Pelger-Huet Anomaly chungchang pawh hriat i duh em? Kan sawi dawn nia!

Thisen test i neih lai khan i thisen var (white blood cells)-a inthlak danglamna tlemte chungchang hi doctor-in a hrilh tawh che em? Pelger-Huet Anomaly pawh a ni thei. A hming hi thil lian tak angin a lang thei a, mahse lungngai suh , a tlangpuiin chutiang chuan a pawi lo. Hemi chungchang hi chipchiar deuhin, a awlsam zawngin sawi ila.

Pelger-Huet Anomaly hi eng nge ni?

A awlsam zawngin sawi ila, Pelger-Huet Anomaly (PHA) hi genetic condition a ni a, kan taksaa thisen var chi khat neutrophils a nghawng a ni. Neutrophils te hi kan taksaa sipai te te ang mai an ni a, kan taksain natna hrik a do theih nan a pui thin.

Hetiang dinhmun hi kan DNA a inthlak danglam vang a ni a, a bik takin Lamin B Receptor (LBR gene) an tih gene a inthlak danglam vang a ni. He LBR gene hi neutrophil cells te lo thanglian leh thang tha tura puitu a ni.

Tunah chuan en teh, neutrophil cell tin hian control center an nei a, chu chu nucleus kan ti a ni. He nucleus hian cell hnathawh leh thanlenna atana a mamawh DNA information zawng zawng a keng tel vek a ni. A tlangpuiin neutrophil hrisel tak nucleus hi hmun thum emaw a aia tam emaw ah then a ni. Mahse, Pelger-Huette vei mi pakhata neutrophil nucleus hian hmun hnih a nei a. Dumbbell ang mai a ni a, a sir lehlamah thau a awm a, a laiah chuan a hring hring bawk. A tlem hle a, mi thenkhatah chuan he neutrophil nucleus hi oval-shaped, chu chu egg ang chi a ni thei.

Mahse hetah hian thil pawimawh tak chu Pelger-Huette anomaly neia piang i nih pawhin a tam zawkah chuan i neutrophil cells te hian hna an thawk dan pangngaiin an thawk thin. Chumi awmzia chu natna laka invenna kawngah nasa takin an tlahniam lo tihna a ni. Chuvangin hriselna lama harsatna lian tham a thlen tlem hle.

Thil dang pakhat chu Pseudo Pelger-Huet Anomaly (PPHA) tih a ni. Hei hi mi thenkhatah chuan nakin lawkah a thleng thei a ni. PPHA hi damdawi thenkhat side effect angin emaw, natna dang, infection ang chi symptom angin emaw a awm thei bawk.

Pelger-Huette anomaly natna lan chhuah dan chu engte nge ni?

Hetah hian a hmaa kan sawi tawh chi hnih hi kan ngaihtuah a ngai a ni.

Hereditary Pelger-Huet Anomaly (HPA) atanga lo chhuak a ni.

Pelger-Huette anomaly (HPA) i neih chuan, chu chu inherited a ni a, a tlangpuiin symptoms i nei lo. Chu natna chu i nei tih pawh i hre lo mai thei. A tlangpuiin chhan dang avanga thisen test an tih hian accident-in a hmuchhuak thin.

A rilru a buai em em a, a rilru a hah em em bawk a. Pseudo Pelger-Huet Anomaly (PPHA) .

Mahse, pseudo-Pelger-Huette anomaly (PPHA) i neih chuan, chu chu a hnuah a lo awm tihna a ni a, a chhan bulpui (underlying condition) nena inzawm symptoms i nei thei a ni.Entirnan, PPHA hi natna hrik avanga lo awm a nih chuan chu natna nena inzawm khawsik leh taksa na ang chi symptoms a awm thei.

Eng thilin nge Pelger-Huette anomaly hi a thlen?

Hei hi a chhan pawh a hmaa kan sawi tawh chi hnih a zirin a inang lo.

