blast, stage-ah an tang a, cancer cell an lo ni ta a ni.

Acute monocytic leukemia hi cancer na tak, a darh chak hle a ni . I doctor chuan i dinhmun enkawlna tha ber zawng turin a pui ang che. Ngaihtuah buai suh, hemi chungchang hi chipchiar zawkin kan sawi dawn a ni.

Hei hi chi hrang hrang a awm em?

Ni e, World Health Organization (WHO) chuan AMoL hi cancer lo ni ta cell chi hrang hrang (i.e., monocytes) a zirin a thliar hrang thin. French-American-British (FAB) classification system hlui zawkah chuan AML-M5 an ti bawk. He system hnuaiah hian AML-M5 hi chi hnih ah then belh a ni a:

A rilru a buai em em a, a rilru a hah em em bawk a.

Hetiang chi ah hian cell 80% tal chu an lo thanglian kim hmain cancer an ni. Hetiang chi hi naupang leh puitling naupangte zingah hmuh tur a tam ber a ni .

A rilru a buai em em a, a rilru a hah em em bawk a. AML-M5b .

Hetah hian cell pangngai lo tak takte chu cell thanna stage hmasawn deuhah cancer an lo ni ta a ni. Hetiang chi hian kum bik a nghawng lo .

Heng classification te hian doctor te chu natna hriatchhuah nan a pui thin. Mahse, chi khat chu a dang aiin a pawi zawk lo. An pahnih hian ngaihvenna level inang vek mamawh condition an ni.

Hei hi eng symptoms nge ni?

AMoL symptoms hi a lang fo a , a kal chak hle bawk . A lan chhuah dan thenkhat chu hetiang hi a ni:

• Bruising leh thisen chhuah awlsamOccurrence (gums thisen chhuak, hnar thisen chhuak fo, etc.) Khawi emaw laiah i inbual mai mai pawhin hliam lian tak i nei ang tih han ngaihtuah teh, emaw, i ha i sil hian i hmuiah thisen a chhuak nasa hle ang tih han ngaihtuah teh.
• Vun hnuaiah hian dots te tak te, purple, red, emaw brown ( petechiae ) te a awm thin. Hengte hi pimples te tak te ang maiin a lang thei a, mahse a takah chuan vun hnuaia thisen chhuak hmun a ni.
• Gums a hring emaw, gum tissue a lo lian lutuk emaw.
• Chak lohna leh hah lutuk . Energy nei lo ang maia inhriat mai mai. Zingkar i thawh lai pawha chau anga inhriatna.
• Thâwk harsa.
• Chaw chu a thlum lo.
• Chhan awm lovin taksa rihna tihtlem . Diet hmang lovin i thau i tihtlem a nih chuan ngaihven tur a ni.
• Vun dum (pale skin) a ni.
• Luak chhuak thei.
• Khawsik.

A châng chuan, acute monocytic leukemia hian i thluak leh central nervous system a nghawng thei . Chutiang a nih chuan hriatreng harsa leh ngaihtuahna seng harsa tih ang chi symptoms i nei thei.

Engvangin nge hetiang natna hi a lo awm?

Medical expert-te chuan AMOL hi eng nge a thlen tih chiang takin an la hre lo. Mahse, genetic mutations , a nih loh leh cell DNA inthlak danglamna avanga lo awm niin an ngai. Heng inthlak danglamna te hian cell hrisel tak chu cancer a nih tir thin a ni.

Zirchiangtute chuan AMoL vei thenkhatah chuan chromosomal rearrangement an tih chu genetic disorder a awm tih an hmuchhuak a. Chumi awmzia chu chromosome pakhat a then chu a inthen a, chromosome dang nen a inzawm tihna a ni. Hei hi chromosomal translocation an ti a . He natna hian cell pakhat chu monocyte angin a lo thanglian tawh lo va, cancer cell a lo ni thei a ni. Thil kal sual ang maiin han ngaihtuah teh.

