I taksaah hian hetiang hian tui a leak em? Capillary Leak Syndrome chungchang hi han sawi ila!

Capillary Leak Syndrome tih hi i hre tawh em? A hming hi a buaithlak deuhin a lang thei. Mahse a awlsam zawngin sawi ila, kan taksa chhunga thisen kalna kawng te tak te, capillaries an tih atanga thisen tui, plasma an tih chu a luang chhuak thinna dinhmun a ni. He tui hi kan taksa ruh, tissue, taksa peng leh taksa peng hrang hrangah a luang lut thin. Hei hi natna khirh tak a nih theih avangin fimkhur a pawimawh hle.

He capillary leak syndrome an tih hi eng nge ni?

Awle, tlem han sawifiah leh ila. I taksa hian tui pipe system a nei ang tih han ngaihtuah teh. Heng pipe te hi kan thisen kalna kawng a ni. Hemi chhunga pipe te tak te, te tak te te hi capillaries an ti a. Hengte hi kan taksa peng zawng zawnga oxygen leh nutrients kalna tube te an ni. Chuvangin, `(Capillary Leak Syndrome)`-ah chuan thisen a liquid part, chu chu plasma , chu heng capillary te tak te hmang hian a leak chhuak thin. Tui pipe atanga tui luang chhuak ang mai a ni.

He fluid leakage hian taksa hmun hrang hrangah tui a khawlkhawm thin. Entirnan, he tui hi taksa ruh, tissue, taksa peng hrang hrangah emaw, taksa peng awmna hmun (body cavities)-ah emaw a luang lut thei a ni.

He `(Capillary Leak Syndrome)` episode hi kum khatah vawi tam tak a awm thei a, dam chhungin vawi khat chauh a awm thei bawk. Mahse, enkawl vat a nih loh chuan i thisen sang chu a tlahniam thut thei a, taksa peng hrang hrang a tichhe thei a, a chang chuan thihna pawh a thlen thei bawk. Chuvangin hei hi ngaihthah tur a ni lo.

Hei hi damdawi nghet tak a la awm lo. Mahse, a natna lan chhuah dan control nan damdawi lam pan vat a pawimawh hle. A châng chuan, damdawi hman chhunzawm zel emaw, saline infusion dawng emaw hian nakin lawka a beihna tur ven theih a ni.

Hei hi chi hrang hrang a awm em? Engtin nge an danglam?

Ni e, `(Capillary Leak Syndrome)` hi chi hnih lian tak a awm. Eng nge an nih i en ang u.

• Systemic Capillary Leak Syndrome: ``Primary Capillary Leak Syndrome'' emaw ``Clarkson's disease'' tia sawi bawk a ni a, hei hi attack a awm fo thinna a ni , mi hrisel pangngaiah pawh.
• Secondary Capillary Leak Syndrome: Hei hi natna dang, dinhmun dang emaw, damdawi dang emaw avanga vawi khat attack a lo awm hian a ni.

A awlsam zawnga sawi chuan pakhat chu thil thleng chhunzawm zel thei a ni a, pakhat zawk chu chhan dang avanga hun eng emaw chen thlenga thil thleng a ni.

He natna hi tuin nge vei tam zawk?

``Systemic Capillary Leak Syndrome'' hi natna awm lo tak a ni.Khawvel pumah mi 500 aia tlem loin he natna hi an vei nia sawi a ni. Kum chanve velah a tam ber. Naupang tê têah a tlem hle. Mahse, he natna vei te hi natna dang nei nia hriat sual an nih fo avangin, he natna vei tak tak hi a tam zawk thei hle.

Mahse, Secondary Capillary Leak Syndrome hi kum eng pawhah a awm thei. Infection thenkhat, damdawi lam dinhmun leh damdawi te hian a thlen thei a ni.

Hetiang a lo thlen hian taksaah eng nge thleng? (Stage thum) 1.1.

He `(Capillary Leak Syndrome)` attack lai hian kan taksaa thil thlengte hi stage thumah then theih a ni. Eng nge an nih i en ang u.

Phase hmasa ber: Natna lan chhuah hma (Prodromal phase) .

Hei hi attack hma ni khat emaw ni hnih emaw chhung chu a ni. Hemi chhung hian symptom thenkhat i nei tan thei.

• Chau tih hriatna
• Tui tuihalna a pung
• Sudden weight gain ang chi thil a thleng thei.

Phase hnihna: Leak emaw resuscitation phase emaw

Hei hi attack a thlen tak tak hun a ni. Thil thleng chu i capillary atang hian i tissue inkar space ah fluid leh albumin (thisen chhunga protein chi khat) a luang lut thin. Hei hian oxygen -carry thisen a tihtlem phah a ni. I thisen sang a tlahniam a, thisen sen (red blood cells) te chu an inzawm khawm a, chu chuan i thisen a ti thim zawk a ni. He tui leak hian thisen volume a tihhniam a, chu chu hypovolemia an ti a ni.

