A châng chuan i chau hle tih i inhria em? Chutih rual chuan, natna mak tak tak, ruh natna, kut zungtang hring, leh a châng chuan khawsik i neih chuan i kut zungtangte chu a dum leh a sen vek tih te i tawng tawh em? Heng natna lan chhuah dan hi vawi khata lo lang vek hian a tibuai che em? Tichuan hei hi thil awm lo tak, Mixed Connective Tissue Disease, a nih loh leh a tawi zawnga kan sawi angin MCTD an tih pawh a ni thei. Ngaihtuah buai suh, he thu hi awlsam takin sawi ila.
MCTD hi eng nge ni tak tak?
A awlsam zawngin MCTD hi autoimmune disorder a ni. Hetiang hian han ngaihtuah teh: kan taksa invenna, immune system hi natna thlentu hrik laka min humhim turin a awm a ni. Mahse he natna chi hrang hrangah hian kan defence system ngei pawhin kan taksa hrisel tak takte hi hmelma angin a ngai sual a, kan bei tan ta a ni.
MCTD danglamna chu natna pakhat a ni lo va, connective tissue natna lian dang pathum symptoms inzawmkhawm a ni zawk. Chuvangin "Mixed" tih a ni. "Overlap syndrome" an ti bawk. Natna pathumte chu:
- Systemic lupus erythematosus (SLE): Hei hi ‘lupus’ kan ti tlangpui.
- Scleroderma: Hei hian vun a ti thim a, a ti khauh bawk.
- Polymyositis: Hei hian taksa ruh a tichak lo va, a ti na bawk.
Mi thenkhat chuan heng natna bakah hian dermatomyositis, rheumatoid arthritis, emaw Sjögren’s syndrome ang chi natna lanchhuahna an nei thei bawk.
MCTD natna lan chhuah dante chu engte nge ni?
Vawi tam tak chu heng symptoms te hi vawi khatah a lang vek lo. Hun kal zelah a hnungzuiin an rawn lang chhuak thin. Chuvangin, a tir lamah chuan MCTD hi hriat chian a harsa thei hle.
| Symptom a ni | A sawifiahna awlsam tak |
|---|---|
| Chau leh nunna nei lo anga inhriatna | Chhan awm lovin a chau hle tih hriat reng reng. I taksa chu nunna nei lo ang maia inhriatna. |
| Taksa lumna (fever) . | Khawsik sang tak a ni lo va, taksa lumna tlemte chauh a ni. |
| Muscle leh ruh natna | Muscle na leh chak lohna, leh ruh hring, khauh tak tak natna nen. |
| Raynaud-a phenomenon chu a ni | Hei hi mi tam tak tan chuan a lan chhuah dan tlangpui a ni. Khawsik emaw, stress hnuaia awm emaw a nih chuan kut, ke, hnar leh beng kawngkhar-a thisen kal chu a tlahniam a, chu chuan rang takin a rawn sen a, a rawn sen leh ta a ni. Tichuan an rawn sen leh a, an dinhmun pangngaiah an kir leh ta a ni. Hetih hun chhung hian i rilru a buai emaw, i na emaw a ni thei. |
| Kut zungtang a hring chhuak | Kut zungtang chu a hring a, a hring bawk. A chang chuan hei hi ni engemaw zat hnuah a bo thin a, mahse hun kal zelah mi thenkhat chuan vun khauh tak tak an nei thei a, chu chuan an kut zungtang ben harsa (sclerodactyly) a ti thei. |
| Vun rawng a awm | Knuckles-ah hian a sen emaw, a sen emaw, a hring emaw a awm emaw, a hliam emaw a awm. |
MCTD a flare hian engtin nge a awm?
