I mit hmuhna inthlak danglamna, mit na, emaw, i taksa peng hrang hranga rilru hah emaw, chak lohna emaw i hmu nghal em? Thil dang pawh a ni thei. Vawiinah hian kan ramah hian a awm ve lo hle a, mahse a fimkhur a pawimawh hle a ni. Chu chu Neuromyelitis Optica Spectrum Disorder , a tawi zawngin NMOSD a ni. Hei hi autoimmune disease a ni a, i mit leh i ruhro a nghawng ber a ni.
NMOSD chu eng nge ni? Engtin nge Enspryng hian hna a thawh?
A awlsam zawngin, NMOSD chu i taksa ngeia immune system, natna laka min humhimtu system-in a tihsual avanga i cell hrisel tak takte a rawn beih tan hi a ni. A bik takin, i taksa chuan i nervous system-a protein bik pakhat `aquaporin-4 (AQP4)' tih laka antibody a siam tan a.
He attack hian i optic nerve (i mit leh i thluak inkara thuchah kengtu nerve) leh spinal cord vel ah inflammation, a nih loh leh inflammation a thlen ber a ni. Hei hi a kal zel chuan mitdelna leh kal harsatna a thlen thei a ni.
NMOSD hi damdawi a la awm lo. Treatments te hi inflammation tihziaawmna, symptoms control , leh relapses venna tur a ni ber.
Hei hi Enspryng a lo lut a, Enspryng hi biologic medicine thar a ni. He damdawi hian NMOSD lo kir leh lo turin a pui thei a, a bik takin i thisenah a hmaa kan sawi tawh anti-AQP4 antibodies i neih chuan.
Enspryng hian kan taksaa protein dang ``interleukin-6 (IL-6) tih chu block-in hna a thawk a ni.`` A chhan chu he protein IL-6 an tih hian anti-APQ4 antibodies avanga inflammation lo awmah pawh a tel ve bawk a ni. Chuvangin IL-6 block a nih chuan inflammation a tlahniam a, symptoms a control a, natna hi a reh thei bawk.
| A nghawngna hmun leh a dinhmun | Symptoms hriat theih te |
|---|---|
| Mit lam natna (Optic Neuritis) a ni |
|
| Transverse Myelitis natna a ni |
He damdawi hi engtin nge ka hman ang?
Enspryng hi vun hnuaia injection a ni a . A tlangpuiin pum hnuai lam emaw, kekawr hmalam lai emaw-ah pek thin a ni.
- Injection hmasa pathum chu kar hnih danah pek tur a ni.
- Chumi hnuah chuan thla khatah vawi khat chauh i hit a ngai a ni.
Heng injection te hi i lak ngai ni dik tak hriat reng a pawimawh hle. Calendar-ah emaw, i phone-ah emaw hriattirna set rawh. Injection i miss a nih chuan i doctor nen eng nge i tih tur tih chu i sawipui ngei tur a ni.
Lungngai suh, i doctor chuan he injection hi i in pek dan tur te, khawiah nge i pek tur tih te, a vawi khatnaah site thlak dan tur te a zirtir ang che. Injection i pek hmain i kut chu uluk takin silfai fo ang che.
Engtin nge damdawi chu ka dahkhawm ang?
He damdawi hi fridge ah dah tur a ni . Mahse freezer-ah dah suh. Tin, damdawi chu vawt suh. Damdawi chu injection hma minute 30-ah la chhuak la, room temperature-ah dah rawh. Damdawi hi microwave-ah emaw, tui lum hmangin emaw tihlum ngai suh.
Enspryng i ei laiin vaccine i dawn tur eng pawh doctor nen inbiakna neih a pawimawh. He damdawi ei lai hian vaccine thenkhat hi a tha lo.
Engtin nge he damdawi hi zirchian a nih?
Enspryng hi a him leh him loh enfiah nan zirchianna lian tak pahnih neih a ni tawh bawk. Hengte hian Enspryng hi placebo nen an khaikhin a, damdawi active ingredient nei lo a ni. Hei hi damdawi chu a hlawkpui tak tak em tih kan hriat theih tak tak hunah a ni.
He zirchiannaa tel zawng zawngte hian NMOSD an nei vek a, relapses history an nei a, Expanded Disability Status Scale (EDSS)-ah score 0 leh 6.5 inkar an nei a, hei hi an disability level tehna scale a ni. (EDSS score 0 chuan rualbanlo a awm lo tihna a ni a, 6.5 chuan kea kal theihnaah harsatna engemaw zat a awm tihna a ni.)
