Tinofanira kunetseka nezve Epithelial Ovarian Cancer here?

Wakambonzwa nezve Epithelial Ovarian Cancer here? Zita racho ringanzwika serakaoma, asi imhando yegomarara remazai rinowanzoonekwa nevakadzi. Ngatitaurei nezvazvo zviri nyore, nenzira yaunogona kunzwisisa. Nekuti zvakakosha kuziva zvinhu zvakaita seizvi.

Chii chinonzi Epithelial Ovarian Cancer?

Zvichitaurwa zviri nyore, kenza yemudumbu ndiyo mhando inonyanya kuzivikanwa yekenza yemudumbu. Kenza iyi inokura muchikamu chekunze cheganda rechibereko, chinonzi epithelial tissue. Funga nezvayo seganda rakatetepa rakakomberedza ganda rechibereko.

Kwete izvozvo chete, asi dzimwe nguva kenza iyi inogonawo kukura muchikamu chemukati memachubhu efallopian kana kunyange muperitoneum, nyama inofukidza nhengo dziri mudumbu. Vanachiremba vanosanganisirawo kenza yefallopian tube uye kenza dzekutanga dzeperitoneal muchikamu chimwe chete nekenza ye epithelial ovarian nekuti zviratidzo nekurapwa kwezvirwere izvi zvakafanana zvikuru.

Gomarara iri rakajairika zvakadii?

Kenza yechibereko ndiyo yechipiri inonyanya kuwanikwa mukenza yemadzimai, mushure mekenza yechibereko/yechibereko. Mukadzi akajairika ane mukana mumwe chete pamakumi manomwe nemasere wekubatwa nekenza yechibereko muhupenyu hwake.

Mugore ra2021 chete, vanhu vanopfuura 21,400 vakaonekwa vaine kenza yemazamu. Vapfumbamwe pagumi vavo vanonzi ndivo kenza yemazamu epaepithelial. Gomarara iri rinonyanya kuwanikwa pakati pevakadzi vane makore anopfuura 65.

Ndeapi marudzi ekenza ye epithelial ovarian?

Zvikamu zvitatu muzvina zvegomarara remazamu epaepithelial igomarara remazamu repamusoro-soro (HGSOC). "Gomarara repamusoro-soro" zvinoreva kuti masero egomarara aya anokura uye anopararira nekukurumidza kupfuura gomarara re "pasi-pasi".

Nyanzvi dzezvekurapa dzinotenda kuti rudzi urwu rweHGSOC runokura zvishoma nezvishoma pakutanga, asi zvinogona kutora kusvika makore matanhatu nehafu kuti rupararire kubva mumachubhu efallopian kuenda kumaovari. Asi kana rwasvika mumaovari, runopararira nekukurumidza. Runowanzo kanganisa dumbu (peritoneum) nedzimwe nhengo dzemuviri. Vanenge 70% yevarwere veHGSOC vanoonekwa vaine chirwere ichi padanho rechitatu kana rechina. Izvi zvinoreva kuti kenza yakapararira kupfuura bundu rekutanga uye ikozvino yava kenza yakapararira.

Kune dzimwe mhando dzisinganyanyi kuwanda dzekenza ye epithelial ovarian:

• Kansa yemukati mechibereko:Rudzi urwu runonyanya kuwanikwa muvanhu vane endometriosis, iyo inokanganisa dumbu rechibereko (endometrium). Runopindura zviri nani kumishonga yekurapa kenza kupfuura mamwe marudzi.
• Kansa yeropa iri muchikamu chepasi (LGSOC): Iyi ikenza inokura zvishoma nezvishoma. Inowanikwa mumadzimai madiki (ari pakati pemakore 45 ne57). Inokonzera 10% yekenza yeropa iri muchikamu chepasi. Chirwere ichi chinowanzo wedzera kana chaonekwa, uye hachipinduri zvakanaka nechemotherapy. Kunyangwe kenza iri muchikamu chepasi ichikura zvishoma nezvishoma, haiwanzova kenza yepamusoro.
• Kansa yemucinous: Mabundu aya akasiyana nemamwe marudzi uye anopindura zvakanaka kana akarapwa. Anowanzova makuru (anenge masendimita masere kana makumi maviri). Anowanzo kanganisa maovari chete.
• Ovarian clear cell carcinoma (OCCC): Vakadzi vekuAsia neavo vane endometriosis vari panjodzi huru yekubata kenza iyi. Chirwere ichi chinowanzo wedzera kana chaonekwa. Hachipinduri zvakanaka kana paine chemotherapy.
• Kansa yeganda inonzi squamous cell carcinoma (SCC) yemuchibereko: Rudzi urwu rweSCC runowanzo buda kubva muzvirwere zvisina njodzi/zvisina kenza. Semuenzaniso, inogona kubva mumasero emuchibereko, endometriosis, kana Brenner tumors (kukura kwakasimba, kusina kujairika mumazamu). Kana ikabatwa nekukurumidza, inopindura zvakanaka pakurapwa.

