Alzheimer natna lo awm hmasa ber pawh i nei ve em? A chanchin hi i zir chiang ang u!

"Aw, tunlai hian engkim ka theihnghilh vek tawh" tih hi a chang chuan i ngaihtuah thin em? A nih loh leh, i ṭhian pakhat hriatrengna emaw, nungchang emaw-ah inthlâk danglamna tê tê i hmu em? Heng thilte hi ngaihtuahawm tur a ni lo mai thei. Amaherawhchu, i upat hma pawha heng thilte hi a la thleng chhunzawm zel a nih chuan tlem tal i enchian a tha. Heng thu hriat hian tlem a tibuai thei a, mahse a pawimawh ber chu hei hi hriat chian a ni.

Early-Onset Alzheimer’s Disease hi eng nge ni?

A awlsam zawngin, Early-Onset Alzheimer’s Disease (EOAD) hi Alzheimer natna chi khat a ni a, kum 65 hnuai lam atanga lo awm a ni a, doctor-te chuan young-onset Alzheimer’s disease an ti \hin. A tam zawkah chuan heng symptoms te hi kum 45 leh 64 inkar ah a lang hmasa ber thin.

Alzheimer natna hi neurodegenerative natna a ni a . Chu chu hun kal zelah kan thluaka cell awmte tichhe leh tichhetu natna a ni tihna a ni. Hei hi dementia , hriatrengna leh finna hloh zauh zauh chhan ber a ni. Mahse, Alzheimer vei zawng zawng zinga 1% aia tlem chuan early onset dementia (EOAD) an vei a ni.

A tirah chuan, nangmah leh nangmah inthlâk danglamna chu hriat harsa i ti mai thei. Mahse, i hnaih berte chuan, i chhûngte leh i ṭhiante ang bawkin, i hriat loh theih loh inthlâk danglamna fiah lo tak takte chu an hmu thei a ni. I hriatrengnaah, i ngaihtuahnaah emaw, nitin hnathawhnaah emaw danglamna i hmuh chuan doctor pan nghal rawh.

Alzheimer’s natna lo awm tan tirh lamah engte nge a lan chhuah?

Alzheimer natna awm tawhte chhinchhiahna hi Alzheimer natna pangngai nen a inang hle. A danglamna ber chu heng natna lan chhuah tan kum hi a ni. Hetiang dinhmun hian rilru lama theihna a tlahniam zauh zauh (progressive cognitive decline) . Chumi awmzia chu thluak a chhiat deuh deuh chuan hun kal zelah a natna lanchhuahna chu a zual zel tihna a ni.

A tirah chuan heng symptoms te hi nangmah ngeiin hriat harsa i ti mai thei. Mahse, i hmangaih tak takte, i chhungte chuan heng inthlâk danglamna tenau te hi an hre mai thei. Nangmah emaw, i rintlak emaw hian heng dementia symptoms te hi i hriat chuan doctor nena inbiakna neih a pawimawh hle.

He dinhmun (EOAD) hian mi zawng zawng a nghawng dan inang lo. Mahse a tlangpuiin, i:

• Hriatrengna
• Ṭawng thiam - tawng thiam leh ziak thiam
• Reasoning thiamna
• Nungchang leh mize
• Spatial awareness - Entirnan, space hriatthiamna.

(EOAD) Symptoms hi a tlangpuiin a nasat em avangin a intan a, hun kal zelah a na zual zel bawk. A tir lamah chuan heng ang inthlak danglamna tenau te hi i hmu mai thei:

• I nungchang emaw, i mizia emaw inthlak danglamna (a bik takin a hma aia thinrim, moody, emaw moody zawk) .(A pung mai thei.) Ngaihtuah teh, tûn hmaa mi rilru hahdam tak takte chu tûnah chuan thil tê tê avângin a thinrim a ni.
• Thusawi emaw, ziak emaw huna thu dik tak zawn harsat . I kâ aṭangin thu a chhuak lo ang maiin a lang.
• Hriatrengna hloh (entir nan, mi hming, hmel emaw, chutih laia thil thleng emaw theihnghilh). Shopping list rawn ken tura an tih kha i theihnghilh fo thin em? A nih loh leh inbiak laia i sawi tur chu i theihnghilh nghal mai em?
• A tlangpuiin awlsam taka i tih theih tur harsatna chu chinfel a harsa hle .
• Thupek pek ni mah se (recipe ang chiah chiah chaw siam ang chi) , tih tur ngaihtuah a, thutlukna siam chu a harsa thei hle
• Vision, balance, leh coordination lama harsatna (furniture-ah i tlu reng emaw, i tlu reng emaw pawh a ni thei).

