Ese nawe wumva urwaye mu buryo butunguranye? Ni iyihe ndwara itera nta mpamvu? (Mast Cell Activation Syndrome)

Ese hari igihe wumva urwaye cyane mu buryo butunguranye? Ni nko kugira allergie ikomeye. Wenda umubiri wawe wose uhinduka umutuku, ukarya, ukabyimba, ukarwara mu nda, ukaruka, cyangwa ukagira ikibazo cyo guhumeka. Ariko ibi ntibibaho kuko wariye ikintu cyangwa wakozeho. Niba ibi bibaye nta mpamvu igaragara, bishobora kuba indwara yitwa `Mast Cell Activation Syndrome (MCAS).` Reka tubiganireho birambuye uyu munsi.

"Indwara yo gukora abarwayi ba Mast Cell Activation Syndrome (MCAS)" ni iki?

Mu magambo make, MCAS ni indwara aho ubwoko bw'uturemangingo mu mubiri wacu twitwa "mast cells" bikora cyane nta mpamvu igaragara, bigatera ibimenyetso bikomeye. Noneho ushobora kuba urimo gutekereza uti "Nibyo allergie." Yego, allergie ikubiyemo no gukora "mast cells." Ariko allergie akenshi iba ifite impamvu isobanutse . Urugero, bamwe bagira allergie ku bimera nk'udusimba, ubunyobwa, cyangwa udusimba. Ariko muri MCAS, biragoye kubona impamvu runaka. Ibi bimenyetso bigaragara mu buryo butunguranye.

Hari ubwo gukora kw'izi selile za mast bishobora gutera ubwivumbure bukomeye cyane, bushobora gushyira ubuzima mu kaga bwitwa anaphylaxis. Ibi bishobora gutera kugorwa no guhumeka no kugabanuka k'umuvuduko w'amaraso. Niba ugize ikibazo gikomeye cya anaphylaxis, ugomba guhamagara 911 cyangwa ujya mu cyumba cyita ku barwayi b'ingoboka kiri hafi yawe ako kanya.

Uturemangingo twa mast ni nk'abasirikare mu budahangarwa bwacu bw'umubiri. Bifasha kurwanya indwara. Ni ibisanzwe rero kugira ubwoba iyo ufite ibi bimenyetso bitaramenyekana. Ariko ni ibisanzwe ko uturemangingo twa mast dukora. Urugero, uturemangingo twa mast dukora mu bihe nka rhinitis ifite allergie, asima, anaphylaxis ku miti cyangwa ibiryo, na mastocytosis. Ibi nibyo bituma tugira ibi bimenyetso birakaza, rimwe na rimwe bikaba byateza akaga.

Ariko, "Mast Cell Activation Syndrome (MCAS)" ni indwara idakunze kugaragara . Abaganga bapima MCAS iyo hari ibintu bikurikira:

• Niba ufite ibimenyetso bigaruka, ukeka ko bishobora kuba ari anaphylaxis nta mpamvu igaragara.
• Niba ibi bimenyetso bigira ingaruka ku ngingo zirenze imwe z'umubiri wawe icyarimwe (urugero, uruhu n'amara).
• Niba ibizamini bigaragaza ibimenyetso by'uko uturemangingo twa mast turimo gukora.
• Niba ibimenyetso byawe byagabanutse bitewe n'imiti igamije kwibasira uturemangingo twa mast.

Uturemangingo tw’imbere mu mubiri n’uruhare rwatwo

Uturemangingo tw’umubiri ni uturemangingo tw’ubudahangarwa bw’umubiri wacu.Igice. Akazi kabo gasanzwe ni ukurinda imibiri yacu indwara ziterwa n’udukoko (urugero: udukoko, virusi) cyangwa ibindi bintu byangiza byinjira mu mibiri yacu. Utu turemangingo tuba mu ngingo zacu, kandi iyo tubonye ikintu bibwira ko ari kibi, dusohora imiti nka histamine, ituma ubudahangarwa bw’umubiri bukora neza kandi ikagerageza kurwanya icyo cyateye.

Hari igihe bigira ingaruka ku bintu batagomba kugira. Ni bwo turwara indwara ya aleriji . Ariko aleriji akenshi itera ibimenyetso bito nko kurira amaso no kuva izuru. Ikibaho muri MCAS ni uko hari ibimenyetso bikomeye kurushaho nta mpamvu igaragara.

"Indwara yo gukora ingirabuzima fatizo za Mast Cell Activation Syndrome (MCAS)" ifite uburemere bungana iki?

