I ruh bulah lumps i nei em? Tumoral Calcinosis chungchang hi han sawi ila!

I elbow, shoulder, emaw knee ang chi joint bulah vun hnuaiah lump emaw, hmun khauh emaw i nei ang maiin i inhria em? I press chuan a na lo mai thei, mahse a lian deuh thei. Hetiang thil i hmuh hian tlem a hlauhthawn hi thil pangngai a ni. Mahse heng lumps zawng zawng hi cancer hlauhawm tak an ni vek lo. Vawiin hian heng symptoms te hi a lantir a, mahse cancer ni lo, a tlem deuh a, mahse hriat a pawimawh hle tih kan sawi dawn a ni. Chu chu ‘Tumoral Calcinosis’ a ni.

Tumoral Calcinosis hi eng nge ni?

A awlsam zawngin, tumoral calcinosis hi genetic condition a ni . Hei hi i thisena chemical phosphate an tih level a san lutuk lai a ni. Phosphate hi electric charged particle, a nih loh leh ion, mineral phosphorus awmna a ni. Chuvangin, tumoral calcinosis vei tan chuan phosphorus leh calcium te hi taksaah an pung khawm a, chu chuan vun hnuaiah, a bik takin ruhkawr vel ah lump a siam thin.

Phosphorus leh calcium te hi kan taksa tan ha leh ruh hrisel, chak tak siam nan a pawimawh hle. Mahse an san lutuk chuan cancer ni lo (benign) growth, chu chu hlauhawm lo, mahse tumor ang maia lang te chu tissue-ah a lo awm tan thin. Hei hi tumoral calcinosis kan tih chu a ni.

Hei hi hming dang a awm em?

Ni e, he natna hi damdawi lam hming kimchang chu ‘Hyperphosphatemic Familial Tumoral Calcinosis’ (HFTC) a ni. Hming sei deuh a ni lo maw? Doctor thenkhat chuan ‘Teutschlaender disease’ an ti bawk. Chu chu German doctor Otto Teutschlaender-a hriatrengna atan a ni a, kum 1930 chho atanga 1950 chho thleng khan he natna hi a zirchiang a ni.

He damdawi lam hming sei tak hian eng nge a awmzia?

He hming hi hmun hrang hrangah kan then a, kan hrethiam dawn em ni? Chu chu a awlsam zawk ang.

• Hyperphosphatemic: Hei hian thisenah phosphate level a sang tihna a ni.
• Chhungkaw lam: Hei hi chhungkaw hrang hranga kal zel, thlahtute atanga lo piang chhuak a ni tihna a ni.
• Tumoral: He thumal hi hman a nih chhan chu heng tumor ang chi te hi cancer tumor ang maia an lan vang a ni.
• Calcinosis: Hei hian i taksa ruh leh ruh leh ruh (musculoskeletal system) tissue chhungah calcium a awm tihna a ni.

Chu hming sei tak awmzia chu tunah hian i hrethiam em?

Tumoral Calcinosis hian engtin chiah nge taksa a nghawng?

Heng lumps, tumoral calcinosis tia koh hi vun hnuaiah, ruhkawr bulah a lo awm fo thin . Joint pakhat aia tamah an lo thang lian thei a, mahse joint tam takah pawh an lo thang lian thei bawk. Hmun tam ber chu:

• Hip joint a awm
• Elbows a ni
• A kekawrte
• Mawng
• Kut zungtang (wrist joints) a awm
• Spinal cord nena inzawm
• Jaw area ah a awm

Hetiang dinhmun hi engtiang chiahin nge a awm?

Medical expert-te chuan he tumoral calcinosis hi mi engzat nge vei tih chiang takin an hre lo. Because it's a very rare condition , African hnam chhuak leh Middle East-a mite zingah a tam ber. Hmeichhia leh mipa a nghawng thei a ni.

Tumoral Calcinosis chi hrang hrangte chu engte nge ni?

