Kune zvimwe zvirwere, chiremba wako anokupa mishonga inorwisa mabhakitiriya, handiti? Kazhinji ndiwo mushonga mukuru watinoshandisa pakurapa hutachiona hwemabhakitiriya. Asi dzimwe nguva, zvisinei nekuti mishonga ipi yatinopa, tinogona kuramba kuirwisa, uye mabhakitiriya ane njodzi (atinodaidzawo kuti 'zvipembenene zvikuru') anogona kupinda mumiviri yedu. Saka tinoita sei munguva dzakadai? Nhasi tichataura nezvekurapa kusinganzwisisike asi kwakasimba zvikuru kunogona kubatsira munguva dzakadai. Ndiko kurapa kwePhage.
Zvichitaurwa zviri nyore, chii chinonzi Phage Therapy?
Phage kana kuti bacteriophage rudzi rwevhairasi. Usatya kubvunza kuti, "Ivhairasi here?" Iyi haisi vhairasi yakaita seCorona kana Dengue inotirwarisa. Chinhu chega chinonangwa uye chikafu chevhairasi idzi mabhakitiriya. Haakuvadzi masero evanhu. Funga nezvazvo semutongi akadzidziswa kuvhima mabhakitiriya.
Phage haisi hutachiona hwakagadzirwa nevanhu. Inowanikwa kwese kwese pasi rose - muvhu, mumvura, uye, zvinoshamisa, mumuviri wako. Saka, kurapwa nephage kunosanganisira kushandisa iyi phage virus, inova 'muvengi' chaiye webhakitiriya iroro, kurwisa mabhakitiriya asingagone kuuraya kunyangwe mishonga inorwisa mabhakitiriya.
Saka kurapwa uku kunoshanda sei?
Iyi inzira inonakidza yechisikigo. Utachiona hwephage hahugone kuzvibereka hwega, kureva kuti, kuwanda. Zvechokwadi hunoda bhakitiriya kuti huite izvozvo.
1. Kuziva chinangwa: Kutanga, hutachiona hwephage hunowana bhakitiriya raunogona kuparadza uye rinozvibatanidza pamusoro paro.
2. Kuisa DNA: Tevere, vhairasi yephage inoisa ruzivo rwayo rwemajini, kureva DNA, musero rebhakitiriya.
3. Kudzora: Sero rebhakitiriya rava pasi pesimba revhairasi yephage. Richishandisa simba rese revhairasi, rinotanga kugadzira mazana emavhairasi matsva ephage richishandisa DNA yapinda.
4. Kuparadzwa nekupararira: Kana pasina nzvimbo mukati mesero rebhakitiriya yekuumbwa kwemavhairasi matsva ephage, sero rebhakitiriya rinoputika. Zvadaro, mazana ezviuru zvemavhairasi matsva aya anobuda, owana mamwe mabhakitiriya, uye otanga kuaparadzawo.
Vanachiremba vanoshandisa nzira iyi nenzira inotevera: Vanoona mabhakitiriya chaiwo ari kukonzera hutachiona mumuviri wako. Zvadaro, kubva mu 'library yephage' ine zviuru zvemaphage akasiyana, vanosarudza phage chaiyo inorwisa mabhakitiriya iwayo voishandisa pakurapa.
Imwe tsvakiridzo yakawana kuti kurapwa ne phage, kana kukabatanidzwa nemishonga inorwisa mabhakitiriya iripo, kunowedzera kushanda kwemishonga iyoyo inorwisa mabhakitiriya.
Kune mamiriro akati wandei apo kurapwa uku kunogona kubatsira:
- Zvirwere zvemapapu zvine chekuita ne cystic fibrosis
- Utachiona hwenzeve hunokonzerwa nebhakitiriya reP. aeruginosa
- Zvimwe zvirwere zvinokonzerwa neE. coli kana P. aeruginosa bacteria
- Utachiona hwemaronda emakumbo asingapore
- Utachiona hwemaziso hunokonzerwa nebhakitiriya
- Sepsis (utachiona hweropa) muvana vacheche
- Utachiona hwemunzira yeweti
- Utachiona hwemaronda mushure mekuvhiyiwa
Ndezvipi zvakanakira uye zvakaipa zvekurapa ne phage?
