I kut zungtang chu a lian a, i nail a danglam tawh em? He Hypertrophic Osteoarthropathy chungchang hi i zir chiang ang u!

I kut zungtang emaw, i ke ruh emaw chu a danglam bik hle a, i nail te chu a hnuai lam emaw, a pianzia danglam tak emaw a ni tih i hmu ngai em? A chang chuan hengte hi kan ngaihven vak lo. Mahse, heng symptoms te hi i hmuh chuan ‘Hypertrophic Osteoarthropathy’ tih natna chhinchhiahna a ni thei. Hei hi a tawi zawngin HOA an ti bawk. Chu dinhmun ngei pawh chu chutiang chuan a hlauhawm lo va, a chhan bulpui dangte chuan enkawl a ngai mai thei. Chuvangin, he HOA chungchang hi chipchiar takin sawi ila, i zir belh leh ang u.

Hypertrophic osteoarthropathy (HOA) hi eng nge ni?

A awlsam zawngin sawi ila, hypertrophic osteoarthropathy (HOA) hi i kut zungtang emaw ke ruh emaw tip a hring a, a round (clubbing) a, i nail a tidanglam thin. HOA vei chuan:

• Kut zungtang emaw ke ruh emaw tip chu a lianin a hring chhuak thin .
• Nail te chu a hnuai lam hawiin a inher a, a hrual ang maiin a inher chhuak a.

HOA hi a chang chuan naupan lai emaw, tleirawl lai emaw atanga tan theih a ni. Mi thenkhat tan chuan nakin lawkah pawh a lo thang lian thei bawk. HOA ngei pawh hi a hlauhawm lo nain, a chhan bulpui (underlying condition) a awm chuan enkawl a pawimawh hle.

Hei hi eng chi hrang hrang nge ni ber?

HOA hi chi hnih a awm a, chungte chu:

1. Primary Hypertrophic Osteoarthropathy (PHO): He chi hi genetic a ni a, nu leh pa atanga fate rochun theih a ni tihna a ni.

2. Secondary Hypertrophic Osteoarthropathy (SHO): He chi hi natna khirh tak tak, lung natna leh lung natna avanga lo awm a ni. Heng dinhmunte hian i thisenah oxygen level a tihhniam fo thin.

He natna hi tuin nge vei tam zawk?

Dik tak chuan tu pawhin, mipa leh hmeichhia emaw, hnam emaw thliar lovin, he natna hi hypertrophic osteoarthropathy an tih hi an nei thei a ni.

Mahse, primary HOA (PHO) hi kum khatna emaw, tleirawl lai emaw a lo lang tlangpui. PHO dinhmun: 1.1.

• Mihring dum zingah a tam zawk.
• Mipaah ​​a tam zawk.

Secondary HOA (SHO) hi kum 55 leh 75 inkar mite zingah hmuh tam ber a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Researcher te chuan HOA vei hi engzat nge awm tih chiang takin an sawi thei lo. Mahse HOA vei zinga 95% leh 97% inkar chuan secondary type (SHO) an nei tih hriat a ni. Chumi awmzia chu mi tam zawk chuan heng kut zungtang inthlak danglamna hi natna dang vangin an nei tihna a ni.

Engvangin nge he HOA hi din a nih? A chhan engte nge ni?

Hei hi eng thil nge a thlen tih i lo en ang u.

Primary HOA (PHO) neih chhan te 1.1.

Hei hi pian tirh atanga genetic mutations awm vang a ni . Naupang chuan he genetic mutation hi nu emaw, pa emaw, an pahnih emaw aṭangin a rochun thei a ni.

Secondary HOA (SHO) neih chhan te 1.1.

Secondary HOA (SHO) thlentu ber chu lung natna a ni . Hetiang dinhmun hi lung natna avanga lo awm a nih chuan Hypertrophic Pulmonary Osteoarthropathy (HPOA) an ti a ni.

HPOA thlen thei lung natna ber chu lung cancer a ni a , a bik takin non-small cell lung cancer a ni. Tin, lung natna dang HPOA thlen thei te chu:

• Pleura-a fibrous tumor tha lo (benign fibrous tumor) a awm thin
• Lung infection rei tak awm thei
• Cystic Fibrosis (genetic natna, thawkna kawng tichhe thei) .
• Mesothelioma (lung chhunga cancer natna) .
• Hmun dang a\anga lo darh chhuak, lung natna (Metastatic lung disease) .
• Pulmonary arteriovenous malformation (lung chhunga thisen kalna kawng dik lo) .
• Pulmonary Tuberculosis natna a ni
• Sarcoidosis (taksa hmun hrang hranga cell inzawmkhawm) .

