Ngaba ugqirha wakho ukunike iyeza loxinzelelo lwegazi oluphezulu okanye, ukuba uyindoda, lokukhulisa i-prostate? Ukuba kunjalo, kusenokwenzeka ukuba eli yeza liyi-alpha-blocker. Nangona igama lisenokuvakala liyinkimbinkimbi, la luhlobo lwamayeza asetyenziswa kakhulu ukunceda ukulawula iimeko ezithile emzimbeni wethu. Ke namhlanje, masithethe ngezi alpha-blockers ngendlela elula onokuyiqonda.
Zisebenza njani ezi alpha-blockers?
Ukuze siqonde oku, makhe sicinge ngenkqubo yonxibelelwano yomzimba wethu. Inkqubo yethu yemithambo-luvo ifana nenkonzo yeposi. Ithumela imiyalezo yamakhemikhali (esiyibiza ngokuba yi-"Neurotransmitters") kwiindawo ezahlukeneyo zomzimba wethu. Ukuze sifumane le miyalezo, iiseli zethu zine "receptors" ezikhethekileyo. Ifana nesitshixo kunye nesitshixo. Kuphela xa umyalezo wamakhemikhali (isitshixo) ufika kwaye ungene kwi-receptor efanelekileyo (isitshixo) apho loo seli isebenza khona.
Ii-alpha-receptors luhlobo lwe-receptor emizimbeni yethu. Zifumaneka kakhulu kwimithambo yegazi nakwiindawo ezifana ne-prostate gland. Xa ezi alpha-receptors zifumana umyalezo, ezo seli ziqala ukucutheka. Umzekelo, xa ii-alpha-receptors kwimithambo yegazi zisebenza, imithambo yegazi iyacutheka kwaye uxinzelelo lwegazi luyanda.
Ngoko ke, into eyenziwa yi-alpha-blocker kukuba ifana nokufaka isitshixo esingalunganga kwi-turtle uze uyivale. Eli yeza liyahamba lize linamathele kwezo alpha-receptors kwaye libathintele ekufumaneni umyalezo ochanekileyo. Oko kukuthi, 'liyazivimba' ezo receptor. Emva koko ezo seli azinciphi, ziyaphumla. Xa iiseli ezikwimithambo yegazi ziphumla, imithambo yegazi iyakhula, kwaye uxinzelelo lwegazi luyehla. Xa izihlunu ezikwi-prostate ziphumla, kuba lula ukuchama. Yiloo nto kanye eyenzekayo.
Iintlobo zee-alpha-receptors kunye nemisebenzi yazo
Kukho iintlobo ezimbini eziphambili ze-alpha-receptors: i-alpha-1 (A1) kunye ne-alpha-2 (A2). Zombini zinemisebenzi eyahlukileyo kancinci.
| Uhlobo lweSamkeli | Indawo kunye nemisebenzi ephambili |
|---|---|
| Isamkeli se-Alpha-1 (A1) |
|
| I-Alpha-2 (A2) receptor |
|
Zeziphi iimeko ezisetyenziselwa i-alpha-blockers?
Olu hlobo lwamayeza lusetyenziswa kakhulu ukunyanga izifo ezahlukeneyo.
1. Uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi oluphezulu)
Le yeyona ndlela iphambili yokusebenzisa. Njengoko besitshilo ngaphambili, ii-alpha-blockers ziphumza imithambo yegazi kwaye zinciphisa uxinzelelo lwegazi. Amayeza afana neDoxazosin, iPrazosin, kunye neTerazosin asetyenziswa kakhulu kule njongo.
2. I-Benign Prostatic Hyperplasia (BPH)
I-BPH yimeko exhaphakileyo eyenzeka kumadoda njengoko ekhula. Kule meko, i-prostate gland iyakhula ize icinezele i-urethra, nto leyo ebangela iingxaki ezifana nobunzima bokuchama kunye nokugcinwa komchamo. Ii-Alpha-blockers ezifana neTamsulosin, Alfuzosin, kunye neSilodosin ziphumza izihlunu ze-prostate kunye nentamo yesinyi, okwenza kube lula ukuba umchamo uphume.
3. Ezinye iindlela zokusetyenziswa (Ukusetyenziswa ngaphandle kweleyibhile)
Ngamanye amaxesha, oogqirha, ngokusekelwe kumava abo kunye nobungqina bezonyango, banika iyeza kwiimeko ezingezizo ezo livunyiweyo. Oku kubizwa ngokuba kukusetyenziswa 'okungekho kwileyibhile'.
- Amatye Ezintso: Amayeza afana neTamsulosin anikwa ukunceda amatye amancinci anamathele kumchamo ukuba adlule lula.
- Ingxaki yoxinzelelo emva kwesiganeko esibuhlungu (amaphupha amabi anxulumene nePTSD): Iyeza iPrazosin ngamanye amaxesha lisetyenziselwa ukunyanga le meko.