He zirchianna hian a bik takin natna hi a lo awm leh theih nan eng chen nge a ngaih tih a en a ni. Hei bakah hian natna tehna `Visual Analog Scale (VAS)` leh hahna tehna `Functional Assessment of Chronic Illness Therapy (FACIT)` tihdanglamna te ngaihven a ni bawk.
Research atanga chhuak chu eng nge ni?
Zirchianna pahnihah hian Enspryng ei thin damlote chu placebo ei thinte aiin relapse an nei tlem zawk tih a chiang hle. Hei hian Enspryng hian i symptoms leh relapses zat a tihtlem thei tihna a ni.
Mahse, anti-AQP4 antibodies nei lo damlote chuan Enspryng hi placebo nena khaikhin chuan an hlawkpui lo hle.
| Anti-AQP4 antibodies nei damlote zingah relapse rates | ||
|---|---|---|
| Zirchianna | Enspryng category ah hian a awm | Placebo group a ni |
| Research 1 (Enspryng chauh) 1.1. | 20% chu a lo let leh ta a ni | 43% chu a lo let leh a ni |
| Zirna 2 (Damdawi dang nena Enspryng) 1.1. | 30% chu a lo let leh ta a ni | 50% chu a lo let leh ta a ni |
Mahse, hengte hi research result a ni tih hre reng ang che. I result pawh a danglam thei. Nang leh i doctor hian he damdawi hi i tan a tha em tih leh a hlawknain a hlauhawmna aiin a tam zawk em tih chu in rel dun tur a ni.
Side effects a lo awm chuan engtin nge kan enkawl ang?
He damdawi hian side effect a neih tam ber chu hnar leh kawr natna, lu na, luak chhuak, vun vun rawng, gastritis, hahna, leh ke ruh emaw ruh natna te a ni. Heng zinga pakhat tal i neih chuan doctor hnenah hrilh rawh.
Infection awm thei te
Enspryng ei lai hian natna tlanglawn emaw, natna khirh tak emaw vei theihna a sang deuh hlek a ni. Infection i neih chuan i doctor hnenah hrilh rawh. Tin, a hnuaia symptoms te hi i neih chuan doctor hnenah hrilh nghal bawk ang che:
- Khawsik, taksa na, khawsik, ril na, khuh chhunzawm zel
- Vun sen emaw, vun hring emaw
- Pum natna, ril\am
- Zun laiin kang emaw, zun a ngai fo emaw
Bawl
Damdawi i ei laiin vun natna i neih chuan doctor hnenah hrilh rawh. I taksaah vun a darh nghal a nih chuan damdawi in emergency room (ETU)-ah kal nghal rawh.
Hengte chauh hi side effect awm thei a ni lo. I rilru tibuaitu symptom i neih chuan i doctor nen sawiho rawh.
Enkawl tan hma leh enkawl lai hian eng test nge tih tur?
Enspryng i tan hmain i doctor chuan thisen test eng emaw zat a nei ang a, i liver function, hepatitis B, tuberculosis, emaw infection dang emaw a enfiah ang. Heng test te hi enkawl laiin tih nawn leh a ngai mai thei. Chuvangin i test te hi a hun taka tihsak a pawimawh hle.
Damdawi dangah harsatna a awm thei em?
Enspryng leh ei leh in emaw damdawi dang emaw inkara inzawmna lian tham a awm lo. Mahse, i damdawi ei zawng zawng (condition dang damdawi, vitamin, herbal remedies, leh supplement te pawh telin) i doctor hnenah hrilh a pawimawh. Hei hian duh loh zawng side effects a awm loh nan a pui thei a ni.
Take-Home Thuchah a ni
- NMOSD hi natna awm lo mahse na tak a ni a, i immune system hian i mit leh i spinal cord a bei thin.
- Enspryng hi damdawi thar a ni a, a bik takin anti-AQP4 antibodies nei damlote tan relapses tihziaawmna a ni.
- Hei hi vun hnuaia injection a ni. Doctor hnen atanga training mumal tak dawn a pawimawh hle.
- Damdawi dang i ei zawng zawng leh enkawlna chhunga a side effect awm apiang chu i doctor hnenah hriattir nghal rawh.
- Doctor thurawn tel lo chuan enkawlna titawp ngai suh, a dose pawh thlak ngai suh.
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