Zing lamah i tho ṭhin a, i ruhro kha a nghet lo va, i ruhro chu a tidik thei lo tihna a ni em? Hetiang natna chi hi, a bik takin hnungzang hnuai lam leh hip-ah te hi hnungzang natna awlsam tak mai ni lovin thil thuk zawk bul tanna a ni thei a, a bik takin i naupan lai hian. Hei hi hnungzang natna awlsam tak mai a ni lo. Vawiin hian chutiang dinhmun pakhat, ankylosing spondylitis (AS) chungchang kan sawi dawn a, chu chu arthritis chi khat hmuh tur awm lo tak a ni. Eng thilin nge a thlen tih leh tute nge a hlauhawm ber tih sawi ila.
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A awlsam zawngin, Ankylosing Spondylitis (AS) hi eng nge ni?
Ankylosing Spondylitis, a tawi zawngin AS hi ruh natna chi khat a ni. A bik takin ruhro a nghawng a ni. Inflammation a siam a, chu chu ruh ruh leh a chang chuan ruh dang, hip ang chi ah te a hring a, a tikhauh tihna a ni. Hei hian zing lamah a tikhauh thei a, a na thei bawk.
He inflammation hi rei tak a awm reng chuan, kan taksain dam a tum angin ruh chi thar a lo piang tan thin. Hei hian side effect a nih angin vertebrae te chu a compress thei a, spine pawh a flexibility a hloh thei bawk. Hei hian ruhro dinglam leh ben a ti harsa hle.
Doctor-te hian a chhan dik tak an hria em?
Dik tak chuan doctor-te chuan AS natna thlentu dik tak chu 100% chiang takin an la sawi thei lo. Mahse, tun dinhmunah chuan thil pahnih inzawmkhawm avanga lo awm a ni tih pawm a ni a, chungte chu kan gene leh environment factors te an ni.
Hetiang hian han ngaihtuah teh: kan genes te hi silai mu hmin ang mai a ni. Mahse a kang theih nan chuan pawn lam meialh a mamawh a ni. Hetah pawh hian chutiang bawk chu a thleng thin. AS vei theihna tur genetic predisposition awm mahse, natna lo awm tur chuan boruak atanga ‘trigger’ emaw ‘spark’ chi khat emaw a ngai a ni.
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Check Availability →Genetic influence leh HLA-B27 te a ni
AS chungchang sawi dawn chuan thil pakhat sawi tur awm tak chu HLA-B27 tih gene hi a ni. Hei hi kan taksaa protein bik, a nih loh leh ‘genetic marker’ siamtu gene a ni. He gene hnathawh ber chu kan immune system tanpui hi a ni . Chu chu taksaa lut bacteria leh virus ang chi thil tha lo hriatchhuah leh dona pui turin a ni.
AS vei tam zawk hian an taksaah he HLA-B27 gene hi an nei a ni. Mahse, hetah hian a pawimawh ber chu:
Mi zawng zawng hian HLA-B27 gene an neih vang mai maiin AS an nei vek lo.Dik tak chuan he gene nei tam zawk hian an dam chhungin AS an nei ngai lovang. Tin, he gene nei lo tan pawh AS a vei thei bawk.
Chu chu HLA-B27 hi thawnthua a then chauh a ni tihna a ni. Scientist te chuan AS nena inzawm gene dang engemawzat an hmuchhuak tawh bawk. Heng gene zawng zawng deuhthaw hi kan taksa hriselna (immune system) hnathawhnaah hian eng emaw ti takin an inrawlh a ni.
A Trigger chu a ni
Okay, chuvangin AS vei theihna tur genetic predisposition, a nih loh leh ‘shotgun’ i nei ta ang u. Tunah chuan a ignite turin 'spark' i mamawh a ni. Scientist te chuan he spark hi eng nge a nih tih an la zirchiang mek a ni.
Theory lian tak pakhat chu he flare-up hi bacteria infection avanga lo awm a ni tih hi a ni . A bik takin, hei hi kan chaw ei dan (digestive system)-a natural defense, chu chu intestines -a a chhiat vang a ni thei niin an ngai. Chutiang a nih chuan intestine atanga bacteria chi hrang hrang thisenah a lut thei a ni.
Chutianga thisenah bacteria a luh chuan, mi genetically predisposed mi immune system chuan a overreact a, a â ta hle a ni. Chuvang chuan immune system chuan taksa peng hrisel tak tak, a bik takin ruhro chhunga ruhkawr te chu a bei tan ta a ni. Hei hi AS hi a intan dan a ni.
Hemi atan hian tute nge hlauhawm ber?
Tu pawhin AS hi an vei thei a, mahse mi thenkhat chu an hlauhawmna a sang deuh hlek a ni. Tute nge an nih i han thlir teh ang.
| Risk Factor a ni | Hrilhfiahna |
|---|---|
| Chhungkaw chanchin | I chhungkuaa mi tu emaw, a bik takin nu emaw, pa emaw, unaupa emaw chuan AS a vei a nih chuan, mi pangngai aiin i vei theihna a sang zawk a ni. Hei hian genes te nghawng a lantir a ni. |
| Kum | AS hi kum 17 leh 45 inkar thalai zingah a intan tam ber a, kum upat ruala lo awm arthritis chi dang aiin a intan hmasa zawk tlangpui. |
| Mipa leh hmeichhe thliarna | Hmeichhia aiin mipa hian AS vei an tam zawk a, a let hnih tal an nei tam zawk. |
| Intestinal infection awm fo thin | Hetiang hlauhawmna hi pum na emaw, chaw ei kawng natna emaw nei fo tan chuan a sang deuh thei a ni. Chu chu a hmaa kan sawi tawh ‘fire spark’ vang a ni. |
| Autoimmune natna dangte | Autoimmune natna dang, psoriasis , Crohn’s disease , emaw ulcerative colitis , i neih tawh chuan AS vei theihna a sang zawk a ni. Heng natna zawng zawngte hian an inang tlangpui chu taksa hriselna (immune system) tha lo (malfunctioning immune system) hi a ni. |
Hetiang hian hnungzang na emaw, a nghet lo emaw i neih chuan, a bik takin zing lamah a na zawk a, darkar chanve aia rei a daih chuan ngaihthah mai mai suh. ‘Hei hi i tar huna thil thleng a ni’ ti mai mai suh. I doctor hmu nghal la , sawi rawh. I natna i hriat chian hma chuan i thunun theihna chance a sang zawk a, i ruhkawr chhiatna a tlem phah a, nun hrisel tak i hmang thei bawk.
Take-Home Thuchah a ni
- Ankylosing Spondylitis (AS) hi ruh natna chi khat a ni a, hnungzang natna pangngai mai ni lovin, ruh natna a nghawng a ni.
- Hei hi a chhan chiang tak awm lo mahse, HLA-B27 ang chi gene leh environmental triggers bacteria infection ang chi te inzawmkhawm vang nia ngaih a ni.
- HLA-B27 gene neih emaw, risk factor dang neih emaw chuan AS i nei ngei ang tihna a ni lo.
- He natna hi kum naupang, kum 17-45 inkar atanga intan a ni fo thin.
- A bik takin zing lamah hnungzang na leh nghet lo i neih leh chuan hun khawhral suh la, doctor pan rawh.
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