Ese nawe wifuza kumenya ibyerekeye Pelger-Huet Anomaly? Reka tubiganireho!

Ese wigeze ubona muganga akubwira ku mpinduka nto mu turemangingo tw’amaraso twera ubwo wapimwaga amaraso? Bishobora kuba Pelger-Huet Anomaly. Izina rishobora kumvikana nk'ikintu gikomeye, ariko ntugahangayike , akenshi ntabwo ari ikintu gikomeye cyane. Reka tubiganireho mu buryo burambuye, mu buryo bworoshye.

Pelger-Huet Anomaly ni iki?

Mu magambo make, Pelger-Huet Anomaly (PHA) ni indwara iterwa n’uturemangingo tw’umubiri (neutrophils), ubwoko bw’uturemangingo tw’amaraso tw’umweru mu mubiri wacu. Neutrophils ni nk’abasirikare bato mu mubiri wacu bafasha umubiri wacu kurwanya mikorobe.

Iyi ndwara iterwa n'ihindagurika rya ADN yacu, cyane cyane muri gene yitwa Lamin B Receptor (gene LBR). Iyi gene ya LBR niyo ifasha uturemangingo twa neutrophil gukura no gukura neza.

Noneho reba, buri selile ya neutrophil ifite ikigo cy’ubuyobozi, twita nucleus . Iyi nucleus ikubiyemo amakuru yose ya ADN akenewe kugira ngo selile ikore kandi ikure. Ubusanzwe, nucleus ya neutrophil nzima igabanyijemo ibice bitatu cyangwa birenga. Ariko, nucleus ya neutrophil ku muntu urwaye Pelger-Huette ifite ibice bibiri. Imeze nk'agahu k'inyuma, gafite ibinure ku mpande zombi n'igice cyo hagati gito. Ni gake cyane, kuri bamwe, iyi nucleus ya neutrophil ishobora kuba ifite ishusho y'urudodo, ni ukuvuga, ifite ishusho nk'igi.

Ariko icy'ingenzi hano ni uko nubwo wavukana Pelger-Huette anomaly, akenshi uturemangingo twa neutrophil dukora neza. Ibi bivuze ko tudakora neza cyane mu kukurinda indwara. Kubwibyo, akenshi bitera ibibazo bike cyane by'ubuzima.

Hari indi ndwara yitwa Pseudo Pelger-Huet Anomaly (PPHA) . Ibi bishobora kubaho kuri bamwe mu bantu nyuma y'ubuzima bwabo. PPHA ishobora kubaho nk'ingaruka mbi z'imiti imwe n'imwe cyangwa nk'ikimenyetso cy'indi ndwara, nk'ubwandu.

Ni ibihe bimenyetso bya Pelger-Huette anomaly?

Aha tugomba kwibanda ku bwoko bubiri twavuze mbere.

Umurage Pelger-Huet Anomaly (HPA)

Niba ufite Pelger-Huette anomaly (HPA), ikomoka ku ruhu, ubusanzwe nta bimenyetso uba ufite. Ushobora no kutamenya ko ufite iyo ndwara. Ubusanzwe iboneka mu buryo bw’impanuka iyo habayeho isuzuma ry’amaraso ku yindi mpamvu.

Pseudo Pelger-Huet Anomaly (PPHA)

Ariko, niba ufite PPHA (pseudo-Pelger-Huette anomaly), bivuze ko yazamutse nyuma, ushobora kugira ibimenyetso bijyanye n'indwara yateye.Urugero, niba PPHA iterwa n'ubwandu, hashobora kubaho ibimenyetso nk'umuriro n'ububabare bw'umubiri bifitanye isano n'ubwo bwandu.

Ni iki gitera Pelger-Huette anomaly?

Impamvu y'ibi nayo iratandukanye bitewe n'ubwoko bubiri twavuze mbere.

