Akohia te maimoatanga Herceptin (Trastuzumab) mō te mate pukupuku ū HER2-pai

Ina kitea koe, tetahi rānei o tō whānau kua pāngia e te mate pukupuku ū, he uaua ki te whakapuaki i te wehi me te manukanuka e pā ana ki a koe. He wā tino kare ā-roto tēnei. Engari, ko te mea nui ko te mea me te pūtaiao hauora matatau kei a tātou i nāianei, ka taea e tātou te whai tumanako. Ka whakaarohia e tō tākuta he maha ngā mea, pērā i te momo mate pukupuku kei a koe, tō tau, me te mea kei a koe ētahi atu mate, kia whiriwhiria ai ngā kōwhiringa maimoatanga pai rawa atu māu. Ko te mate pukupuku ū te tikanga ka rongoatia mā te huinga o te pokanga, te chemotherapy, me te radiation.

I tēnei rā, e kōrero ana tātou mō tētahi maimoatanga rerekē, motuhake ake. Ka kiia tēnei ko te "whakaora arotahi ". Ko Herceptin tētahi o aua rongoā. Ko tōna ingoa hauora ko Trastuzumab . Kua rongo pea koe i ētahi atu ingoa pēnei i a Kanjinti, Herzuma, Ogivri. Ka kiia ēnei ko ngā "biosimilars". Ki te kī māmā noa, he tārua koiora ēnei o te rongoā kotahi ki a Herceptin.

He aha te Whakaora Whaiaro me te Herceptin?

Whakaarohia, ko ngā rongoā chemotherapy auau ehara i te mea ka pā ki ngā pūtau matepukupuku anake, engari ki ngā pūtau hauora hoki e tere wehewehe ana. Engari ehara i te mea pērā ngā rongoā kua whakaritea. Ka mahi rātou mā te arotahi ki ngā whāinga motuhake. Ka whakahaere ēnei rongoā i ngā pūmua motuhake e āwhina ana i ngā pūtau matepukupuku kia tipu me te horapa. Koia te take kāore e mahi mō ngā matepukupuku katoa. Me nui te pūmua e arotahihia ana e te rongoā i roto i aua pūtau matepukupuku.

Ka aro te rongoā Herceptin ki tētahi pūmua e kiia nei ko te HER2 . (Ko te ingoa katoa o tēnei ko te 'human epidermal growth factor receptor 2'). Nō reira, ki te nui rawa te whakaputanga o tēnei pūmua HER2 i roto i ngā pūtau matepukupuku, ka kiia taua momo matepukupuku ū he 'HER2-positive' matepukupuku ū. Ka tukuna noa te maimoatanga Herceptin ki te hunga matepukupuku ū 'HER2-positive'.

He pēhea te mahi a tēnei rongoā Herceptin i roto i te tinana?

Hei mārama ki tēnei, me titiro tuatahi tātou ki te aha te HER2. He kaiwhakawhiwhi te HER2 i runga i te mata o ngā pūtau. Whakaarohia he pūihi iti i runga i te mata o te pūtau. Ko ēnei pūihi ngā mea e whiwhi ana i ngā tohu mai i waho o te pūtau, ā, e mahi ana ki a rātou. I roto i te pūtau hauora, kei reira ngā kaiwhakawhiwhi HER2 hei whakahaere i te tipu o te pūtau.

Engari he rerekē te āhua o ngā pūtau matepukupuku 'HER2-positive'. He tārua anō ō ēnei pūtau o ngā ira e hanga ana i te pūmua HER2. Nō reira, he nui rawa te pūmua HER2 e hangaia ana e ēnei pūtau. Me te mea he maha rawa ngā pūihi i runga i te pūtau. Kātahi ka whiwhi ngā pūtau matepukupuku i te maha rawa o ngā tohu hei "tipu, hei wehewehe," ā, ka tipu tere atu i waho o te mana whakahaere.

He pai te rongoā Herceptin mō taku mate pukupuku?

He pātai tino nui tēnei. Mēnā he `HER2-negative` tō matepukupuku ū, arā, kāore he pūmua HER2 tāpiri i roto i ngā pūtau matepukupuku, kāore e mahi te maimoatanga Herceptin. He `HER2-negative` te nuinga o ngā matepukupuku ū. Tata ki te 20% he HER2-pai. Mā tō tākuta koe e kī atu ki a koe te momo matepukupuku kei a koe mā roto i ngā whakamātautau.