He natna vei te hian a chang chuan symptom na tak tak an nei thei a. Hei hi ‘flare-up’ kan ti a. Hetih hun chhung hian ruh natna leh taksa ruh na hi tuar theih loh khawpin a awm thei a ni. `Rheumatoid arthritis` vei ang bawkin ruhte chu a hring thei a, a nghet thei a, a na thei bawk. `Raynaud-a phenomenon` hi a thleng fo thei a, a na zawk bawk.
MCTD hi eng thilin nge a thlen?
He natna thlentu dik tak hi hriat chian a la ni lo. Direct-a rochun natna a ni lo. Mahse, zirchianna chuan chhungkaw zinga mi pakhatin connective tissue natna a neih chuan midangte chu an vei theihna tur hlauhawmna engemaw chen an nei tih hmuhchhuah a ni. Hei bakah hian virus thenkhat, chemical `polyvinyl chloride` leh `silica` te nena inhmuhna te pawhin hetiang hi a thlen thei nia rinhlelh a ni bawk.
He natna vei theihna hlauhawm ber chu tute nge ni?
MCTD hi hmeichhia kum 20-40 inkar ah a tam ber.A inkar ah chuan. Mahse chu chu mipa emaw, kum dang emaw pawhin an hmu thei lo tihna erawh a ni lo. Tu pawhin, kum eng pawh ni se, he natna hi an vei thei a ni.
MCTD avanga harsatna awm thei te chu engte nge ni?
MCTD hi a chang chuan harsatna lian tham a thlen thei a, chuvangin he natna hi thunun reng a pawimawh hle.
Mi zawng zawng hian heng harsatna zawng zawng hi an nei vek dawn lo tih hre reng ang che. Chung zinga tam tak chu uluk taka enkawl chuan ven theih a ni.
Harsatna lian ber ber thenkhat chu hetiang hi a ni:
- Pulmonary hypertension: Hei hi MCTD vei zingah thihna thlentu lian ber a ni. Chu chu lung lama thisen phurtu thisen kalna kawng hrang hranga pressure a san chuan a thleng thin.
- Interstitial lung disease: Lung chhunga tissue te a inflammation leh scarring awm thin.
- Lung natna
- Kidney a chhiat phah
- Digestive tract tihchhiat a ni
- Thisen tlakchhamna (Anaemia).
- Tissue thihna (necrosis) 1.1.
- Hriatna hloh
Engtin nge doctor hian MCTD hi a hriat theih ang?
Kan sawi tawh ang khan he natna lan chhuah dan hi hun kal zelah a lo lang zauh zauh avangin hriat a harsa thei hle. MCTD a nih leh nih loh hriat nan kum tam tak a ngai thei. Heng symptoms te hi i neih chuan, ruh leh autoimmune natna lama tui doctor, rheumatologist tia koh hnenah hruai i ni mai thei.
Doctor pakhat chuan MCTD rinhlelhna tur thil pawimawh pali a zawng a:
1. Thisenah anti-U1-RNP antibodies a tam: Hei hi MCTD hriat theihna atana test ber a ni.
2. Kidney emaw central nervous system emaw lama harsatna na tak nei lo: Heng harsatna hi lupus (SLE) vei te tan chuan a na thei tlangpui.
3. Arthritis na tak leh pulmonary hypertension awmna: Hengte hi lupus emaw scleroderma emaw ah chauh hmuh tur a awm lo.
4. Raynaud-a phenomenon leh kut zungtang a hring: Heng symptoms te hi lupus vei zinga 25% chauh ah a awm thin.
MCTD enkawlna tur engte nge ni?
