Kana vanachiremba vakakuongorora kuti une kenza yemazamu, chiremba wako anogona kukurudzira chemotherapy. Zvakajairika kuti unzwe kutya uye kunetseka kana ukanzwa izvi. Asi kana ukaziviswa zvakanaka nezvemishonga iyi, unogona kukunda kutya ikoko. Kune mhando dzakasiyana dzemishonga yechemotherapy. Mishonga yeAlkylating ndeimwe yemishonga mikuru inoshandiswa pakurapa kenza yemazamu. Saka, ngatitaurei nezvazvo zvakadzama uye zviri nyore nhasi.
Mishonga iyi inonzi Alkylating Agents inoshanda sei chaizvo?
Kuti tinzwisise izvi, tinofanira kutanga tafunga nezvemasero ekenza. Masero ekenza masero anopatsanuka uye anowanda nekukurumidza pasina kudzora. Mishonga yeAlkylating yaive imwe yemishonga yekutanga yakawanikwa ichirwisa kenza. Ichiri kushandiswa zvakanyanya nanhasi.
Zvichitaurwa zviri nyore, rudzi urwu rwemushonga runoshanda nekumisa masero egomarara kuti asazviite mamwe, kureva kuti, kuti asapatsanuke uye akure. Unoita izvi ne:
Sero rega rega rine purani yakazara, kana kuti "purani," yesero iroro. Tinoridaidza kuti DNA. Zvinoitwa nemakemikari e alkylating ndezvekuenda zvakananga kuDNA yesero rekenza uye kuzvibatanidza. Kungofanana nekiyi imwe isingashande kana ukainamatira kune imwe, kana mushonga uyu wakabatana neDNA, sero iroro harigone kupatsanuka.
Kana kupatsanurwa kwemasero kwamira nenzira iyi, masero egomarara anofa zvishoma nezvishoma. Mukurapa, tinoti maitiro aya apoptosis . Kureva, kufa kwemasero kwakarongwa.
Chimwe chinhu chinoshamisa chemishonga iyi ndechekuti inogona kurwisa nekuparadza sero rekenza chero padanho ripi zvaro rehupenyu hwayo. Izvi zvinonzi `cell-cycle phase nonspecific`. Saka, inoshanda zvikuru pakurwisa mhando dzakawanda dzekenza, kunyanya idzo dzinokura nekukurumidza.
Mushonga uyu unogona kupihwa kwauri sepiritsi kana semushonga wesaline kuburikidza netsinga (IV - intravenous). Kazhinji, chiremba wako anokupa mushonga uyu pamwe chete nemimwe mishonga yechemotherapy (combination therapy).
Ndeapi marudzi eAlkylating Agents?
Boka iri remishonga rakakamurwa kuita mapoka makuru akati wandei. Kunyangwe mazita emishonga iyi akaomarara zvishoma, zvakanaka kuziva nekuti unogona kuwana imwe yemishonga iyi yakanyorwa papepa rako remishonga.
| Boka reMishonga | Mishonga iri muchikamu ichocho (Mienzaniso) |
|---|---|
| Masitadhi eNitrogen | bendamustine, chlorambucil, cyclophosphamide , ifosfamide, mechlorethamine, melphalan |
| Ethylenamine uye zvinobva mumethylenamine | altretamine, thiotepa |
| Alkyl sulfonates | busulfani |
| Triazenes | dacarbazine, procarbazine, temozolomide |
| Mishonga ine platinum | carboplatin , cisplatin, oxaliplatin |
| Nitrosoureas | carmustine, lomustine, streptozocin |
Pakati peizvi, boka remishonga inonzi Nitrosoureas rakasiyana zvishoma. Nekuti mishonga iyi inogona kuyambuka jira rekudzivirira rinonzi 'blood-brain barrier' rinodzivirira uropi hwedu. Mishonga mizhinji haigone kuyambuka gomba iri. Saka, inokosha pakurapa kenza dzine chekuita neuropi.
Ndeapi marudzi anonyanya kushandiswa pakurapa kenza yemazamu?
Mishonga iri muzvikamu zve ' Nitrogen Mustards' uye 'Ethylenamine uye methylenamine derivatives' inowanzo shandiswa mukurapa nhanho dzakasiyana dzekenza yemazamu.
Cytoxan (Cyclophosphamide)
Uyu mushonga uri muboka re'Nitrogen mustard'. Unogona kuutora sepiritsi kana kuupa semutsinga wetsinga. Unowanzo shandiswa pa:
- Dzivirira kenza iri padanho rekutanga kuti isadzoke mushure mekuvhiyiwa.
- Kana kenza yakura, deredza bundu usati wavhiyiwa.
- Rapa kenza yakura mushure mekuvhiyiwa uye mamwe marapirwo.
Thiotepa
Uyu mushonga unobva ku 'Ethylenamine'. Unowanzo pihwa nemutsinga. Unoshandiswa pa:
- Mukutanga kwegomarara, deredza njodzi yekudzokororwa kwaro .
- Rapa kenza yedanho repamusoro.
Carboplatin
Uyu mushonga une platinum. Ndiwo wega mushonga weplatinum unotenderwa kurapa kenza yemazamu. `Carboplatin` inowanzopihwa kune kenza yakakwira, uye pamwe chete nemimwe mishonga yechemotherapy. Inopihwawo semushonga weIV.
Ndeipi migumisiro yemushonga uyu?
