Zvakaoma kutaura kutya nekuvhunduka kwaunonzwa paunoziva kuti une kenza yemazamu . Une mibvunzo yakawanda mupfungwa dzako. Zvakajairika kuva nemibvunzo yakaita sekuti, "Sei izvi zvakaitika kwandiri?", "Ndoita sei izvozvi?", "Izvi zvinogona kurapwa here?". Murwendo urwu, ndiri kuedza kutsanangura zvinhu zviri nyore uye nemutauro waunonzwisisa. Kuziva rudzi rwekenza yaunayo kwakafanana nekunzwisisa muvengi usati watanga hondo. Ndiyo danho rekutanga uye rakakosha pakusarudza kurapwa kwakakunakira.
Kenza yezamu ine mahormone anobatsira pakurapa kenza yemazamu
Iyi ndiyo mhando yekenza yemazamu inonyanya kuwanikwa. Zvichitaurwa zviri pachena, kenza yemazamu inosvika 80 pa100 yega yega inowira muchikamu ichi.
Saka izvi zvinorevei "kutsamira pamahormone"?
Ingofunga nezvazvo. Miviri yedu, kunyanya miviri yevakadzi, ine mahormone maviri anowanikwa muzvisikwa anonzi estrogen neprogesterone . Aya akakosha pakuita kwakajairika mumiviri yedu. Zvisinei, mamwe masero ekenza "anopindwa muropa" nemahormone aya. Kureva kuti, pamusoro pemasero aya ekenza, pane "mareceptor" madiki kana magonhi ayo mahormone aya anogona kuuya onamatira paari. Kana hormone yeestrogen yasvika yogogodza pamusuwo iwoyo, sero rekenza rinogamuchira chikafu kubva mariri uye rinotanga kukura nekupatsanurana. Kungofanana nekudiridza chirimwa, chinokura.
Kana gwaro rako rezvekurapa richiti `ER-positive` (Estrogen Receptor-Positive), zvinoreva kuti masero ako ekenza anonzwa hormone yeestrogen. Kana richiti `PR-positive` (Progesterone Receptor-Positive), zvinoreva kuti rinonzwa hormone yeprogesterone. Kana richinzwa chimwe cheizvi, kenza inonzi hormone receptor-positive cancer.
Aya mashoko akanaka chaizvo. Nekuti kana tikaziva zvinoshandiswa nekenza kukura, tinogona kuivhara uye kudzora. Ndizvo zvinoshandiswa "kurapwa nemahormone" .
Kurapwa nemahormone kunowanzoitwa mushure mekuvhiyiwa, chemotherapy, kana radiation kudzivirira kenza kuti isadzoke. Mishonga iyi inoshanda nekuvhara "masuo" emasero ekenza, kana nekumisa muviri kugadzira estrogen.
| Chikamu chekurapa | Tsananguro iri nyore uye mienzaniso |
|---|---|
| MaSERM (Selective ER Modulators) | Izvi zvinovhara hormone receptor iri pasero rekenza, zvichidzivirira hormone kuti isapinde. Mienzaniso: Tamoxifen, Toremifene . |
| SERDs (Zvinoderedza Estrogen Receptor) | Izvi hazvingodziviriri chete receptor, asiwo zvinoiparadza. Mienzaniso: Fulvestrant (Faslodex), Elacestrant (Orserdu) . |
| Zvinodzivirira Aromatase | Izvi zvinomisa muviri kugadzira hormone inonzi estrogen (inowanzopihwa vakadzi vapedza kuenda kumwedzi). Mienzaniso: Anastrozole (Arimidex), Letrozole (Femara) . |
| LHRH Agonists | Izvi zvinomisa kwenguva pfupi maovari kuti asagadzire estrogen. Mienzaniso: Goserelin (Zoladex), Leuprolide (Lupron) . |
| Mamwe Marapirwo Akanangwa | Mimwe mishonga inowedzera kubudirira kwekurapwa nemahormone. Mienzaniso: Palbociclib (Ibrance), Ribociclib (Kisqali), Alpelisib (Piqray) . |
Kenza yezamu ine HER2-Positive
Ngatitaurei nezverumwe rudzi. Mamwe masero ekenza yemazamu (anenge 20% yekenza dzese) anogadzira puroteni yakakosha yakawandisa pamusoro pawo inonzi HER2 (Human Epidermal growth factor Receptor 2) .
Funga nezveHER2 sekanyanga kadiki kanoudza sero rekenza kuti "rikure nekukurumidza, riparare nekukurumidza." Sero rakajairika rine mashoma eaya maantenna. Asi sero rekenza rine HER2-positive rine akawanda eaya maantenna. Ndosaka mhando idzi dzekenza dzichigona kuva nehasha .