Ubukana bwa MCAS buterwa n'ibimenyetso ubona. Hari abantu bashobora kugira ibimenyetso byoroheje, bafite ibimenyetso by'uruhu gusa. Abandi bashobora kugira indwara zikomeye cyane, nka anaphylaxis. Anaphylaxis ishobora kwica iyo idavuwe neza. Ariko, ingaruka zishobora gushyira ubuzima kuri MCAS ni gake cyane .

Ni ibihe bimenyetso bya `Mast Cell Activation Syndrome (MCAS)`?

MCAS ishobora gutera ibimenyetso bikomeye kandi bigaruka mu bice bitandukanye by'umubiri wawe. Ibi bimenyetso bishobora kuba birimo:

• Umuvuduko w'amaraso uri hasi.
• Uruhu ruhinduka umutuku, umutuku, kandi rushyushye (`Flushing`).
• Uruhu ruryana.
• Kuziba izuru.
• Kubyimba - cyane cyane mu maso, ku minwa, mu maso, ku rurimi cyangwa mu muhogo (`Angioedema`).
• Kurya impatwe cyangwa impiswi (wenda byombi bisimburana).
• Kubabara mu gifu.
• Kugorwa no guhumeka.
• Intege nke cyangwa gucika intege.
• Gutakaza ubwenge cyangwa kugorana gutekereza (ubwonko).
• Gucika intege.
• Kubabara ingingo.
• Anaphylaxis (ingaruka zikomeye z'ubwivumbure hamwe n'ikimenyetso kimwe cyangwa byinshi muri ibi byavuzwe haruguru).

Kugira ngo ukeke ko MCAS ari ikibazo, ibi bimenyetso bigomba kugira ingaruka ku mubiri wawe nibura ebyiri. Ni ukuvuga:

• Udutsi two mu bwonko (ubwonko n'imitsi).
• Uduce tw'ubuhumekero (ibihaha n'inzira z'ubuhumekero).
• Umutima n'imitsi (umutima n'imitsi ijyana amaraso).
• Igogora (igifu n'amara).

Bimera bite iyo uturemangingo twa mast tugize umubiri mu buryo butunguranye?

Niba wigeze kugira allergie, ushobora kuba uzi uko biba bimeze iyo uturemangingo twa mast tugize umubiri. Ariko ku bantu bafite MCAS, iyi ndwara irakomeye kurusha allergie isanzwe, kandi ifata ibice byinshi by'umubiri. Uruhu rwawe rushobora kubyimba, rugahinduka umutuku, rugatangira kuribwa, cyangwa se rukava amaraso. Ushobora kugira impiswi no kuruka. Mu bihe bikomeye, isura yawe n'umuhogo bishobora kubyimba, kandi umuvuduko w'amaraso ushobora kugabanuka. Wibuke ko niba ubonye ibi bimenyetso bikomeye, ugomba guhamagara 911 cyangwa uhite ujya kwa muganga uri hafi yawe.

Ni izihe mpamvu zitera `Mast Cell Activation Syndrome (MCAS)`?

MCAS iterwa n'uko uturemangingo twawe tw’imbere dukora ibikorwa mu gihe bitabaye ngombwa. Uturemangingo twambere dutekereza ko hari ikintu kibi cyinjiye mu mubiri kandi ko gikeneye kurindwa. Icyo gihe ni bwo turekura poroteyine zitera ibimenyetso. Mu ndwara ya aleriji, dushobora kumenya icyatuma umubiri urushaho kugira aleriji. Ariko muri MCAS, biragoye kubona impamvu isobanutse neza ituma uturemangingo twambere durekura izo poroteyine.

Mu by’ukuri, nta muntu n’umwe uracyazi neza impamvu uturemangingo tw’umusemburo twibasirwa n’ibintu bidakenewe.

Ni izihe mpamvu zishobora gutuma uturemangingo twa mast tuvugururwa?

Nubwo ibintu byinshi, nk'ibiribwa n'umukungugu, bishobora gukora uturemangingo twa mast no kurekura histamine, ntabwo bishoboka kuvuga ko ibimenyetso bikomeye bya MCAS biterwa n'ikintu runaka kigutera allergie. Ariko, ushobora gusanga ibi bimenyetso bikomeye cyane iyo hari impinduka mu buzima bwawe cyangwa aho utuye, urugero, mu bihe by'imihangayiko myinshi cyangwa iyo ikirere gihindutse. Niba ibimenyetso byawe bigaragaye gusa nyuma yo guhura n'ikintu runaka, bwira muganga wawe. Muri icyo gihe, ushobora kuba udafite MCAS, ahubwo ufite allergie.