Chii chinokonzera kenza ye epithelial ovarian?

Kutaura zvazviri, chikonzero chaicho chekenza zhinji, kusanganisira kenza ye epithelial ovarian, hachisati chazivikanwa. Zvisinei, tsvakurudzo itsva inoratidza kuti kenza zhinji dze ovarian dzinotangira mumasero ari kumagumo emachubhu e fallopian. Dzinozopararira kusvika kumaovaries.

Ndezvipi zvinhu zvinokonzera gomarara iri?

Vanhu vanodarika hafu yeavo vakaonekwa vaine kenza yemazamu vane makore anopfuura makumi matanhatu nemashanu ekuberekwa uye vakambosvika panguva yekuenda kumwedzi, zvichireva kuti nguva yavo yekuenda kumwedzi yamira.

Zvimwe zvinhu zvinogona kuwedzera njodzi yekubatwa nekenza yemazamu. Izvi ndeizvi:

• Kana mumwe munhu mumhuri yako akambova nekenza yemazamu, kenza yemazamu, kana kenza yemudumbu/yemudumbu.
• Kana wakagara nhaka shanduko (mutation) mujini reBRCA.
• Kana wakagara nhaka jini rine chekuita nezvirwere zvegomarara remhuri, zvakaita seLynch syndrome.
• Kana uri kutora mushonga wemahormone kudzora zviratidzo zvekusvika pakuguma kuenda kumwedzi.
• Kuva nemwana mushure memakore makumi matatu nemashanu kana kusambobereka mwana kusvika nguva yake yakwana.
• Kufuta zvakanyanya .

Ndezvipi zviratidzo zvekenza ye epithelial ovarian?

Iri idambudziko revanhu vazhinji. Kenza yemudumbu inowanzova nezviratidzo zvishoma pakutanga. Zviratidzo zvinoonekwa chete kana chirwere chapararira zvishoma. Kana chikapararira kusvika paganda rinofukidza nhengo dzemudumbu (peritoneum), mvura inoyerera inogona kuungana mudumbu. Izvi zvinonzi ascites.

Mukuwedzera, zviratidzo zvinotevera zvinogona kuitika:

• Kurwadziwa kwemudumbu.
• Kuomerwa nekudya kana kunzwa kuguta mushure mekudya zvishoma.
• Kusvotwa nekurutsa.
• Kuzvimba.
• Kurwadziwa kwechiuno.

Kunewo zviratidzo zvisingawanzoonekwi:

• Kurudzira kusazvidzora kana kuita weti kakawanda (dundira rinoita basa rakawandisa).
• Kubuda ropa kusina kujairika kwechikadzi.

Zvakakosha: Kuva nezviratidzo izvi hazvirevi kuti une kenza. Zvisinei, kana zvikaramba zviripo, zvakanaka kuti ubvunze chiremba kuti akupe mazano.

Kenza ye epithelial ovarian inoonekwa sei?

Zvinosuwisa kuti hapana bvunzo dzakatarwa dzinokwanisa kuona kenza yemuchibereko ichiri kutanga. Kuongororwa kunowanzoitwa chete kana uine zviratidzo kana kuti uri panjodzi huru. Chiremba wako anogona kutanga aita bvunzo yechiuno kuti aone kana paine mapundu asina kujairika kana kuzvimba.

Zvadaro, unogona kuongororwa ropa kuti uone huwandu hwepuroteni inonzi `CA-125`. Iyi `CA-125` inomiririra cancer antigen 125. Kana huwandu hwacho hwakakwira, uchafanirwa kuita bvunzo dzakawanda.

Kuongororwa kwemifananidzo yakaita seyi kunogona kubatsira kuona kenza yemazamu:

• Kuongororwa kwe ultrasound kwe transvaginal.
• Kuongororwa kweCT scan.
• Kuongororwa kweMRI (MRI).
• Kuongorora kwePositron emission tomography (PET).
• MaX-ray epachipfuva (kuona kana kenza yapararira kumapapu).

Dzimwe nguva nzira inonzi laparoscopy inogona kuitwa. Izvi zvakafanana nekuvhiyiwa, asi zvinoitwa pasina kuchekwa kukuru. Izvi zvinobvumira chiremba kutarisa nhengo dzako dzekubereka. Vanogonawo kutora sampuli yenyama (biopsy) kubva pabundu kuti vaone kana paine masero ekenza ipapo. Iyi biopsy ndiyo chete nzira yekuziva zvechokwadi kana uine kenza yemuzai.