Secondary HOA (SHO) tichhe thei thil dang pawh a awm a:

• Liver, bile, leh gallbladder natna (hepatobiliary conditions): 1.1.
• Biliary Atresia (Naupang Tleirawlte Bile Duct tihkhawtlai) .
• Ngawt
• Cirrhosis natna (liver) a awm
• Primary Biliary Cholangitis natna a ni
• Wilson natna (taksa chhunga copper awm khawm) .
• Lung natna: 1.1.
• Atrial myxoma (cancer nei lo tumor, thinlunga lo awm) .
• Cyanotic Heart Disease (thinlung natna, thisenah oxygen tlahniam) .
• Thinlung chhungril lam natna (Infective Endocarditis) .
• Gastrointestinal dinhmun: 1.1.
• Laxatives hmansualna
• Achalasia (esophageal sphincter hnathawh dan lama harsatna) .
• Ngawt
• Familial Adenomatous Polyposis (intestine lian tak chhunga lo thang te te) .
• Inflammatory Bowel Dise natna a awm thei

Hei bakah hian natna dang engemaw zatin SHO a thlen thei bawk:

• Celiac Disease (gluten allergy) vang a ni thei.
• Intestinal infection, dysentery ang chi te pawh a awm thei
• Graves natna (hyperthyroidism) natna a ni.
• Hyperthyroidism natna (Hyperthyroidism) a awm
• Myelofibrosis (ruh ruh natna) .
• POEMS syndrome tih hi a ni
• Thymoma (thymus gland-a natna hrik awm) .

Ngaihtuah teh, i hriat mi pakhat chu hun engemaw chen a khuh a, an kut zungtang te chu hetiang hian a inthlak a, doctor an hmuh hnuah chauh lung lam harsatna a ni tih an hmuchhuak ta a ni. Chuvangin heng symptoms te hi ngaihven a pawimawh hle.

HOA natna lan chhuah dante chu engte nge ni?

HOA chhinchhiahna ber chu kut zungtang emaw ke ruh emaw a club emaw, a hring emaw a ni. Hei hian taksa sir lehlamah inang tlangin a nghawng tlangpui. Hetiang thil hi i hmu mai thei:

• Kut zungtang emaw ke ruh emaw tip chu a hring a , a round bawk .
• Kut zungtang bula joint-a wrinkles te chu a bo vek tawh.
• Nail te chu hnuai lam hawiin a inher a, a inphah ang maiin a lang.
• Nail bul lama vun chu a eng a , a hring bawk .
• Nail te chu a nem ta hle mai .
• Kut zungtang emaw ke ruh emaw tip chu a sen a , a lum hle .

HOA feature dang i hmuh theihte chu:

• Glandular hypertrophy a awm thei. Hei hian hmai vun, thawk hah lutuk (hyperhidrosis), mitmeng chunglam tlak (upper eyelid ptosis), leh seborrheic dermatitis te ang chi natna a thlen thei a ni.
• Periostitis chu ruh khuh tu membrane inflammation a ni. Hei hian ke ruh, kutphah, khup emaw a ti na thei a ni.
• Ke ruh nêm tak takte a hring (non-pitting edema).
• Ankles leh wrists ah ruh a thim thin.
• Vun a thim (Pachydermia). Hmai leh lu vun vun chu a hring thei a, hruihrual thuk tak a nei thei bawk.

Secondary HOA (SHO) hian eng thil bik nge a neih?

A hmaa kan sawi tawh HOA symptoms tlangpui bakah hian secondary HOA (SHO) vei te pawhin joint effusions an nei thei bawk . Hei hi ruh chhung leh a chhehvela tissue-a extra fluid a lo awm hian a ni. Joint effusions hian hetiang hian a thlen thei:

• Na
• A sen hring
• Stiffness a awm
• Vung

SHO nena inzawm joint swelling hi khup leh kutphah ah hmuh tur a tam ber .

Engtin nge hei hi i hmuh? Doctor-te hian eng test nge an tih?