Kufanana nemamwe marapirwo, uyu une zvakanakira uye njodzi. Ngatitarisei zvese zviri zviviri. Ngatitangei nekukurukura nezvezvakanakira.
| Kubatsirwa | Tsananguro |
|---|---|
| Chinangwa chaicho | Patinoshandisa mishonga inorwisa mabhakitiriya, inouraya mabhakitiriya akaipa nemabhakitiriya akanaka anobatsira miviri yedu. Asi mushonga we phage therapy wakanyatsojeka. Unongorwisa mabhakitiriya akaipa ari kukonzera chirwere ichi chete. Saka hapana kukuvara kudiki kune mamwe masero mumuviri kana mabhakitiriya akanaka. |
| Kuwanikwa kwakakura | Kana bhakitiriya rikaramba mushonga unorwisa mabhakitiriya, mamwe maantibiotic atinofanira kushandisa anogumira. Asi kune mamiriyoni emaphages aripo. Kana phage imwe ikasashanda, pane mukana wekuti pachawanikwa imwe phage yakakodzera mabhakitiriya akafanana. |
| Kugadzirwa nekukurumidza | Zvinotora makore kugadzira mushonga mutsva unorwisa utachiona, asi mushonga wekurapa unokodzera hutachiona hwemurwere unogona kuonekwa uye kuenzaniswa mukati memazuva mashoma. Izvi zvinoreva kuti kurapwa kunogona kutanga nekukurumidza. |
Izvi zvinogona kukonzera kukuvara here? Ndezvipi njodzi dziripo?
Pane zvinhu zvakati wandei zvinonetsa vanachiremba pavanenge vachitaura nezvekurapa uku.
- Kushaikwa kweruzivo rwakakwana: Kunyangwe hazvo kurapwa kwe phage kwave kuchishandiswa kwenguva yakati munyika dzakadai seRussia nePoland, miedzo mikuru yekiriniki yepasi rose ichiri muchikamu chekutanga. Nokudaro, hapana ruzivo rwakakwana rwekutaura zvine chokwadi che100% kuti mhedzisiro yekurapa uku ndeyei kwenguva pfupi uye kwenguva refu.
- Njodzi yeSeptic Shock: Iyi ndiyo njodzi huru. Kana mavhairasi ephage achikurumidza kupwanya masero ebhakitiriya, zvinhu zvine chepfu zvinonzi endotoxins zviri mukati memasero iwayo zvinogona kuburitswa mumuviri. Izvi zvinogona kukanganisa masoja emuviri, kukonzera kuderera kweropa kamwe kamwe, uye kukonzera kutadza kushanda kwenhengo dzemuviri. Asi yeuka, njodzi iyi yakafanana kana uchishandisa mishonga inorwisa mabhakitiriya yakasimba.
- Njodzi yekutamiswa kweDNA: Mavhairasi ePhage anogona kutamiswa DNA kubva kune rimwe bhakitiriya kuenda kune rimwe. Saka vamwe vanhu vanotenda kuti kutamiswa kweDNA uku kunogona kutungamira mukuumbwa kwemarudzi matsva, ane njodzi emabhakitiriya. Asi hapana chikonzero chekunetseka, nekuti masayendisiti anonyatsoongorora maphage anoshandiswa mukurapa uku uye vanongosarudza chete ayo asina chepfu kana majini anokuvadza.
Mushonga uyu unowanikwa here kuSri Lanka?
Panguva ino, kurapwa kwe phage hakusati kwave kurapwa kwakajairika munyika dzakawanda pasi rose, kusanganisira Sri Lanka. Kuchiri muchikamu chekutsvagisa, kana kuti kuri pasi pechikamu che "kushandiswa kwetsitsi." Izvi zvinoreva kuti vanachiremba vanogona chete kupa kurapwa uku mune emergency, kana mamwe marapirwo ese akatenderwa akundikana uye pasina imwe sarudzo yekuponesa hupenyu , nemvumo yakakosha.
Nzira iyi yekurapa ine makore anopfuura zana. Kunyangwe yaishandiswa zvakanyanya kunyangwe muAmerica muma1940, yakapera zvishoma nezvishoma nekuwanikwa kwemishonga inorwisa mabhakitiriya. Asi ikozvino sezvo dambudziko remabhakitiriya asingaurayiwi nemishonga inorwisa mabhakitiriya rave dambudziko guru pasi rose, kwave nekufarira patsva mukurapa kwephage. Saka, tsvakiridzo pane izvi iri kuitika nekukurumidza pasi rese.
Mharidzo Yekuenda Nayo Kumba
- Kurapa nePhage (phage therapy) kushandisa rudzi rwakasiyana rwevhairasi (phage) kuparadza mabhakitiriya.
- Iyi inogona kuva mhinduro yakakosha mune ramangwana yezvirwere zvakakomba zvakaita se 'superbugs' dzisingaurayiwi nemishonga inorwisa mabhakitiriya.
- Nekuti mushonga uyu unorwisa mabhakitiriya akaipa chete, hapana kukuvadza kwakanyanya mabhakitiriya anobatsira mumuviri.
- Izvi zvichiri muchikamu chekutsvagisa munyika dzakawanda pasi rose uye hazvisati zvabvumidzwa kushandiswa nevanhu vose.
- Kana iwe kana mumwe munhu waunoda aine hutachiona hwemabhakitiriya hunogara kwenguva refu, chinhu chakanakisa chekuita kutaura nachiremba wako mokurukura nzira dzese dzekurapa dziripo.
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