- I-Pheochromocytoma: Olu luhlobo lwethumba olukhula kwiindlala ze-adrenal kwaye luvelise iihomoni ezininzi kakhulu. Ii-Alpha-blockers zikwanikwa ukulawula uxinzelelo lwegazi oluphezulu olubangelwa zezi thumba.
Zithini iziphumo ebezingalindelekanga kunye neengozi ze-alpha-blockers?
Njengayo nayiphi na imithi, ii-alpha-blockers zinokuba nemiphumo emibi. Yiyo loo nto oogqirha belumkile kakhulu xa benika la mayeza. Iziphumo ebezingalindelekanga ozifumanayo zinokwahluka ngokuxhomekeke kuhlobo lwamayeza owathathayo.
Into ebaluleke kakhulu "yimpembelelo yedosi yokuqala." Xa usela ipilisi yokuqala ye-alpha-blocker, uxinzelelo lwakho lwegazi lunokwehla ngequbuliso kakhulu. Oku kunokubangela isiyezi , umbono ofipheleyo, kunye nokuziva uwile xa usukuma (orthostatic hypotension) . Ukunciphisa lo mngcipheko, ugqirha wakho uya kukuxelela ukuba uthathe iyeza ngaphambi kokuba ulale kwaye uqale ngedosi ephantsi.
Nazi ezinye zeziphumo ebezingalindelekanga eziqhelekileyo:
- Ukuba nesiyezi okanye ukubona izinto ezingacacanga (ingakumbi xa umi)
- Intloko ebuhlungu
- Ndiziva ndidiniwe
- Ukuxinana kwempumlo
- Ukubetha kwentliziyo ngokukhawuleza (i-tachycardia)
- Iziphumo ekusebenzeni ngokwesondo: Amanye amadoda anokufumana imeko ebizwa ngokuba yi-anejaculation. Kunqabile kakhulu ukuba kubekho ukudumba okubuhlungu okuhlala iiyure ezingaphezu kwe-4 (priapism). Le yimeko efuna unyango olungxamisekileyo.
Izinto ekufuneka uzikhumbule xa usebenzisa eli yeza
- Ukusebenzisana namanye amayeza: I-Alpha-blockers inokusebenzisana namanye amayeza oxinzelelo lwegazi, amanye amayeza okungasebenzi kakuhle kwe-erectile, kunye namanye amayeza. Ngoko ke, kubalulekile ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo.
- Ukusela utywala: Ukusela utywala kunokunyusa iziphumo ebezingalindelekanga ezifana nesiyezi .
- Utyando lwe-cataract: Ukuba uceba ukwenza utyando lwe-cataract, ngokuqinisekileyo kufuneka wazise ugqirha wakho wamehlo ukuba usebenzisa i-alpha-blockers, kuba la mayeza anokubangela iingxaki ngexesha lotyando.
- Ukuyeka amayeza: Ungaze uyeke ukuthatha la mayeza ngequbuliso ngaphandle kokubonisana nogqirha wakho. Ukwenza njalo kunokubangela iziphumo ebezingalindelekanga, ezifana noxinzelelo lwegazi oluphindaphindeneyo. Ukuba kufuneka uyeke ukuwasebenzisa la mayeza, yenza njalo ngendlela ekhuselekileyo nangokwemiyalelo kagqirha wakho.
Ufanele ufune nini ingcebiso kagqirha?
Ukuba unemibuzo malunga namayeza, okanye ukuba iziphumo ebezingalindelekanga zenza kube nzima ukwenza imisebenzi yemihla ngemihla, thetha nogqirha wakho.
Nangona kunjalo, ukuba ufumana naziphi na kwezi mpawu zilandelayo, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele ngoko nangoko:
- Ukulahlekelwa yingqondo okanye ukuquleka
- Intlungu yesifuba (`(Angina)`)
- Ubunzima bokuphefumla
- Ukubetha kwentliziyo okukhawulezayo okanye okungahambelaniyo (i-palpitations)
- Ukuma okubuhlungu okuhlala ixesha elingaphezu kweeyure ezi-4 (`(Priapism)`)
- Iimpawu zempendulo enkulu ye-allergy (umz., ukurhawuzelela, ukurhawuzelela, ukudumba kobuso/umphimbo, ubunzima bokuginya)
Umyalezo Wokuya Ekhaya
- Ii-Alpha-blockers ziluhlobo olubalulekileyo lwamayeza anyanga izifo ezifana noxinzelelo lwegazi oluphezulu kunye ne-benign prostatic hyperplasia (BPH).
- Ezi zisebenza ngokukhulula imithambo yegazi kunye nemisipha ye-prostate gland.
- Xa uqala amayeza, ingakumbi emva komthamo wokuqala, unokuba nesiyezi , ngoko ke thatha ebusuku, njengoko ugqirha wakho eyalele.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
- Ungaze uyeke ukuthatha la mayeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinzulu, funa ingcebiso kagqirha ngoko nangoko.
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