Doctor i pan dawn chuan an tih hmasak ber tur chu i kut zungtang emaw i ke ruh emaw ah clubbing a awm leh awm loh an enfiah thin. Chu bakah, taksa enfiahna neih chhungin a hnuaia mite hi an zawng bawk ang:

• Hmai lam chu a rough tawh em?
• I ke a hring tawh em?
• I ke ruh, khup emaw, i kutphah emaw i press hian natna a awm em?
• Ankles leh wrists ruh te hi a thick em?

Doctor chuan HOA an tih natna a rinhlelh chuan test engemaw zat a ti thei a, chungte chu:

• Lovibond-a profile-a a hming chu:I kut zungtang chu a sir atanga i en chuan "V" ang chi angle zau tak i hmu tlangpui a, chutah chuan nail plate leh nail bul lama skin fold (proximal nail fold) a inhmu a ni. HOA i neih chuan i nail chu hnuai lam hawiin a ben a, hei hian he angle hi a ti sang a ni. Nail pangngaiah chuan he angle hi 160 degree aia tlem a ni. Clubbed nail-ah chuan 180 degree emaw a aia sang emaw a ni.
• Phalangeal depth ratio: I kut zungtang pakhatah ruh (phalanges) pathum i nei a. Nail chelhtu ruh (distal phalange) hi a kianga ruh (middle phalange) aiin a tawi zawk tlangpui. HOA i neih chuan i middle phalange chu i distal phalange aiin a tawi zawk.
• Schamroth chhinchhiahna: I kut zungtang (index fingers) nail te chu dah khawm la. Nail bul leh cuticles inkarah hian diamond ang maia gap (window) zawng rawh. Gap a awm loh chuan HOA i nei ngei ang.

Secondary HOA (SHO) hriat theihna turin test dang neih belh a ni.

Doctor chuan damdawi lam dinhmun dangin HOA a thlen nia a rinhlelh chuan test dang engemaw zat a rawt thei ang:

• Angiography (thisen kalna kawng enfiah) .
• Arterial thisen gas test a ni
• Thisen test a ni
• Ruh scan a ni
• Chest X-ray neih a ni
• CT scan (Computed Tomography scan) emaw ultrasound scan (Ultrasound) emaw hmanga tih theih a ni.
• Echocardiogram emaw, Electrocardiogram (EKG) emaw hmanga tih theih a ni.
• MRI Scan (MRI - Magnetic Resonance Imaging) hmanga tihchhuah a ni.
• Pulmonary function testing neih a ni

Heng test te hian i doctor chu i HOA chhan a hriat theih nan a pui thei a ni. Scan-a a lo thang dan pangngai lo (tumor ang) a lan chuan i doctor chuan biopsy (cell sample lak a, test) a rawt thei bawk. Hei hian a lo thang lian chhan dik tak hriat theih nan a pui ang.

Hei hi engtin nge enkawl a nih?

HOA chi hrang hrangah enkawl dan a inang lo.

Primary HOA (PHO) enkawl dan tur .

Natna i neih loh emaw, i natna lan chhuah dan a na lo emaw a nih chuan primary HOA (PHO) tan hian enkawlna bik i mamawh lo mai thei. Mahse, symptom i neih chuan damdawi te chu i hmang thei mai thei a, chungte chu:

• Non-steroidal anti-inflammatory drugs (NSAIDs) hmanga enkawl theih a ni.
• COX-2 inhibitor te hi a ni
• Bisphosphonates a awm bawk
• Octreotide a ni

Secondary HOA (SHO) enkawl dan tur .

Secondary HOA (SHO) enkawlnaah chuan a bulpui ber enkawl hi a ni . Enkawlna atan hian:

• Tuberculosis enkawlna atana antimicrobial therapy hman a ni
• Lung cancer enkawl nan Chemotherapy hman a ni
• Liver grafts emaw liver transplant emaw hmanga liver natna awm thei
• Cystic fibrosis natna vei tan lung transplant surgery neih a ni
• Lung tumor tan radiofrequency ablation (tumor tihchhiat nan lumna hmanga) .
• Lung natna emaw, lung cancer emaw avanga surgery neih a ni

SHO thlentu underlying condition chu enkawl theih a nih loh chuan doctor chuan a symptoms control nan damdawi a rawn rawt thei a ni.

Enkawlna atanga dam leh theih nan eng chen nge a duh?

