Ukuba une-Ankylosing Spondylitis, okanye i-AS, uyazi ukuba kunzima kangakanani ukufumana iintlungu zomqolo kunye namalungu kunye nokuqina. Nangona abantu abaninzi befumana isiqabu ngamayeza akhoyo, ayinguye wonke umntu okwaziyo ukuwasela. Abanye abantu banokufumana iziphumo ebezingalindelekanga. Yiyo loo nto izazinzulu zihlala zizama ukufumana unyango olungcono lwesi sifo. Olunye unyango oluthembisayo lunyango lweeseli ze-stem, okanye njengoko sonke sisazi, 'Unyango lweeSeli ze-Stem.' Makhe sithethe ngalo ngamazwi alula namhlanje.
Zithini ezi stem cells?
Ngamafutshane, zonke ezinye iiseli emzimbeni wethu, ezinje ngeeseli zegazi, iiseli zemisipha, kunye neeseli zolusu, zenziwa okokuqala kwezi 'seli zingoomama' ezibizwa ngokuba ziiseli ze-stem. Zicinge njengephepha elingenanto. Ezi seli zinokwenza iikopi zazo. Zinokuba nalo naluphi na uhlobo lweseli olufunwa ngumzimba. Umzekelo, ezi seli zinamandla amangalisayo okulungisa izicubu kunye namalungu omzimba awonakeleyo.
Ngoko ke, kolu nyango lwee-stem cell, ii-stem cells eziphilileyo ziyangeniswa emzimbeni kwaye zincede umzimba ukuba uziphilise kwisifo. Kukho iintlobo ezimbini eziphambili zale ndlela yonyango lwee-cell:
- I-Autologous: Iiseli ezithathwe kumntu ofumana unyango ziyasetyenziswa.
- I-Allogenic: Isebenzisa iiseli ezifunyenwe komnye umntu ophilileyo (abazali, abantakwabo, okanye umntu onikelayo onganxulumananga naye).
| Imithombo ephambili yeeseli ezisisiseko | Iimeko ezivunyiweyo ngoku zonyango |
|---|---|
| Iiarhente ezifana ne-FDA e-US okwangoku zivumile olu nyango kwinani eliqingqiweyo lezifo. Ezona ziphambili zizifo zomhlaza kunye nezifo ezinxulumene negazi okanye inkqubo yomzimba yokuzikhusela.
|
Ingaba olu nyango lwe-AS luyasebenza ngokwenene?
Kukho ingongoma ekufuneka siyilumkele kakhulu apha. Nangona unyango lwe-stem cell luthembisa ukunyanga izifo ezininzi kwixesha elizayo, alukavunywa ngokusemthethweni njengonyango lwe-Ankylosing Spondylitis (AS). Alukavunywa nakwiimeko ezifana ne-arthritis kunye nentlungu engapheliyo.
Ngoko ke, lumka kakhulu "kwiikliniki" ezingalawulwayo okanye "kwiziko lezonyango" ezibhengeza unyango olupheleleyo lwe-AS. Kukho ithuba elikhulu lokuba uya kwenzakaliswa lunyango olungavunywanga.
Kodwa, akufuneki silahle ithemba ngokupheleleyo. Kusenokwenzeka ukuba oku kungaba lunyango oluvunyiweyo kwixesha elizayo. Izazinzulu zisaphanda ngeentlobo ezahlukeneyo zeeseli ze-stem.
Iiseli zeMesenchymal stem (iiMSC)
Ezi luhlobo olukhethekileyo lweeseli ezinceda ekulungiseni izinto ezifana namathambo, i-cartilage, izihlunu kunye namafutha emizimbeni yethu. Zikwanceda ekulawuleni inkqubo yomzimba yokuzikhusela kunye nokulawula ukudumba emzimbeni.
Enye ingcamango phakathi kwezazinzulu kukuba kusenokwenzeka ukuba kukho into engalunganga ngezi MSC ezivela kwizigulane ze AS. Ke ngoko, bakholelwa ukuba ukufaka i-MSC kumntu ophilileyo kunokulungisa ukungalingani kwenkqubo yomzimba yokuzikhusela esisiseko se AS.
Izifundo ezimbalwa ezincinci kakhulu zibonise iziphumo ezithembisayo:
- Kolunye uphando, iiseli ze-MSC ezifunyenwe kwigazi le-umbilical cord zanikwa izigulane ezihlanu ze-AS, kwaye iintlungu kunye neempawu zazo zancitshiswa.
