Dzimwe nguva unonzwa sekuti chimwe chinhu mumuviri wako hachisi kushanda zvakanaka here? Kune zvimwe zvirwere zvisinganzwisisike, mazita azvo anogona kutyisa zvishoma. Chimwe chirwere chakadaro chisinganyanyi kunzwiwa, asi chakakosha kuziva nezvacho, iPseudohypoparathyroidism (PHP). Kunyangwe zita racho ringaita serakareba zvishoma, ngatirambei takariverenga.

Chii chinonzi pseudohypoparathyroidism?

Zvichitaurwa zviri nyore, ichi chirwere chisingawanzoitika mumajini . Tine magland madiki mumiviri yedu anonzi parathyroid glands. Aya anogadzira hormone inonzi Parathyroid Hormone (PTH). Iyi PTH hormone inokosha zvikuru kumiviri yedu. Nekuti, iyi hormone inobatsira kuchengetedza huwandu hwakakwana hweCalcium, Phosphorus, uye Vitamin D muropa redu.

Zvino, unoziva here zvinoitika kumunhu ane pseudohypoparathyroidism (PHP)? Kunyangwe parathyroid glands yavo ichigadzira PTH hormone kazhinji, masero ari mumuviri wavo haapindure nayo zvakanaka, zvichireva kuti havagone "kuiona". Zvakafanana nemunhu ari kutaura newe asi haugone kumunzwa. Tinodaidza izvi kuti Parathyroid Hormone Resistance .

Chii chinoitika nekuda kweizvi? Mazinga ecalcium muropa anodzikira, ukuwo mazinga ephosphorus achikwira. Kusawirirana uku kunogona kukonzera kugwinha kwetsandanyama, kusanzwa, pfari, uye matambudziko emazino.

Chinokosha ndechekuti chirwere ichi chinonzi PHP chakasiyana nechirwere chinonzi Hypoparathyroidism. Vanhu vane hypoparathyroidism havagadzi hormone yePTH yakakwana pakutanga. Zvisinei, muPHP, hormone inogadzirwa, asi muviri hauishandisi.

Ndeapi marudzi makuru ePHP?

Kune mhando dzinoverengeka dzemamiriro aya ePHP. Ngationei kuti ndeapi.

Mhando yePHP-1

Iyi ndiyo mhando yePHP inonyanya kuwanikwa . Pamusoro pekusagona kwehomoni yePTH yambotaurwa, dzimwe shanduko muhurongwa hwemapfupa dzinogona kuonekwa. Semuenzaniso:

• Kutenderera kwechiso
• Kureba kwakaderera (kupfupika kwehurefu)
• Kurwadziwa kwemutsipa
• Kutyoka kwemaoko netsoka

Vanachiremba vanoti izvi zvinosanganisa zviratidzo zvinonzi Albright Hereditary Osteodystrophy (AHO) . Vanhu vane PHP-1 vane dambudziko iri nekuda kwerudzi rwejini rinonzi `GNAS' ravanogara nhaka kubva kune mumwe wevabereki vavo.

Pseudopseudohypoparathyroidism (PPHP)

Iyi imhando yePHP-1 shoma. Vanhu vane PPHP (Pseudopseudohypoparathyroidism) vanogona kunge vaine zviratidzo zvemuviri zvinoonekwa muAHO (sekumeso kwakatenderera uye mupfupi), asi havana PTH hormone resistance . Izvi zvinoreva kuti calcium nephosphorus yavo zvakajairika.

Mhando yePHP-2

Vanhu vane PHP-2 vane PTH hormone resistance, zvinoreva kuti vane calcium shoma uye phosphorus yakawanda. Asi havana chimiro chemuviri (sekumeso kwakatenderera uye mupfupi) chinoonekwa muAHO. Vaongorori havasati vawana kuti chii chinokonzera chirwere chemajini cherudzi urwu chePHP-2.

Ndezvipi zviratidzo zvePHP?

Zviratidzo zvePHP zvinogona kusiyana kubva pamunhu kuenda kune mumwe . Izvi zvinoreva kuti havasi vese vanozosangana nezviratidzo zvakafanana. Zvimwe zviratidzo zvakajairika zvinosanganisira:

• Kurwadziwa kwetsandanyama
• Kurwadziwa kwetsandanyama nguva nenguva : Kunzwa sekunge gumbo riri kudhonzwa.
• Kunzwa kusanzwa kana kukwenya mumakumbo
• Kubatwa nepfari
• Kunonoka kubuda kwemeno
• Kupera simba kwe enamel yemazino
• Kuderera kweropa
• Vhudzi nenzara zvisina kusimba
• Kunetseka
• Kuora mwoyo

