Tiyeni tiphunzire za chinsinsi cha ubongo chomwe chimatonthoza maganizo anu - GABA (gamma-aminobutyric acid)?

Kodi nthawi zina mumamva kutopa, kuda nkhawa, kapena kungokhala ndi mantha? Kapena mumavutika ndi kusowa tulo usiku? Kumbuyo kwa zinthuzi kungakhale ndi kamtumiki kakang'ono ka mankhwala muubongo mwathu. Ndicho chimene tikambirane lero. Ndi GABA. Imagwira ntchito ngati batani 'lozizira' muubongo mwathu.

Kodi GABA (gamma-aminobutyric acid) ndi chiyani?

Mwachidule, GABA ndi mankhwala omwe amatumiza mauthenga pakati pa maselo amitsempha (ma neuron) muubongo wathu. Ali ngati positi wanzeru m'thupi lathu. Koma chomwe chili chapadera ndichakuti "amatonthoza" ntchito zosafunikira za ubongo. Izi zikutanthauza kuti, amaletsa maselo amitsempha muubongo kuti asakopeke kwambiri. Asayansi amatcha mitundu iyi ya mankhwala a neurotransmitters. Ganizirani za GABA ngati "buleki" yomwe imayang'anira liwiro la dongosolo lathu la mitsempha, lomwe limaphatikizapo ubongo wathu ndi msana. Ndi zomwe zimatithandiza kuti tisamasangalale kwambiri kapena kuchita mantha.

Kodi GABA imagwira ntchito bwanji? Kodi chimachitika n’chiyani muubongo mwathu?

Tsopano onani momwe GABA iyi imagwirira ntchito mkati mwa ubongo wathu. Ndi njira yodabwitsa kwambiri. Tili ndi maselo amitsempha mamiliyoni ambiri mu ubongo wathu. Tiyenera kutumiza uthenga kuchokera ku selo imodzi yamitsempha kupita ku ina. Pali kusiyana pang'ono pakati pa maselo awiriwa amitsempha. Zimenezo zimatchedwa `(Synapse)` kapena kulumikizana kwa mitsempha.

Cholumikizira cha `(Neurotransmitter)` monga GABA chimachita izi potenga uthengawo kudutsa pa malo olumikizirana awa ndikulumikiza ku `(Receptors)` yeniyeni pa selo lotsatira la mitsempha. Zili ngati kiyi yolowera mu loko. Monga momwe si kiyi iliyonse yomwe ingatsegule loko iliyonse, si `(Neurotransmitter)` iliyonse yomwe ingalumikizidwe ku `(Receptor)` iliyonse. GABA ilinso ndi `(Receptors)` ziwiri zenizeni zomwe zimazindikira - `(GABA-A)` ndi `(GABA-B)`.

Choncho, GABA ikapita ndi kumangirira ku ma receptor amenewa, imachepetsa mphamvu ya selo lotsatira la mitsempha kuti liyankhe. Izi zikutanthauza kuti, imachepetsa mwayi wa selo limenelo kupanga uthenga wosafunikira kapena kuutumiza kwa wina. Ichi ndichifukwa chake GABA imatchedwa "inhibitory" kapena softening neurotransmitter.

Kodi GABA imapereka maubwino otani pa thanzi?

Ndiye, kodi timapeza ubwino wotani pa thanzi kuchokera ku GABA, yomwe imachepetsa ubongo motere? Pali zambiri. Tangoganizirani, muli ndi "stress" kwambiri, kutanthauza kuti, mukakhala ndi nkhawa kwambiri, maganizo anu sali pamalo amodzi, mumakhala ndi nkhawa kwambiri, ndipo chifuwa chanu chimamva ngati chikugunda. Panthawi ngati imeneyo, ngati mulingo wa GABA m'thupi lanu uli woyenera, udzatonthoza maganizo anu ndikukuthandizani kuchepetsa nkhawa imeneyi .