MCTD hi damdawi a la awm lo. Mahse, i natna lan chhuah dan thunun thei tur, harsatna lo thleng tur venna tur leh nun pangngaia nunpui thei tur enkawlna tha tak tak a awm nual. Enkawlna chu i natna lan chhuah dan nasat dan leh eng taksa peng nge a nghawng tih te a innghat a ni.
| Ruihhlo chi hrang hrang | Hman tumna |
|---|---|
| Corticosteroid hmanga tihdam theih a ni | Ex: Prednisone hman a ni. Taksa chhunga inflammation tihziaawmna leh immune system hnathawh tihtawp. |
| Malaria dona damdawi | E.g. Hydroxychloroquine hmanga siam a ni. Flare-ups ven la, symptoms na lo tak tak control bawk. |
| Calcium channel blocker a ni | Raynaud-a phenomenon chu control rawh. Chungte chuan thisen kalna kawngkhar chhunga ruh (muscles) te chu a ti hahdam a ni. |
| Immunosuppressant dangte pawh a awm bawk | Organ lian ber ber (lung, thinlung ang chi) a nghawng chuan immune system kha khauh takin control rawh. |
| Antihypertensive damdawi hman tur | Pulmonary hypertension control tur a ni. |
Mahni inenkawl turin eng thil nge i tih theih ang?
Damdawi ei bakah hian i nunphungah inthlak danglamna tenau te siam hian heng natna lan chhuahnate hi thunun theihna kawngah nasa takin a pui thei a ni.
- Painkiller hman dan: Natna leh hliam na lo tak tan chuan non-steroidal anti-inflammatory drugs (NSAIDs) Ibuprofen ang chi i ei thei a, i doctor i zawh hnuah .
- Khawsik laka invenna: Hei hi Raynaud-a phenomenon ven nan a pawimawh hle. Khaw lum laia chhuah dawnin gloves leh earflaps vuah thin ang che. Tui lum leh refrigeration tam lutuk nena inhnaih loh tur.
- Meizial zuk loh tur:Meizial zuk hian thisen kalna kawng a tikhawtlai thin. Hei hian Raynaud-a chu a ti na zual thei. Chuvangin zu i in a nih chuan bansan a pawimawh hle.
- Stress tihziaawm: Stress hian Raynaud-a phenomenon hi a tichhuak thei bawk. Chuvangin thawk lak exercise leh meditation ang chi thil hmangin i rilru tihlum tum ang che. A tul chuan mental health counselor tanpuina zawng rawh.
Engtikah nge Doctor i hmuh a ngaih?
A hmaa kan sawi tawh ang khan symptoms i neih chuan, a bik takin nitin hnathawhna tibuaitu a nih chuan doctor pan a tha. Muscle emaw joint na thar i neih chuan, i kut zungtang a hring a, Raynaud’s symptoms i neih chuan doctor pan a, enfiah tir a tha ber.
Doctor hnena zawhna i zawh theih ṭhenkhat chu:
* Ka natna lan chhuah chhan hi eng nge ni?
* Connective tissue natna pakhat aia tam ka nei em?
* Eng test nge ka tih ngai?
* He natna hi eng enkawl dan nge ni?
* Flare-ups ven nan eng nge ka tih theih ang?
He natna nena nun hi a chang chuan a harsa thei hle. Mahse enkawl dan dik leh nunphung dik tak nen chuan i nung tha thei ang. I doctor nen inzawmna nei reng la, i ngaihtuahnate chu tlang takin sawi rawh.
Take-Home Thuchah a ni
- MCTD hi natna buaithlak tak, hmuh tur awm lo tak a ni a, natna engemaw zat symptoms a inzawm khawm tir thin.
- A lan chhuah dan chu a hnu pakhatin a lo lang a, chuvang chuan natna dik tak hriat theih nan hun engemaw chen a la ngai thei a ni.
- He natna hi tihdam kim theih ni lo mah se, a natna lan chhuah dan thunun theih a ni a, harsatna lo thleng tur ven theih a ni a, nun pangngaia nun theih a ni bawk.
- Khawsik laka invenna te, zu in loh te, leh stress control te hian symptoms tihziaawmna kawngah kawng thui tak a zawh a ni.
- I dinhmun chungchang hi doctor nen sawiho fo la, test leh enkawlna dik tak chu chhunzawm zel rawh. Nangmah chauh i ni lo!
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