Kodi dokotala wanu wakupezani kuti muli ndi khansa ya m'mawere kapena ya munthu amene mumamukonda? Ndiye kuti mwamvapo mawu oti 'chemotherapy'. Ndizachilendo kumva mantha pang'ono komanso nkhawa mukamva izi. Koma ngati tadziwitsidwa bwino za mankhwalawa , mantha amenewo amatha kuchepetsedwa kwambiri. Chifukwa chake, imodzi mwa mitundu yofunika kwambiri ya mankhwala omwe amagwiritsidwa ntchito pochiza matenda a chemo imatchedwa anthracyclines . Lero, tikambirana izi mosavuta, m'njira yomwe mungamvetse.
Kodi mankhwalawa amagwira ntchito bwanji m'thupi?
Mwachidule, mankhwala otchedwa anthracyclines ndi mtundu wa mankhwala opha majeremusi omwe amathandiza kupha maselo a khansa. Koma sali ngati mankhwala opha majeremusi omwe timamwa pa chimfine kapena fuluwenza. Amapangidwa ndi mtundu wa bowa wotchedwa Streptomyces, womwe umakhala m'nthaka.
Ganizirani za selo la khansa ngati makina ojambulira zithunzi omwe amapanga makope popanda kulamulira. Makinawa amapitiliza kupanga makope ambirimbiri okha. Umu ndi momwe zotupa zimapangikira ndikukula. Zimene anthracyclines amachita ndikuphatikiza ku 'master copy' ya DNA mu makina ojambulirawo. Kenako sangathe kupanga makope atsopano. Izi zikutanthauza kuti mphamvu ya maselo a khansa yogawanitsa ndikukula mofulumira imayimitsidwa kwathunthu.
Mankhwalawa nthawi zambiri amaperekedwa kwa inu ngati jakisoni kapena ngati yankho la saline mumtsempha (m'mitsempha kapena m'mitsempha). Dokotala wanu adzasankha kuchuluka kwa mankhwala omwe muyenera kutenga komanso nthawi yomwe muyenera kupitiliza chithandizo kutengera gawo ndi momwe khansa yanu ilili.
Nthawi zambiri, khansa ya m'mawere ikayamba kumene, opaleshoni imachitidwa kuti ichotse chotupacho. Kenako, chemotherapy imaperekedwa kuti iwononge maselo ang'onoang'ono a khansa omwe angakhalebe m'thupi. Timatcha "Adjuvant Chemotherapy" . Izi zimachepetsa kwambiri mwayi woti khansayo ibwererenso. Anthracyclines ndi imodzi mwa mitundu yayikulu ya mankhwala omwe amagwiritsidwa ntchito mu "Adjuvant Chemotherapy".
Kodi mankhwala a anthracycline amagwira ntchito bwanji?
Kafukufuku wambiri wasonyeza kuti njira zochiritsira za chemotherapy zokhala ndi anthracyclines ndizothandiza pang'ono kuposa njira zomwe sizili nazo.
Mu kafukufuku wina waukulu, akazi oposa 4,000 omwe ali ndi khansa ya m'mawere yoyambirira, omwe anali pachiwopsezo chachikulu chobwereranso, adagawidwa m'magulu awiri ndipo adapatsidwa chithandizo chamankhwala awiri.
1. Gulu la Anthracycline (TaxAC):Anthuwa anapatsidwa mankhwala ena a chemotherapy kuwonjezera pa anthracyclines.
2. Gulu lopanda anthracycline (TC): Anthu awa adapatsidwa mankhwala osiyanasiyana a chemotherapy omwe analibe anthracycline.
Atayang'ana magulu onse awiri kwa zaka pafupifupi zitatu, ofufuzawo adayang'ana nthawi yomwe adakhala ndi thanzi labwino popanda khansa kubwerera. Zotsatira zake zinali motere:
- Mu gulu la anthracycline (TaxAC), 92.4% ya khansa sinabwerenso.
- Mu gulu la non-anthracycline (TC), 91.7% ya khansa sinabwerenso.
Zotsatirazi zikusonyeza kuti, ngakhale kuti kusiyana si kwakukulu, mankhwala okhala ndi anthracycline amatha kuchepetsa pang'ono chiopsezo cha kubwereranso kwa khansa.
Kodi pali zotsatirapo zilizonse za mankhwalawa?