GABA ilinso ndi luso lodabwitsa loletsa nkhawa . Imathandiza kuchepetsa mantha osafunikira komanso nkhawa pa chilichonse.

Chinanso n'chakuti, anthu ena sangagone usiku. Amangoyendayenda akagona, koma saoneka ngati akugona konse. Kafukufuku waposachedwapa akusonyeza kuti GABA imathandizanso kugona bwino komanso kopumula .

GABA ndi Glutamate: Kusintha kwa 'On-Off' kwa Ubongo

Pamodzi ndi GABA, palinso `(Neurotransmitter)` yofunika kwambiri muubongo mwathu. Ndi `(Glutamate)`. Awiriwa amagwira ntchito ngati mbali ziwiri za ndalama, kapena ngati ma switch awiri a 'on' ndi 'off'. Ndiko kuti, mbali zosiyana.

• GABA: 'Imaletsa' ntchito ya ubongo ndikuutonthoza (yoletsa).
• Glutamate: 'Imayatsa' ndipo imalimbikitsa ntchito ya ubongo (cholimbikitsa).

Kotero, kuti ubongo wathu ugwire ntchito bwino komanso moyenera, pamafunika kukhala ndi mgwirizano wosavuta pakati pa mphamvu yotonthoza ya GABA ndi mphamvu yolimbikitsa ya `(Glutamate) . Monga momwe zimakhalira ndi accelerator ndi brake ya galimoto. Pokhapokha ngati zonse zikugwira ntchito bwino komanso panthawi yake ndi pomwe tingayende bwino komanso mosamala. Ngati mgwirizanowu watayika, mavuto osiyanasiyana amabuka. Chodabwitsa n'chakuti, wothandizira wotonthoza uyu wotchedwa GABA amapangidwanso kuchokera ku `(Glutamate). `(enzyme)` yapadera imakhudzidwa nayo, kutanthauza, enzyme (`glutamic acid decarboxylase`).

GABA imagwiranso ntchito limodzi ndi serotonin, yomwe ndi neurotransmitter ina. Ndipotu, ma neurotransmitter ambiri amagwira ntchito limodzi, nthawi zina motsutsana, kuti matupi athu ndi ubongo wathu zigwire ntchito bwino.

Matenda omwe angayambitsidwe ndi kuchepa kwa GABA

Tangoganizirani zomwe zikanachitika ngati kusinthana kwa uthenga wa GABA sikunagwire ntchito bwino, zomwe zikutanthauza kuti kuchuluka kwa GABA muubongo kunali kochepa? Izi zingayambitse mavuto osiyanasiyana amitsempha ndi matenda amisala. Kafukufuku wapeza kuti kuchepa kwa ntchito ya GABA kungayambitse matenda monga:

• Nkhawa ndi mavuto a maganizo: Kumva mantha nthawi zonse, nkhawa, kutaya chimwemwe, komanso kulephera kuganizira bwino.
Schizophrenia : Matenda amisala ovuta omwe amadziwika ndi kutayika kwa kulumikizana ndi zenizeni, kuwona, kumva, ndi kuganiza zinthu zomwe si zenizeni.
• Matenda a Autism: Matenda a chitukuko omwe amadziwika ndi kulephera kwa anthu komanso kulankhulana.
• Kuvutika maganizo: Kumva chisoni kwa nthawi yaitali, kutaya chidwi ndi chilichonse, komanso kumva kutopa ndi moyo.
• Khunyu ndi khunyu: Matenda monga khunyu ndi khunyu zomwe zimachitika m'thupi chifukwa cha kugwira ntchito mopitirira muyeso kwa maselo a mitsempha muubongo.