Indwara ya Pelger-Huette (Hereditary Pelger-Huette anomaly)

Ibi biterwa n’impinduka mu ngirabuzimafatizo ya Lamin B Receptor (LBR), nk’uko twabivuze mbere. Iyi ngirabuzimafatizo ya LBR itegeka umubiri wacu gukora poroteyine zikenewe kugira ngo zirinde uturemangingo twa neutrophil no kuziha imiterere ikwiye. Muri Pelger-Huytt anomaly, iyi mpinduka mu ngirabuzimafatizo ibangamira iyo gahunda, bigatuma imiterere ya neutrophil ifata iyo shusho ya dumbbell. Iyi ni indwara ishobora kuragwa n’ababyeyi ku bana.

Pseudo Pelger-Huette anomaly (PPHA)

Iyi si indwara iterwa n'uturemangingo. Hari ibintu byinshi bishobora gutera iyi ndwara:

• Indwara z'umusemburo w'amagufwa: Ingero zirimo indwara za kanseri y'amagufwa nka myelodysplastic syndrome na myeloid leukemia ikabije (AML).
• Hari indwara zimwe na zimwe: cyane cyane indwara ziterwa n'udusimba.
• Imiti igabanya ubudahangarwa bw'umubiri: Iyi miti, itangwa ku ndwara zimwe na zimwe, ishobora kuba ari nayo itera.
• Guhura n'imirasire: Urugero, mu gihe cyo kuvura kanseri.

Iyo umuganga akubwiye ko ufite `PHA` cyangwa `PPHA`, ni ngombwa cyane kumenyesha umuganga imiti yose ufata, ndetse na vitamine.

Ni ibihe bintu bishobora gutera iyi ndwara?

Impamvu nyamukuru ishobora gutera Pelger-Huette anomaly (PHA) ni ukugira umubyeyi ubyara ufite iyo ndwara. Ibi bivuze ko niba mama wawe cyangwa so bafite PHA, ufite amahirwe agera kuri 50% yo kuyizungura. Ni nko kuzunguza igiceri, ntushobora kwemeza neza, ariko birashoboka.

Ku kibazo cya `PPHA`, guhura n’indwara cyangwa uburyo bwo kuvura bwavuzwe haruguru ni ibintu bishobora gutera ibyago.

Ese hari ingorane ziterwa n'iyi ndwara?

Ubusanzwe, Pelger-Huette anomaly (PHA) yo mu bwoko bwa hereditary ntabwo itera ingorane zikomeye. Kuko, nubwo ihindura imiterere y'uturemangingo twa neutrophil, ntabwo ihindura cyane uburyo dukora. Ikomeza kurwanya mikorobe.

Ariko, niba ufite pseudopelgar-huwat anomalous (PPHA), indwara yateye iyi ndwara (nka leukemia) ishobora gutera ingorane. Rero, ni ngombwa kuvugana na muganga wawe kuri ibi no kumenya icyo ugomba kwitega.

Ni gute abaganga basuzuma Pelger-Huette anomalie?

Abaganga bakoresha cyane cyane ibipimo by'amaraso kugira ngo bamenye iyi ndwara. By'umwihariko,Ikizamini cyitwa peripheral blood smear kirakorwa. Iki kizamini kigizwe no gufata igitonyanga cy'amaraso yawe, ukagishyira ku kirahuri gito, hanyuma ukagisuzuma ukoresheje mikorosikopi.

Ibi bisuzumwa n'inzobere mu ndwara cyangwa inzobere mu maraso.

Niba ufite ikibazo cya Pelger-Huette, iki kizamini kizagaragaza neza imiterere idasanzwe y'uturemangingo twa neutrophil (nk'agapira k'inyuma).

Ese hari uburyo bwo kuvura Pelger-Huette anomaly?

Dore inkuru nziza! Indwara ya Hereditary Pelger-Huette (PHA) ubusanzwe nta bimenyetso itera, bityo ntisaba ubuvuzi bwihariye. Nubwo waba ufite iyi ndwara, ushobora kubaho ubuzima busanzwe.

Ariko, ku bijyanye na `PPHA`, ni ngombwa kuvura indwara y’ibanze yayiteye. Iyo iyo ndwara imaze gukira, `PPHA` ishobora no kugenda.

Ni ryari ngomba kujya kwa muganga?