Phase thumna: Attack hnuah `(Post-leak phase emaw recruitment phase emaw)`

Hei hi attack a zawh hnu hun a ni. Thil thleng chu i capillaries te hian tissue atang hian fluid leh albumin an la lut tan leh thin. Mahse, he hun chhung hian i taksa hian tui a khawlkhawm tam lutuk thei (fluid overload) . Chuvang chuan i taksain zun tam lutuk (polyuria) a siam chhuak thei a, i lung chu tuiin a khat thei bawk (pulmonary edema).

Ngaihtuah teh, sponge tui hip ang mai a ni. A hmasa berin, tui chu taksa atangin a chhuak a, chumi hnuah a hip leh rang lutuk chuan a hip tur aia tam a hip lut leh thin.

Eng thilin nge hei hi a thlen?

Tunah hian he `(Capillary Leak Syndrome)` hi eng nge thlen thei tih hi han en ila.

`(Systemic Capillary Leak Syndrome)` awm chhan te

Dik tak chuan Systemic Capillary Leak Syndrome thlen chhan dik tak hi hriat a la ni lo. Zirchiangtute chuan natna emaw, hri kai emaw kan taksa hriselna (immune system)-in a chhân lêtna avânga lo awm a ni thei niin an ngai.

`(Secondary Capillary Leak Syndrome)` awm chhan te

Hei hi chhan hrang hrang a awm a. A chhan tam ber chu sepsis an tih hi a ni . Chu chu infection avanga nunna atana hlauhawm complication a ni. Hei bakah hian a chhan dang a awm bawk:

• Autoimmune natna: 1.1.Hemi kawngah hian thil thleng chu kan taksa hriselna (immune system) hian kan cell hrisel tak takte hi a bei a ni.
• Differentiation syndrome: Leukemia chi hrang hrang (acute promyelocytic leukemia emaw acute myeloid leukemia) enkawl laiin harsatna awm thei.
• Engraftment syndrome: Ruhro thlak hnua harsatna awm thei.
• Hemophagocytic lymphohistiocytosis: Immune system chak lutuk avanga nunna atana hlauhawm thei natna.
• Ovarian hyperstimulation syndrome: Naupai enkawlna lama harsatna awm thei.
• Ricin rimchhia a awm.
• Rul seh a ni.
• Viral hemorrhagic fevers: Virus avanga natna hrik kai theih pawl.

Damdawi thenkhat, cancer dona damdawi gemcitabine (gemcitabine - Gemzar®) leh tagraxofusp (tagraxofusp - Elzonris®) te pawhin hei hi a thlen thei bawk (Secondary Capillary Leak Syndrome).

He natna lo chhuah hma hian eng symptoms nge awm thin?

A tlangpuiin, ``Capillary Leak Syndrome'' attack hma ni khat emaw ni hnih emaw, chu chu ``prodromal phase'' lai hian, hetiang hian symptoms i nei thei a:

• Pum na emaw, taksa ruh na emaw (myalgia).
• Chauh lutuk emaw chak lohna emaw.
• Lu na .
• Tui tuihalna a pung.
• Thinrimna, thinrimna rang.
• Luhai.
• Sudden thau lutuk.
• Viral infection emaw upper respiratory tract infection emaw a lan chhuah dan.

Hetiang symptoms i neih chuan, "Aw, khawsik mai mai a ni mai thei," tiin ngaihthah suh, a bik takin hetiang thil hi i lo tawn tawh a nih chuan.

Natna i neih hian eng symptoms nge lo awm?

`(Capillary Leak Syndrome)` attack lai, chu chu `(leak or resuscitation phase)` lai hian mi hrang hrangah symptom a inang lo thei. Mahse, a hnuaia mite hi a lan chhuah dan tlangpui chu a ni.

• A hring, a bik takin ke ruh (peripheral edema).
• Kawthalo.
• Thisen sang hniam (hypotension).
• Thisen zam (hypercoagulability) - Hei hi thisen sen (hematocrit) a pun vang emaw, thisen var (leukocytosis) a pun vang emaw a ni thei.

Doctor-te hian engtin nge hei hi an hriat?

Doctor chuan i medical history zawtin leh taksa enfiahna hmangin Capillary Leak Syndrome a nei tih a hmuchhuak ang. I thisen sang a hniam em tih an enfiah ang.

Tin, hei hi Capillary Leak Syndrome a ni tih finfiah hmain condition dang pawh paih chhuah a ngai bawk. Chutiang ti tur chuan thisen test eng emaw zat an ti thei a ni:

• Hematocrit (thisen chhunga thisen sen awm zat) a sang em tih enfiah thin ang che.
• Hemoglobin level sang (thisen sen chhunga protein awm) a awm leh awm loh enfiah thin ang che.
• Thisenah protein tlem (hypoalbuminemia) a awm leh awm loh enfiah thin ang che.

Tin, thisen test hmangin thisenah hian immune protein pangngai lo ``monoclonal gammopathy, or M protein'' an tih chu enfiah theih a ni bawk. ``Capillary Leak Syndrome'' vei te hian an thisenah he ``M protein'' danglam tak hi an nei thei a ni.

Engtin nge enkawl a nih? Dam theih a ni em?

