Ko BP yako haisati yadzikama here kunyangwe watora mishonga? Chikonzero chingave chiri Hyperaldosteronism!

Une BP yakakwira here, kana kuti " pressure " sezvatinozviziva tese? Pamwe uri kutora mushonga mumwe, miviri, kana kupfuura wakanyorerwa nachiremba wako. Asi zvinokuomera here kudzora BP yako kunyangwe mushure mekutora mishonga yakawanda kudaro? Kana zvakadaro, chikonzero cheizvi chingave chisiri chinhu chinowanzo fungwa nemunhu wese. Nhasi tichataura nezvechirwere chakakosha chinogona kukonzera BP yakakwira isingadzoreki nyore nemishonga. Ndiyo Hyperaldosteronism. Kunyangwe zita racho rakaoma zvishoma, ngatirinzwisise zviri nyore.

Chii chinonzi Hyperaldosteronism?

Zvichitaurwa zviri nyore, Hyperaldosteronism kugadzirwa kwehomoni "Aldosterone" yakawandisa neadrenal glands mumuviri wedu.

Zvino ungangove uri kufunga kuti, ma "adrenal glands" aya chii? Chii chinonzi aldosterone hormone iyi?

Fungidzira, pamusoro peitsvo mbiri dziri mumuviri wedu, pane magland maviri madiki, akaita semakanda maviri madiki. Ndizvo zvatinodaidza kuti magland eadrenal. Aya ndiwo chikamu chakakosha chehurongwa hwedu hwe endocrine . Magland maviri madiki aya anogadzira marudzi akasiyana emahormone akakosha pamabasa ezuva nezuva emuviri wedu.

Homoni yakakosha inogadzirwa nemagland aya inonzi aldosterone . Basa guru rehomoni iyi nderekudzora BP yedu. Inoita izvi nekudzora huwandu hwesodium nepotassium muropa redu. Homoni iyi inoshanda mumuviri wedu semupurisa wemumugwagwa anodzora traffic mumugwagwa.

Saka, kana paine Hyperaldosteronism, chinoitika ndechekuti iyi aldosterone hormone inogadzirwa yakawandisa. Ipapo huwandu hwesodium mumuviri wedu hunowedzera uye huwandu hwepotassium hunoderera. Mugumisiro weizvi iBP yakakwira (Hypertension) uye potassium shoma muropa (Hypokalemia) .

Kune mhando mbiri huru dzeizvi.

Vanachiremba vanopatsanura chirwere ichi mumhando mbiri huru, zvichienderana nechikonzero chacho.

1. Kurwara kwakanyanya kweropa:Izvi zvinonziwo "Conn's syndrome." Izvi zvinokonzerwa nedambudziko riri mumagland eadrenal pachawo, izvo zvinoita kuti agadzire aldosterone yakawandisa. Chikonzero chacho chiri mugland pachayo.

2. Secondary Hyperaldosteronism: Pano hapana dambudziko neadrenal glands. Asi nekuda kwedambudziko riri kune imwe nzvimbo mumuviri, adrenal glands dzinokurudzirwa mukupindura uye dzinogadzira aldosterone yakawanda.

Ndiani anonyanya kubatwa nechirwere ichi?

Dambudziko iri rinowanzobata vanhu vane makore ari pakati pe30 ne50. Ongororo yakaratidzawo kuti dambudziko iri rinowanzoitika kuvakadzi kupfuura varume.

Dzimwe ongororo dzinoratidza kuti pakati pe5% ne10% yevanhu vane BP yakakwira vanogona kunge vaine chirwere ichi. Nyanzvi dzinotenda kuti vanhu vanosvika 25% vane BP inoramba kushandiswa nemishonga vanogona kunge vaine chirwere ichi.

Ndezvipi zviratidzo zveizvi?

Dzimwe nguva, kana chirwere chacho chiri chishoma, panogona kunge pasina zviratidzo zvachose. Zvisinei, vanhu vazhinji vanotanga kuva nezviratidzo.

Chiratidzo chikuru uye chinowanzoonekwa muchirwere ichi iBP yakakwira (Hypertension) , kunyanya BP yakakwira iyo inonetsa kudzora kunyangwe uchishandisa mishonga yakati wandei.

