I thisen kalna kawngah harsatna i nei em? Polyarteritis Nodosa chungchang hi i zir dawn teh ang!

A chang chuan kan nunah hian kan hriat ngai loh natna kan hre fo thin a ni lawm ni? Awle, vawiinah hian natna chi hrang hrang kan sawi dawn a, mahse, kan zavaia kan hriat chian a pawimawh hle. Hei hi Polyarteritis Nodosa , a tawi zawngin PAN an ti a. He hming hi i la hre ngai lo mai thei. Mahse chu chu a pawi lo, i hriatthiam theih tur awlsam takin engkim kan sawi dawn a ni.

He Polyarteritis Nodosa hi eng nge ni?

A awlsam zawngin sawi ila, polyarthritis nodosa (PAN) hi kan taksa chhunga thisen kalna kawngte a lo hring, a nih loh leh a lo hring chhuak thin a ni. Damdawi lamah chuan hetiang thisen kalna kawng hring hi vasculitis an ti a. Hetiang dinhmunah hian PAN hian kan taksaa thisen kalna kawng lian lo (medium-sized blood vessels) a nghawng ber a ni.

Hetiang hian han ngaihtuah teh: kan taksa pum puia thisen kalna kawngte hi tui pipe ang mai a ni. Heng pipe te hian kan taksa peng hrang hrangte mamawh oxygen leh nutrient te an phur a. Chuvangin, heng thisen kalna kawngte hi a lo hring chhuak a, tui pipe a inkhar ang bawkin, chu taksa peng hrang hrangah chuan thisen a kal tha lo hle. Tichuan, chu taksa peng hrang hrangte hnathawh chu a tichhe thei a, a châng chuan a tawp vek thei bawk.

Hei hian engtin nge thisen kalna kawngte a nghawng?

He PAN dinhmun hian kawng hrang hrangin thisen kalna kawng a tichhe thei a ni:

• Thisen kalna kawngte chu a chak lo thei a, a inzawm thei bawk a, rubber tube hlui ang maiin a inzawm thei bawk. Hei hian thisen kalna kawngte chu balloon ang maiin a tipung thei a, chu chuan aneurysms kan tih ang chi hi a thlen thei a ni.
• Thisen kalna kawng bang chu a chak lo thei a, a puak thei bawk , chu chuan a chhehvel tissue-ah thisen a luang lut thei a ni.
• Thisen kalna kawng a zim thei a , a block vek thei bawk . Chutiang a nih chuan chu thisen kalna atanga thisen dawngtu taksa peng chu oxygen leh nutrients a tlachham ang a, a chhiat phah ang.

A pawimawh ber chu hetianga thisen kalna kawng a chhiat chuan taksa peng chhia te hnathawh chu a tlahniam thei a, a bo vek thei bawk.

PAN hian eng organ nge a nghawng nasa ber?

Polyarthritis nodosa natnain a nghawng theihna tur taksa peng hrang hrangte chu:

• Kidney a ni
• Junction a ni
• Nerves (kan taksa peng hrang hrangte hriatna leh hnathawh dan thununtu) .
• Alimentary tract (intestine ang chi) 1.1.
• Vun
• Muscle te hi a ni

Vawi tam tak chu PAN nei mi pakhatin hmun khat aia tam symptoms a nei ang. Mahse, a tlem hle a, mi thenkhat chuan vunah chauh (cutaneous PAN) symptom an nei thei. Chuti chung pawh chuan doctor-te chuan taksa peng dangte a nghawng em tih an enfiah chhunzawm zel ang che.

Thu lawmawm tak chu polyarthritis nodosa hian a tlangpuiin lungah symptom a siam lo.

Polyarthritis nodosa (PAN) hi engtiang chiahin nge a tlem?

Hei hi a ni tak zet a niNatna hmuh tur awm lo tak a ni. Ngaihtuah teh, America rama mi maktaduai khat zingah hian kum tin mi sawm aia tlem lovin he natna hi an vei tih hmuhchhuah a ni. England ramah pawh hetiang dinhmun hi a ni. Chuvangin hei hi a tlem zia chu i ngaihtuah thei ang.

He natnaah hian eng symptoms nge hmuh theih?