Ni gute indwara ya Mast Cell Activation Syndrome (MCAS) ipimwa?

Muganga ashobora gukeka ko ufite MCAS nyuma yo kugusuzuma, kukubwira ibimenyetso byawe, n'amateka y'ubuzima bwawe. Abaganga bazagusuzuma niba ibi bikurikira byubahirijwe:

• Niba ufite ibimenyetso byo gukora kwa mast cell.
• Niba witabiriye neza imiti yo gukoresha uturemangingo twa mast.
• Niba ibizamini bigaragaza ibimenyetso by'uko uturemangingo twa mast tukora.
• Niba ufite umubare usanzwe w'uturemangingo twa mast mu mubiri wawe (kuba ufite uturemangingo twinshi cyane bivuze ko ushobora kugira ikindi kibazo cy'uturemangingo twa mast, nka mastocytosis).

Isuzuma rya MCAS

Kugira ngo urebe MCAS, muganga wawe ashobora gukora isuzuma ry'amaraso kugira ngo arebe niba hari ikinyabutabire cyitwa ``tryptase'' mu maraso yawe. ``tryptase'' ni ikintu cyiyongera iyo ``mast cells'' zikora. Iki kizamini kizakenera gukorwa inshuro nyinshi - haba iyo umeze neza ndetse n'igihe ufite ibimenyetso bikomeye. Ariko ibuka ko ``tryptase'' ishobora no kwiyongera mu zindi ndwara. Bityo rero ``tryptase'' yonyine ntishobora kumenya niba ufite MCAS. Hari abantu bashobora kugira ``tryptase'' iri hejuru kurusha uko byari byitezwe nubwo badafite ibimenyetso.

Muganga wawe ashobora kandi gupima uruhu rw'allergie cyangwa gupima amaraso y'allergie kugira ngo arebe izindi mpamvu.

Icy'ingenzi: Nubwo ikizamini cy'amaraso cya histamine cyagaragaza urugero rwinshi rwa histamine, abaganga ntibafata umwanzuro ko ufite MCAS.

Indwara yo gukora ku ngirabuzima fatizo (MCAS) ivurwa ite?

Abaganga bakoresha uburyo bwo kuvura indwara ya MCAS no kugabanya ibimenyetso by'indwara. Niba udakize imiti irwanya uturemangingo tw'imitsi, birashoboka ko udafite MCAS.

Bitewe n'ibimenyetso byawe, muganga wawe ashobora kukwandikira imiti nk'iyi:

• Imiti igabanya ububabare bwa Histamine type 1 (Antihistamines) : Iyi ni imiti ikoreshwa mu kuvura ibimenyetso by'ubwivumbure. Urugero: Loratadine, Cetirizine, Fexofenadine.
• Imiti igabanya aside yo mu gifu ya histamine type 2 (antihistamines igabanya aside yo mu gifu) : Iyi miti itangwa ku isesemi no kubabara mu gifu. Urugero: Ranitidine cyangwa Famotidine.
• Aspirine : Aspirine ishobora gutangwa kugira ngo igabanye gushyuha.
• Uburyo bwo guhindura leukotriene : Ibi bifasha koroshya guhumeka. Ingero: Montelukast, Zafirlukast.
• Omalizumab (XOLAIR®) : Ibi bishobora kugabanya ibyago byo kurwara indwara ya anaphylaxis.
• Epinephrine : Abaganga bakoresha epinephrine kugira ngo bahagarike anaphylaxis. Ushobora kugumana inshinge za epinephrine (EpiPen®, Auvi-Q®) hafi yawe mu gihe uhuye n'ikibazo cya anaphylaxis.
• Ibifasha mu kubungabunga uturemangingo twa mast : Imiti nka cromolyn sodium ibuza irekurwa ry'imiti iva mu turemangingo twa mast (degranulation).
• Corticosteroids : Izi zigabanya ububyimbirwe, zifungura inzira z'ubuhumekero, kandi zigabanye amazi mu ngingo. Ariko, kubera ibyago byo kugira ingaruka mbi, abaganga ntibakunze gutanga imiti ya steroide kuri MCAS.

Ese indwara ya Mast Cell Activation Syndrome (MCAS) izigera ikira burundu?

Oya, nta muti uhari wa MCAS. Niba ufite MCAS, uzakenera kuyivura ukoresheje imiti.

Imyaka yo kubaho y'umuntu urwaye MCAS ni iyihe?