Hei hi a tam ber chu Hyperphosphatemic Familial Tumoral Calcinosis a ni a, a hmaa kan sawi tawh ang khan. Chu bakah, chi dang hmuh tur awm lo tak tak a awm bawk:

• Hyperphosphatemia-hyperostosis syndrome (HHS): Hei hi ruh lian lutuk leh cancer ni lo ruh natna lo awm thei a ni.
• Normophosphatemic tumoral calcinosis: Hetiang chi hi kal (kidney failure) nei te zingah hmuh tur a awm fo thin. Hyperparathyroidism tih natna a thlen thei a, chu chu parathyroid gland overactive tak a ni.

Tumoral Calcinosis hi eng thilin nge a thlen?

Tumor calcinosis hi metabolic disorder a ni a , chu chu rochun atanga lo chhuak a ni . Hetiang natna vei hmun thuma ṭhena hmun khat vel chuan an FGF23 gene-ah hian inthlak danglamna, a nih loh leh mutation an nei a ni. FGF23 gene hian kan ruh cell te chu fibroblast growth factor (FGF) tih protein siam turin a pui a 23. Mi thenkhat pawhin GALNT3 leh KL genes inthlak danglam avangin he natna hi an nei ve bawk. Heng genes te hian FGF23 siamchhuahna an control a ni. Nomophosphatemic tumor calcinosis vei te hian SAMD9 gene ah mutation an nei a.

A tlangpuiin protein `FGF23` hian kan kal (kidney) hian thisen atanga phosphate engzat nge a lakluh leh tur tih a hrilh thin. Mahse genetic mutation a awm chuan he process hi a kal sual thin. Tichuan, kal (kidney) hian a mamawh aia tam phosphate chu a reabsorb leh ta a ni. A tlangpuiin kal hian phosphate tam lutuk chu zunah a paih chhuak thin. Mahse tumoral calcinosis-ah chuan he phosphate hian calcium a binding a, soft tissue-ah tumor a siam thin.

He natna hi tuin nge vei thei ang?

Tumorous calcinosis hi autosomal recessive natna a ni a . Hei hi hriatthiam a harsa deuh a, mahse a awlsam zawngin sawi ila, natna i neih theih nan chuan i nu leh pa pahnih hnen atangin gene mutation hi i rochun a ngai a ni. I nu leh pate hi mutation carrier an ni thei a, mahse natna hi an nei lo mai thei.

Nu leh pa pahnih hi carrier an nih chuan an fate hian a hnuaia chance te hi an nei vek a ni.

• Mutated gene neih loh theihna chance 4 zinga 1 a awm (natna vei theihna risk a awm lo).
• Tumoral calcinosis vei theihna chance 4 zinga 1 a awm.
• He natna vei lo carrier nih theihna chance 2 in 2 a awm.

Tumoral Calcinosis natna lan chhuah dan chu engte nge ni?

Hetiang dinhmun hian joint pakhat emaw a aia tam emaw bulah lumps lian leh te a siam thin. Heng lumps te hi naupan lai emaw tleirawl lai emaw ah a lang fo thin . Mahse, nausen leh puitling kum upa zawkah pawh an lo thang lian thei a ni. A châng chuan, dam chhungin lump tlemte chauh a lo awm ṭhin. A nih loh leh, vawi khatah lumps tam tak a lo awm thei bawk.

Hetiang symptoms hi i nei thei ang:

• Joint natna chu uluk taka sawn emaw, ben emaw harsa.
• Lump khauh tak, natna nei lo (lump thenkhat chu khawih pawhin a na deuh thei).
• Musculoskeletal natna a awm.

Tumoral Calcinosis hi engtin nge an hriat theih?

Orthopedist chu ruh leh ruh inzawmna lama harsatna nei doctor a ni. A enfiah ang che a, i symptoms te a zawt ang che. Chumi hnuah chuan heng tumor leh ruh lama harsatna dangte zawng turin a hnuaia X-ray pakhat emaw a aia tam emaw a ti thei ang:

• X-ray hmanga enfiah `(X-ray)`
• CT scan a ni
• MRI scan `(MRI)` tih a ni

Eng dinhmun dang nge Tumoral Calcinosis ang chi natna lan chhuah?

