Tose tinotya kurasikirwa nendangariro sezvatinokura, handiti? Kunyanya kana mumwe munhu mumhuri mako akambova nechirwere chakadai seAlzheimer 's, mubvunzo wekuti 'Ndichachiwanawo here?' ungangove uri mupfungwa dzako. Majini edu anokanganisa sei izvi? Tsvagiridzo yazvino inoratidza kuti pane hukama hwakasimba pakati pejini rakati rinonzi APOE4 nechirwere cheAlzheimer's kupfuura zvaifungwa kare. Saka nhasi, ngatitaurei nezveizvi, kana zvichikukanganisa iwe, uye zvatinogona kuita nezvazvo.
Chii chaizvo chinonzi gene iri rinonzi APOE4?
Zvichitaurwa zviri nyore, APOE ijini riri mumuviri wedu. Basa rayo guru nderekutakura mafuta , akadai secholesterol, pakati pemasero edu (lipid transport). Funga nezvemasero ari mumuviri wedu sedzimba diki. Dzimba idzi dzinoda mafuta kuti ashande, aavake, uye agadzire simba. Jini reAPOE rakafanana ne'basa rekuendesa mafuta' rinounza mafuta aya kupinda nekubuda mumasero. Kana basa iri rikasashanda zvakanaka, matambudziko anogona kumuka, kunyanya mumasero europi.
Munhu wese ane jini reAPOE iri here?
Ehe, tese tine jini reAPOE iri mumiviri yedu. Asi hazvina kufanana. Zvakafanana nekuti, kunyangwe mu 'delivery service' imwe chete, vamwe vashandi vakangwara zvikuru, vamwe vane mwero, uye vamwe vane usimbe zvishoma. Kune mhando nhatu huru. Ngationei kuti musiyano uripi.
| Rudzi rweMajini | Chii chinoitika (Mhedzisiro) |
|---|---|
| APOE2 | Iyi ndiyo mhando yakanakisisa . Kana uine iyi, hauzove nematambudziko akawanda ekushandiswa kwemafuta mumuviri. Zvinonziwo inopa dziviriro kubva kuchirwere cheAlzheimer. |
| APOE3 | Iyi ndiyo mhando yakajairika . Vanhu vazhinji vane izvi. Hapana chakanaka kana chakaipa. Hazviwedzere njodzi kana dziviriro. |
| APOE4 | Iri ndiro dambudziko . Hariite basa raro rekutakura mafuta nemazvo. Kuva nekopi imwe kana mbiri dzejini iri kunowedzera zvakanyanya njodzi yekubatwa nechirwere cheAlzheimer. |
Chidzidzo chitsva ichi chinoti chii?
Taimbofunga kuti APOE4 ingori 'njodzi' yeAlzheimer's. Kureva kuti, kuva nayo hazvirevi kuti uchava nechirwere ichi, asi zvinoreva kuti mukana wacho wakakwira.
Asi chidzidzo chitsva ichi chinoratidza kuti kuva nemakopi maviri ejini reAPOE4 hakusi kungokonzera njodzi chete, asi kunogona kunge kuri rudzi rwemajini rwechirwere cheAlzheimer's pacharo. Izvi zvinoreva kuti vanhu vane majini ese ari maviri vari panjodzi huru yekubata chirwere ichi. Uye zviratidzo zvinogona kutanga pazera diki.
Tinowanzoziva kuti majini anokonzera chirwere cheAlzheimer ndi `(APP)`, `(PSEN1)` uye `(PSEN2)`. Haawanzoitiki. Asi chidzidzo ichi chaunza jini reAPOE4 pedyo navo. Vakaona kuti 95% yevanhu vane makopi maviri eAPOE4 vane huwandu hwakanyanya hwe`(beta amyloid)`, puroteni inokuvadza inobatanidzwa nechirwere cheAlzheimer, muuropi pavanosvika makore makumi matanhatu nemashanu.
Kuva nejini reAPOE4 zvinoreva here kuti zvechokwadi uchabatwa nechirwere cheAlzheimer's?
Kwete. Hazvina chokwadi zvachose. Asi njodzi yacho yakakura zvikuru. Zvakafanana nekutyaira mota nekumhanya zvakanyanya uye kuita tsaona kunowedzera mikana yako yekuita tsaona. Hazvizoitiki, asi zvinowedzera mikana yako. Vanhu vanosvika 2% vane makopi ese ejini reAPOE4. Pakati pe15% ne25% vane kopi imwe chete.
Ndingazviedza here kuti ndione kana ndine jini iri?
