Ngaihtuah teh, nakin lawkah Alzheimer natna i vei ngei ang tih i hriat lawk chuan engtin nge i tih ang? Dik tak chuan chutiang thil kan hriat hnuah eng nge kan tih theih ang? Hei hi tunlai doctor leh zirchiangtu tam takin harsatna lian tak an tawh a ni. Tun hnaiah zirchiangtu pawl pakhat chuan Alzheimer natna vei zinga 20% vel chu an gene en mai maiin an hriat hmasak theih thu an hmuchhuak a. Chuvang chuan he thu hi sawi chhuah a pawimawh em em a ni.
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Hei hi eng nge ni APOE4? Engvangin nge Alzheimer natna nen a inzawm?
A awlsam zawngin sawi ila, he APOE hi kan taksaa gene pakhat a ni. A hnathawh ber chu kan thisena cholesterol ang chi thau phurh chhuahnaah a pui a ni. He APOE gene hi chi hrang hrang a awm a. He gene hi kan hmu a, pakhat chu kan nu hnen atangin kan hmu a, pakhat chu kan pa hnen atangin kan hmu bawk.
Mi tam zawk chuan APOE3 tih variant an nei a, mahse mi thenkhat chuan APOE4 tih variant an nei mai thei.
- A vaiin mipui 20% velin APOE4 gene copy khat an nei a.
- Mahse, mipui 2% vel chuan APOE4 gene copy pahnih (nu leh pa hnen atangin) an rochun a ni. Damdawi lam hawi chuan heng mite hi (APOE4 homozygotes) kan ti a.
Hun rei tak atang khan APOE4 gene copy pahnih nei te hian Alzheimer natna vei theihna an nei sang hle tih hriat a ni tawh a .
Research thar ber berte hian eng nge a sawi?
Tun hnaia zirchianna pakhat, medical journal hmingthang tak Nature Medicine-a tihchhuah chuan hei hi thuk zawkin a chhui a ni. An thluak pek mi 3,300 leh mimal 10,000 te hriselna data an zirchiang a ni.
Chutah chuan mak tak mai an hmuchhuak a: APOE4 gene copy pahnih nei zinga 95% chuan an thluak emaw taksa tuiah emaw Alzheimer natna nena inzawm inthlak danglamna (biomarkers) an nei a.
Heng inthlak danglamna te hi kum 55 vel atang khan a intan tlangpui a, kum 65 vel atang khan a lan chhuah dan a intan a, a tawpah chuan dementia , hriatrengna leh ngaihtuahna thiamna tlahniam nasa tak chu kum 74 vel atang khan hmuhchhuah a ni.
A awlsam zawngin, zirchiangtute chuan APOE4 copy pahnih neih hi ‘risk tihpun’ aiin deterministic zawk a ni an ti. Hei hi a dik a nih chuan Alzheimer natna hi khawvela natna hrin atanga lo chhuak tam ber a ni thei ang.
Hemi chungchanga thil tha ber chu nakin lawkah thluak natna vei te chu a lan chhuah hmaa hriatchhuah leh enkawl theihna hun remchang a awm mai thei.
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Check Availability →Chuti a nih chuan, mi zawng zawng hian he test hi an neih a ngai em?
Hetah hian zawhna pawimawh ber chu a awm. A chhanna chu, ni lo! Tuna kan dinhmun ngaihtuah hian medical association-te chuan mi zawng zawng tan he test hi an rawt lo a , symptoms eng pawh ni se. Chutiang a nih chhan hi eng emaw zat a awm.
He zirchianna hian a tih theih chin chu hrethiam rawh
- Hnam: He zirchianna hi European hnam chhuak mipa hringte chunga tih a ni ber. Chuvangin heng result te hi kan ram chhunga mi, chu chu Asia mite tan eng chen nge a hman tih hriat a la ni lo.
- Sample awm dan: Data hi Alzheimer’s research-a telte hnen atanga lakkhawm a nih avangin mipui zawng zawng aiin he natna vei duhna hi a danglam deuh thei a ni.
Mi zawng zawng hian symptom an nei vek lo.