Hei hi a pawimawh hle. A chhan chu diagnosis dik tak neih a pawimawh em em a ni . A chhan chu natna dang, a lan chhuah dan inang, mahse a na zawk a awm vang a ni. Heng condition thenkhat chu:

• Benign soft tissue tumor leh malignant soft tissue tumor te a awm bawk
• Calcific myonecrosis (ke ruh chhunga calcium awm zat tumor) .
• Calcific tendonitis (calcium awm zat leh tendonitis) .
• Calcinosis circumscripta (kut leh ke vun leh tissue-a calcium awm) .
• Calcinosis of chronic kidney (renal) failure (dialysis hmangtute zingah calcium awm zat) .
• Calcinosis universalis (vun, tissue, tendon leh muscle-a calcium salt awm) .
• Connective tissue natna te
• Gout tih hi a ni
• Myositis ossificans (thau ruh a inthlak) .
• Osteosarcoma leh sarcoma (ruh cancer) te .
• Synovial chondromatosis (hnah ruh chhunga cartilage nodules) .

Hmu? A lan chhuah dan inang viau mah se, a chhan chu a danglam thei hle. Chuvang chuan thil awmdan dik tak hriatchhuah a pawimawh.

Surgery ni lo enkawlnate chu engte nge ni?

I doctor chuan i thisenah phosphate awm zat a tihniam thei a ni.Phosphate-binding damdawi pawh a pe thei bawk. Heng phosphate-binding damdawi te hi acetazolamide (epilepsy leh glaucoma atana hman tlanglawn) an tih damdawi nen an inzawm chuan taksain phosphorus a lakluh theihna a tikhawlo thei a ni. Phosphorus tlem diet ei a ngai mai thei bawk .

Phosphorus tlem ei hi eng nge ni?

Tumoral calcinosis i neih chuan i doctor chuan phosphorus tlem ei tur a rawt thei ang. Phosphorus hi a pianphungah sa, sangha leh bawnghnute atanga siamah te a awm a. Phosphorus hi ei tur dang thenkhatah pawh preservative emaw flavoring emaw atan an dah tel bawk.

Phosphorus tamna ei leh in te tihtlem tum ang che, chungte chu:

• Beer, colas, iced tea leh chocolate in tur te pawh a awm bawk.
• Chocolate leh caramel chi hrang hrang.
• Bawnghnute atanga siam (milk, cheese, ice cream, Greek ni lo yogurt, creamy soup) te.
• Seafood te chu oyster leh sardine te ang chi te, chhungril lam thil te chu bawnghnute leh vawk liver te ang chi te an ni.
• Sa siam chhuah (hot dog, chawhmeh sa, bacon, sausage) te.
• Oat bran atanga siam thil chi hrang hrang.

Hemi chungchang hi doctor emaw nutritionist emaw nen inbiakna neih a tha ber.

Surgery hmanga enkawlnate chu engte nge ni?

Tumor lian lutuk, a thawk tha thei lo tihbo nan operation i mamawh mai thei. Mahse, heng tumor te hi an lo thang leh thei zawk . I doctor chuan tissue lakchhuah sample a la thei bawk a, biopsy a nei thei bawk a, chu chuan a natna hmuhchhuah chu a nemnghet thei a ni.

Tumoral Calcinosis avanga harsatna awm thei te chu engte nge ni?

A tlem hle a, he natna hian i thisen kalna kawng emaw thluak emaw a nghawng thei a, hriselna lama harsatna lian tak tak, heart attack leh stroke te i neih theihna a tipung thei a ni.

Chu bakah, he natna hian a hnuaia mite hi a thlen thei bawk:

• Mit mitmeng (cornea)-ah hian mit (corneal calcifications) emaw angioid streaks (red streaks) emaw a awm thin.
• Ha lam harsatna a awm.
• Ruh lian lutuk (hyperostosis).
• I ke emaw, i kut emaw ruh sei (diaphysis) a inflammation.

Tumoral Calcinosis hi a veng thei em?