Ndezvipi zvikamu zvekenza ye epithelial ovarian?

Kuziva danho regomarara kunobatsira vanachiremba kunzwisisa kufambira mberi kwegomarara. Zvakakoshawo pakuona kana gomarara rapararira uye pakusarudza marapirwo aro. Danho regomarara rinoonekwa nemiedzo yakafanana inoshandiswa kuongorora gomarara.

Kune matanho mana makuru ekenza yemuzai. Mamwe matanho ane zvikamu zvidiki. Nhamba yezvikamu yakakwira, kenza yacho inowedzera kukura.

• Danho rekutanga: Kenza iri muchibereko chimwe chete kana muchubhu imwe chete yefallopian.
• Danho rechipiri: Gomarara rapararira kusvika muchibereko kana mudumbu (peritoneal cavity).
• Danho rechitatu: Kenza yapararira kune dzimwe nhengo dziri kunze kwechiuno, kusvika kuma lymph nodes, kana zvese zviri zviviri.
• Danho rechina: Masero egomarara aripo mumvura yakakomberedza mapapu, lymph nodes munzvimbo yehudyu, dzimwe nhengo dzemuviri, kana dzimwe nhengo dzemuviri.

Ko kenza ye epithelial ovarian inogona kurapwa here?

Vanachiremba vanovhiya vanobvisa kenza yakawanda sezvinobvira. Izvi zvinoteverwa nechemotherapy. Kunyange zvazvo vanhu vazhinji vanopora pakutanga, chirwere ichi chinogona kudzoka kuvanhu vazhinji gare gare.

Varwere vari padanho rekutanga vanogona kusarudza kubvisa ovary ne fallopian tube chete.

Kune vanhu vane kenza yepamusoro, kuvhiyiwa kwekubvisa bulking kunowanzoitwa kubvisa nhengo dzemuviri dzakadai se:

• Kubviswa kwemachubhu ese efallopian nemazai ese ari maviri (bilateral salpingo-oophorectomy).
• Kubviswa kwechibereko (hysterectomy).
• Kubviswa kwenyama ine mafuta (omentum) inofukidza dumbu (omentectomy).
• Kubviswa kwema lymph nodes akapoteredza.
• Kubviswa kwezvimwe zvikamu zvine chirwere (senge ura diki, ura hukuru, kana chirwatata).

Ndezvipi zvimwe zvekurapa?

Zvichienderana nerudzi rwegomarara, unogona kupihwa imwe kana kupfuura yemishonga iyi mushure mekuvhiyiwa:

• Kurapa nemakemikari: Kuuraya masero egomarara. Izvi zvinoshandisa mishonga yakaita seplatinum compounds (carboplatin) uye paclitaxel (Taxol®) kana docetaxel (Taxotere®).
• Mishonga yekurapa kenza yemudumbu: Kurapa kenza yemudumbu yedanho rechitatu, mishonga ye cisplatin ne paclitaxel inobayiwa zvakananga mudumbu kuburikidza ne catheter inopinzwa nekuvhiyiwa (chubhu yakatetepa, isina chinhu).
• Mishonga yakanangana nayo: Mishonga yakaita seBevacizumab (Avastin®) inomisa kukura nekuwedzera kwemasero egomarara.
• Kurapa nemwaranzi: Kunoshandisa mwenje weX-ray une simba guru kuparadza masero ekenza.

Kenza ye epithelial ovarian inogona kudzivirirwa here?

Ongororo inoratidza kuti vakadzi vanotora mapiritsi ekudzivirira pamuviri ane mahormone kwemakore mashanu kana kupfuura vanogona kuderedza njodzi yavo yekubatwa nekenza yemazamu nehafu.

Kumwe kuvhiyiwa kunogonawo kuderedza njodzi yekenza. Kuvhiyiwa kwekudzivirira kenza kunonzi prophylactic surgery. Izvi zvinosanganisira kubvisa machubhu efallopian nemaovaries, ane chibereko kana asina. Izvi zvinowanzo fungwa nezvevakadzi vari panjodzi huru nekuda kwenhoroondo yemhuri (senge avo vane BRCA mutation kana Lynch syndrome). Zvisinei, vanachiremba vanokurudzira kuti maitiro aya aitwe chete kana zvichidikanwa nachiremba. Izvi zvinodaro nekuti kubvisa maovaries kunogona kukonzera kutanga kwemenopause, izvo zvinogona kukanganisa muviri.