Zvimwe zviratidzo zvinokonzerwa nezvinhu zviviri: BP yakakwira uye potassium shoma muropa (Hypokalemia). Ngatinyatsosiyanisa zviratidzo izvi.

Sei chirwere ichi cheHyperaldosteronism chichiitika?

Sezvatakambokurukura, zvikonzero zveizvi zvinosiyana zvichienderana nemhando mbiri huru.

Zvinokonzera Hyperaldosteronism Yekutanga

Dambudziko riri pano riri muadrenal gland pachayo.

• Chikonzero chinonyanya kukosha: Kazhinji, izvi zvinokonzerwa nebundu risiri rekenza (adrenal adenoma) rinokura muadrenal gland. Iri harisi kenza, saka hapana chekunetseka nezvaro. Bundu iri rinoburitsa hormone aldosterone yakawandisa.
• Zvimwe zvikonzero zvisingawanzoitiki:
• Kukura kwegland rimwe chete readrenal (unilateral adrenal hyperplasia).
• Kugadzirwa kweAldosterone negomarara (adrenocortical carcinoma) (izvi hazviwanzoitiki).
• Chirwere chemajini chinopfuudzwa kubva kuzvizvarwa zvichienda mberi (Familial hyperaldosteronism).

Zvinokonzera Hyperaldosteronism Yechipiri

Pano ma "adrenal glands" ane hutano. Asi anosimudzirwa nechimwe chikonzero. Chikonzero chikuru ndechekuderera kweropa rinosvika kuitsvo .

Kuti tinzwisise izvi, tinofanira kuziva zvishoma nezvesisitimu inonakidza kwazvo mumuviri wedu inodzora BP. Inonzi Renin-Angiotensin-Aldosterone System .

Funga nezveizvi se "chain reaction":

1. Kana BP yedu yadzikira kana kuti sodium iri muropa redu yadzikira, itsvo dzedu dzinoinzwa.

2. Itsvo dzinobva dzaburitsa enzyme inonzi "Renin" muropa.

3. Renin iyi inoshandura puroteni inonzi "Angiotensinogen" inogadzirwa nechiropa kuita "Angiotensin I".

4. Tevere, iyi angiotensin I inova "Angiotensin II".

5. Pakupedzisira, iyi angiotensin II ndiyo inowedzera BP nekudzvanya tsinga dzeropa uye kukurudzira adrenal glands kuti igadzire aldosterone.

Zvino, mu secondary hyperaldosteronism, chinoitika ndechekuti nekuda kwechimwe chirwere, huwandu hweropa hunoenda kuitsvo hunoderera. Ipapo itsvo dzinofunga zvisirizvo kuti kumanikidzwa mumuviri kwakaderera. Saka, itsvo dzinoda rubatsiro uye ketani iyoyo inotanga. Nekuda kweizvozvo, dzinogadzira hormone yakawanda ye aldosterone, kana pasina chikonzero chayo.

Zvirwere zvinoderedza ropa rinoenda kuitsvo uye zvinokonzera hyperaldosteronism yechipiri:

• Chirwere chetsinga dzeitsvo dzinoita sedzinovhara.
• Zvirwere zvinokonzera kuti mvura iungane mumuviri, zvakaita sekushaya simba kwemoyo.
• Kurwara kwechiropa.
• Nephrotic syndrome, chirwere cheitsvo.

Chiremba anoongorora sei chirwere ichi?

Kana ukaudza chiremba wako nezvezviratidzo zvako, kunyanya BP yakakwira isingadzoreki nemishonga, anogona kufungidzira kuti une chirwere ichi. Zvadaro, vanogona kuraira bvunzo dzinoverengeka kuti vasimbise izvi.