A hnuah chuan natna lan chhuahna na zawk i hmu thei a, chungte chu:

• I awmna leh engtin nge i thlen theih tih theihnghilh .
• Chu aia pawi zawk chu hriatrengna hloh (hun rei tak chhunga i hriatrengna hmun thenkhat pawh i theihnghilh theihna tur khawpa) hi a ni.
• Hmangaihte (i hriat chian em em i tihte pawh) rinhlelhna leh rinhlelhna .
• Thusawi leh inbiak thiamna a chanve (or complete) hloh .

Alzheimer’s natna lo awm tan tirh chhante chu engte nge ni?

Alzheimer natna a thlen hma chhan ber chu thluaka protein awm dan pangngai lo vang a ni a, a bik takin protein chi hnih amyloid leh tau an tih te hi a ni.

Kan thluak hian nerve cell maktaduai tam tak a nei tih i hria a, chu chu neurons . Heng nerve cell te hi ngaihtuahna, zir, hriatrengna leh ruahmanna siam tura min puitu an ni. Chuvângin, amyloid protein chu thluak cell chhungah a inzawm khawm a, plaques an tih clump a siam a ni. Tau protein te chu an inzawm khawm a, tangle an siam . Heng plaques leh tangles te hian nerve cell te chu a thawk tha thei lo. An kal tlang electrical leh chemical signal te chu an block thin.

Amyloid leh tau protein te thluaka an lo punkhawm chuan zawi zawiin nerve cell te an that thin. Hei hi Alzheimer natna lan chhuahna thlentu chhiatna nghet tak thlentu a ni. Nerve cell te hi thluak hmun khatah an thi tan a, chutah chuan hmun dangah an darh leh thin. A tam zawkah chuan EOAD hi kan hriatrengna thununtu thluak hmun - hippocampus -ah a intan thin.

Mithiamte chuan heng protein te hi engvangin nge an lo insiam tih hriat tumin an la bei mek a ni. Researcher te chuan he proteins build-up hi symptoms a lan hma rei takah a thleng thin niin an ngai. Kum 10 vel pawh a rei thei a, chu chu symptoms i neih tan hmain a ni.

Alzheimer natna lo awm hma hi genetic a ni em?

Ni e, a hun hmaa Alzheimer natna hi genetic condition a ni.A theih a ni. Heng (Early-Onset Alzheimer’s disease ) dinhmun tam zawk hi chromosome 1, 14, emaw 21-a genetic changes nen a inzawm tih hmuhchhuah a ni a, tin, (APOE e4 gene) tih gene neih hian a hlauhawmna a tipung bawk. Mahse (APOE e4) gene nei zawng zawng hian Alzheimer’s an vei vek dawn lo. Risk tipung thei thil pakhat chauh a ni.

Alzheimer natna hi chhungkuaah pawh a kal thei bawk. Chumi awmzia chu i nu leh pa emaw, i unaute emawin he natna hi an neih chuan i vei theihna a sang zawk tihna a ni. I unau pahnih emaw, i nu leh pa pahnih emaw pawhin an neih chuan i risk chu a sang zawk a ni.

Risk factors chu engte nge ni?

He kum aia hmaa Alzheimer natna lo awm chhan hi zirchiangtute chuan an la zirchiang mek a ni. Risk factor thenkhat chu:

• Chhungkaw hnai tak (nu leh pa, unau) ah Alzheimer natna vei.
• Environmental factors (i chenna, hnathawhna, emaw i tlawh fona hmuna thil awm).
• Lu hliam na tak (traumatic brain injury) .
• Meizial zuk.
• I hriselna zawng zawng.

Hriselna lama harsatna thenkhat chuan Alzheimer’s vei theihna a tipung thei a, chung zingah chuan:

• Lung leh thisen zam natna
• Zunthlum
• Down syndrome avanga lo awm (Trisomy 21) .
• Thisen sang a sang
• Cholesterol sang tak a ni
• Thau lutuk

Alzheimer’s natna lo awm tan tirh hian eng harsatna nge a thlen?

Alzheimer natna lo awm tan tirh lama harsatna lian ber chu i thluak a tihchhiat vang a ni. I ngaihtuahna te, i taksa i hman dan te, leh i mizia te chu a tidanglam reng thei a ni. Natna a zual zel chuan harsatna i tawk thei a, chung zinga ṭhenkhat chu nunna atana hlauhawm thei a ni.

Hengte hi harsatna (complication) anga ngaih theih a ni:

• Taksa hriselna zawng zawng a tlahniam.
• Infection (entir nan , pneumonia emaw vun natna emaw).
• Seizures a awm thin .
• Thâwk harsa.
• Chaw ei harsat.