Kuvhiyiwa uku hakubvisi zvachose njodzi yekenza. Vamwe vanhu vanogona kunge vaine kenza isingawanikwe panguva yekuvhiyiwa. Vanhu vane BRCA gene mutations vanogona kuramba vachiwana kenza yekutanga yeperitoneal kunyangwe machubhu avo efallopian nemaovari akabviswa. Bvunza chiremba wako nezvekuongororwa kweBRCA kuti uone kana uine BRCA gene.

Ndeipi tarisiro yevanhu vane kenza ye epithelial ovarian?

Vanhu vanopfuura 13,000 vanofa nekenza yemazamu gore rega rega. Ndiyo honzeri yechishanu inotungamira mukufa kwekenza pakati pevakadzi. Zvisinei, pane tariro yekurapa kutsva kuri kuitwa mukuyedza kwekiriniki. Vatsvagurudzi vari kushandawo kuti vaone chirwere ichi vachiri padanho rekutanga.

Kana kenza ye epithelial ovarian ikaonekwa isati yapararira, huwandu hwevanhu vanopona hunopfuura 90%. Zvisinei, kana kenza yapararira (metastasized), huwandu uhwu hunoderera kusvika pa30%.

Zvinhu zvakawanda zvinopesvedzera fungidziro yekenza:

• Kupararira kwakaita kenza kusvika papi.
• Kubudirira kwekurapwa.
• Nzvimbo, saizi, uye huwandu hwemabundu ekenza (danho rekenza).

Unofanira kuona chiremba rini?

Kana uine chimwe chezviratidzo izvi, enda kuna chiremba nekukasika:

• Kuchinja kwehuwandu kana kukurumidza kwekuita weti.
• Kushaya chido chekudya kana kunzwa kuguta mushure mekudya zvishoma.
• Kurwadziwa kunogara kuripo mudumbu kana muhudyu pasina chikonzero.

Mibvunzo ipi yaunofanira kubvunza chiremba wako?

Unogona kubvunza chiremba mibvunzo yakaita seiyi:

• Ndinofanira kuongororwa BRCA here?
• Nderudzii rwekenza ye epithelial ovarian yandinayo?
• Ndeipi nzira yakanakisisa yekurapa?
• Ndezvipi migumisiro yekurapa?
• Ndiri panjodzi yekubatwa nekenza yakapararira here? Ndingaderedza sei njodzi iyoyo?
• Ndinofanira kunetseka nezvematambudziko here?

Ndeipi mhando yekenza yemazamu inonyanya kurwadza?

Kenza yemhando yepamusoro yegomarara remazamu (HGSOC) igomarara remazamu rinonyanya kukura. Kunyangwe kenza iyi ichitanga kukura zvishoma nezvishoma mumachubhu emudumbu, inopararira nekukurumidza kana yasvika mumachubhu emudumbu. Zvinosuwisa kuti vanhu vazhinji vane HGSOC vane kenza yemazamu yakakura/yakapararira kana vaonekwa kuti vane chirwere ichi.

Zvinokwanisika here kuva nema cysts epithelial ovarian asina cancer (asina cancer)?

Ehe. Kutaura zvazviri, mabundu mazhinji emudumbu epaepithelial haasi ekenza. Mamwe mabundu anonzi mabundu emuganhu kana kuti mabundu anowanzo pararira. Aya aimbonzi mabundu ane simba shoma.

Mumabundu ari pamuganhu, masero asina kujairika anokura kuita epithelial tissue asi haapindi muchikamu chinotsigira ovary (stroma). Masero aya anowanzo kuwanikwa muovary pachayo uye haawanzova kenza. Kana kenza ikaitika, matatu pamana ari padanho rekutanga (akaganhurirwa kuovary uye ari nyore kurapa). Mabundu aya anowanzo kanganisa vanhu vadiki.

Mharidzo Yekuenda Nayo Kumba

Kenza yeEpithelial ovarian ndiyo inonyanya kuwanikwa mukenza yemuchibereko. Inosanganisirawo kenza yemudumbu uye kenza yemudumbu. Kenza yemudumbu inowanzova nezviratidzo zvishoma pakutanga kwayo. Chirwere ichi chinowanzo svika padanho repamusoro zvekuti hachionekwe kana chaonekwa. Izvi zvinonyanya kuitika kune mhando yekenza yemudumbu inonzi `HGSOC`.

Kana uine mukana mukuru wekuva nekenza yemazamu (senge nhoroondo yemhuri), zvakakosha kubvunza chiremba wako kana nzira dzekudzivirira dzakakunakira. Gara uchitarisira muviri wako. Usafuratira chero zviratidzo zvisinganzwisisike. Tsvaga mazano echiremba.

` Kenza yechibereko, kenza ye epithelial, hutano hwevakadzi, zviratidzo zvekenza, kurapwa kwekenza, gene reBRCA, gynecology