Chimwe chezvinhu zvikuru zvinonetsa ne chemotherapy ndechekuti haigone kusiyanisa masero ekenza nemasero ane hutano. Mishonga iyi inotarisa masero anopatsanuka nekukurumidza. Masero ekenza, semamwe masero ane hutano mumiviri yedu (semuenzaniso, masero anoumba bvudzi redu, masero ari pamuromo nedumbu redu, uye masero eropa), anopatsanuka nekukurumidza. Saka mishonga iyi inokanganisawo masero ane hutano, ndosaka ichikonzera migumisiro yakaipa.
Migumisiro iyi haiitike kune wese munhu nenzira imwe chete. Vamwe vanhu vanogona kuva nezvakawanda, vamwe vanogona kuva nezvishoma. Usazvidya mwoyo nezvazvo. Chiremba wako anogona kukubatsira kugadzirisa zvinhu izvi zvakawanda.
| Rudzi rwemhedzisiro yakaipa |
|---|
| Migumisiro inowanzoonekwa nevanhu vazhinji |
| Kusvotwa nekurutsa, kurasikirwa nechido chekudya, kudzikira kwehuremu, kurwadziwa mudumbu, manyoka |
| Kuneta |
| Kudonha kwebvudzi, maronda emuromo kana erurimi |
| Kuchinja kweruvara rweganda, ruvara kana kukura kwenzara dzeminwe nedzezvigunwe |
| Kuderera kwehuwandu hwemasero machena eropa (izvi zvinogona kuwedzera njodzi yehutachiona) |
| Kuenda kumwedzi kusingaenderani nevakadzi |
| Zviratidzo zvakakomba zvinofanira kuudzwa chiremba wako nekukasika |
| Fivha, dzihwa, pahuro (zviratidzo zvehutachiona) |
| Kupora zvishoma nezvishoma kwemaronda, maronda asina kujairika kana kubuda ropa |
| Tsvina nhema kana kuti yakamira, kurwadziwa pakuita weti, kana ropa muweti |
| Mapundu eganda, mapundu, kuvaviwa |
| Kuoma kufema kana kumedza, kupfupika kwemweya, kukosora |
| Kuzvimba kwemakumbo, zvitsitsinho, kana tsoka, kurwadziwa kwechipfuva |
| Kutsvuka kweganda kana maziso (zviratidzo zvejaundice) |
Dambudziko! (or) Njodzi!
Kana ukaona chimwe chezviratidzo zvinotevera, enda kuchipatara chiri pedyo neEmergency Department (ETU) nekukasika kana kufonera amburenzi ye1990:
* Zvigaro zvitema
* Kubuda ropa kusingagone kumiswa
* Kuoma kwakanyanya kufema
* Kurwadziwa kwechipfuva
* Zviratidzo zvekurwara zvakanyanya (sekuzvimba kwechiso, miromo)
Kashoma, mishonga iyi inogona kukuvadza mupfupa wedu. Mupfupa ndipo panogadzira masero matsva eropa mumuviri wedu. Pane mukana mudiki wekuva nerumwe rudzi rwekenza, senge leukemia, nekuda kwekukuvara uku. Njodzi iyi inowanzowedzera zvishoma sezvo mushonga uchiwedzera. Usazvidya mwoyo nezveizvi zvisina basa.Usati watanga kurapwa, taura nachiremba wako pachena nezvenzira dzekuderedza njodzi yekubatwa nekenza yechipiri yakaita seiyi. Iye achakupa mazano ese aunoda.
Zvimwe zvinhu zvekufunga nezvazvo kana uchirapwa
Nekuti iyi mishonga ine simba guru, zvakakosha kuudza chiremba wako nhoroondo yako yese yehutano kuitira kuti agadzire hurongwa hwekurapa hunoenderana newe uye kuderedza migumisiro yakaipa. Iva nechokwadi chekukurukura zvinotevera nachiremba wako:
- Nezve allergies dzaunadzo (kumishonga, chikafu).
- Nezve chero mavhitamini, mishonga yekuwedzera, kana mishonga yemiti yaunoshandisa.
- Nezve mamiriro ako eitsvo kana chiropa .
- Kana wakamborapwa chemotherapy, tiudze nezvazvo.
- Kana uine pamuviri, uchiyamwisa, kana kuti uchironga kuva nemwana munguva pfupi iri kutevera .
- Kana muchida kuvhiyiwa mune ramangwana, taurai nezvazvo.
Tevedzera mirairo yachiremba wako nemazvo, kunyanya kana uri kutora mapiritsi. Kana ukakanganwa kutora mushonga, tora mushonga unotevera sezvawakaronga. Usambofa wakatora mishonga miviri panguva imwe chete kuti udzorere mushonga wawakarasikirwa nawo. Gara uchitaura nachiremba wako usati warega kurapwa.
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeAlkylating imhando yemushonga une simba wechemotherapy unokuvadza DNA yemasero ekenza uye unoamisa kupatsanuka.
- Nekuti mishonga iyi inokanganisa masero egomarara uye kupatsanura masero ane hutano nekukurumidza, inogona kukonzera migumisiro yakadai sekusvotwa uye kurasikirwa nebvudzi. Izvi zvinogona kudzorwa.
- Zvakakosha zvikuru kutaura pachena nachiremba wako nezvenhoroondo yako yese yezvekurapa, mimwe mishonga yauri kutora, uye allergies.
- Kana ukaona zviratidzo zvakakomba zvakaita sekuoma kwekufema kana kubuda ropa zvakanyanya, enda kuchipatara kuEmergency Department (ETU) nekukasika.
- Haufanire kuchinja mushonga kana kurega kurapwa usina kurairwa nachiremba wako.
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