Hei hi HOA i neih chi hrang hrang, i natna nasat dan leh i enkawlnaah a innghat tak zet a ni. A hnuaia natna awm chu enkawl a nih chuan clubbing hi a bo thuai thei.

Hetiang thil lo thleng tur tihtlem nan hian kan tih theih tur a awm em?

Primary HOA (PHO) hlauhawmna a awm

PHO hi genetic a nih avangin a siam chhuah tihtlem nan engmah tih theih a awm lo.

Secondary HOA (SHO) hlauhawmna a awm

SHO vei theihna tihtlem nan nunphung hrisel zawm a pawimawh hle . Hei hi thinlung natna emaw, lung natna emaw vei theihna i neih chuan a pawimawh hle. I tih theih ṭhenkhat chu hetiang hi a ni:

• Rihna hrisel tak vawn reng.
• Thinlung hrisel ei leh in.
• Exercise neih fo thin.
• Zu leh ruihhlo hman tlem.
• Meizial zuk bânsan. Hei hi a pawimawh hle a, a chhan chu meizuk hi lung natna tam tak thlentu lian tak a ni.
• Stress tihziaawmna.

HOA neitu tan chuan hmalam hun eng nge awm ang?

Primary HOA (PHO) nei tan chuan .

PHO hi a mah chauhin a chhe zual zel mai thei. A châng chuan, a bîk takin tleirâwl hnuah pawh a ṭha vek thei bawk.

Secondary HOA (SHO) nei tan chuan .

A chhan bulpui chu hlawhtling taka enkawl a nih chuan a natna chu a dam vek thei a ni. Mahse, a chhan bulpui ber chu hlawhtling taka enkawl theih a nih loh chuan (entir nan, cancer na tak) chu natna chu a awm reng thei a ni.

HOA dinhmun hi rei tak a daih chuan eng nge thleng ang?

HOA dinhmun hi rei tak a lo awm tawh a nih chuan hetiang hi i tawng mai thei:

• Joint-a range of motion hloh
• Osteoarthritis (ruh natna) 1.1.
• Na

Mahse, heng natna lan chhuahna tam tak hi enkawlna dik tak hmanga thunun theih a ni tih hre reng ang che .

HOA a awm chuan engtin nge i in enkawl ang?

HOA i vei chuan i tih theih tha ber chu i natna lan chhuah dan control nan enkawlna pek che kha i ei chhunzawm zel hi a ni. Doctor thupek zawm a pawimawh hle.

Engtikah nge doctor i hmuh ang?

Heng thilte hi i fimkhur tur a ni:

• Enkawl hnuahClubbing symptoms a lo lang leh a nih chuan doctor pan tur a ni. Hei hian a hnuaia dinhmun lo awm lehna a tilang thei a ni.
• Enkawlna atanga side effects awm tur chungchangah ngaihtuahna i neih chuan .
• Hun engemaw chen enkawl ni mahse hmasawnna hmuh tur a awm loh chuan .

Chutiang hunah chuan i doctor chuan i tana ṭha tur enkawlna dang a rawn rawt thei a ni.

Thupui: Hriatreng tur (Take-Home Message) .

Okay, kan sawi tawh kha tawi te tein han sawi nawn leh ila.

Hypertrophic osteoarthropathy (HOA) hi kut zungtang tip a hring a, nail a deformed a ni. Primary (genetic) emaw secondary (natna dang avanga lo awm) emaw pawh a ni thei. Secondary HOA thlentu ber chu lung leh lung natna a ni.

• A lan chhuah dan: Kut zungtang a hring, ke ruh nail a lo thang lian, ruh na, vun a thim.
• Diagnosis: Medical examination, special test (Lovibond, Shamroth scores), leh scan hmanga a chhan bulpui zawn.
• Enkawl dan: PHO tan chuan a natna lan chhuah dan azirin damdawi pek thin a ni. SHO tan chuan a bulpui ber chu natna hnuaia awm enkawl hi a ni.
• A pawimawh ber: I kut zungtangah danglamna i hmuh chuan ngaihthah suh la, damdawi lam thurawn la rawh. A chhan chu, HOA hi a hlauhawm loh laiin, a bulpui natna thlentu chu a hlauhawm thei a ni.

He thu hi i tangkaipui ngei ka beisei. Hrisel takin awm rawh!

` Hypertrophic Osteoarthropathy, kut zungtang na, nail thlak, PHO, SHO, lung natna, thinlung natna, ruh natna, clubbing