PAN hian taksa peng hrang hrang a nghawng avangin symptoms a inang lo thei hle. A lan chhuah dan tlangpui thenkhat chu:

• Feeling generally unwell: Thil pakhat dik lo anga inhriatna mai.
• Chauhna: Chauhna mai ni lovin, chakna zawng zawng hloh vek tawh anga inhriatna. Zing i harh phei chuan chakna nei tawh lo ang maiin i inhria.
• Zan lama thawmhnaw: Mut laiin thawk hah tam.
• Fever: Chhan awm lova khawsik lo awm.
• Chaw ei chakna hloh leh taksa rihna tlahniam: Chaw ei i duh loh avangin i thau a tlahniam.
• Muscle leh/ emaw ruh natna: A châng chuan, khawsik hi ruh natnain a zui thei a, chu chu tisaah chuan hnim hring ang maiin a awm thei. A nasat em avangin i kal tha thei lo pawh a ni thei.
• Lu na: Hei hi mi zawng zawngah a thleng lova, mi thenkhatah erawh a thleng thei.
• Vun natna: A châng chuan vunah hliam na tak, na tak angin a lang thei a, a nih loh leh ulcer angin a lang thei bawk.
• Pum natna: Pum natna nasa tak a awm nghal thei a, a chang chuan rilru hahna a awm thei bawk.
• Ek leh zun chhunga thisen awm: Hei hi chhinchhiahna pawi tak a nih avangin doctor pan nghal tur a ni.
• Thâwk a tawi.
• A rilru a na.
• Thisen sang a sang.
• Testicles na: Mipain he symptom hi an nei thei.
• Nausea leh luak chhuak.
• Kut emaw ke emaw-a rilru hah emaw, chakna hloh emaw: Hei hi nerve a nghawng chuan a thleng thei.

Heng symptoms pakhat emaw a aia tam emaw i neih chuan hlauthawng lo la, doctor thurawn lak a tha ber.

Polyarthritis nodosa (PAN) hi eng nge a thlen?

Dik tak chuan medical expert-te chuan polyarthritis nodosa hi eng nge a thlen tih chiang takin an la hre lo . Genetic predisposition (chu chu chhungkaw hrang hranga kal thil) emaw thisen lama harsatna hrang hrang nen a inzawm thei niin an ngai.

Mahse, zirchianna atanga a lan dan chuan i immune systemHemi kawngah hian hmun pawimawh tak a chang a ni. Kan taksa hriselna (immune system) hi natna laka kan taksa vengtu sipai ang a ni tak zet a ni. Mahse a chang chuan, he sipaite hian tihsualin anmahni cell-te chu an bei tan thin. Chutiang bawkin PAN-ah pawh immune system hian a thisen kalna kawng leh tissue te a tichhia a, a hring chhuak thin.

Thil dang pakhat chu hepatitis B virus infection (leh a chang chuan hepatitis C infection) vang pawh a ni thei tih hmuhchhuah a ni. Hepatitis B vaccine hman a nih atang khan he PAN natna report hi nasa takin a tlahniam a, hei hi thil tha tak a ni.

Tute nge he natna vei theihna sang zawk? (Risk Factor hrang hrang) 1.1.

Polyarthritis nodosa vei theihna tipungtu risk factor engemaw zat a awm a:

• Hmeichhia aiin mipain he natna hi an vei tam zawk.
• Kum 45 leh 65 inkar mite pawh an hlauhawmna a sang zawk.
• Hepatitis B natna vei te tan .

PAN avanga harsatna awm thei te chu engte nge ni?

He natna hi uluk taka enkawl a nih loh chuan harsatna lian tham thenkhat a awm thei a ni. Chung zingah chuan:

• Aneurysms , chu chu thisen kalna kawng (blood vessel bulges) a ni a, chu chuan i liver leh kidney-a kalna thisen kalna kawng a tichak lo thei a ni. Chungte chu a puak chuan nunna atana hlauhawm tak a ni thei.
• Thisen kalna kawng chhungah thisen zam a lo awm thei (hei hi a tam vak lo).
• Tissue chhiatna hi oxygen leh nutrients tlakchham vang a ni .
• Gangrene hi tissue thihna a ni.
• Heart failure (hei pawh hi a awm lo).
• Kidney failure (hei pawh hi a awm lo).

Chuvang chuan natna lanchhuahna a lan veleh damdawi lam thurawn lak a pawimawh hle.

Engtin nge polyarthritis nodosa (PAN) hi hmuhchhuah a nih?

Doctor chuan polyarthritis nodosa a hriat theih nan thil engemaw zat a hmang a:

• I damdawi lam chanchin: Natna hmasa i neih tawh ang chi thil te, i chhungkuaah hetiang natna hi an nei tawh em tih te.
• Taksa enfiahna: Doctor chuan eng taksa peng nge a nghawng tih leh, chutiang bawka natna dang i neih leh neih loh a enfiah ang che.
• Thisen test a ni.
• Imaging test bik neih a ni.

Diagnostic test te hi engte nge ni?