Heng genetic changes chungchangah hian zirchianna hi kalpui mek a ni. Cancer hnuaia genetics hriatthiamna hian mithiamte chu a do theihna tur enkawlna tha zawk siam turin a pui dawn a ni.

He natna vei theihna tur risk factors te chu engte nge ni?

Acute Monocytic Leukemia vei theihna tipung thei thil engemaw zat a awm. Chung zinga ṭhenkhat chu hetiang hi a ni:

• Meizial zu leh secondhand smoke nena inzawmna . Meizial zu lo pawh nise, zu in mi bula awm hi a risky bawk.
• Tun hmaa cancer enkawlna i lo dawng tawh a nih chuan, entirnan chemotherapy leh radiation therapy.
• Hun rei tak chhung carcinogens , benzene leh formaldehyde ang chi chemical (factory leh paint thenkhatah hmuh theih) te nena inzawmna.
• Nuclear reactor accident emaw atom bomb emaw avanga radiation laka invenna.
• Genetic disease i neih chuan thlah kal zelah, entirnan , Li-Fraumeni syndrome .
• Ruhro nena inzawm natna i neih chuan, myeloproliferative neoplasms .

Mahse, risk factor neih hian cancer i vei ngei ang tihna a ni lo tih hriat reng a pawimawh . Mahse, i thunun theih tur risk, meizuk loh ang chite chu pumpelh a tha zawk.

He natna hian eng harsatna nge a thlen theih?

AMoL i neih hian i ruhroah cell pangngai lo tak tak a lo awm thei a ni . I hriat angin bone marrow hi thisen cell siamna hmun a ni. Chuvangin heng cancer cell te hi an lo thang lian chuan thisen cell hrisel te chu an crowd out thin. Hei hian thisen sen (red blood cells), thisen var (white blood cells), leh platelet te a tlahniam thei a, chu chuan harsatna chi hrang hrang a thlen thei a ni. Entir nan:

• Anemia : Thisen sen (red blood cells) tlahniam avanga lo awm thin. Hei hian hahna leh paleness a thlen thei.
• Neutropenia : Thisen var chi khat neutrophils a tlahniam a, chu chuan hri kai theihna a tipung a ni.
• Thrombocytopenia : Platelets tlahniam, thisen zam a pui thin. Hei hian hliam tenau a\ang pawhin thisen chhuahna a tipung thei a ni.

He natna hi engtin nge i hriat chian?

Doctor-te chuan AML an hriat theih nan test hrang hrang an hmang a. World Health Organization chhinchhiah dan chuan mi pakhat chu a thisen cell 20% aia tam chu a pangngai lo, cell puitling lo a nih chuan AML nei anga ngaih a ni. Tin, chutiang cell pangngai lo zinga 80% aia tam chu monocyte emaw monocyte precursor emaw an ni tur a ni.

I doctor chuan thisen sample a la ang a, a nih loh leh tissue, fluid emaw bone marrow emaw sample a la ang. Hengte hi a takah chuan lab-ah an test thin.

Hengte hi AMOL hriat theihna atana hman thin test te chu a ni:

• Thisen test : Thisen chhiar kim (CBC ) chuan AMoL chhinchhiahna a lang thei a, chu chu thisen var cell count a sang tih te hi a ni. Peripheral blood smear hmangin cell pangngai lo a awm leh awm loh enfiah theih a ni.
• Bone marrow biopsy : He test atan hian i doctor chuan i ruh (a tlangpuiin i hip bone) atanga tissue emaw fluid emaw sample a la thin. Chumi hnuah sample chu microscope hmangin cancer cell awm leh awm loh enfiah a ni. Hei hi a hrehawm deuh thei a, mahse diagnosis atan chuan a pawimawh hle.
• Spinal tap : Cancer cells te chu thluak emaw central nervous system ah emaw a darh tawh em tih hriat nan doctor chuan i spinal fluid sample a la a, a test thin.
• Immunophenotype hmanga tih a ni: He test hian cell chunglama protein bik a zawng thin. Heng protein te hian cell te chu AMoL cell anga hriat theih nan a pui thin.
• Cytogenic analysis : Hetiang analysis hian AMoL nena inzawm cell chhunga chromosomes-a translocations emaw rearrangement emaw a awm leh awm loh a enfiah thin.