Vanduaithlak takin Capillary Leak Syndrome hi damdawi nghet a awm lo. Doctor-te chuan a symptoms control leh complication ven tumin an bei thin.

``Capillary Leak Syndrome'' attack lai hian doctor te chuan thisen sang control an tum a, taksa peng hrang hranga thisen kal dan tur dik tak vawng reng turin an bei thin. Tin, a hring tam lutuk leh tui a tam lutuk loh nan an bei bawk. An hmang thei ang:

• Glucocorticoids: Hengte hi steroid chi khat a ni a, capillary atanga tui chhuak tihtlem nan a pui thin.
• Intravenous fluids: Saline ang chi thil hi kal ang chi taksa peng hrang hranga thisen kal tam nan pek a ni.

Attack i neih hnuah damdawi inah dah i ngai tlangpui ang. Enkawl lai hian i doctor chuan i thisen sang leh thisen sang chu a enfiah chhunzawm zel ang a, i taksaah tui tam lutuk a awm loh nan a enkawl chhunzawm zel ang a, chu chuan harsatna dang a thlen thei a, chu chu pulmonary edema leh sudden cardiac arrest te a ni.

Capillary Leak Syndrome, post-leak phase emaw recruitment phase tia hriat, a attack hnuah doctor chuan i taksaa tui tam zawk awm zat tihtlem nan diuretic ( zun tam zawk siam chhuahna damdawi) a pe thei a ni.

Systemic Capillary Leak Syndrome (SCLS) hi a lo awm leh tawh loh nan ven theih a ni em?

Systemic Capillary Leak Syndrome hi a tir lamah chuan i veng thei lo. Mahse, vawi khat attack i neih chuan condition i nei tih i hria.

Mahse, damdawi ei fo emaw, saline infusion dawn emaw hian nakin lawka attack lo awm tur venna atan a pui thei a, a nasat dan pawh a ti tlem thei bawk. Heng enkawlnate hi a hnuaia mi ang hian a ni thei:

• Thla tin thisen kal tlanga immune globulin (IVIG) dawng thin .
• Asthma damdawi ei tur, theophylline (theophylline - Elixophyllin®), terbutaline (terbutaline - Brethine®), leh montelukast (montelukast - Singulair®) te hi a ni.
• Inflammation tihziaawmna turSteroids te pawh a awm.

Hetiang dinhmun neia khawsa te tan hian hmalam hun eng nge ni? `(Hmuh dan)`

Systemic Capillary Leak Syndrome hi a tlangpuiin invenna hmanga enkawl theih a ni. Enkawlna hi a hlawhtling zawk a, chu chu natna hi hriat hmasak a nih a, harsatna a awm tlem chuan a hlawhtling zawk a ni. Capillary Leak Syndrome avanga harsatna lian tham lo awm thei thenkhat chu:

• Compartment syndrome: Muscle chhunga pressure sang leh thisen kal tlem.
• Thinlung leh lung chhehvela tui awmkhawm (cardiac tamponade, pericardial effusion, leh pleural effusion).
• Lung lam chak lohna.
• Kidney tha lo a awm.
• Neuropathy natna a ni.
• Pulmonary edema a awm thin.
• Rhabdomyolysis: Taksa thau (muscle) a chhiat avangin kal (kidney) a chak lo.
• Thai.

Hengte hi hlauhawm tak angin a lang thei a, mahse a hmaa kan sawi tawh ang khan enkawl vat leh enkawl dan dik hi a pawimawh hle.

Engtikah nge Doctor ka hmuh ang?

Capillary Leak Syndrome attack i nei nia i hriat chuan doctor pan nghal rawh. I natna lan chhuah dan enkawl nan an pui thei a, hahdamna an pe thei bawk.

Hei hi thil awm lo tak ni mah se, a natna lan chhuah dan hriat a pawimawh a, rinhlelhna i neih chuan doctor thurawn lak vat a pawimawh tih hre reng ang che.

Take-Home Thuchah a ni

Okay, chuvangin `(Capillary Leak Syndrome)` chungchanga kan sawi tawh pawimawh ber berte kha han sawi nawn leh ila:

• Hei hi kan taksa chhunga thisen kalna kawng te tak te (capillaries) atanga thisen tui (plasma) a luang chhuah hian a ni.
• Hei hi vawi khat emaw, vawi tam tak emaw a thleng thei.
• Enkawl loh chuan harsatna lian tak tak a awm thei a, chuvangin damdawi lam pan vat a pawimawh hle.
• Damdawi nghet awm lo mah se, natna lan chhuah dan thunun tur leh nakin lawka beih tur venna tur enkawlna a awm.
• Heng symptoms zinga pakhat tal i rinhlelh chuan doctor pan nghal rawh. Natna i hriatchhuah thuai a, enkawl i tan chuan i dam theihna chance a sang zawk.

Chuvangin, he thu hi in tan a tangkai ngei ka beisei. Hrisel takin awm rawh!

` Capillary Leak Syndrome, Plasma Leak, Thisen sang hniam, Clarkson natna, Edema, Taksa chhunga Fluid Leak