Doctor chuan hetiang test hi a ti thei ang:

• Thisen test leh zun test: Hengte hian taksaah inflammation a awm em tih emaw, taksa peng eng emaw zat a nghawng em tih ngaihdan engemaw zat a pe thei.
• X-ray hmanga tih a ni.
• CT Angiogram (Computed Tomography - CT angiogram): Hei hian thisen kalna kawngte dinhmun a hriat chian theih nan a pui thei a ni.
• MRA Scan (Magnetic Resonance Angiogram - MRA scans): Hei hi thisen kalna kawng enfiah dan dang a ni.
• Biopsy: Test dangah thil pangngai lo a awm chuan a natna tissue te tak te chu lak a ni a, microscope hmangin an enfiah thin. Hei hian vasculitis hmuhchhuah a nih thu a nemnghet dawn a ni.

Polyarthritis nodosa (PAN) hi engtin nge enkawl a nih?

Polyarthritis nodosa enkawlna ber chu immunosuppressive damdawi a ni a, chu chuan i immune system hnathawh a ti tlem a ni .

Enkawlna tum ber chu thisen kalna kawnga inflammation tihziaawm hi a ni. He inflammation hi a bo a, natna chu control theih a nih chuan doctor-te chuan "remission"-ah i awm tih an sawi a, chu chu natna chu a dam tawh tihna a ni. I dinhmun a ṭhat chhoh zel chuan damdawi ei tur chu tihhniam zauh zauh theih a ni a, a tawpah chuan tihtawp theih a ni.

Damdawi hman chi hrang hrang

PAN hian i taksa peng lian ber ber (entir nan, kal, thinlung, nervous system) a nghawng a nih chuan damdawi chi khat aia tam hman a ngai mai thei. Enkawlna tlanglawn tak takte chu:

• Corticosteroid damdawi, prednisone emaw prednisolone emaw pek theih a ni. Chungte chuan swelling a tihziaawm thuai.
• Chutih rual chuan immunosuppressive damdawi dang, cyclophosphamide te pawh pek theih a ni bawk.

Cancer chi thenkhat nei te chu cyclophosphamide dose sang tak pek an ni. Amaherawhchu, vasculitis vei te chu cancer natna dose pek aiin a let 10 atanga a let 100 in a hniam zawk an pe thin. Polyarthritis nodosa vei tan chuan he damdawi hian immune system a ti hniam a, inflammation a thlen loh nan a titawp a ni.

Cyclophosphamide hi natna remission-a a kal hma loh chuan hman a ni tlangpui a, chu chu thla thum atanga thla ruk vel a ni. Chumi hnuah chuan natna a lo let leh tawh loh nan immunosuppressant dang, methotrexate emaw azathioprine emaw hmangin i thlak thei bawk (maintenance).

He maintenance immunosuppressive damdawi hi i ei hun chhung hi mi hrang hrangah a inang lo. Mi tam zawk chuan he damdawi hi kum khat emaw kum hnih emaw tal an ei a ngai a, chu mi hnuah chuan i doctor chuan zawi zawiin a dose chu a tihtlem ang a, chawlhsan a tum ang.

Mahse, a tlem hle a, i PAN dinhmun hian i nervous system, thinlung, kal, emaw, i intestines emaw a nghawng loh chuan corticosteroid damdawi chauh hmanga hlawkna hmu thei tur mi an awm.

Hepatitis B infection nena inzawm PAN ang chi vasculitis condition nei te chu hepatitis enkawl rawh.Antiviral damdawi pawh pek theih a ni.

Enkawlna avanga side effects te pawh i hrechiang ang u.

Heng immunosuppressive damdawi te hian side effect engemaw zat a nei thei a ni. Entirnan, rilru put hmang inthlak danglam te, natna hrik kai theihna a sang a, a hring (swelling) te. Chuvangin heng side effects te hi ngun taka ngaihven a pawimawh hle. Tichuan, ven theih emaw, tihtlem emaw theih a ni. A châng chuan a tirah chuan damdawi chu i tuar a nih pawhin hun kal zelah side effect a awm thei. Chuvang chuan damdawi lam enkawlna hnuaia awm chhunzawm zel a pawimawh. A then phei chuan damdawi ei i chawlhsan hnuah pawh hun rei tak chhunga nghawng a neih dan tur ngaihtuah a ngai a ni.

I taksa hriselna tichhe thei damdawi i ei hian natna hrik do theihna i neih chu a tlahniam deuh a ni. Chuvangin, flu emaw pneumonia ang chi natna laka invenna tur vaccine lak hi a pui thei hle.

PAN status neia i awm lai hian eng nge i beisei theih ang?