Hei hi eng enkawl dan nge ni ang?

Enkawlna tum ber chu cancer chu remission ah dah a ni . Chu chu i ruhroah emaw, i thisenah emaw cancer cell awm tawh lohna hmun thlengin a ni. Mahse hei hi damdawi nen chuan inzawm tir tur a ni lo . Damdawi chu cancer chu a bo vek tawh a, a lo kir leh tawh lohna state a ni.

Chemotherapy hmanga enkawl a ni

Acute monocytic leukemia enkawlna ber chu chemotherapy a ni . Hei hian a hnuaia stage hrang hrangte hi a huam thei a ni:

• Induction therapy : He enkawlna hian chemotherapy damdawi inzawmkhawm hmangin AMoL chu remission-ah dah a ni. Enkawlna hi a tlangpuiin ni engemaw zat chhung session tam tak neih a ni a, tlawh nawn leh a ngai bawk.
• Consolidation therapy : He enkawlnaah hian cancer cell la awm zawng zawng tihhlum turin chemo dose sang tak i dawng chhunzawm zel ang. Hei hian cancer cells te lo kir leh theihna chance a ti tlem dawn a ni. Enkawlna hi thla thum atanga thla li chhung a ni tlangpui a, ni engemaw zat chhung a ni.
• Maintenance therapy : Stabilization therapy hnuah thla engemaw zat emaw kum tam tak emaw chhung chu low-dose chemo i mamawh thei.

Targeted therapy hmanga enkawlna

He enkawlna hian cancer cell-a mutations emaw, inthlak danglamna emaw bik a target a ni. Chemotherapy a hlawhtlin loh chuan targeted therapy i mamawh mai thei . A nih loh leh, cancer cell-ah hian genetic mutation bik a awm a nih chuan, chu mutation dodaltu targeted therapy drug pek i ni thei bawk.

Stem cell thlak danglam a ni

Acute monocytic leukemia tihdam vek theihna awmchhun chu allogeneic stem cell transplant hi a ni . Hei hi remission-a i kal hnuah a ngai mai thei. A nih loh leh, remission-a i kal hnua cancer a lo let leh chuan he transplant hi tih theih a ni. Hetiang tih danah hian doctor chuan nangmah ngeiin i stem cell te chu donor atanga stem cells hmangin a thlak thin. A tlangpuiin thisen petu hi thisen inzawm hnai tak a ni. A nih loh leh, national emaw international registry-a donor inzawm lo a ni thei bawk.

Mahse mi zawng zawng hian stem cell transplant an nei thei lo. Side effect na tak a thlen thei bawk. I doctor-in a rawt chuan a thatna leh that lohna an hrilhfiah ang che.

Clinical trial neih a ni

Clinical trial chu enkawlna thar a him leh him loh enfiahna a ni. I natna hmuhchhuah dan azirin hei hi i tan chuan enkawlna tha ber a ni thei. Clinical trial-ah i tel tur em tih doctor zawt rawh.

Engtin nge he dinhmun hi i nunpui? / Dam leh theihna chance engzat nge awm?

Acute monocytic leukemia (AMoL) vei tan chuan a tlangpuiin acute myeloid leukemia (AML) vei tan chuan a hmalam hun chu a inang vek a ni. AMoL vei mi 10 zinga 3 vel chu an hmuhchhuah atanga kum nga hnuah pawh an la dam .