- Kolunye uphando, xa izigulane ezingama-31 ze-AS zanikwa iiseli ze-MSCs ezivela kumongo wethambo, ezisi-7 kwezili-10 zafumana isiqabu. Nangona kunjalo, ezi ziphumo zahlala ixesha elifutshane elimalunga neeveki ezisi-7.
- Uphando olusebenzisa iimpuku lubonise ukuba ii-MSC zinokutshintsha iiseli ezibangela ukudumba.
Kodwa kwakhona, khumbula, ezi zizifundo ezincinci kakhulu. Asinakufikelela kwizigqibo eziqinileyo de sibone iziphumo ezivela kwizifundo ezinkulu.
Lukhuselekile kangakanani olu nyango?
Kukho izinto ezilungileyo nezingalunganga kulo naluphi na unyango lwezonyango, kodwa unyango lwe-stem cell oluvunyiweyo ngokusemthethweni ludlula kuthotho lovavanyo oluqatha ngaphambi kokuba lufumaneke kuluntu.
Kwizilingo zeklinikhi ze-AS, unyango lwe-MSC lubonakalisiwe lukhuselekile ngokubanzi kwaye alubangeli miphumo mibi. Nangona kunjalo, olu nyango alusebenzi kuwo wonke umntu. Abanye abantu abafumani tshintsho kwiimpawu zabo, kodwa akukho ngxelo yokuba isifo siya sibi.
Iziphumo ebezingalindelekanga eziqhelekileyo zolu nyango zezo zibangelwa yinkqubo yokufakwa kwe-infusion.
- Umkhuhlane owenzeka okwethutyana emva konyango.
- Intlungu kwindawo yokufaka inaliti.
Abantu abafumana unyango lwee-stem cell kwizifo ezinje ngomhlaza banokunikwa i-chemotherapy okanye i-radiation, enokunyusa umngcipheko wokopha nokosuleleka. Ke ngoko, kubalulekile ukuxoxa ngale nto nogqirha wakho kwaye ucacelwe zizo zonke iingozi .
Iindleko kunye novavanyo lwezonyango
Olu nyango lunokubiza amakhulu amawaka eedola. Kwaye ngenxa yokuba luselunyango oluvavanywayo lwe-AS, i-inshorensi yakho yezempilo isenokungayigubungeli.
Enye indlela yokwenza oku kukujoyina uvavanyo lwezonyango . Ezi zizifundo ezivavanya ukusebenza kakuhle kunye nokhuseleko lwamayeza amatsha okanye unyango ngaphambi kokuba lufumaneke kuluntu.
Ungangena njani kwisilingo seklinikhi?
Ungabuza ugqirha wakho malunga novavanyo lweklinikhi olunokuba lufanelekile kuwe. Usenokuba nolwazi ngamaziko aziwayo asebenza kweli candelo.
Ngaphambi kokuba uthathe inxaxheba kuphando olunjalo, qwalasela ngononophelo zonke izinto ezilungileyo nezingalunganga. Le mibuzo iza kukunceda wenze njalo:
- Yintoni injongo ephambili yolu phando?
- Yintoni ekufuneka ndiyenze ukuze ndithathe inxaxheba?
- Ngaba kuya kufuneka ndichithe imali?
- Olu phando luza kuhlala ixesha elingakanani?
- Ngaba oku kuya kuphazamisana nezinye iindlela zonyango endizisebenzisayo ngoku?
- Kuza kwenzeka ntoni ukuba kukho into engahambanga kakuhle?
Umyalezo Wokuya Ekhaya
- I-Ankylosing spondylitis (AS) yimeko engapheliyo. Unyango lwangoku lulawula iimpawu.
- Unyango lwe-stem cell lunyango oluthembisayo, kodwa olusavavanywayo, lwe-AS. Alukavunywa ngokusemthethweni okanye unyango lwesifo.
- Lumka kakhulu kwiindawo ezingavunywanga kunye nonyango olubhengeza ukuba "luphilisa ngokupheleleyo i-AS."
- Ukuba ucinga ngalo naluphi na unyango olutsha, soloko uthetha nogqirha wakho ngaphambi kokuba wenze isigqibo kwaye waziswe ngokucacileyo ngezinto ezilungileyo nezingalunganga.
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