Mi thenkhat tan chuan polyarthritis nodosa hi zawi zawiin a lo awm thin. Mi dangte tan chuan thla engemaw zat chhungin a na hle thuai thei a, nunna atana hlauhawm pawh a ni thei. A bik takin, digestive system, heart, kidney, leh/ emaw central nervous system symptom nei te chuan a nei lo te aiin an thlirna a chhe zawk thei.

Mahse, polyarthritis nodosa hi natna khirh tak, rang tak ni thei mah se, PAN vei tam zawk chu an dam tha hle . I dam leh that dan chu i dinhmun nasat danah a innghat. Mahse, i polyarthritis nodosa hi eng ang pawhin na mahse, enkawl vat leh damdawi lam enkawlna hnai tak i neih chuan remission i hmu thei a ni.

A dam leh hnuah polyarthritis nodosa hi a lo lang leh thei a, a lo lang leh thei bawk . Hei hi a thlen theihna chance hi 10% atanga 40% thlengin a inang lo. Relapse symptoms chu natna hmuhchhuah hmasak ber nen a inang thei a, a danglam thei bawk. Relapse enkawl dan chu natna vei thar tan chuan a inang reng a ni. Polyarthritis nodosa vei tam zawk chu an dam thei.

PAN dinhmun thlirletna

Polyarthritis nodosa enkawlna i hmuh chuan kum nga chhung dam theihna chance 80% tal i nei a ni . Mahse, enkawlna i dawng lo a nih chuan kum nga chhung dam theihna chance chu 15% aia tlem lovah a tlahniam a ni . Hei hian enkawlna pawimawhzia a tilang a ni lawm ni?

Polyarthritis nodosa (PAN) hi ven theih a ni em?

Polyarthritis nodosa vei theihna tur risk factor thenkhat, kum ang chi te hi tihdanglam theih a ni lo. Amaherawhchu, hepatitis B laka invenna tur vaccine a awm a, chu chuan mi thenkhatah PAN a thlen thei a ni. Chuvangin, vaccine lak hian eng emaw chen chu he natna lakah hian a humhim thei che a ni.

Engtin nge ka in enkawl ang? (Mahni inenkawlna) .

Relapse na tak a awm loh nan thil engemaw zat i tih theih a awm a:

• Symptom thar i hmuh veleh doctor hnenah hriattir nghal rawh. Minor chauh pawh ni se, i doctor hnenah hrilh rawh .
• A hun takah doctor hmu rawh (follow-up appointment). I doctor-in a sawi ni-ah chuan checkup turin kal ngei ngei tur a ni.
• Thisen test ang chi monitoring lab test te pawh uluk taka tih tir rawh.

Heng thilte dik taka i tih hian i dinhmun i enfiah thei a, a tul chuan rang takin enkawlna i tan thei bawk.

Engtikah nge Doctor ka hmuh ang?

PAN symptoms thenkhat i nei nia i hriat chuan doctor pan la, thurawn la rawh. Amaherawhchu, i rilru a na a, thawk harsa i tih chuan emergency room-ah kal nghal mai tur a ni. Tihkhawtlai suh.

Doctor hnenah eng zawhna nge ka zawh ang?

I doctor hnenah hetiang zawhna hi zawh a tha ang:

• Eng damdawi nge ka tan a tha ber?
• Min pui thei tur support group a awm em?
• He natna thlentu awm thei hi i hre thei ang em?
• Eng chen nge damdawi hi ka ei a ngai dawn?

Polyarthritis nodosa symptoms leh damdawi ei avanga side effects te hmachhawn hi a harsa thei hle. I dinhmun hrethiam mi i biak a ngai a nih chuan counselor tanpuina zawng hlau suh. Tin, i hriat chian loh thil eng pawh i doctor zawt hreh ngai suh.

A tawp berah chuan take-home message

Polyarthritis nodosa (PAN) hi a awm lo hle a, mahse a na thei hle. Mahse, hlauthawng suh. A pawimawh ber chu he natna hi hriat chian a, a lan chhuah veleh damdawi lam thurawn la a, enkawlna dik tak lak a ni.

Hriat tur chu a hmaa hriatchhuah leh enkawl dan dik a nih chuan PAN vei tam tak chuan an dinhmun an thunun thei a, nun pangngai an hmang thei a ni. Nangmah chauh i ni lo va, i tanpui theitu doctor leh healthcare professional an awm bawk.

He thu hi i tangkaipui ngei kan beisei! Hrisel takin awm rawh!

` Polyarthritis nodosa, PAN, vasculitis, thisen kalna kawng natna, immune system, hepatitis B, corticosteroids te