Asi kune mashoko akanaka pano zvakare. Nekufambira mberi kwesainzi, ikozvino kwave ne " nzira dzekurapa dzakanangwa" dzinonanga nekuparadza idzi antennae dzeHER2. Nekuti idzi dzinowana nekurwisa masero ane HER2 yakawandisa chete, hapana kukuvara kudiki kumasero akajairwa.
Mushonga mukuru uye unoshanda zvikuru unopihwa weizvi ndiTrastuzumab (Herceptin) . Izvi zvinobatsira zvikuru mukudzivirira kenza kuti isadzoke. Zvisinei, pane mukana mudiki wekuti zvimwe zvirwere zvinogona kuitika pamoyo kana mapapu paunenge uchitora mushonga uyu. Usazvidya moyo nazvo , chiremba wako anogara achitarisa kuti hauna.
| Mimwe mishonga inoshandiswa pakurapa kenza yeHER2-positive | |
|---|---|
| Pertuzumab (Perjeta) | Ado-trastuzumab emtansine (Kadcyla) |
| Lapatinib (Tykerb) | Neratinib (Nerlynx) |
| Tucatinib (Tukysa) | Enhertu (Fam-trastuzumab deruxtecan-nxki) |
Kenza yezamu "Ine Hanya Katatu"
Iyi ndiyo mhando yechitatu huru. Inenge 10%-20% yegomarara remazamu inowira murudzi urwu. Unoziva here kuti sei richinzi "triple-negative" kana "triple negative"?
Nekuti mumasero egomarara aya,
1. Hapana estrogen receptor (ETU) .
2. Hapana progesterone receptor (PR).
3. Hakuna mapuroteni akawanda eHER2 .
Nekuti masero egomarara aya haana zvinangwa zvikuru zvitatu zvatakakurukura kare, kurapwa nemahormone kana mishonga inotarirwa neHER2 seHerceptin hazvishande paari. Saka kuarapa kunogona kuoma zvishoma.
Rudzi urwu rwegomarara runowanzo kukonzerwa neBRCA1.Zvinobatanidzwa nekuchinja kwemajini kunonzi . Saka kana uine kenza ine triple-negative, chiremba wako anogonawo kukurudzira kuongororwa kwemajini.
Rudzi urwu runonyanya kurapwa nekuvhiyiwa, chemotherapy, uye nemwaranzi . Zvisinei, ikozvino kune nzira itsva dzekurapa dzakanangana nerudzi urwu.
- Zvinodzivirira kenza: Mishonga yakaita seOlaparib (Lynparza) neTalazoparib (Talzenna) inoshandiswa kuvanhu vane BRCA gene mutations. Izvi zvinodzivirira kugona kwemasero ekenza kuzvigadzirisa.
- Kurapa Nezvirwere Zvemuviri: Mishonga yakaita seAtezolizumab (Tecentriq) inobatsira kurwisa masero egomarara nekushandisa masero edu ekudzivirira chirwere.
Zvese izvi zvingaita sezvakaoma zvishoma. Izvozvo zvakajairika. Chinhu chakakosha ndechekuyeuka kuti zvisinei nerudzi rwegomarara rwaunarwo, kune mishonga iripo nhasi yakakodzera. Chiremba wako nechikwata chekurapa vachashanda newe kugadzira hurongwa hwakanakisa hwekurapa kwako.
Mharidzo Yekuenda Nayo Kumba
- Kenza yemazamu yakakamurwa kuita mhando nhatu huru: Hormone Receptor-Positive, HER2-Positive, uye Triple-Negative .
- Kuziva rudzi rwegomarara raunaro kwakakosha pakuronga kurapwa.
- Kenza dzine mahormone dzinopindura zvakanaka kana munhu akabatwa nemahormone.
- Kunyangwe kenza yeHER2-positive ichikura nekukurumidza, kune nzira dzekurapa dzinoshanda zvikuru dzakagadzirwa zvakanangana nadzo.
- Kunyange zvazvo kurapa magomarara ane triple-negative kwakaoma, anogona kurwiswa ne chemotherapy uye mishonga mitsva yakanangwa.
- Kana uine mibvunzo nezvechero chinhu chiri munhoroondo yako yezvekurapa, usatya kubvunza . Bvunza chiremba wako kuti akutsanangurire zvakajeka. Hausi wega, uye kune vanhu vazhinji vanogona kukubatsira.
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