Dambudziko riripo kuvanhu vazhinji mazuva ano nderekuwedzera kwemafuta akadai secholesterol ne triglycerides muropa. Asi dzimwe nguva mafuta aya, kunyanya triglyceride mazinga, akakwira zvisingawanzoitiki, zvakapetwa kazviuru kupfuura zvakajairwa. Chikonzero cheizvi chingave chirwere chemajini chisingawanzoitiki chinopfuudzwa kubva kuvabereki. Nhasi tiri kutaura nezvechimwe chezvirwere zvakadaro, Familyal Hyperchylomicronemia Syndrome, kana kuti FCS muchidimbu. Kunyangwe iyi iri nyaya yakaoma, ngatiinzwisise zviri nyore.
Zvichitaurwa zviri nyore, chii chinonzi FCS?
FCS chirwere chisingawanzoitiki chaunowana kubva kuvabereki vako. Munhu ane chirwere ichi haakwanise kugaya, kana kugaya, mafuta, kunyanya triglycerides .
Fungidzira kuti miviri yedu ine fekitari diki inoputsa mafuta. Mukurapa, iyi ienzyme inonzi lipoprotein lipase (LpL) . Mumunhu ane FCS, 'fekitari' iyi haishande nemazvo, kana kuti haishande zvachose.
Nekuda kweizvozvo, mafuta ari muchikafu chatinodya, anonzi triglycerides, haagone kutorwa nemuviri asi anoungana muropa semadonhwe emafuta anonzi chylomicrons . Kuunganidzwa uku kwe chylomicrons ndiko kwatinodaidza kuti chylomicronemia syndrome. Izvi zvinokonzera huwandu hwe triglycerides hwakakwira zvisingawanzoitiki muropa.
Hazviwanzoitiki kuti munhu mumwe chete kana vaviri pavanhu miriyoni pasi rose vabatwe nechirwere ichi. Chinowanzoonekwa vasati vasvitsa makore gumi, uye vamwe vana vanoonekwa vaine chirwere ichi mugore rekutanga rehupenyu hwavo.
Sei izvi zviri kuitika?
Chikonzero chikuru cheizvi ikuchinja kwemajini. Chikonzero cheizvi idambudziko riri mumajini anobatanidzwa mukugadzira enzyme inonzi lipoprotein lipase (LpL) yatakataura nezvayo.
Chinhu chakakosha ndechekuti kuti uve nechirwere ichi, unofanira kugara nhaka jini iri risina kunaka kubva kuna amai vako nababa vako. Kana ukarigara nhaka kubva kumubereki mumwe chete, hauzove nechirwere ichi, asi uchava 'mutakuri' wejini iroro. Izvi zvinoreva kuti une mukana wekupa jini iri kuvana vako.
Enzyme yeLpL inogadzirwa nepancreas yedu. Basa rayo guru nderekupwanya ma chylomicrons muropa uye kubatsira muviri kushandisa mafuta ari maari kuti uwane simba. Saka kana LpL isiri kushanda zvakanaka, mafuta haagone kupwanywa uye huwandu hwe triglycerides muropa hunokwira zvakanyanya.
Ndezvipi zviratidzo zveizvi?
Zviratidzo zveFCS zvinokonzerwa nehuwandu hwakawanda hwe triglycerides muropa. Huwandu hwe triglycerides mumunhu ane hutano huri pasi pe150 mg/dL. Zvisinei, kune munhu ane FCS, huwandu uhwu hunogona kudarika 1,000 mg/dL. Zvakakosha kuziva zviratidzo izvi.
| Chiratidzo | Tsananguro iri nyore |
|---|---|
| Kurwadziwa kwedumbu | Ichi ndicho chiratidzo chinowanzoitika. Kurwadziwa uku kunogona kutanga mudumbu repamusoro kwozosvika kumusana. Dzimwe nguva kunogona kuva kwakanyanya. |
| Chipembenene | Izvi zvinowanzo kukonzera kurwadziwa mudumbu. Pancreas inhengo inokosha iri mudumbu medu. Apa ndipo painozvimba. Zviratidzo zvakaita sekusvotwa, kudikitira, kunzwa kusasimba, uye kutsvuka kwemaziso neganda zvinogonawo kuuya neizvi. |
| Kuchinja kweganda | Vamwe vanhu vanowana chirwere chinonzi cutaneous xanthomas . Aya mapundu madiki asingarwadzi, matsvuku-yero, anoonekwa panzvimbo dzakadai semagaro, mabvi, nemagokora. Aya anoumbwa nemafuta. Kana ukaona izvi, zvinogona kuva chiratidzo chemafuta akawanda muropa. |
| Kuchinja kwemaziso | Lipaemia retinalis chirwere chinoita sekuti tsinga dzeropa dziri mukati meziso dzinoita semukaka. Izvi zvinokonzerwa nekuunganidzwa kwemafuta. Zvisinei, hazvikanganisi kuona. |
| Kukura kwechiropa nespleen | Kunyanya muvana vadiki, rudzi rwemasero machena eropa (macrophages) runoedza kupinza mafuta akawandisa mumuviri. Masero aya anopinza mafuta acho oaisa muchiropa nemuchirebvu, zvichiita kuti nhengo idzodzo dzikure. |
| Zviratidzo zvepfungwa uye zvepfungwa | Vamwe varwere vanogona kuva nematambudziko akadai sekuora mwoyo, kutadza kurangarira zvinhu, uye dementia. |
Izvi zvinoongororwa sei uye zvinorapwa sei?