Hei hi thlamuantu pawimawh ber a ni. Research ngei pawhin APOE4 copy pahnih nei zawng zawng hian symptoms an nei vek lo tih a sawi . Mi thenkhat chu kum 80 vel thlengin an dam tha hle a, dementia chhinchhiahna engmah an nei lo. Tin, natna lan chhuah tan kum hi mi hrang hrangah a inang lo thei hle bawk.
| Test lakna a thatna | Test lak avanga Cons & Risks te |
|---|---|
| Risk chu i hre lawk thei ang. | Stress leh lungkhamna nasa tak a awm thei. |
| Nunphung (ei, in, exercise) thlak danglam tura thlemna nasa tak a awm a. | Results hi 100% a chiang lo. He natna hi a lo awm dawn nge kum engzat nge a lo awm dawn tih chiang taka sawi theih a ni lo. |
| Nakin lawkah chuan enkawlna thar emaw, zirchianna thar emaw i dawng thei ang. | Tunah hian natna laka invenna tur damdawi nghet a la awm lo. |
| Chhungkaw tinte pawhin an hlauhawmna tur ngaihtuahna engemaw zat an nei thei bawk. | Insurance leh hnathawhna ang chi thilte hi nakin lawkah a nghawng thei (ethical issues). |
He test hi i ngaihtuah a nih chuan eng nge i tih ang?
I chhungkuaa mi pakhatin Alzheimer’s natna a vei a, chu chu i lungngai hle ang tih han ngaihtuah teh. He APOE4 test hi i ngaihtuah a nih chuan i ngaihtuah reng tur thenkhat chu hetiang hi a ni.
1. Test mai mai suh: Hetiang test hi hriat duh vang mai maiin ti suh. A bik takin online-a test order-naah fimkhur hle ang che.
2. I Doctor nen inbia: A hmasa berin i chhungkaw doctor emaw, neurologist emaw hnenah hemi chungchang hi sawipui rawh. I chhungkaw chanchin leh i hlauhthawn te chu inhawng takin sawi rawh.
3. Genetic Counseling hi a pawimawh : Hetiang test i neih dawn chuan report lak mai mai a ni tur a ni lo. Genetic counselor emaw, he thila specialist doctor emaw nena inbiakna neih hma leh hnua inbiakna neih a pawimawh hle . Chumi rah chhuah awmzia te, i nun a nghawng dan te, leh rilru lama nghawng a neih tur chu engtin nge i hmachhawn ang tih te i sawifiah a ngai a ni.
4. I thunun theih thilte ngaihtuah rawh: Kan genes hi kan thlak danglam thei lo. Mahse, kan thunun theih tur thil tam tak a awm. Kan tih theih tha ber chu thluak hriselna atana tha nunphung kan neih hi a ni .
- Ei leh in inthlau tak ei rawh.
- Exercise tih fo thin ang che .
- Zan mut nuam tak nei rawh.
- Thisen sang, zunthlum, leh cholesterol level control.
- Thluak tibuaitu thil (lehkhabu chhiar, puzzle chinfel, thil thar zir) ti rawh.
- Social takin awm rawh.
Doctor veteran pakhat chuan, "Tunlai hian damlote hnena ka tawng hman pawh ka thlak danglam tawh. Mi pakhat chu 'natna vei' a ni tih ka sawi ngai lo," a ti. 'Neurocognitive changes nen an nung' ka ti a ni." Hei hian beiseina leh rilru tha neih a pawimawh zia a tilang chiang hle.
Take-Home Thuchah a ni
- APOE4 gene hi Alzheimer natna vei theihna tur risk factor lian tak a ni a, a bik takin copy hnih i neih chuan nasa takin a tipung a ni.
- Tun hnaia zirchianna chuan he inzawmna hi a nemnghet lehzual a, mahse a result hi kan population nena a inmilna tur hriat chian nan zirchianna dang neih belh a ngai a ni.
- He gene nei zawng zawng hian he natna hi an nei vek dawn lo. Symptom nei lo kum upa lam mi an awm.
- Tunah hian APOE4 hi asymptomatic individual-ah routine taka test a tha lo.
- Hemi chungchangah hian ngaihtuahna emaw zawhna emaw i neih chuan a tha ber chu i doctor nen sawiho la, genetic counseling pawh a tel.
- Genes chungchang ngaihtuah lovin, kan thunun theih tur thluak nena inmil nunphung hmangin i hlauhawmna chu i tihtlem thei a ni.
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