Abaganga biteze ko abantu benshi barwaye MCAS bazabaho igihe kirekire nk'icy'umuntu utayirwaye. Ariko kubera ko iyi ari indwara nshya yasuzumwe, ntabwo dushobora kuvuga neza uburyo izagira ingaruka ku buzima bwe.

Nitwara nte?

Dore bumwe mu buryo ushobora kwiyitaho ukoresheje MCAS:

• Andika ibimenyetso byawe. Andika ibimenyetso byawe, ibyo wariye n'ibyo wanyoye icyo gihe, n'ibindi wahuye na byo. Tekereza ku byari bitandukanye muri ibyo bihe ugereranije n'igihe utari ufite ibimenyetso. Niba ubonye ibimenyetso, bwira muganga wawe.
• Bwira inshuti zawe za hafi, abavandimwe, cyangwa abantu ukunda kubana nabo uko wakwitwara muri iki kibazo, n'aho inshinge zawe za epinephrine cyangwa indi miti yihutirwa iri.

Ni ryari nkwiye kujya mu ishami rishinzwe ubutabazi bwihutirwa (ETU) ?

Nubwo ingaruka zikomeye kuri MCAS zidakunze kubaho, niba ubonye ibimenyetso by'ingaruka zikomeye kuri allergie cyangwa anaphylaxis, koresha inshinge za epinephrine niba uzifite. Hanyuma hamagara 911 cyangwa ujye mu cyumba cy'ubutabazi cya hafi yawe ako kanya. Ibimenyetso bya anaphylaxis birimo:

• Kubyimba mu maso, iminwa, ururimi, cyangwa umuhogo.
• Kugorwa no guhumeka cyangwa kumira.
• Umutima utera cyane.
• Umuvuduko w'amaraso uri hasi.

Ni ibihe bibazo ngomba kubaza muganga wanjye?

Bishobora kuba byiza kubaza muganga wawe ibibazo nk'ibi:

• Nkwiye gukora iki niba iyi ndwara irushijeho gukomera/izamuka kuri njye?
• Ni gute nkwiye gufata umuti wanjye?
• Ni gute kandi ryari nkwiye gukoresha inshinge zanjye za epinephrine?
• Ni ryari nkwiye kujya mu cyumba cy’ubutabazi bw’ibanze?
• Ni ryari nkwiye kuzaza kureba?

Ese "Gukora kwa mast cell" ni indwara y’ubwiyongere bw’umubiri?

Oya, MCAS si indwara y’ubwiyongere bw’umubiri.

Tekereza ijwi ry'umuziki. Inzego z'umutekano ziraje. "Selile za mast" zawe zabonye akaga kandi zirahamagara. Ariko ... nta kaga gahari. Kimwe n'umukinyi w'urwenya, "selile za mast" zawe zirimo gusa guhanura nta bwihutirwa. Aho kukurinda indwara, ni zo zigutera indwara.

Nubwo tutazi neza impamvu uturemangingo twa mast twa bamwe dukira cyane, hari uburyo bwo gucunga MCAS. Menya ibimenyetso by'ibanze by'ingaruka mbi. Niba wumva ibimenyetso byawe birimo kugenda bikura mu buryo butunguranye, vugana na muganga wawe. Icy'ingenzi ni uguhora witwaje inshinge za epinephrine kandi ukamenya uburyo n'igihe cyo kuzikoresha. Ushobora kutazigera uzikenera, ariko kwitegura ingaruka zitunguranye bishobora kuguha amahoro yo mu mutima.

Ibintu ukeneye kumenya (Ubutumwa bwo kujyana mu rugo)

• Indwara yo gukora abarwayi ba mast cell (MCAS) ni indwara idakunze kugaragara itera ibimenyetso bikomeye by’ubwivumbure nta mpamvu igaragara ihari.
• Ibi bishobora kugira ingaruka ku mikorere y'umubiri myinshi icyarimwe.
• Indwara zishobora gushyira ubuzima mu kaga nka 'Anaphylaxis', bityo rero shaka ubufasha bwa muganga vuba niba ubonye ibimenyetso bikomeye.
• Nubwo MCAS idashobora gukira burundu, ibimenyetso bishobora kugenzurwa n'imiti.
• Menya ibimenyetso byawe, shyira inshinge za epinephrine hafi yawe kugira ngo uzikoreshe mu buryo bwihutirwa, kandi ubibwire umuryango wawe.
• Niba ufite ikibazo icyo ari cyo cyose kuri MCAS, ntutinye kubaza muganga wawe.

Uturemangingo tw’imbere mu mubiri, MCAS, allergie, anaphylaxis, histamine, tryptase, ubudahangarwa bw’umubiri