Hereditary Pelger-Huette anomaly (HPA) atanga lo chhuak a ni.

Hei hi a hmaa kan sawi tawh ang khan Lamin B Receptor (LBR) gene-a mutation awm vang a ni. He LBR gene hian kan taksa chu neutrophil cells venhimna atana mamawh protein siam tur leh an pianzia dik tak pe turin a hrilh a ni. Pelger-Huytt anomaly-ah chuan he genetic mutation hian chu process chu a tibuai a, chu chuan neutrophils nuclei te chu chu dumbbell angin a siam ta a ni. Hei hi nu leh pa atanga fate rochun theih dinhmun a ni.

A rilru a buai em em a, a rilru a hah em em bawk a. Pseudo Pelger-Huette anomaly (PPHA) .

Hei hi genetic condition a ni lo. Hetiang dinhmun thlentu hi thil engemaw zat a awm a:

• Bone marrow natna: Entirnan, leukemia natna, myelodysplastic syndrome leh acute myeloid leukemia (AML) te hi a ni.
• Infection thenkhat: a bik takin tick-borne diseases.
• Immunosuppressants: Heng damdawi, natna thenkhat atana pek thin te hi a chhan pawh a ni thei.
• Radiation exposure: Entirnan, cancer enkawl lai hian.

Doctor-in `PHA` emaw `PPHA` emaw i nei tih a hrilh che chuan i damdawi ei zawng zawng, vitamin pawh hi doctor hnenah hriattir a pawimawh hle.

Hetiang dinhmun hi engte nge ni?

Pelger-Huette anomaly (PHA) vei theihna tur risk factor ber chu he natna nei nu leh pa dik tak neih hi a ni. Hei hian a awmzia chu i nu emaw i pa emaw hian PHA a neih chuan 50% velin i rochun theihna chance i nei tihna a ni. Coin flipping ang mai a ni a, chiang takin i sawi thei lo, mahse a thleng thei.

`PPHA` dinhmun tan chuan a hmaa kan sawi tawh damdawi lam dinhmun emaw enkawlna emaw nena inzawmna hi risk factor a ni.

Hetiang dinhmunah hian harsatna a awm em?

A tlangpuiin hereditary Pelger-Huette anomaly (PHA) hian harsatna lian tham a thlen lo. A chhan chu, i neutrophil cells te hmel chu tidanglam mahse, an hnathawh danah nasa takin a tidanglam lo. Hrik an do chhunzawm zel a ni.

Mahse, pseudopelgar-huwat anomalous (PPHA) i neih chuan a chhan bulpui (leukemia ang chi) hian harsatna a thlen thei a ni. Chuvangin, he thu hi i doctor nen inbia a, beisei tur hriat a pawimawh.

Engtin nge doctor-te chuan Pelger-Huette anomaly hi an hriat theih?

Doctor-te chuan he natna hi hriat theih nan thisen test an hmang ber a ni. A bik takin, .Test pakhat peripheral blood smear an tih chu an ti thin. He test hi i thisen sample drop khat lak a, glass slide-ah te te tein theh darh a, microscope hmanga en a ni.

Hei hi pathologist emaw hematologist emaw in an enfiah thin.

Pelger-Huette anomaly i neih chuan he test hian i neutrophil cells nuclei pianzia danglam tak (dumbbell ang chi) chu chiang takin a tarlang ang.

Pelger-Huette anomaly hi enkawlna a awm em?

Hetah hian chanchin lawmawm chu a awm e! Hereditary Pelger-Huette anomaly (PHA) hian a tlangpuiin symptom a nei lo va, chuvangin enkawlna bik a ngai lo. Hetiang dinhmun hi nei mah la, nun pangngaiin i nung thei a ni.

Amaherawhchu, `PPHA` chungchangah chuan a bulpui natna thlentu enkawl a pawimawh. Chu natna chu a dam tawh chuan `PPHA` dinhmun pawh a reh thei bawk.