Vanhu vane PHP-1 vanogona kusangana nezvimwe zviratidzo zvinoperekedza chirwere cheAlbright hereditary osteodystrophy (AHO) chambotaurwa. Vamwe vanhu vane PHP vanogonawo kusangana nezviratidzo izvi:

• Kutenderera kwechiso
• Kureba kupfupi (kupfupika kwehurefu)
• Kurwadziwa kwemutsipa
• Mapfupa mumaoko netsoka : Magunwe, kunyanya emunwe wechina newechishanu, anogona kuita seakatenderedzwa mukati.
• Kufuta : Zvinoreva kufuta.
• Kutadza kuona zvakanaka : zvinhu zvakaita sematarakita, kuona zvisipo, uye kunzwa chiedza.
• Mapundu ari pasi peganda rako
• Kunonoka kukura : Vamwe vana vanogona kusangana nekunonoka kukura.

Ndezvipi zvikonzero zvePHP?

Chikonzero chikuru chechirwere ichi kusiyana kwemajini edu, kunyanya mujini rinonzi `GNAS` . Vamwe vanhu vanochigara nhaka kubva kuvabereki vavo . Izvi zvinoreva kuti chinogara nhaka. Asi dzimwe nguva chirwere ichi chinogona kuitika pasina nhoroondo yemhuri uye hapana chikonzero chingawanikwa.

PHP inowanzoonekwa muhucheche kana muhudiki , asi dzimwe nguva inogona kuonekwa muhukuru.

Ndezvipi zvinetso zvinogona kuitika nePHP?

Kana uine PHP, une mukana wekuva nemamwe matambudziko e endocrine system . Matambudziko aya ane chekuita nemahormone anogona kukonzera zviratidzo zvakaita sekushaya simba uye kushaya chido chebonde.

Vamwe vanhu vane PHP vari panjodzi huru yekubatwa nezvirwere zvakaita se:

• Kurwara neParkinson: Kuratidza zviratidzo zvakafanana nechirwere cheParkinson.
• Kuoma nehunyanzvi hwekufambisa makumbo : Izvi zvinoreva kuoma nemabasa akanaka akadai sekudzvanya mabhatani kana kunyora.
• Carpal Tunnel Syndrome : Kunyanya kune avo vane PHP-1. Ichi chirwere apo tsinga iri muruoko inomanikidzwa, zvichikonzera kusanzwa uye kurwadziwa muruoko.
• Stenosis yemusana
• Kusagona kufema zvakanaka : Kunyanya kuvana.

Vanachiremba vanoongorora sei PHP?

Kana uchifungidzira kuti une PHP, chiremba wako anotanga akuongorora muviri . Vachakubvunzawo nezvenhoroondo yemhuri yako. Vanogona kuita mimwe miedzo yakati wandei kuti vasimbise chirwere chacho. Izvi zvinosanganisira:

• Kuongororwa kweropa : Kuyera huwandu hwemahormone, kunyanya calcium, phosphorus, uye PTH.
• Kuongororwa kweweti : Tarisa huwandu hwecalcium nephosphorus muweti.
• Kuongororwa kwemajini : Tarisa shanduko dziri mujini re'GNAS'.
• Electrocardiogram (EKG) : Inotarisa kusashanda zvakanaka kwemoyo.
• X-ray yemaoko : Tarisa kana mapfupa akatyoka uye zvimwe shanduko.
• Kuongororwa kweCT (CT - Computed Tomography scan) : Kuona kana paine shanduko dziri kuitika muuropi.

Zvichibva paruzivo rwakawanikwa kubva muongororo idzi kuti chiremba anogona kunyatsosimbisa mamiriro ePHP.

PHP inobatwa sei?

Hapana mushonga wechirwere ichi parizvino . Asi usazvidya moyo. Nekurapwa uye kurapwa kwakakodzera, unogona kudzora zviratidzo zvako uye kurarama hupenyu hwakajairika.

Chinangwa chikuru chekurapa ndechekuchengetedza huwandu hwakakwana hwecalcium nephosphorus muropa rako . Kuchengetedza huwandu uhwu kunogona kuderedza zviratidzo zvikuru. Uku kurapa kwehupenyu hwese .

Sarudzo dzekurapa dzingasanganisira:

• Zvinowedzerwa zvecalcium nevhitamini D : mumapiritsi kana muchimiro chemvura.
• Macapsule eCalcitriol : Uyu mushonga unowedzera huwandu hwecalcium mumuviri.
• Jekiseni reCalcitriol
• Kurapa kwehomoni yekukura kana thyroid hormone : kana zvichidikanwa.
• Kudya kune calcium yakawanda uye phosphorus shoma : Sezvakakurudzirwa nenyanzvi yezvekudya.