Niba usanze ufite Pelger-Huette anomaly, menya neza ko wabibwiye muganga wawe niba hari ibimenyetso bishya ugaragaje (nk'umuriro, umunaniro ukabije, kwandura indwara kenshi). Hanyuma muganga wawe ashobora kumenya niba ibimenyetso bifitanye isano na `PHA`, `PPHA`, cyangwa ikindi kintu.

Iyo ugiye kwa muganga, ni byiza kandi kubaza ibi bibazo:

• Ese mfite ikibazo cy’uko Pelger-Huette ari nyirabayazana (HPA)` cyangwa `PPHA` y’ubusembwa?
• Ese birashoboka ko abana banjye bazaragwa iyi ndwara? (Niba ari HPA)
• Ni kangahe nkwiye kujya kwa muganga?
• Ni ibihe bimenyetso ngomba kumenya by'umwihariko?

Ni iki nkwiye kwitega muri iki kibazo?

Pelger-Huette anomaly (PHA) ubwayo ntabwo igutera ububabare cyangwa ngo igire icyo ihindura mu buzima bwawe. Akenshi ntabwo igira ingaruka ku bikorwa byawe bya buri munsi.

Ariko, niba ufite iyi ndwara (cyane cyane ubwoko bwa `PPHA`), ishobora kuba ikimenyetso cy'indi ndwara y'ubuzima. Niyo mpamvu abaganga bayihangayikishijwe. Niba muganga wawe akeka ko ufite `PHA` cyangwa `PPHA`, azakora ibizamini bikenewe kugira ngo yemeze ko ari yo, kandi anafate ingamba zo gukuraho izindi ndwara.

Ushobora kuba ufite Pelger-Huette anomaly (PHA) ariko ntubimenye kuko nta bimenyetso ufite. Ushobora kwibaza uti: "Niba bitambangamiye, kuki mbitekerezaho?" Nibyo koko ushobora kuba utari urwaye kubera iyi mihindagurikire y'uturemangingo. Ariko ni ngombwa kumenyesha muganga wawe ibyayo. Muganga wawe arahari kugira ngo agufashe kugira ubuzima bwiza. Kandi birafasha kumenya utwo tuntu duto mu mubiri wawe. Kuba ufite Pelger-Huette anomaly ni ikindi kintu kigutera "wowe." Nta mpamvu yo guhangayikishwa na yo.

Incamake (Ubutumwa bwo kujyana mu rugo)

Sawa, reka dusubiremo bimwe mu byo twaganiriyeho:

• Pelger-Huet Anomaly (PHA) ni indwara iterwa n’uturemangingo duto dutuma imiterere y’uturemangingo tw’amaraso tumeze nk’uturemangingo tw’amaraso (neutrophils) iba idasanzwe.
• Ibi ubusanzwe ntabwo ari bibi kandi ntibitera ibimenyetso. Uturemangingo twa neutrophil dukora neza.
• Hari ubwoko bubiri bw'ibi: `HPA`, ari yo ikomoka ku ruhererekane rw'indwara, na `PPHA`, iterwa nyuma n'izindi ndwara cyangwa imiti.
• Ubusanzwe HPA ntikenera kuvurwa. Ku bijyanye na PPHA, impamvu nyamukuru iravurwa.
• Iyi ndwara ipimwa binyuze mu gupima amaraso (peripheral blood smear).
• Nusanga ufite iyi ndwara, ntugahangayike. Ariko, vugana na muganga wawe kandi ubone inama zikenewe. Bibwire muganga wawe niba ibimenyetso bishya bigaragaye.

Ndizera ko iyi nkuru yasubije ibibazo byinshi wabajije ku bijyanye n'indwara ya Pelger-Huette. Wibuke ko, ku kibazo icyo ari cyo cyose cy'ubuzima, ni byiza kuganira na muganga wawe mu buryo bweruye.

Pelger -Huet Anomaly, Neutrophils, Uturemangingo tw'Amaraso Yera, Indwara z'Uturemangingo, Ibipimo by'Amaraso, PPHA, HPA