Kan sipai ngei, kan taksa natna laka humhim tura ngaih kan immune system , hian rang takin kan hrethiam lo va, kan taksa peng tha tak takte chu kan rawn bei tan a nih chuan eng nge thleng ang tih han ngaihtuah teh? Chu chu chutiang natna hmuh tur awm lo mahse na tak tak, Goodpasture Syndrome an tih chu a ni. He natnaah hian kan taksa hriselna hian kan taksa peng pawimawh ber pahnih, lung leh kal a tichhe ber a ni . Hei hi hriat chian a pawimawh hle a, a chhan chu hriatchhuah leh enkawl vat loh chuan nunna atana hlauhawm a ni thei a ni.
Goodpasture Syndrome hi eng nge ni tak tak?
A awlsam zawngin Goodpasture Syndrome hi autoimmune natna a ni. Chu chu kan taksa invenna system, immune system chu haywire-in a kal a, mahni cell leh tissue te chu a bei tihna a ni.
He natnaah hian immune system hian kan lung leh kal (kidney)-a awm protein bik collagen , dotu antibody a siam a. He collagen hi kan taksa peng hrang hrang inzawmkhawmtu glue angin han ngaihtuah teh. Chuvangin heng antibodies te hian chu collagen chu an beih chuan lung leh kal te chu nasa takin a chhe tan thin.
Hei hi natna awm lo tak ni mahse, a lan chhuah veleh hriat chian a, enkawl tan a pawimawh a, chuti lo chuan a rah chhuah chu a na hle thei a ni.
Eng thilin nge hetiang dinhmun hi a thlen?
Kan immune system hian hetiang hian a taksa peng hrang hrang a beih sual chhan hi doctor-te chuan an la hre chiang lo hle. Mahse, thil engemaw zat a awm nia ngaih a ni.
- Genetic influence : He natna hi chhungkaw thenkhatah a kal avangin genetic predisposition a awm thei niin an ngai.
- Environment factors: Chemical thenkhat , hydrocarbon solvent leh herbicides paraquat ang chi te nena inzawmna.
- Metal dust: Metal dust-a awm reng.
- Ruihhlo: Cocaine ang chi ruihhlo hman.
- Meizial zuk: Zuk leh hmuam hi hei hi a hlauhawmna lian tak a ni.
- Viral infection: He natna hi virus infection thenkhat hnuah a awm thei.
He natna hi tlangval zingah hmuh tam ber a ni a, a bik takin kum 20 leh 30 inkar leh kum 60 chunglamte zingah a langsar ber.
Eng nge a lan chhuah dan? Engtin nge hei hi i hriat chian?
He natna hi a tir lamah hian a lan chhuah dan tlangpui, chiang lo tak tak a lang thin. Chuvangin a chang chuan thil pawi tak angin a lang lo mai thei. Mahse he dinhmun hi a kal chak hle.
Heng symptoms te hi eng nge an nih tih chu a hnuaia table hi en la.
| Mihring ziarang chi khat | Symptoms hmuh theih a awm |
|---|---|
| Initial leh common features te |
|
| Lung a nghawng chuan | |
| Kidney a nghawng chuan |
He natna hian lung atanga nunna atana hlauhawm thisen chhuak thei mahse, hun rei tak chhunga lung chhiatna hi a tlem ber tlangpui. Mahse, he natna avanga thil thleng pawi ber chu kal (kidney failure) a ni . Chutiang a nih chuan dam chhung zawng dialysis emaw, kal thlak emaw i mamawh mai thei.
He natna hi engtin nge doctor hian a hriat theih ang?
Kan sawiho tawh symptom pakhat emaw a aia tam emaw i neih chuan tihkhawtlai suh . Doctor pan vat rawh. A bik takin thisen i khuh a, thawk harsa i tih emaw, i zun a thisen i pass emaw a nih chuan emergency a ni.
Doctor chuan a natna hriat chian nan test eng emaw zat a ti thei ang:
- Urinalysis: He test hian zun chhunga protein leh thisen sen (red blood cells) a tam em tih a enfiah thin. Hei hian kal (kidney) a chhiat leh chhiat loh hriat theih nan a pui thei a ni.
- Thisen test: I thisenah hian lung leh kal (kidney) beitu antibodies bik a awm leh awm loh enfiah thin a ni.
- Chest X-ray: Hei hian lung tihchhiatna a zawng thei a, chu chu thisen chhuahna avanga hmun dum danglam tak tak te hi a ni.
- Biopsy: A chang chuan kal emaw lung emaw atanga tissue te tak te la chhuakin microscope hmangin an enfiah thin. Hei hian Goodpasture Syndrome antibodies a awm leh awm loh leh kal (kidney) a chhiatna engzat nge a thlen tih a nemnghet thei a ni.
Hei hi eng enkawlna nge ni?
He natna hi hriatchhuah a nih veleh enkawlna chu rang tak leh nasa takin tan a ngai a ni. Enkawlna tum berte chu:
- Antibody tha lo dona.
- Taksa chhunga tui tam lutuk awm zat control.
- Thisen sang control dan tur.
- Lung leh kal chhiatna tihtawp.
Enkawlnaah hian a tlangpuiin a hnuaia mite hi a tel thin:
1. Immunosuppressive drugs: Damdawi cyclophosphamide leh corticosteroid ang chi te pek thin a ni. Heng damdawi te hian kan taksa hriselna (immune system) hnathawh a tihtlem bakah antibody tha lo siam chhuah a titawp a ni. A châng chuan lung chhunga thisen chhuak control nan steroid dose sang tak chu thisen kal tlanga pek a ngai thei bawk.
2. Plasmapheresis: Hei hi a buaithlak deuh deuh a ni. A awlsam zawngin, i thisen tlemte lak a, machine bik-a dah a, antibody tha lo tak tak awmna liquid part, plasma an tih chu thliar hran a ngai a ni. Tichuan, thisen hmun tha la awm (red leh white blood cells) te chu plasma substitute dang nen an pawlh a, i taksaah an rawn let leh thin. Hei hian thisen atanga antibody hlauhawm tak takte chu a paih chhuak thin. He enkawlna hi nitin kar engemaw zat chhung tih a ngai mai thei.
He enkawlna hian thla 6 atanga thla 12 chhung a daih thei. A dam kim theih nan kar tlemte atanga kum hnih chhung a ngai thei. Hetih lai hian damlo thenkhat chuan supplemental oxygen emaw ventilator emaw pawh an mamawh thei. Thisen pek pawh a ngai mai thei.
Take-Home Thuchah a ni
- Goodpasture Syndrome hi a awm lo hle a, mahse a na hle a, kan taksa hriselna (immune system) hian lung leh kal (kidney) a bei thin.
- Thisen khuh, thawk harsa, zun chhunga thisen, taksa vulh te hi vaukhânna chhinchhiahna pawimawh tak a ni.
- Heng symptoms te hi i neih chuan tihkhawtlai suh la , doctor pan nghal rawh . Enkawl tan hma chuan a rah a tha zawk.
- Enkawlnaah hian immune system control thei damdawi leh thisen tithianghlimtu plasmapheresis ang chi hmanrua te a tel a ni.
- Nangmah emaw, i hriat miin emaw he thil chungchangah hian rinhlelhna emaw zawhna emaw i neih chuan i doctor nen zalen takin sawipui rawh.
Goodpasture Syndrome Sinhala, lung natna, kal natna, immune system, autoimmune natna sinhala, khuh thisen, thisen zun
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