Mahse, heng number te hian enkawlna thar a lantir lo tih hriat reng a pawimawh. Enkawlna thar avang hian AMoL hmanga dam rei zawk an awm thei ta a ni. Tin, i prognosis , a nih loh leh i dam theihna chance chu thil engemaw zatah a innghat bawk. Entir nan:

• Kum : Kum 65 hnuai lam te hian AMoL atanga dam leh theihna chance an nei sang zawk.
• White blood cell count : White blood cell count tlem te chuan dam theihna chance an nei tha zawk.
• Enkawlna dawn dan : Chemotherapy hmasa ber (induction chemotherapy) hnua remission a awm chuan dam leh theihna chance a sang hle.

Engtin nge i in enkawl ang?

Leukemia natna nena nun hi a buaithlak thei hle . Remission i neih hnuah pawh cancer chu a lo let leh mai ang tih hlauhna chu i la hmachhawn a ngai mai thei. Cancer enkawlna avanga hun rei tak chhunga nghawng tha lo awm thei te pawh i hmachhawn a ngai mai thei bawk. I in enkawl dan tha ber chu i hman theih zawng zawng hmang tangkai hi a ni . Chûng zîngah chuan:

• Cancer damchhuahna programme : Cancer vei midang nena inzawmna siam hian i mamawh tanpuina a pe thei che a, nangmah chauh ni lo ang maia i inhriat theih nan a pui thei bawk.
• Palliative care : Palliative care hian cancer natna lan chhuah dan leh cancer enkawlna avanga a side effects te a enkawl thei a ni. Eng prognosis pawh nise, hei hi resource hlu tak a ni.
• Therapy : Cancer vei tam tak chuan lungkhamna leh lungngaihna an nei thin. Cancer damchhuakte nena thawk ho thin mental health counselor nen inhmuhkhawmin tanpuina i dawng thei ang. Counselor chuan cancer hmuhchhuah a nih avanga nitin harsatna lo thleng thinte chu a enkawl thei che a ni.

Engtikah nge Doctor i hmuh a ngaih?

Enkawlna i dawn dan enfiah turin i doctor i pan fo a ngai dawn a ni. I taksaah cancer a lo let leh tawh tih tilang thei thil danglam a awm chuan an hriattir ang che. Engmah titawp lovin doctor nen inbiakna nei rawh .

Doctor hnenah eng zawhna nge i zawh tur?

I doctor zawh theih tur zawhna thenkhat chu hetiang hi a ni:

• Eng enkawlna nge ka mamawh?
• Eng side effect nge ka beisei ang a, engtin nge ka enkawl theih ang?
• Clinical trial-ah hian ka tel a ngai em?
• Follow-up appointment atan engzat nge ka lo kal a ngai ang?
• Eng resources nge min pui thei ang?

A tawp berah chuan thil hriat reng tur

Nangmah emaw i fa emaw hian acute monocytic leukemia (AMoL) an vei tih i hriat chuan thil mak tak a ni thei. Thisen cancer hi natna khirh tak a ni a, a enkawl dan pawh a harsa thei hle. Ni, kar leh thla lo awm turteah hian enkawlna round engemaw zat i hmachhawn ngei ang.

Mahse hei hi hriat reng a pawimawh: Heng enkawlnate hian mite chu a hma aia rei zawkin a pui mek a ni . Mi thenkhat tan chuan enkawlnate hian cancer chu a ti bo vek thei hial a ni. I doctor hnenah eng result nge i beisei theih tih zawt rawh. Treatment option tinte thatna leh that lohna chungchang sawipui rawh. Anni chuan thil lo thleng tûr hmachhawn tûrin an ṭanpui thei che a ni.

Hei hi hre reng ang che: He zinkawngah hian nangmah chauh i ni lo. Doctor te, chhungte leh thiante te chu tanpui turin an awm vek a ni. Chak takin awm rawh!

` Acute monocytic leukemia, AMoL, thisen cancer, leukemia symptoms, chemotherapy, ruhro transplant, cancer enkawlna