Kuongorora chirwere
Nekuti chirwere ichi hachiwanzoitiki, dzimwe nguva zvinotora nguva kuti chirwere chiongororwe nemazvo. Kana uine kurwadziwa mudumbu nguva dzose, pancreatitis inoramba ichiitika, uye triglycerides yakawanda muropa rako, chiremba wako angafungidzira kuti une FCS.
Miedzo inotevera inoitwa kuti isimbise chirwere ichi:
- Kuongororwa ropa re triglyceride yekutsanya: Kuongororwa uku kunoitwa mushure mekutsanya kwemaawa akati wandei. Kana huwandu hwe triglyceride hwakakwira kupfuura 750 mg/dL, hunogona kunge huri FCS. Dzimwe nguva ropa rinogona kutaridzika semukaka.
- Kuongororwa kwemazinga eLipase: Jekiseni rakakosha (heparin) rinopihwa kuyera kuti enzyme yeLpL yakawanda sei inogadzirwa nemuviri.
- Kuongororwa kwemajini: Iyi ndiyo nzira chete yekuva nechokwadi che100%. Inogona kutarisa kana jini rakakanganisika rakagara nhaka kubva kuvabereki vese.
- CT scan: Izvi zvinobatsira kuona kana paine kukuvara kwenhengo dzemuviri dzakadai sepancreas nechiropa.
Nzira dzekurapa
Kudya ndiko mushonga mukuru wekurapa FCS, uye kunewo mushonga mutsva wakabvumidzwa munguva pfupi yapfuura.
Chinhu chinonyanya kukosha: Mishonga yakaita se statins ne fibrates, iyo inowanzopihwa cholesterol, haishande kuFCS. Nekuti kuti mishonga iyoyo ishande, enzyme yeLpL yatataura nezvayo pakutanga inofanira kushanda zvakanaka mumuviri.
Kudya kweFCS
Ichi ndicho chikamu chakakosha pakutarisira. Zvakakosha kushanda nachiremba wako pamwe nenyanzvi yezvekudya kuti mugadzire chirongwa ichi chekudya.
- Deredza mafuta: Huwandu hwemafuta anodyiwa pazuva hunofanira kunge huri pasi pe20 gramu.
- Rega kunwa doro zvachose: Doro rinowedzera huwandu hwe triglycerides mumuviri.
- Deredza shuga nemakabhohaidhiretsi zviri nyore: Dzivisa zvinhu zvakaita sezvinwiwa zvine shuga nemasiwiti.
- Zvekudya: Muriwo, michero, nyemba, zviyo, mazai machena, zvigadzirwa zvemukaka zvisina mafuta, uye nyama isina mafuta akawanda.
- Mavhitamini ekuwedzera: Chiremba wako anogona kukurudzira kutora mavhitamini anonyunguduka mumafuta akadai sevhitamini A, D, E, naK, ayo muviri unoda kuderedza mafuta.
Mushonga mutsva
Olezarsen (Tryngolza)Mushonga mutsva wakatenderwa muna Zvita 2024. Ijekiseni rinopinzwa pasi peganda kamwe chete pamwedzi. Zvichitaurwa zviri nyore, rinoshanda nekuderedza kugadzirwa kweprotein mumuviri inonzi apoC-III, iyo inobatsira mafuta kuungana muropa. Unogona kudzidza zvakawanda nezveizvi kubva kuna chiremba wako.
Matambudziko ekurarama neFCS
FCS chirwere chinogara kwenguva refu chinofanira kutarisirwa. Chinogona kukanganisa hutano hwemuviri nehwepfungwa.
- Matambudziko ekudya: Kudya kunze uye kuenda kumapati zvinogona kuoma zvikuru.
- Migumisiro yepfungwa: Kurwadziwa nguva nenguva, kutya remangwana, kuzvidya mwoyo, uye "pfungwa dzisina kujeka" zvinogona kuitika.
- Kukanganiswa kwehupenyu hwevanhu nehwebasa: Kugara uchigara muchipatara kunogona kuita kuti zviomere kuchengetedza hukama hwemagariro evanhu nebasa.
Saka, zvakakosha zvikuru kushanda pamwe chete nechikwata chenyu chekurapa uye, kana zvichidikanwa, tsvaga rutsigiro rwemupi wezano wehutano hwepfungwa.
Mharidzo Yekuenda Nayo Kumba
- FCS chirwere chisingawanzoitiki chemajini chinoita kuti muviri usakwanise kugaya mafuta (triglycerides).
- Izvi zvinokonzera huwandu hwakawanda hwe triglycerides muropa, uye zviratidzo zvikuru kurwadziwa kwakanyanya mudumbu uye kuzvimba kwepancreas (pancreatitis).
- Chikamu chikuru chekurapa ndechekutevedzera kudya kwakasimba kunoderedza mafuta . Doro rinofanira kudziviswa zvachose.
- Mishonga yenguva dzose yecholesterol haishande padambudziko iri, asi kune mushonga mutsva wakaunzwa.
- Kugadzirisa dambudziko iri idambudziko rehupenyu hwese, saka zvakakosha kuti uwane rutsigiro kubva kuna chiremba wako, nyanzvi yezvekudya, uye mhuri.
- Kana iwe kana mumwe munhu wemumhuri mako aine zviratidzo izvi, kurumidza kuona chiremba wako uye tsvaga mazano.
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