Inde, monga mankhwala ena aliwonse a chemotherapy, anthracyclines ingayambitse zotsatirapo zoyipa. Koma si aliyense amene amalandira, ndipo zambiri mwa izo zimatha kulamulidwa. Dokotala wanu adzatha kukupatsani upangiri pa izi.
| Mtundu wa zotsatira zoyipa | Zizindikiro zomwe zingatheke |
|---|---|
| Zotsatirapo Zochepa Kapena Zochepa | |
| Zinthu zodziwika bwino | Kusanza ndi nseru, kuzizira ndi kutentha thupi, kutsegula m'mimba, kupweteka m'mimba, kupweteka kwa thupi, kutopa. |
| Khungu ndi misomali | Kutupa pakhungu, kuyabwa, kusintha kwa mtundu wa misomali, kusintha kwa mtundu wa khungu. |
| Zotsatira zina | Kusanduka mtundu wa mkodzo (wofiira), kusowa chilakolako cha kudya, kusamva kuwala, kutha kwa msambo, komanso kuchepa kwa umuna mwa amuna. |
| Zokhudzana ndi magazi | Kutuluka magazi, kuchepa kwa maselo oyera a m'magazi (zomwe zimawonjezera chiopsezo cha matenda), komanso kufooka kwa mafuta m'mafupa. |
Dziwani zotsatirapo zoyipa kwambiri
Chotsatira chachikulu komanso chachikulu cha mankhwalawa ndi chiopsezo cha kuwonongeka kwa mtima. Mankhwalawa akagwiritsidwa ntchito kwa nthawi yayitali, pamakhala chiopsezo cha matenda monga kulephera kwa mtima, komwe kungafooketse minofu ya mtima. Komanso, mankhwala ena a anthracyclines ali ndi chiopsezo chochepa kwambiri chotenga khansa yamtundu wina, monga khansa ya m'magazi, nthawi zina.
Chifukwa cha zoopsazi, dokotala wanu wa khansa ndi dokotala wa mtima adzagwira ntchito limodzi kuti ayang'anire momwe mtima wanu umagwirira ntchito panthawi yonse ya chithandizo chanu kuti achepetse kuwonongeka kulikonse komwe kungachitike. Choncho musachite mantha ndi izi.
Kodi izi ndizoyenera kwambiri pa mitundu ina ya khansa ya m'mawere?
Inde. Si khansa yonse ya m'mawere yomwe ndi yofanana. Chifukwa chake, dokotala wanu adzasankha chithandizo chomwe chili choyenera kwa inu. Izi zidzadalira zinthu zingapo:
- Gawo la khansa
- Kaya khansa imakhudzidwa ndi mahomoni (mkhalidwe wa mahomoni)
- Matenda a khansa a HER2
- Kaya khansa yafalikira ku ma lymph nodes
- Zaka zanu ndi thanzi lanu lonse
Mwachitsanzo, ngati munthu ali ndi zaka zoposa 60, ali ndi kuthamanga kwa magazi, komanso ali ndi matenda a mtima, dokotalayo angakulangizeni njira yochizira yomwe siili ndi mankhwala a anthracycline.
Kafukufuku wasonyeza kuti anthu omwe ali ndi mitundu yoopsa ya khansa, monga khansa ya triple-negative, komanso omwe khansa yawo yafalikira ku lymph nodes amapindula kwambiri ndi mankhwala okhala ndi anthracycline.
Kodi chimachitika ndi chiyani ngati khansa yayamba kukana mankhwala a anthracycline?
Nthawi zina, pakapita nthawi, maselo a khansa amatha kukhala osagwira ntchito ndi mankhwalawa, zomwe zikutanthauza kuti mankhwalawa sagwira ntchito. Musadandaule ngati izi zitachitika. Ngati zitachitika, pali mankhwala ena ndi njira zina zomwe dokotala wanu angagwiritse ntchito.
Zitsanzo zina ndi izi:
- Capecitabine (Xeloda)
- Eribulin (Halaven)
- Gemcitabine (Gemzar)
- Vinorelbine (Navelbine)
- Mankhwala amakono monga ma antibodies drug conjugates
Palinso njira zamakono zochiritsira, monga mankhwala ochizira matenda ndi chitetezo chamthupi. Chofunika kwambiri ndikulankhulana ndi gulu lanu lachipatala nthawi zonse.
Uthenga Wopita Nawo Kunyumba
- Mankhwala a Anthracycline ndi gulu la mankhwala amphamvu komanso ogwira mtima omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere.
- Ntchito yawo yaikulu ndikukhudza DNA ya maselo a khansa, kuwaletsa kugawikana ndi kukula.
- Monga mankhwala ena onse, palinso zotsatirapo zake. Makamaka chifukwa cha zotsatira zake pamtima, ndikofunikira kulandira chithandizo motsogozedwa ndi dokotala.
- Chisankho chokhudza ngati mupatsidwa mankhwala a anthracycline chidzapangidwa mutaganizira zinthu zambiri, monga mtundu wa khansa yanu komanso thanzi lanu.
- Musamaope kulankhula momasuka ndi dokotala wanu za chithandizo chanu, zotsatira zake, kapena mafunso aliwonse, mantha, kapena nkhawa zomwe mungakhale nazo. Kudziwa bwino ndiye chida chabwino kwambiri chopambana nkhondoyi.
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