Breast cancer leh i genes inzawmna (Breast Cancer & Genes): Hei hi kan hriat chian a ngai em?

I chhungkuaa mi tu emaw, i nu emaw, i farnu emaw, i fanu emaw pawhin hnute cancer a vei tih i hriat chuan tlem chuan hlauhna leh lungkhamna i neih chu thil pangngai a ni. "An nei a nih chuan kei pawhin ka hmu dawn em ni?" I ngaihtuah mai thei. Breast cancer leh kan genes te hi inzawmna a awm tak tak em? Ni e, eng emaw chen chu inzawmna a awm. Mahse kan ngaihtuah angin a awlsam lo. Hemi chungchang hi vawiin hian chipchiar tak leh awlsam takin i sawi dawn nia.

A hmasain ‘gene’ tih awmzia hi i hrethiam ang u.

Okay, hei hi a awlsam hle mai. Kan taksa hi building lian tak a ni tih han ngaihtuah teh. He building chhunga cell tin hi brick ang mai a ni. Chuvangin heng brick tin hian an awm dan tur leh tih tur chungchangah instruction book lian tak an nei vek a ni. Chu instruction book chu gene kan tih chu a ni . Chûngte chu DNA an tih thil aṭanga siam thil te tak te an ni.

Kan taksa cell tinah hian heng genes hi 20,000 chuang a awm a. Heng genes pakhat zel hi copy hnih kan hmu a, pakhat chu kan nu hnen atangin leh pakhat chu kan pa hnen atangin kan dawng bawk. Chuvangin heng genes te hian kan vun rawng leh sam texture ang chi thil chauh ni lovin kan cell te lo thanglian dan leh hnathawh dan pawh an control a ni.

A chang chuan heng genes-ah hian inthlak danglamna tenau leh tihsual te a awm thei bawk. Heng mutations te hi kan ti a ni . Chu instruction bu phek khata lehkha pakhat chu a dik lo a nih chuan eng nge thleng ang tih han ngaihtuah teh? Instruction zawng zawng chu a danglam vek a ni lawm ni? Chu chu gene pakhata mutation a awm chuan a thleng thin. Cell hnathawh dan pangngai a tidanglam thei a ni.

Breast cancer nena inzawm genes lian ber berte chu engte nge ni?

Breast cancer nena inzawm gene engemaw zat awm mahse, a pawimawh ber leh sawi hlawh ber pahnih chu gene BRCA1 leh BRCA2 te hi an ni.

A tlangpuiin heng BRCA gene pahnih hi kan taksa tan a pawimawh hle. An hna chu cancer laka invenna a ni. Kan cell vengtu ang mai an ni. Cell-te chu thunun theih loha ṭhan an tum hian heng gene-te siam protein-te hi a chhuak a, a titawp a ni.

Mahse, i nu emaw i pa emaw hnen atanga mutated BRCA1 emaw BRCA2 gene i rochun chuan a venhimna chu a tlahniam thin. Hei hian chu cell pangngai lote chu thunun theih lohvin an lo thang lian a, cancer an nih theihna chance a tipung a, a nih loh leh a hlauhawmna a tipung bawk. Hereditary breast cancer 20% atanga 25% vel hi heng BRCA genes a mutations vang a ni .

Hei hi genetic risk a ni em tih rinhlelhna siamtu thudik

Breast cancer vei zawng zawng hian hetiang genetic predisposition hi an nei vek lo. Mahse thil engemaw tak chuan ngaihtuahna tlem a pe thei che a ni. A hnuaia mi hi i tan a hman theih chuan hnute cancer nena inzawm genetic mutation i nei thei a ni. Hemi chungchangah hian doctor nen inbiakna neih a pawimawh.

Engtin nge heng genes te hi thlah khat atanga thlah dangah an lo chhuah?

I nu emaw i pa emaw hian he mutated BRCA gene hi nei ta se han ngaihtuah teh. Tichuan 50% chance i nei ta a ni. Coin flipping ang bawkin lu emaw tail emaw hmuh theihna chance 50% a awm. Chu gene chu i neih chuan i fate pawhin an neih theihna chance 50% an nei a ni.

Heng genetic mutations te hian eng risk nge a neih?

Hmeichhiain BRCA1 gene mutated a rochun chuan kum 70 a tlin chuan hnute cancer vei theihna chance 55% atanga 65% a nei a, mutated BRCA2 gene nei tan chuan he risk hi 45% vel a ni.

He hlauhawmna bakah hian thil dang engemaw zat a awm a:

• Kum naupang takah cancer: A tlangpuiin menopause hmain cancer vei theihna a sang zawk .
• Cancer pahnihna: BRCA gene mutation nei chuan hnute pakhata cancer a tihdam hnuah hnute cancer pahnihna (cancer thar hran) a vei theihna a sang hle.
• Cancer hlauhawm dang: Heng genetic mutations te hian hnute cancer chauh ni lovin, a bik takin ovarian cancer vei theihna nasa takin a tipung a ni. Mipaah ​​pawh prostate cancer leh pancreatic cancer vei theihna a tipung thei bawk.

Genetic testing hi tuin nge ti thin?

Tunah chuan heng BRCA1 leh BRCA2 gene-a mutation awm leh awm loh enfiah nan thisen test a awm tawh a ni. Mahse hei hi mi zawng zawng tan fiahna a ni lo.

Heng genetic test te hi a chunga kan sawi tawh, chhungkaw history nghet tak nei te tan chauh tih a ni tlangpui. He test hian hmeichhe hnute cancer vei tawh tan cancer pahnihna emaw ovarian cancer emaw a neih theihna tur a hriat theih bawk.

Hetiang test hi i doctor nen uluk taka i sawiho hnuah i tih leh neih loh i rel tur a ni.I chhungkaw chanchin, i kum leh risk factor dangte a zirin thurawn tha ber ber a pe ang che. He test result (e.g., screening tam zawk, risk-reducing surgery) hmanga tih leh tur chu i doctor nen in sawiho thei bawk.