I taksa i thunun theih loh hunah chuan:

• Bedsores te chu .
• Dehydration emaw ei leh in tha lo emaw .
• Tlu, ruh tliak, leh hliam na tak dangte.
• Urinary incontinence leh bowel incontinence te a awm bawk .
• Ha hring, ha hring, leh ha lama harsatna dangte.

Engtin nge Early-Onset Alzheimer natna hi hriat theih?

Doctor-te chuan Alzheimer natna an hriat dan ang bawkin EOAD an hmuchhuak bawk. Taksa enfiahna kimchang leh thluak enfiahna an nei bawk.Tichuan, chutiang bawka hriatrengna lama harsatna leh chhinchhiahna dang thlen thei natna dang chu an paih chhuak ta a ni.

I doctor chuan i hriselna leh nitin nun a hriatthiam theih nan zawhna a zawt ang che. Tin, i hriat loh mai thei, mahse i hnaih bertuin a hriat chhuah inthlâk danglamnate pawh an sawipui ang che. I doctor chuan hetiang hi a zawt thei ang:

• I hriselna zawng zawng.
• I damdawi lam chanchin .
• Tunah hian eng damdawi emaw supplement emaw nge i ei mek?
• I rilru put hmang, nungchang leh mize inthlak danglamna.
• I hna pangngai i thawh theihna.

Doctor hian test eng emaw zat a ti dawn bawk a, chungte chu:

• Thil hriatna (cognitive test) te .
• CT scan hmanga tihchhuah a ni .
• Thluak MRI scan hmanga enfiah a ni .
• PET scan hmanga enfiah a ni .
• Thisen test a ni.
• Zun test a ni.

Alzheimer natna lo awm tan tirh atanga hriat chian theihna tur test pakhat mah a awm lo. Mahse, heng test tinte a\anga thu lakkhawmte hmang hian doctor chuan natna dang, chutiang bawka chhinchhiahna awm thei chu a paih chhuak thei a ni.

Alzheimer natna lo awm hmasa ber enkawlna tur engte nge ni?

I doctor chuan i dementia , chu chu hriatrengna leh finna hlohna a ni, a lo zual zel tur tihziaawmna tur enkawlna a rawt ang. Alzheimer natna chi hrang hrang hi damdawi a awm lo . Mahse, enkawlna hian natna lan chhuah dan a thunun thei a, natna zual zel pawh a tikhawlo thei bawk.

A hma thei ang bera enkawl tan hi i dam chhung zawnga thluak hriselna vawn thatna tha ber a ni. Mahse, tuna enkawlna engmah hian thluak chhiatna emaw, hriatna tlahniam emaw chu a tidanglam thei lo.

I doctor chuan EOAD tan hian standard Alzheimer’s treatment a pe mai thei. Hetiang damdawi hi i mamawh mai thei:

• (Cholinesterase inhibitor) te hi a tha hle.
• (Donanemab) a ni.
• (Lecanemab) tih a ni.
• (NMDA dodaltu te) .

Aducanumab hi EOAD enkawlna thar tak a ni. Mithiamten an la zirchiang mek a ni. Thluaka amyloid protein awmkhawm chu a ti tlem a ni.

Symptom bik control nan damdawi

I doctor pawhin symptom thenkhat control nan damdawi a pe thei bawk. Entir nan:

• Antidepressants : Heng damdawi te hian lungkhamna, hahdam lohna, rilru natna, leh lungngaihna te a tidam thei a ni.
• (Antipsychotics (neuroleptics)) : Hengte hian paranoia, hallucinations, leh agitation a thlen thei.Chutiang thil chu enkawl theih a ni.
• (Antiseizure damdawi) : Heng damdawi te hian a chang chuan mood swing a tidam thei.

Clinical trial neih a ni

Scientist te chuan EOAD leh a enkawl dan tur an zirchiang reng a ni. I doctor hnenah clinical trial i tanpui thei tur a awm em tih zawt rawh. Hengte hi test emaw zirchianna emaw, Alzheimer natna lo awm tan tirh lama volunteer-te telna a ni. Chûngte chuan enkawlna thar, a la hman tam lohte chu enchhin theihna hun a pe thei che a ni.

Alzheimer’s natna vei hmasa berte dam rei zawng chu engzat nge ni ang?

Premature Alzheimer natna hian mi tin a nghawng dan a inang lo. Mi thenkhat chu kum sawm tam tak chhung an dam a. Midangte chu an natna hmuhchhuah atanga kum 10 chhungin an thi bawk. Eng chen nge i dam theih ang tih hi thil hrang hrangah a innghat a ni:

• I rilru theihna a tlahniam zel (cognitive decline) .
• Natna i vei tih hmuhchhuah a nih lai khan i kum.
• I hriselna zawng zawng leh natna dang i neih theih apiang.