Chinhu chinonyanya kukosha ndechekunyatsotevera mazano echiremba uye kuongororwa panguva.

Ndinofanira kuona chiremba rini?

Kana uine PHP, zvakakosha kuti ugare uchiona chiremba wako kuti calcium nephosphorus zviongororwe . Kuongororwa uku nguva dzose kuchakubatsira kuti zvinhu zvese zvirambe zviri pasi pesimba rako.

Kana ukaona zviratidzo zvakakomba zvakaita sekuoma kufema kamwe kamwe, kugwinha kwetsandanyama kwakanyanya, kana pfari , enda kuchipatara chiri pedyo nekukurumidza kana kufonera 1990.

Chii chaungatarisira kana uchirarama nemamiriro ezvinhu ePHP?

Kana uine PHP, unofanira kuramba uchishanda naChiremba wako Mukuru . Nekuti PHP inogona kukanganisa nhengo dzakasiyana dzemuviri, ungangoda kuona nyanzvi dzakasiyana kuti dzigadzirise zviratidzo zvako. Chikwata chako chekurapa chinogona kusanganisira:

• Nyanzvi dzeEndocrinologists : Nyanzvi dzemahormone.
• Vanachiremba vemapfupa : Kune matambudziko ane chekuita nemapfupa.
• Vanachiremba vevana : Kana ari mwana.
• Vanachiremba vepfungwa : Kune matambudziko ane chekuita nehurongwa hwetsinga.
• Varapi vemuviri
• Varapi vepabasa
• Nyanzvi dzezvekudya
• Vanachiremba vemazino
• Nyanzvi dzezvemajini
• Nyanzvi dzekurapa marwadzo

Zvingangoitika kuti uchafanira kutora mishonga iyoyo kweupenyu hwako hwese .

Kukura uye kugona kwepfungwa zvinogona kusiyana zvakanyanya zvichienderana nerudzi uye kuoma kwechirwere. Zvisinei , kazhinji, vanhu vane PHP vane nguva yekurarama yakajairika kana tichienzanisa nevanhu vasina PHP . Chiremba wako anogona kukuudza zvekutarisira zvichienderana nemamiriro ako ezvinhu.

Nekuti PHP chirwere chisingawanzoitiki, zvinogona kuoma kuwana vamwe vane chirwere chakafanana newe . Chinogonawo kunzwa kusurukirwa dzimwe nguva. Kana iwe kana mwana wako akaonekwa kuti ane PHP, taura nachiremba wako nezvemapoka ekutsigirana uye zvekushandisa pakudzidzisa . Izvi zvinogona kukubatsira kuwana nzira dzekuvandudza zviratidzo zvako uye hupenyu hwako hwese.

Mharidzo Yekuenda Nayo Kumba

Zvakanaka, ngatitarisei zvimwe zvinhu zvekurangarira nezve pseudohypoparathyroidism (PHP) yatave tichitaura nezvayo.

• PHP chirwere chisingawanzoitiki chemajini umo muviri usingapindure zvakanaka kune parathyroid hormone (PTH).
• Izvi zvinoita kuti calcium muropa iderere uye phosphorus iwedzere.
• Kune mhando huru dzakasiyana-siyana : PHP-1, PHP-2, uye PHP-3.Ehe. PHP-1 inogona kukonzera shanduko mumapfupa inonzi AHO.
• Zviratidzo zvakasiyana-siyana zvinogona kuitika, zvakaita sekugwinha kwetsandanyama, kusanzwa, pfari, matambudziko emazino, kupfupika kwehurefu, uye kumeso kwakatenderera .
• Chikonzero chikuru ndechekushanduka kwejini re'GNAS' .
• Kunyange zvazvo pasina mushonga wakakwana, zviratidzo zvinogona kudzorwa nekurapwa kwehupenyu hwese (calcium, vhitamini D, kudya kwakakosha).
• Kuongororwa nachiremba nguva dzose uye rutsigiro rwevanachiremba vane hunyanzvi zvakakosha.
• Vanhu vazhinji vanogona kurarama hupenyu hwakajairika .
• Rubatsiro kubva kumapoka ekutsigirana rwakakosha zvikuru kuti pfungwa dzirambe dzakasimba.

Usakanganwa kuti hausi wega. Kunyangwe ichi chiri chirwere chisingawanzoitiki, chinogona kurapwa zvakanaka nemazano ekurapa akakodzera uye rutsigiro. Yeuka kuti vanachiremba, mhuri, neshamwari varipo kuti vakubatsire kana uchida simba.

` Pseudohypoparathyroidism, PHP, parathyroid hormone, calcium, phosphorus, zvirwere zvemajini, AHO