Kuwonjezera pa matenda akuluakulu awa, palinso matenda ena ambiri omwe amaganiziridwa kuti akugwirizana ndi kusalinganika kwa GABA:

• Kusowa kwa pyridoxine:Matendawa ndi osowa kwambiri. Amayambitsidwa ndi kusowa kwa vitamini B6 (pyridoxine), yomwe ndi yofunika kwambiri popanga GABA. Izi nthawi zambiri zimayambitsa khunyu pafupipafupi mwa ana aang'ono. Khunyu izi zimakhala zovuta kuzithetsa ndi mankhwala ochiritsira khunyu, koma zimatha kuchiritsidwa ndi mavitamini owonjezera.
• Matenda a chiwindi: Matenda aakulu a chiwindi omwe amakhudza ntchito ya ubongo.
• Matenda a Huntington: Matenda obadwa nawo omwe amawononga pang'onopang'ono maselo a ubongo.
• Kutopa ndi kutsekeka kwa minofu: Matenda omwe amadziwika ndi kuuma kwa minofu kosazolowereka komanso kugwedezeka.
• Kugona mopitirira muyeso: Kumva tulo tofa nato kapena kugona kwambiri masana.

Kodi kuwonjezeka kwa GABA kumapereka ubwino pa thanzi?

Ofufuza akuphunzirabe za zotsatira za kukwera kwa GABA. Ngakhale kuti umboni sunadziwike bwino, akufufuza ngati GABA ingathandize kuchiza kapena kupewa matenda ena. Mwachitsanzo:

• Kuthamanga kwa magazi
• Kusowa tulo
• Matenda a shuga

Kafukufuku wowonjezereka akufunika pa izi.

Mitundu ya mankhwala omwe amayang'ana GABA

Chifukwa cha kufunika kwa GABA kumeneku, opanga mankhwala apanga mankhwala ambiri omwe amalimbana ndi GABA "receptors". Izi zimagwira ntchito pothandiza kapena kukulitsa mphamvu zachilengedwe za GABA zotonthoza. Mwina munamvapo izi:

• Benzodiazepines: Mankhwalawa akuphatikizapo diazepam (yomwe imadziwikanso kuti Valium) ndi alprazolam (yomwe imadziwikanso kuti Xanax) ndipo amagwiritsidwa ntchito pochiza nkhawa, kusowa tulo, khunyu, komanso kusiya kumwa mowa. Amagwiritsidwanso ntchito ngati mankhwala oletsa ululu panthawi ya opaleshoni.
• Ma Barbiturates: Awa ndi mtundu wa mankhwala ogonetsa omwe amayambitsa kugona. Komabe, kugwiritsa ntchito kwawo sikuli kofala masiku ano.
• Vigabatrin (Sabril®): Mankhwala ogwiritsidwa ntchito pochiza khunyu ndi kupweteka kwa minofu mwa ana aang'ono.
• Flumazenil (Romazicon®): Imagwiritsidwa ntchito pochiza kuchuluka kwa mankhwala a benzodiazepine. Imagwiritsidwanso ntchito pochiza matenda a chiwindi, matenda omwe amayamba chifukwa cha matenda a chiwindi.
• Valproic acid: Iyi ndi mankhwala oletsa kukhumudwa omwe amaletsa khunyu.
• Zolpidem (yomwe imadziwikanso kuti Ambien® kapena Edluar®): Iyi ndi mankhwala akuluakulu ochizira kusowa tulo.
• Propofol (yomwe imadziwikanso kuti Diprivan®): Mankhwala omwe amagwiritsidwa ntchito pochepetsa ululu ndikugonetsa wodwala panthawi yopuma.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): Yotsitsimula minofu.

Kumbukirani: Mankhwala awa ndi ena ofanana nawo ayenera kugwiritsidwa ntchito pokhapokha ngati dokotala akuyang'anira. Kugwiritsa ntchito nokha, kapena chifukwa choti winawake amene ali pafupi nanu wakuuzani, kungayambitse mavuto aakulu. Choncho samalani.

Kodi zowonjezera za GABA ndizothandiza?