Alzheimer natna lo awm hmasa ber hi Alzheimer natna pangngai aiin a zual chak zawk tlangpui. Hei hian kum 65 hnua natna hmuhchhuah tawh aiin natna khirh tak tak i nei hma thei tihna a ni a, i doctor nen early-onset Alzheimer’s disease (EOAD) nena nun chungchang sawipui rawh. Ani chuan thiltum leh beisei tûr dik tak siam tûrin a ṭanpui thei che a ni.

Engtin nge Alzheimer’s natna lo awm hmasa ber vei nun danah i insiamrem?

Alzheimer natna lo awm hmasa ber nena nun chu a harsa tak zet thei a ni. Alzheimer natna (EOAD) vei hmasa berte chu hna an la thawk tlangpui a, chhungkaw naupang tak tak, naupang tê tê nei pawh an nei thei bawk . Hei hian Alzheimer natna pangngai nei te’n an neih loh harsatna a thlen thei a ni. Hei hi harsatna tak tak a ni thei a, mahse, he zinkawngah hian nangmah chauh i ni lo tih hre reng ang che.

I hnathawhna hmuna i mamawh service zawng turin dikna i nei a ni. I doctor chuan i tanpui thei tur thil dang a hrilh thei bawk che a ni. I natna lan chhuah dan a zual hmain hmalam hun tur ruahmanna i siam tan thei ang. Entirnan, advanced directives , legal leh financial plans te ngaihtuah i duh mai thei.

Puihna i mamawh chuan rilru lam hriselna lama mithiamte biak rawh . It’s very common for people with early-onset Alzheimer’s disease leh an chhungte chuan extra stress, anxiety, and sadness , a bik takin an hmuhchhuah hnuah. Chu rilru put hmang chu a tak tak leh dik tak a ni a, mahse i nun a thunun a ngai lo. Mental health professional chuan i ngaihtuahna leh rilru put hmang hriatthiamna leh i hmachhawn theih nan a pui thei che a ni.

Engtikah nge Doctor ka hmuh ang?

I hriatrengna emaw, i ngaihtuahna emaw-ah harsatna i neih chuan doctor pan nghal rawh .

I doctor hnenah check-up neih fo a ngai dawn a ni. I dinhmun kal zel dan a enfiah ang a, a tul angin i enkawlna chu a siamrem ang.

I doctor hnenah hetiang zawhna hi i zawt thei bawk ang:

• Ka chhungte leh kei hian eng symptom emaw, inthlak danglamna emaw nge kan ngaihven tur?
• He natna hi engtiang chiahin nge a lo zual zel dawn tih sawi lawk theih dan a awm em?
• Ka tan enge inenkawlna tha ber?
• Hetiang dinhmunah hian ka chhungte insiamrem thei tur khawtlang tana thil tangkai tak tak i rawn rawt thei ang em?

Mi zawng zawng hian a chang chuan thil tenawm tak tak an theihnghilh vek a, a nih loh leh an inbiak laiin an sawi tur chu an theihnghilh nghal vek a ni. Thil ngaihtuah tur a ni lo. Nang aia i rilru leh taksa hrechiang an awm lo. Mahse, i hriatrengna emaw, i ngaihtuahna emaw a danglam nasa hle tih i ngaihtuah a nih chuan—a bîk takin a thleng thut a nih chuan—doctor pan rawh.

Chuti a nih chuan, he thuziak a\ang hian in lama kan hruai duh berte chu engte nge ni?

Early-Onset Alzheimer’s Disease hi natna khirh tak a ni a, kum 65 hnuai lam pawh a nghawng thei a, a hmaa a lan chhuah dan , hriatrengna hloh, thumal hmuh harsa, leh nungchang inthlak danglamna te i hriat chuan doctor thurawn lak nghal a pawimawh hle

Hetiang dinhmun hi damdawi awm lo mah se , a hmaa hriatchhuah leh enkawl hian natna lan chhuah dan a thunun thei a, natna zual zel pawh a tikhawtlai thei bawk. Nangmah chauh i ni lo tih hre reng ang che. He harsatna hi i hmachhawn theih nan nang leh i chhungte tanpui theitu doctor te, rilru lam hriselna lama mithiam te, leh support group te an awm a.

I thluak hriselna hi enkawl rawh. Inthlâk danglamna i hmuh chuan ngaihthah suh.

` Alzheimer's, theihnghilh, hriatrengna, thluak natna, thluak lam natna, dementia, EOAD