Ehe, kune bvunzo dzemajini dzeizvi. Asi iyi haisi bvunzo inowanzo nyorwa nachiremba wako uye inogona kuitwa zviri nyore muchipatara. Izvi hazviwanzoitika muSri Lanka. Kunyangwe kune dzimwe nyika, hazviwanzo vharwa neinishuwarenzi.
Bvunzo idzi dzinogona kubhadharwa kuburikidza nemasangano akazvimirira. Kuti unosarudza here kana kuti kwete, chisarudzo chako ndechega. Kana nhengo dzakawanda dzemhuri yako dziine chirwere cheAlzheimer, ungangoda kutaura nachiremba wosarudza nezvazvo.
Pasinei nenjodzi iripo, chii chatingaita kudzivirira chirwere ichi?
Heino chikamu chakakosha. Hatigone kuchinja majini edu. Asi tinogona kurwisa njodzi inouya nawo. Kunyangwe tisingakwanise kugadzirisa chirwere ichi kana chakura zvakakwana, mararamiro edu anogona kunonotsa kana kudzivirira kuti chisaitike.
Chinhu chinonyanya kukosha ndechekuvaka kusimba muuropi. Funga nezveuropi hwako sechivako chikuru chakavakirwa pambiru. Mushure memakore makumi maviri, zvinhu zvatinoita zvinoputsa mbiru idzi, kana kuti tinovaka mbiru itsva toita kuti dziwedzere kusimba.
1. Ngatitangei nekudya kunovaka muviri.
Ongororo dzakaratidza kakawanda kuti kudya kunonyanya kushandiswa muzvirimwa kunogona kuderedza njodzi yeAlzheimer's neinenge 50%. Izvi zvinoreva kudya kwakawanda mumiriwo, michero, nyemba, nzungu, uye zviyo zvakakwana . Kudya kweMediterranean kunobatsirawo.
2. Kurovedza muviri hakusi kungofamba chete.
Kurovedza muviri chimwe chishandiso chine simba chekuderedza njodzi. Asi kungofamba mubindu hakuna kukwana. Ndirwo rudzi rwekurovedza muviri runokuita kuti udikitire uye unzwe kuneta mumuviri runoshanda chaizvo muuropi hwako. Kurovedza muviri nesimba , sekusimudza masimbi , kwakakosha zvikuru. Imwe ongororo yakaratidza kuti vanhu vane pre-dementia vakaita maekisesaizi ekusimbisa makumbo vakaderedza njodzi yavo yekubata chirwere ichi ne40%.
3. Rovedzawo pfungwa dzako
Kurovedza muviri mupfungwa kwakakosha sekurovedza muviri. Izvi zvinosimbisa kubatana pakati pemasero anonzi ma neuron muuropi.
- Dzidza chimwe chinhu chitsva (mutauro, chiridzwa chemimhanzi).
- Gadzirisa mapuzzle, Sudoku, nezvimwewo.
- Pinda zvakadzama muchinhu chaunoda.
- Kutarisana nematambudziko matsva.
Zvinofanira kuzivikanwa nemunhu wese nezve majini, kunyangwe asingazvizive
Chirwere cheAlzheimer hachitangi nechiratidzo chekutanga chekurasikirwa nendangariro. Kuchinja kwezvirwere muuropi kunokonzerwa nechirwere ichi kunotanga makore 20-30 zviratidzo zvekutanga zvisati zvaonekwa .
Izvi zvinoreva kuti isu tese tiri mumakore edu ekuma30, 40, uye 50 tinofanira kufunga nezvehutano hwehuropi hwedu iye zvino.
Taura nachiremba wako udzidze nezvehuwandu hwecholesterol yako, BP, uye HbA1c test values, izvo zvinoratidza mamiriro ako echirwere cheshuga. Kudzora izvi ndeimwe yemari yakawanda yaunogona kushandisa mukudzivirira uropi hwako.
Mharidzo Yekuenda Nayo Kumba
- Jini reAPOE4 chinhu chikuru chinokonzera chirwere cheAlzheimer. Kuva nemakopi maviri aro, kunyanya, kunowedzera mukana wekuwana chirwere ichi.
- Zvisinei, haisi vimbiso ye100%. Kunyangwe paine njodzi yemajini, chirwere ichi chinogona kudzorwa nekunonotswa nekuchinja mararamiro.
- Kudya kwakanaka, kurovedza muviri kwakasimba, uye mabasa epfungwa anoedza uropi ndizvo zvombo zvako zvine simba.
- Usamirira kusvika wakura kuti ufunge nezvehutano hwepfungwa. Tanga uchiri mudiki.
- Taura nachiremba wako nezve BP yako, cholesterol, uye huwandu hweshuga uye zvichengetedze pahutano hwakanaka.
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