Tsopano ena angafunse kuti, 'Nanga bwanji sitingathe kugula GABA ngati chowonjezera?' Inde, GABA ikupezeka ngati chowonjezera pazakudya. Koma pali vuto laling'ono apa. Sizikudziwikabe kuti ndi GABA ingati yomwe timamwa pakamwa imalowa muubongo mwathu.

Chifukwa, ubongo wathu uli ndi nembanemba yapadera yoteteza yotchedwa "chotchinga magazi ndi ubongo". Izi zili ngati chipata, chomwe sichimalola mankhwala onse kulowa mu ubongo mosavuta, koma chimangolola osankhidwa okha. Chifukwa chake, palibe umboni wokwanira wasayansi wosonyeza ngati zowonjezera za GABA izi zimakhudzadi ubongo kapena ayi. Chifukwa chake, kafukufuku wambiri uyenera kuchitidwa pa izi pogwiritsa ntchito gulu lalikulu la anthu. Poganizira momwe zinthu zilili pano, sikwanzeru kugwiritsa ntchito zowonjezera za GABA popanda kulankhula ndi dokotala.

Kodi pali zakudya zilizonse zomwe zili ndi GABA?

GABA imapezekanso mwachibadwa mu zakudya zina. Mwachitsanzo:

• Zakudya zowiritsa: zinthu monga kimchi (kaloti wa ku Korea), miso (phala la soya la ku Japan), ndi tempeh (chogulitsa cha soya cha ku Indonesia).
• Mitundu ya tiyi: Tiyi wobiriwira, tiyi wakuda, ndi tiyi wa oolong alinso ndi GABA.
• Zakudya zina: Zakudya monga mpunga wofiirira, soya, nandolo, chestnuts (mtundu wa mtedza), bowa, tomato, sipinachi, broccoli, kabichi, kolifulawa, Brussels sprouts (mtundu wa kabichi kakang'ono), tirigu womera (monga nyemba zobiriwira zikamera), ndi mbatata zotsekemera zimakhalanso ndi GABA kapena zimathandiza thupi kupanga GABA.

Koma monga tanenera za zakudya zowonjezera, palibe kufotokozera momveka bwino kuchuluka kwa GABA kuchokera muzakudya izi komwe kumafika ku ubongo. Ndibwino kuziphatikiza ngati gawo la zakudya zabwino, koma sikoyenera kudalira zakudya izi zokha ngati chithandizo chenicheni cha vuto linalake. Komanso, funsani upangiri wa dokotala pankhaniyi.

Pomaliza, zinthu zoti muzikumbukira (Uthenga Wopita Nawo Kunyumba)

Kotero, mwina tsopano mukumvetsa kuti GABA (gamma-aminobutyric acid) yomwe tidakambirana lero ndi neurotransmitter yomwe imachepetsa ubongo wathu ndipo ndi yofunika kwambiri pa thanzi lathu la maganizo, tulo, komanso magwiridwe antchito a thupi lathu lonse.

Zimathandiza kuchepetsa nkhawa, kupsinjika maganizo, ndi kusowa tulo. Kuchepa kwa GABA kungayambitse matenda osiyanasiyana amitsempha ndi matenda amisala. Mankhwala ena amagwira ntchito poyang'ana dongosolo la GABA.

Kafukufuku wowonjezereka wa sayansi akufunika pa ubwino wa zakudya zowonjezera za GABA ndi zakudya zokhala ndi GABA. Chifukwa chake, ngati muli ndi nkhawa, kukayikira, kapena mafunso okhudza GABA, chinthu chabwino komanso chotetezeka kuchita ndikuwona dokotala wa banja lanu, kukambirana za vuto lanu, ndikupeza upangiri woyenera.Musapite kuntchito chifukwa cha zongopeka kapena zongopeka. Thanzi lanu ndi lofunika kwa inu.

GABA , gamma-aminobutyric acid, neurotransmitter, ubongo, thanzi la maganizo, nkhawa, tulo