Engtikah nge Doctor ka hmuh ang?

Pelger-Huette anomaly i vei tih i hriat chuan, natna lan chhuahna thar (khawsik, hahna nasa tak, natna hrik kai fo ang chi) i neih chuan doctor hnenah hrilh ngei ang che. Chumi hnuah chuan i doctor chuan a natna lan chhuah dan chu `PHA`, `PPHA`, emaw thil dang nen a inzawm em tih a hre thei ang.

Doctor hmu tura i kal dawnin heng zawhnate hi zawh a tha bawk ang:

• Hereditary `(HPA)` emaw pseudo `(PPHA)` emaw Pelger-Huette anomaly ka nei em?
• Ka fate hian he dinhmun hi an rochun thei ang em? (HPA a nih chuan)
• Doctor hi engzat nge ka hmuh ang?
• Eng symptom nge ka hriat bik tur?

Hetiang dinhmun hi eng nge ka beisei ang?

Pelger-Huette anomaly (PHA) ngei pawh hian natna a thlen lo va, i nunah danglamna lian tham a thlen lo. A tlangpuiin i nitin hnathawhna a nghawng lo.

Mahse, he natna (a bik takin `PPHA` chi) i neih chuan, a hnuaia hriselna dinhmun dang chhinchhiahna a ni thei. Chuvang chuan doctor ten an buaipui a ni. I doctor-in `PHA` emaw `PPHA` emaw i neih a rinhlelh chuan a tul angin test an ti ang a, chubakah damdawi lam thil dang tih loh nan hma an la bawk ang.

Pelger-Huette anomaly (PHA) i nei a, symptom i neih loh avangin i hre lo mai thei. "Min tibuai lo a nih chuan engvangin nge ka ngaihtuah pawh ka ngaihtuah?" He cell mutation bik avang hian natna i nei lo mai thei tih hi a dik a ni. Mahse, i doctor hnenah hriattir a pawimawh. I doctor chu hriselna atana pui turin a awm reng a ni. Tin, i taksaa heng thil tenawm tak takte hriat hian a pui bawk. Pelger-Huette anomaly i neih vang mai mai chu thil dang pakhat chauh a ni a, chu chuan "nangmah" a siam che a ni. Ngaihtuah buai tur a ni lo.

Thupui tawi (Take-Home Message) 1.1.

Okay, chuvangin kan sawi tawh thenkhat kha han recap leh ila:

• Pelger-Huet Anomaly (PHA) hi genetic condition a ni a, thisen var chi khat neutrophils nucleus pianzia dik lo tak a siam a ni.
• Hei hi a tlangpuiin a hlauhawm lo va, symptom a awm lo. Neutrophil cell te hian hna an thawk dan pangngaiin an thawk thin.
• Hei hi chi hnih a awm a, chu chu `HPA` a ni a, chu chu rochun a ni a, `PPHA`, a hnu lama natna dang emaw, damdawi dang emaw avanga lo awm a ni.
• HPA hian enkawl a ngai lo tlangpui. PPHA chungchangah chuan a chhan bulpui ber chu enkawl a ni.
• He natna hi thisen test (peripheral blood smear) hmanga hriat theih a ni.
• Hetiang dinhmun hi i nei tih i hriat chuan lungngai suh. Mahse, i doctor nen sawiho la, a tul anga thurawn la rawh. Symptom thar a lo lang chuan doctor hnenah hriattir rawh.

He thuziak hian Pelger-Huette anomaly chungchanga i zawhna tam zawk chu a chhang ngei ka beisei. Hriselna lama harsatna eng pawh nei ila, i doctor nen zalen taka inbiakna neih a tha ber tih hre reng ang che.

` Pelger-Huet Anomaly, Neutrophils, Thisen Var Cells, Genetic Diseases, Thisen Test, PPHA, HPA