Ankylosing Spondylitis (AS) vanga hnungzang natna damdawi thar: JAK Inhibitors chungchang zawng zawng

Zingkar i thawh veleh i ni chu hnungzang khauh leh natna nen i tan thin em? He natna hi tlem i kal a, thil tangkai tak i tih hian a tlahniam a, i la awm laiin a pung leh thin em? Hengte hi Ankylosing Spondylitis (AS) an tih natna lan chhuah dan tlangpui a ni thei. Hei hi nitin nun tibuaitu dinhmun tibuaitu tak a ni. Hemi enkawlna atan hian doctor-te chuan natna tidamtu (NSAID) an pe hmasa thin. Hengte hian natna an thunun loh chuan biologics an tih injection-ah an hruai thei che a ni. Mahse, mi thenkhat chuan heng enkawlna atang hian hahdamna an hmu lo va, a nih loh leh an side effect te chu tuar harsa tak a ni. Chutiang bawk chu i tawng ve em? Chutiang a nih chuan lungngai suh. Medical science hmasawnna avang hian tunah chuan enkawlna thar leh hlawhtling tak dang a rawn lang leh ta a ni. Chu chu Janus Kinase (JAK) inhibitors a ni . Hemi chungchang hi vawiin hian han sawi ila.

JAK Inhibitor te hi eng nge ni?

JAK inhibitors hi ankylosing spondylitis enkawlna atana damdawi class thar a ni. Biologics ang bawkin damdawi chi khat, disease-modifying antirheumatic drugs (DMARDs) an tih zingah an tel a ni. "Disease-modifying" tih hian heng damdawi te hian natna a tiziaawm mai lo tihna a ni. Tin, ruh leh ruh dangte chhiatna an control bawk a, natna zual zel tur a tikhawtlai bawk.

Mahse hengte hi Ankylosing Spondylitis tan chauh hman a ni lo. Hetiang damdawi hi autoimmune natna dang engemaw zat tan pawh phalsak a ni. Chu chu taksa invenna (immune system) in mahni cell a beih nana natna te a ni.

• Rheumatoid arthritis natna a ni
• Polyarticular course naupang rilru natna (JIA) te hi a awm a.
• Psoriatic arthritis natna a ni
• Ulcerative colitis a awm thei

Ankylosing Spondylitis hi eng chi nge hman thin?

Tunah hian Ankylosing Spondylitis enkawlna atan JAK inhibitor chi hnih phalsak a ni.

• Tofacitinib (brand hming: Xeljanz, Xeljanz-XR) tih a ni a, a man hi a to hle.
• Upadacitinib (brand hming: Rinvoq) a ni.

Hengte hi TNF inhibitor tia koh biologic damdawi pakhat emaw a aia tam emaw hmanga an natna lan chhuah dan control loh, emaw, chu damdawi avanga side effects tuar thei lo damlote hnenah pek a ni tlangpui. Chuvangin, i doctor chuan he damdawi hi a pek hmain i medical history kimchang chu uluk takin a enfiah hmasa ang.

He damdawi hian engtin nge hna a thawh?

Hei hi hrethiam tur chuan entirnan tlem han la ila. Kan taksa invenna (immune system) hi sipai lian tak a ni tih han ngaihtuah teh. Ankylosing Spondylitis ang natnaah hian he sipaite hian thuchah dik lo an dawng a, anmahni ram (kan taksa ngei) ruhte chu an bei tan ta a ni. He attack hian natna leh swelling (inflammation) a thlentu a ni.

Heng thu dik lo thawn thin "messenger" thenkhat an awm. Anni hi JAK enzyme an ti a . Heng enzyme te hi immune cells te chu "go and attack" turin signal petu an ni a, chemicals cytokines an tih te hi an ni.

JAK inhibitor tia koh damdawi te hian an tih chu chu messenger tak tak (JAK enzymes) te chu an block a ni. Hei hian chu thuchah dik lo kal zel chu a titawp a, immune system-in ruhkawr a beih theihna a ti tlem bawk.

Biologic drugs hian hna a thawk dan a danglam deuh hlek a. Biologic hian cytokine bik, TNF emaw IL-17 emaw ang chi chu a target a, a block bawk. JAK inhibitor te hian vawi khatah cytokines tam tak siam chhuah a tikhawlo thin. A awlsam zawngin sawi ila, a tir lamah chuan buaina chu an block thin.

Side effect a awm em?

Damdawi dang ang bawkin side effect a awm theihna a awm. Mahse mi tam zawk tan chuan an him. He damdawi hi i ei tan hma leh i ei lai hian i doctor chuan uluk takin a lo enkawl ang che.

Side effect na tak tak chungchang tlem tal sawi belh leh ila

Heng damdawi te hian immune system a tihbuai avangin taksain natna hrik, bacteria leh virus te a do theihna chu eng emaw chen a tlahniam a ni. Hei hian hri kai theihna a tipung a ni.

Pawimawh: He damdawi hi i ei lai hian vaccine nung lak loh tur a ni. Entirnan, measles, mumps, rubella (MMR), leh rotavirus te hi a ni. Heng vaccine te hian natna a thlen thei che a, a chhan chu chutih lai chuan i immune system a chak lo a ni. Vaccine engmah i lak hmain i doctor nen inbiakna neih hmasak phawt ang che.

Damdawi ka ei tan dawnin eng nge ka beisei ang?

Mi thenkhat chuan he damdawi hi an ei tan atanga kar hnih chhung lek chhungin an natna lan chhuah dan atanga hahdamna an nei tan thin. Mahse, mi thenkhat tan chuan thla 6 vel a ngai thei a, hahdamna famkim an nei thei. Hei hi mi tin a inang lo.

Thla engemaw zat damdawi i ei hnua i rilru a hahdam loh chuan hlauthawng suh la, i doctor nen sawiho la, i tih leh tur chungchangah thurawn la rawh.