Nang leh i kawppui nen hian tumoral calcinosis thlentu gene mutation in neih ve ve a nih chuan, i fate’n mutation an rochun theihna tur tihtlem dan tur genetic counselor nen in inbia thei ang. Mi thenkhat chuan Preimplantation Genetic Diagnosis (PGD) tih chu an thlang thin. Hei hian mutation nei lo embryo te hriatchhuah a huam a ni. Chumi hnuah i doctor chuan In Vitro Fertilization (IVF) tih hmangin nausen hrisel tak takte chu hmeichhe nau neihna system-ah a transfer a ni. Hetiang tih dan hmang hian i fa hian natna thlentu gene mutation chu a rochun dawn lo.

Tumoral Calcinosis vei tan chuan eng nge a hmalam hun?

Tumoral calcinosis vei tam zawk chu nun famkim, active takin an hmang thin . He dinhmun hian hriselna lama harsatna lian tak a thlen tam lo hle. Mahse, i doctor pan fo a ngai ang a, a lo lang leh leh awm loh enfiah a ngai ang.

Engtikah nge Doctor ka hmuh ang?

Heng symptoms te hi i neih chuan doctor pan rawh:

• Joint pakhata range of motion tlahniam.
• Joint na, ruh na emaw, taksa ruh na emaw.
• Vun hnuaia tumor emaw lump emaw lo lang.

Ka doctor hnenah eng nge ka zawh ang?

Doctor hnenah hetiang zawhna hi i zawt thei ang:

• Engvangin nge tumoral calcinosis ka neih?
• Ka tan enge inenkawlna tha ber?
• Surgery ka mamawh em?
• Eng ang ei tur nge ka tihtlem ang?
• Complication chungchangah hian ka ngaihtuah tur em ni?
• Ka chhungkaw dangte hian genetic testing an nei tur em ni?

Tumoral Calcinosis hi Cancer a ni thei em?

A hmingah hian "tumoral" tih thumal awm mahse, tumoral calcinosis avanga lo awm tumor te hi a takah chuan cancer an ni lo . Heng tumor te hi malignant a nih theihna tur a awm lo. Chuvangin ngaihtuah buai suh.

Tumoral calcinosis avanga vun hnuaia tumor awm hi a nuam lo deuh a, a hlauhawm deuh thei tih chu a dik a ni. Mahse mi tam zawk tan chuan heng tumor te hian harsatna lian tham a thlen lo. Damdawi hian thisenah phosphorus level a tihniam thei a ni. I doctor pawhin phosphorus tlem ei tur ei tura pui turin nutritionist hmu turin a rawt thei bawk. I ruh, ruh emaw, i taksa ruh emaw a na a, chu chuan i kal theihna a tikhawtlai a nih chuan doctor hnenah hrilh rawh. Tumor te hi operation hmanga lakchhuah theih ni mahse, a lo kir leh thei tih hre reng ang che.

Take-Home Message (Hriatreng tur thil) .

Okay, chuvangin Tumoral Calcinosis chungchanga vawiin a kan sawiho pawimawh ber berte kha han sawi nawn leh ila:

• Hei hi thil awm lo, thlahtute atanga lo chhuak a ni. Thisenah phosphate level a san chuan calcium nen an inzawm khawm a, ruh bulah lump an siam thin.
• Heng tumor te hi cancer a ni lo .
• Hengte hi a na lo fo a, mahse ruh incheina a tibuai thei.
• Enkawlna atan hian phosphate tihhniamna damdawi te, phosphorus tlem ei te, a tul chuan operation te a tel a ni.
• Hetiang lump i hmuh chuan hlauthawng suh la, damdawi lam thurawn zawng rawh. Diagnosis dik tak neih a pawimawh hle.
• Mi tam tak chuan he natna hi neiin nun pangngai, active takin an hmang thin.

Chuvangin, nangmah emaw, i hriat miin emaw heng symptoms te hi an neih chuan doctor pan a, thurawn lak a tha ber.

` Tumorous calcinosis, joint cyst, phosphate, calcium, genetic natna, vun nodules, ruh natna