1. Kuongororwa kweropa:

• Kana panel yeropa re electrolyte yenguva dzose ikaona huwandu hwe sodium hwakakwira zvishoma (Hypernatremia) uye huwandu hwakaderera hwe potassium (Hypokalemia) , fungidziro inowedzera.
• Tevere, kune bvunzo mbiri dzeropa dzinogona kushandiswa kuongorora chirwere ichi: Plasma Renin Concentration (PRC) kana Plasma Renin Activity (PRA) .
• Kana uine chirwere chePrimary Hyperaldosteronism, huwandu hwe renin yako (PRC nePRA) huchava hwakaderera pane hwakajairwa.
• Kana uine hyperaldosteronism yechipiri , huwandu hwe renin yako huchava hwakakwira kupfuura zvakajairwa.

2. Kuedzwa kweAldosterone Depression:

• Kuongororwa uku kunosanganisira kukupa sodium yakawedzerwa (munyu) kwenguva yakati rebei. Inogona kuva mushonga waunonwa nemuromo kana mushonga wesaline waunoisa mutsinga.
• Zvadaro, weti yako inounganidzwa mukati memaawa makumi maviri nemana uye huwandu hwealdosterone muweti iyoyo hunoyerwa.
• Mumunhu ane hutano hwakanaka, kunwa sodium yakawanda kunoderedza kugadzirwa kwealdosterone mumuviri. Zvisinei, mumunhu ane hyperaldosteronism, izvi hazviitike.

3. Miedzo yeMifananidzo:

• Kana bvunzo dzeropa dzikaonekwa kuti une chirwere cheprimary hyperaldosteronism, chiremba wako acharaira kuti uedze seCT scan (Computed Tomography scan) kuti aone chikonzero. Izvi zvinogona kutarisa bundu riri paadrenal gland.

Ndezvipi zvinorapwa izvi?

Kurapwa kunoenderana nechikonzero chechirwere ichi. Zvisinei, chinangwa chikuru ndechekudzora BP yako.

• Kune chirwere chepfungwa chinonzi primary hyperaldosteronism chinokonzerwa nebundu:

Kazhinji, vanachiremba vanokurudzira kubviswa kwebundu pamwe chete negland rinobatana naro.. Huwandu hweropa revanhu vazhinji uye potassium zvinodzokera pahunhu hwavo mushure mekuvhiyiwa uku. Zvisinei, vamwe vanhu vanogona kuramba vaine BP yakakwira mushure mekuvhiyiwa, uye vachafanira kuramba vachitora mishonga.

• Kune zvimwe zvikonzero uye hyperaldosteronism yechipiri:

Muzviitiko izvi, kurapwa kunoitwa nemushonga . Zvakare, kana chiri chirwere chechipiri, zvakakosha kurapa chirwere chiripo (semuenzaniso, chirwere chemwoyo).

Mimwe yemishonga inonyanya kushandiswa pachinangwa ichi ndeiyi:

• Spironolactone (Spironolactone - Aldactone®)
• Eplerenone (Eplerenone – Inspra®)
• Amiloride (Amiloride - Midamor®)

Chii chichaitika mushure mekurapwa? Uye matambudziko acho ndeapi?

Kufanotaura kwechirwere ichi, kureva kuti, mamiriro eramangwana, kunoenderana nechikonzero chacho.

Kurwara kwechirwere cheprimary hyperaldosteronism kunowanzo bvumidzwa zvakanaka kana kukaongororwa nekukasika uye kukarapwa zvakakodzera . Muchirwere chechipiri chehyperaldosteronism, mhedzisiro yacho inoenderana nekuti chirwere chiripo chinogona kudzorwa here.

Matambudziko makuru anogona kuitika muchirwere ichi anokonzerwa neBP yakakwira isingadzoreki kwenguva yakareba. Aya matambudziko akakomba ane chekuita nehurongwa hwemwoyo.

Saka, zvakakosha zvikuru kudzora BP nemazvo.

Mamiriro ezvinhu aya anogona kudzivirirwa here?

Kazhinji, hapana chatingaita kudzivirira chirwere ichi kuti chisaitike. Nekuti chinokonzerwa nekuchinja kunoitika mumuviri wedu. Asi chinhu chakanakisa ndechekuti kana changoonekwa, chinogona kurapwa uye matambudziko anogona kudzivirirwa.

Hyperaldosteronism, aldosterone, adrenal glands, Conn's syndrome, BP yakakwira, BP, pressure, potassium, sodium, itsvo, mahormone