Ka whakamahia te maimoatanga Herceptin i ngā wāhanga tōmua o te mate pukupuku ū, tae atu ki ngā wāhanga kua horapa te mate pukupuku (metastatic).

• Mō te mate pukupuku wāhanga tōmua: Mena he HER2-pai tō mate pukupuku, ā, he wāhanga tōmua, ka hoatu te Herceptin hei ārai i te hokinga mai o te mate pukupuku i muri i te pokanga. He maha ngā wā ka hoatuhia tēnei me te chemotherapy, te rongoā endocrine rānei. He nui ake te tūponotanga ka hoatuhia tēnei maimoatanga mena he nui te mate pukupuku, kua horapa rānei ki ngā kōpū lymph.

• Mō te mate pukupuku kua horapa haere: Mena kua horapa te mate pukupuku ki ngā wāhanga tawhiti o te tinana (metastatic), ka taea e Herceptin te āwhina ki te aukati, ki te whakaroa rānei i tōna tipu. I ētahi wā, mena he nui rawa te pukupuku kāore e taea te tango mā te pokanga, ka taea e Herceptin me ētahi atu maimoatanga te whakaiti i mua i te pokanga.

He aha ngā mea me tumanako atu koe ina whiwhi maimoatanga koe?

Ka hoatu te Herceptin hei werohanga (ā-uaua - IV) ki roto i te uaua. Ka hoatu hei wai tote. Ka mahia tēnei nā te mea me werohanga tika te rongoā ki roto i te toto. Ka roa pea i waenga i te 30 me te 90 meneti hei whakaoti.

Tērā anō tētahi momo o tēnei ka hoatu hei werohanga. Ko te ingoa ko 'Herceptin Hylecta'. Kua whakaatuhia e ngā rangahau he rite tonu te whai huatanga o tēnei ki te werohanga IV. Mā tō tākuta e whakatau ko tēhea tikanga te mea pai māu.

Ko te roa me te auau o te tango i te Herceptin ka whakawhirinaki ki te taumata o tō mate pukupuku me ngā rongoā kē atu e tangohia ana e koe. Mena kua horapa te mate pukupuku (metastatic), me haere tonu pea te maimoatanga mena kei te mahi tonu te rongoā, ā, kāore he pānga kino kino.

He mea tino nui: Ka tirohia e tō tākuta te mahi o tō ngākau i mua atu, i te wā hoki e rongoā ana i a Herceptin, nā te mea ka pā pea tēnei rongoā ki te ngākau i ētahi wā.

Haunga tēnei, tera pea ka puta ētahi atu pānga taha. Nō reira, i mua i te tīmatanga o te maimoatanga, me āta mōhio koe ki ngā tohu hei tūpato, me te wā me whakamōhio tonu atu ki tō tākuta. Kāore te maimoatanga Herceptin e hoatu ki ngā wāhine e hapu ana, e ngana ana rānei kia hapu.

He pēhea te angitu o tēnei maimoatanga?

He rongoā a Herceptin i tino huri i te maimoatanga o te mate pukupuku ū HER2-pai i muri i tōna whakaaetanga i te tau 1998.

• Mō te mate pukupuku kua pāngia e te mate pukupuku: Ka taea e te Herceptin, ina hoatu ko ia anake, ina hoatu tahi rānei me te chemotherapy, te whakaroa i te tipu o te mate pukupuku, ā, ka āwhina i ngā tūroro kia roa ake te ora. Heoi, i ētahi wā ka mahi te rongoā mō tētahi wā, kātahi ka mutu te mahi.

• Mō te mate pukupuku o te wāhanga tōmua: Koinei te wāhi e kitea ai te angitu nui. Kua whakaatuhia e ngā rangahau mā te tāpiri i te Herceptin ki te chemotherapy i muri i te pokanga ka taea te whakaiti i te mōrearea o te hokinga mai o te mate pukupuku mā te 50% . Ko te tikanga he nui ake ngā wāhine e tango ana i te Herceptin e ora roa ake ana me te kore mate pukupuku.

Ahakoa ka tukuna te maimoatanga mō te tau, e rua rānei i te tīmatanga, e whakaatu ana ngā rangahau hou he rawaka te tango i te Herceptin mō te ono marama noa iho mō te tini o te tangata. He rongo pai tēnei mō te hunga e āwangawanga ana mō ngā pānga taha.